Back To The Age Of The '80s

"New antibiotics?!" A group of professors couldn't help but talk to each other. Since penicillin was used in clinical practice in 1943, antibiotics have been developed one after another.But most of them are too toxic to be suitable for human clinical treatment.

Unlike paamine, which treats cryocytosis, antibiotics have an extraordinary place in the history of medicine.During the Second World War, the United States put the development of penicillin and the development of the atomic bomb on an equally important position.Antibiotics are closely related to everyone, and they are really life-saving medicines in critical moments!

Antibiotics have always been a hot topic in the field of biopharmaceuticals. Numerous laboratories around the world continue to study day and night, but those few are actually used in clinical practice, which is also an important reason for the emergence of drug-resistant bacteria.Bacteria are the same as people, the same method is effective once or twice, and drug resistance will appear after hundreds of times and thousands of times.

A brand new antibiotic!How can this be!

"Accurately speaking, it is only a brand-new antibiotic for clinical use." If he remembers correctly, as early as 76, Merck researchers discovered thiamycin, and in 77, it was registered in the United States for the first time in history. A core patent of carbapenem antibiotics, counting the time, now imipenem may have been submitted for drug marketing approval.

The professors looked at each other in blank dismay. They naturally understood the meaning of Li Zheng's words, a new clinical antibiotic, that is, this antibiotic may have been developed, but it has not had time to be applied clinically.

Also, Li Zheng's amazing performance at the Asian Biopharmaceutical Conference has won the favor of many world-class biopharmaceutical experts. It is not surprising that he has private contacts to obtain some information.

But they also knew that even those with a bit of brains in their profession would not reveal important information about drugs that hadn't been marketed yet, and the person who mentioned this to Li Zheng only gave a little direction.Li Zheng is actually able to propose a molecular structure of a brand-new antibiotic through such a point, this talent is already amazing.

"Take a dead horse as a living horse doctor, Pseudomonas aeruginosa..." Professor Zhao shook his head, and he said, "Li Zheng, tell us what to do."

In fact, the professors didn't have much hope for Li Zheng, and rushed to develop a new antibiotic to treat drug-resistant bacteria that there is no medicine on the market to fight against. It's a dream!

But seeing their friends struggling on the line of life and death, if they don't do anything, they will not be able to pass this level, and almost everyone has this mentality.

Li Zheng also knew that it was impossible to develop a new antibiotic out of thin air. Even if someone pointed out the general direction under the pretext, it would be a miracle to take out the molecular structure and extract it overnight.He didn't expect these old professors to trust him, all he needed was execution.

"Then I won't be polite." The corners of Li Zheng's lips curled up slightly, and he issued a series of orders in succession.

"Professor Sun, Professor Qian, and Professor Wang, you are a team of three to separate and extract thiamycin. There is a detection reagent in the refrigerator. If the reagent turns red, the extraction is successful."

"Zhang Yuejun, you are responsible for helping the three professors to record data."

"Professor Zhao, please join me as a team." Li Zheng adjusted the temperature control and said to Professor Zhao with a smile.

Professor Zhao nodded, consciously walked to Li Zheng's side, and helped Li Zheng.

"The temperature rises another ten degrees, and Zhang Yuejun observes the performance of bacteria."

"How about bacterial activity?"

"Remember, at 64.3 degrees Celsius, the bacteria differentiated, and the bacterial activity was obvious."

…………

From noon to night, everyone didn't even have time to drink saliva. Wang Jing came back in the middle and brought back the patient's medication and reaction records from last night. As expected, the effect of several antibiotics combined was still not obvious. , Some patients have already experienced dehydration and difficulty breathing.All the doctors at Queen Mary Hospital worked continuously for 48 hours, and no one took a minute of rest.

The dean of Queen Mary Hospital made phone calls all night, begging the British General Hospital for help to let the British laboratory test the samples they sent in advance, and the British General Hospital agreed.Queen Mary Hospital received the sample test results at [-]:[-] pm. The sample results showed that the patient was infected with Pseudomonas aeruginosa. The British side suggested centralized isolation, abandoning invasive treatment methods, and improving patient comfort.

In other words, there is no cure, so stop using drastic treatment methods to increase the suffering of patients, and let them live the time before death.

When Wang Jing repeated this passage, her whole body was choked with sobs, "The hospital has begun to concentrate the infected people, and those who are under observation have also been isolated. Are they...really hopeless?" Looking at the familiar patients The patients were pushed out one by one, and they were gathered in an empty isolation room like pigs suffering from the plague. All the medical staff felt uncomfortable.

This is also a great psychological trauma to the patients. Many patients cried and begged if they could stay in the ward with a fever and die with dignity.Nurses and doctors can only say sorry over and over again, because Queen Mary Hospital is not a traditional hospital for infectious diseases, and the medical conditions in the 80s are not as good as those of later generations. The disinfection measures in ordinary wards are far from ensuring the isolation of drug-resistant bacteria. Quantities are limited.

A huge isolation room, with rows of sickbeds put together, is already the acme of what a hospital can do.They are responsible for the health of the remaining patients.

"I will never give up treating you until the last moment, but I'm sorry, I can't bet on the lives of other patients." A female doctor pushed a patient who she had rescued twice from the operating table into the isolation room with red eyes. .

"We didn't want to. Before the British test report came out, Professor Chen and the doctors had been trying to isolate the infected patients in the ward. Many patients are very smart. As soon as they entered the isolation room, they knew what happened. What happened, this is a great blow to the patient's will to survive, but the most important thing at this moment is the patient's own willpower!" Wang Jing was very emotional.

There was a silence in the laboratory, and the worst happened.Li Zheng concluded early that the sample was Pseudomonas aeruginosa, but he never reported it to Queen Mary Hospital. He was worried about this result. He was afraid that the patient would give up his will to survive before he extracted the carbapenem antibiotics. .

"Where's Professor Xu? He also entered the isolation room?" Li Zheng asked hoarsely.

Wang Jing shook her head, "That's not true. Professor Xu and those special patients are still isolated separately. Professor Chen didn't tell Professor Xu that it was Pseudomonas aeruginosa..."

Yes, no matter what era there are privileged classes.Li Zheng breathed a sigh of relief, he was glad that Xu Mingsheng was a privileged class.

"Tell Professor Chen, continue to take medicine, don't give up, and work hard to physically cool down, there is still hope on my side." Li Zheng said to Wang Jing seriously.

Wang Jing's eyes lit up when she heard the words. The little nurse had limited understanding of drug-resistant bacteria, and could only tell from the hospital's response that Pseudomonas aeruginosa was a very terrible drug-resistant bacteria, but she had no idea how terrible it was. What a concept.She heard that Li Zheng said there was hope, and she didn't have any doubts about it.

"Then leave it to Mr. Li Zheng." She bowed deeply.

Li Zheng nodded, regardless of his concealment, directly selected the correct microorganism, and adjusted the instrument to the temperature in his memory.

He knew he had succeeded when he saw the slightly reddish bottom of the reagent.

"Zhang Yuejun, is the mouse here?" Li Zheng asked.

The three of Professor Wang, who were still doing experiments on the separation of crude extracts extracted from moldy buns and fermented beer, stopped what they were doing when they heard this.

"Successful?" They couldn't believe it!

"Successful." There was no time left, he could only succeed, Li Zheng smiled wryly.He doesn't care about the doubts from the outside world.What else could explain it other than genius?Events such as rebirth, in the modern society that pays attention to science, no one would really believe it.

A group of people stared at the reagent in Li Zheng's hand almost cautiously.

Whether they doubt it or not, this is their only hope now.

Li Zheng handed the experiment notes to everyone, "Follow the steps to extract, the more the better, the experiment on mice requires a lot of dosage."

Zheng Lingling had already prepared the mice, and as soon as Zhang Yuejun called, rows of mice were sent to the laboratory.

Li Zheng looked at his watch. It was 45:[-] pm. According to Wang Jing, their time was running out.

Another night.

In the evening, Zheng Lingling, Liu Menglin, and two professors from the School of Medicine of Xiangjiang University also joined the experiment. Although Zheng Lingling and Liu Menglin were a little raw, they were students of the School of Medicine of Xiangjiang University, and they did a good job in data recording and analysis.

This evening is also lucky to have a girl named Zheng Lingling. These experimental dogs have never known to eat since they entered the experimental state. Li Zheng, Zhang Yuejun, and Liu Menglin are young people who are hungry for a meal or two. While ordering food and data analysis, ordering food and pouring water, taking care of things other than experiments in an orderly manner.A little girl stayed with these men for more than 20 hours without crying out that she was tired.

This dissipated a lot of Li Zheng's unhappiness about bringing the students into the No. [-] laboratory in the morning. In addition to professional knowledge and professionalism, he can't do this job without certain feelings, but People who have been up and down in society for a long time lack such a feeling.

"Dingling." The sound of the phone was particularly harsh in the silent laboratory.

Zheng Lingling ran over and answered the phone immediately.

"Hey, it's Mr. Li Zheng. May I ask if your medicine is ready? A patient in the isolation ward has been declared dead, and Professor Xu's condition is not very good. Professor Chen said, if it doesn't work, let you and the professors come and see Look at Professor Xu."

"Patter" Zhang Yuejun lost his grip on the reagent and fell to the ground. The liquid crystal splashed on his pure white white coat, dyeing it bright red.

Liu Menglin hurriedly disposed of the medicine on the ground, wiped it dry and disinfected it.

"Brother, go change your clothes."

Zhang Yuejun was pushed into the locker room almost at a loss. He is a graduate student of Professor Xu, and his three-year relationship cannot be faked.

Li Zheng took a deep breath, took out a portable incubator, and put dozens of tubes of extracted carbapenem antibiotics into the incubator.

"Go, go to the hospital!" He said.

Professor Zhao looked at Li Zheng's actions, and said, "You are crazy, look at the experimental data, the survival rate of the mice is less than 30.00%! This antibiotic is not up to the standard for clinical trials, let alone give it to patients." Injected directly!"

Yes, the data from staying up all night is not satisfactory.The mice injected with Pseudomonas aeruginosa were injected with the extracted carbapenem antibiotics after infection.Less than 30.00% of the mice were cured normally, and the rest of the mice showed severe drug reactions, and even died within 5 minutes after the injection of antibiotics.

Based on such experimental data, all professors believe that this type of antibiotic, like many discovered antibiotics, is too toxic to be used as a clinical treatment for humans.

But they also acknowledge that the carbapenem antibiotic is indeed effective against Pseudomonas aeruginosa, which is an exciting result, and as long as it goes down this road, Pseudomonas aeruginosa infection will no longer be There is no cure!

But how many years will this road take, one year, two years, five years?This may not be a big deal to the whole human progress, but to the patients who are currently lying in the isolation ward, and to Xu Mingsheng who is struggling on the line of life and death, this is the distance between life and death.

"It's really effective against Pseudomonas aeruginosa, isn't it? This is the only way!" Li Zheng had never tried to extract carbapenem antibiotics in his previous life. Even if he knew the extraction steps and molecular formula, he couldn't be so short-lived. Time to make perfect toxicity control in the lowest carbapenem antibiotics.

This is already the best he can do. He knows that carbapenem antibiotics have greater nephrotoxicity, but for patients who are already struggling with life and death, these nephrotoxicities are nothing.After all, mice are not humans. As long as they are combined with some drugs to relieve kidney toxicity, he is [-]% sure that most people can overcome the side effects of drugs.

He has no time to do the experiment with the injection of relieving drugs, he is [-]% sure, he can only take a gamble.

"No! Absolutely not! If something goes wrong, Li Zheng, do you know what the result will be?" Professor Wang strongly objected. No one knew better than them what Li Zheng's actions meant.

Once Li Zheng does this, it’s best for the patient to be safe and sound. Once someone dies due to drug toxicity, the spittle stars of the world will drown the young man, and the media will put all the unbearable hats on the young man’s head. What kind of human body? Experiment, what kind of butcher, are there few such examples in the history of pharmacy?How many amazing and talented geniuses fell because of this, disappeared in this circle, and some even committed suicide due to the pressure.

No one will care why you do this, they only know that injecting into the human body without reaching the standard is anti-humanity!No one will work with a biologist who wears the title of Anti-Humanity.Once it fails, Li Zheng's career will face a devastating blow.

The professors must not just watch Li Zheng do this.

Li Zheng looked at the professors who were emotionally opposed to him, and she felt warm in her heart, but her thoughts became more and more firm, "Professor, compared with the lifeline of more than 100 lives, my I feel like I can bear the consequences."

Li Zheng had already prepared for the worst in his heart. Is he sure that none of the patients will have an accident?No.But he did the math, he had a lot of money on hand, and if he really couldn't enter the laboratory again, he wouldn't starve to death.

And it's not without wiggle room.Find someone you trust to put on the table, and he just hides behind the scenes.It's just that the Nobel in his dream is going to be ruined. It is impossible for him to stand on the stage and accept any honor on the bright side.

Also, Li Zheng has always felt that his own luck is pretty good, otherwise he would not have died suddenly in front of the experiment table and still be reborn, God...he probably wouldn't have just watched him finish the game like this.

"Li Zheng..." Professor Zhao wanted to say something more.

Li Zheng waved his hand, "Professor, if I go on, I will have no chance to contribute. Don't worry, I will protect myself to the greatest extent possible." As he spoke, he winked at Zhang Yuejun, Zhang Yuejun nodded, and ran quickly Went out for a drive.

Professor Zhao could hardly catch his breath, he was so angry.You are going to go shirtless, so why are you talking about protecting yourself?But while angry, he was more moved, envious and ashamed.

Touched by Li Zheng's choice, envious of that old boy Xu Mingsheng for having such a good student, he felt ashamed... He raised his head and looked at each other's old buddies, and they could see the shame in each other's eyes. I am used to being respected, but I no longer have the courage to put all my eggs in one basket.

"Let's go, we'll go with you!" Professor Zhao said.

All the professors nodded at the same time. Going with Li Zheng means that they know and support this matter. This is also a great risk for all the professors.If some patients really died due to the injection of antibiotics, although they would not be forced out of the circle like Li Zheng, it is inevitable that they will be scolded and their reputation damaged.

Li Zheng looked at them in surprise, and it took a long time for a helpless smile to appear on his face, "Well, you can do whatever you want." These stubborn bulls, if you strongly refuse, will make them feel that you look down on them.Li Zheng, who has been a scholar for two lifetimes, understands their psychology too well.

At 100:100 in the morning, a van carrying more than [-] lives, more than [-] families, and hundreds of hopefuls drove slowly out of Qingyuan and headed for Mary Hospital in the urban area in the dark.

At [-]:[-] in the morning, the nightlife in Xiangjiang is not over yet, the dazzling neon lights, the sports cars carrying beauties, and the joyful shouts of young people, they don’t want to fight, not far from them, a group of people are Struggling on the line of life and death, trying to gain hope of life.

Zhang Yuejun's car was driving fast, and God probably was on their side today, and they didn't encounter a single red light along the way.

Li Zheng looked at his watch when he saw the four large characters of Queen Mary Hospital from a distance. It was 45:[-].

Queen Mary Hospital had been cordoned off, and officers saw the approaching van, waving flashlights on and off.

"Don't come near, don't come near."

Zhang Yuejun made a beautiful drift, the car stopped in front of the blockade, Li Zheng and others got out of the car quickly, and the police were about to step forward to negotiate with them.

Chen Sufen and Wang Jing in white coats rushed out of the cordon.

"You are here!"

The leading policeman knew Chen Sufen, so he didn't go forward when he saw this, shrugged and returned to his seat.

Li Zheng is still wearing the protective clothing of the laboratory. The protective clothing of Li Zheng's laboratory are all of the highest international standards. The effect of isolating bacteria is much better than that of doctors' white coats in Queen Mary Hospital.

"Go in, Lao Xu is still conscious now." Chen Sufen didn't take Wang Jing's hope to heart at all. Their doctors who have been working on the front line of the clinic know better about the horror of Pseudomonas aeruginosa. She told Li Zheng and others He came here entirely with the idea of ​​letting Lao Xu see his colleagues and proud disciples for the last time.

There were already many people in Xu Mingsheng's ward, young people in their twenties, and some older people in their thirties and forties. A young man in his thirties was sitting on the head of Xu Mingsheng's bed with a sad face. Zheng and his party came in and said, "Dad, Uncle Zhao and the others are here."

This is Xu Mingsheng's son, Xu Keqiang, who is a doctoral candidate at Harvard Medical School.

"Old Xu!" Several professors stepped forward.

In the ward, there were repeated greetings, and it seemed that these people were Xu Mingsheng's students.

Li Zheng stepped forward, put the refrigerated box aside, and then picked up Xu Mingsheng's case hanging at the end of the bed.

From the medication records, it can be clearly seen that Chen Sufen has tried all available antibiotics on Xu Mingsheng, but they didn't work very well.

The high temperature caused Xu Mingsheng to show signs of dehydration and breathing difficulties, so he couldn't wait any longer.

"Old Zhao, you guys have a few points for the project funding I applied for this year. Just remember that the hospital must not take it back! Not to mention the old fellows in the humanities department!" Xu Mingsheng's voice was a little weak, and the high temperature His whole body was weak.

"What nonsense! The funding you applied for with great difficulty, you just spend it on your own. If we lack it, we will naturally grab it from the old guys in the humanities department. There is no need for you to be humble here." The professors said this , There was no trace of sadness on their faces, as if this was just an ordinary daily conversation among colleagues.

When Xu Mingsheng heard this, his face relaxed a lot. He looked at everyone with a smile, "You're still being polite to me."

Turning his gaze to Li Zheng, Xu Mingsheng showed a kind smile on his face, "My good boy, I'm very proud. Although to be honest, I didn't teach you anything, I'm still very proud."

Li Zheng felt that his eyes were astringent, and he took two steps forward, "Teacher, since you know that you haven't taught me anything, should you reflect on yourself and try to find something that you can teach me in the days to come?" .”