Back To The Age Of The '80s

"Teacher, I have extracted a brand new antibiotic, which is effective against Pseudomonas aeruginosa in biological tests, but no one has tried it clinically."

There were rustling discussions immediately in the ward. Xu Mingsheng was full of peaches and plums. Although many of his students had given up the pharmaceutical industry, they still had the basic professional ability. Brand new antibiotics?

Everyone's eyes could not help but fall on this famous "little junior brother".

Chen Sufen was taken aback for a moment, then remembered what Wang Jing had sworn to say when she came back in the evening, her heart couldn't help beating fast.

"A new antibiotic that is effective against Pseudomonas aeruginosa?" Chen Sufen almost tremblingly took the stack of materials in Li Zheng's hand, but the light in her eyes gradually dimmed as she read each item of data.

Li Zheng's experimental data is really not good-looking. Looking at these experimental data alone, judging by the strict antibiotic experimental standards, the antibiotics extracted by Li Zheng are too toxic, and they are not suitable for human clinical treatment.

"Thank you Xiaozheng, it's just that your carbapenem antibiotic needs to be perfected." Even at this point, Chen Sufen still maintains the tolerance and gentleness of a high-end intellectual woman.

"Master..." He considered his words for a while.If it was someone else, since they themselves refused, Li Zheng would never say a word more, but this person in front of him was Xu Mingsheng, the teacher he recognized.

"Teacher and wife, I'm [-]% sure." Li Zheng said, this is already the biggest guarantee he can make.

Due to the particularity of the pharmaceutical industry, no matter whether it is a doctor or a pharmacist, they will never make any guarantees to patients or their families. What they say most is that I will do my best.Because the weight of life is too heavy for doctors or anyone to bear.

This kind of words that sound perfunctory to the patient or the patient's family is the protection of these practitioners for themselves.Ever since Li Zheng set foot in the field of biopharmaceuticals in his previous life, his mentors have continuously instilled this idea in him.

"If you're not [-]% sure, never make any guarantees to anyone!" The words were still in his ears, but Li Zheng still spoke, "The molecular structure of carbapenems is already very stable, and its kidney toxicity can be treated with auxiliary medicines." The most important thing is that Pseudomonas aeruginosa is sensitive to it. Teacher, I know that in your opinion, I may be experimenting with your life...but..." Li Zheng He never felt that he was a talkative person, and he couldn't even express himself well when it came to excitement.

Beads of sweat dripped from his forehead. After two lifetimes, this pharmaceutical genius who was praised by many people on a high altar has completely lost his usual prudence, wisdom and calmness.

A group of professors could not help but feel their eyes heat up. They fully understood how much risk Li Zheng had taken by saying these words.

Chen Sufen couldn't help being a little moved, as a doctor's reason and her sensibility as a family member of a dying patient were in a fierce struggle in her heart. Reason and professional ethics told her that she must never allow patients to inject medicines that failed clinical trials, but her Her husband is dying. Like those patients in the isolation room, the drug-resistant strains are infected with high temperature and dehydration, and then the internal organs fail. Her husband is running out of time!

Perhaps... this so-called carbapenem antibiotic can really work miracles!

Xu Mingsheng's consciousness was a little confused because of the high temperature, and his ears were buzzing.Although Chen Sufen didn't say anything, but Xu Mingsheng came from the front line of clinical practice, so he couldn't be sure that so many antibiotics would be of no use at all.Is he infected with a drug-resistant strain, or a multi-drug resistant strain that is not sensitive to all antibiotics on the market.

Facing the imminent death, Xu Mingsheng couldn't tell what it was like, maybe because the fever was too high, he had no strength to think about it.

In a daze, he seemed to hear Li Zheng talking about drug-resistant strains and antibiotics, and Xu Mingsheng's spirit was lifted.

"Do you have the experimental data on drug-resistant strains? Show me!" Xu Mingsheng still remembered that he was only halfway through the project on drug-resistant strains. No, it should be said that he had just prepared the preliminary data and completed the preparations for the start of the experiment.

As soon as the old man's scholar's excitement came up, he felt that his head, which was dazed by the high fever, had woken up a lot, and he tried hard to support himself.

Seeing this, Xu Keqiang quickly took a cushion and put it on Xu Mingsheng's back.

He took the information handed over by Li Zheng, "Old Chen, give me the glasses."

Chen Sufen glared at him, but still brought Xu Mingsheng the glasses on the cabinet.

Xu Mingsheng flipped through the pages one by one, sometimes clapping his hands and sometimes laughing, but he didn't know that others could hear how hard he was laughing, and Xu Keqiang and his disciples couldn't help but get red in their eyes.

After seeing the biological experiment data of carbapenem antibiotics on the last page, Xu Mingsheng was silent for a minute, then turned to look at Chen Sufen, "You have a clinical trial agreement, take a copy."

Chen Sufen's complexion changed drastically, "Why are you crazy! Didn't you read the experimental data! Less than 30.00%, this is not up to the standard for human clinical trials! Even if you sign the clinical trial agreement, it is invalid!"

Yes, every stage of a drug trial has its criteria.In the biological test stage, if the experimental standard is not met in the living things such as mice, it cannot enter the next stage.Strictly speaking, a drug like Li Zheng, whose survival rate in mice is less than 30.00%, enters the human clinical stage without authorization is a crime at all!

"Old Chen, don't forget who brought you out. I understand my own body, and the existing antibiotics are completely ineffective for me. The reason why I can still talk to you clearly like this is because You use physical cooling 24 hours a day. But it’s useless, maybe in less than half a day, I will lose consciousness, and then my whole body’s organs will slowly fail.”

Xu Mingsheng was very calm. He turned over the page with the experimental data printed on it, and wrote word by word in the blank part of the back:

"I, Xu Mingsheng, voluntarily accepted the injection of the carbapenem antibiotics developed by Mr. Li Zheng. I have fully understood the dangers of this experiment. I shall bear all the consequences arising from it, and no one shall do any further work in any form." investigation."

Signed Xu Mingsheng, February 1983, 2.

"I don't agree! I don't agree! At least not now! I don't agree!" Chen Sufen couldn't help screaming when she saw Xu Mingsheng's movements. At this time, Professor Chen was completely a family member of a patient who had collapsed, "It can't be Now, not now!" She kept repeating.

Chen Sufen also understood that Li Zheng's antibiotics might be Xu Mingsheng's only hope, but the probability of this hope was too low.If he didn't accept the drug injection, Xu Mingsheng might have three or five days left, and what miracle could happen within these three to five days?

What she hopes is to wait a little longer, to wait a little longer, although she doesn't know when it will be suitable, but now!She can't take it!

"Old Chen, as a biologist and the dean of the School of Medicine of Xiangjiang University, I hope that even if you die, you will have dignity and value. There are still many infected people out there..." Once the excitement passed, Xu Mingsheng's spirit He weakened all of a sudden, and it was already a little difficult for him to speak.

"Why, why do you do the experiment for them, not they for you!" Chen Sufen finally said what was in her heart. As soon as the words came out, her face turned pale, and she covered her face and went out. This proud Professor Chen understood that she Having lost her benevolence and professional ethics as a doctor, she needs to calm down.

"Li Zheng, right? I heard my dad mention you several times. At first I was still very unconvinced, but the facts have proved that I am not as good as you. You..." Xu Keqiang was silent for two seconds, "Do you know Mr. Kent from Merck? "

Merck?A gleam flashed in Li Zheng's eyes. In the Chinese translation, Merck of the United States was translated as Merck, Kent Blair, the chief director of the New York laboratory under the name of Merck.He had dealt with that old man in his previous life, a very cunning old fox.

"I don't know." Li Zheng remembered Xu Mingsheng's introduction to his son, a doctoral student at Harvard Medical School, and he had some vague guesses.

"Really..." Disappointment flashed across Xu Keqiang's face.

Kent Blair once gave a speech at Harvard. During the speech, he mentioned that a brand-new antibiotic had been born in Merck’s New York laboratory. Of course, he only mentioned a little bit, but rumors spread in the Harvard pharmaceutical laboratory. Antibiotic discovered by Merck's New York lab may be effective against Pseudomonas aeruginosa!

After learning that his father was infected with Pseudomonas aeruginosa, Xu Keqiang contacted his mentor as soon as possible, hoping that he could lead him to get the medicine that his father could use from Merck New York Laboratory.

But obviously his mentor didn't have the face to let Mr. Kent break the rules of the laboratory. He called Kent Blair countless times until Blair was annoyed by his phone and turned off.But from the irritable Blair, he heard a term, carbapenem...

Therefore, when he heard about carbapenem antibiotics from Li Zheng, he was trembling with excitement.

"I will persuade my mother, and my father will leave it to you!" He also signed his name on the agreement written by Xu Mingsheng, and then bowed deeply to Li Zheng.

Li Zheng raised his eyebrows slightly, he nodded, and took out a tube of reagents from the freezer without any nonsense.

"Wang Jing, please ask Professor Chen to come in, and ask her to prescribe the medicine for protecting the kidney and alleviating nephrotoxicity."

"Hey!" Wang Jing responded crisply, and then quickly ran to the door of the ward.

But before she ran to the door, the door of the ward was pushed open, and Chen Sufen came in from outside the ward calmly holding a tray of medicines.

"No need, I have prepared the medicine, let's start." She said calmly.

The bright red liquid slowly entered Xu Mingsheng's body along the transparent polyvinyl chloride tube, and the people in the ward watched without blinking as the liquid in Li Zheng's hand was slowly pushed out.

He put the discarded needles into the metal tray, then took a step back, and said to Chen Sufen: "The kidney protection medicine will be injected in half an hour, and the oral toxicity-relieving medicine can be taken now."

Chen Sufen nodded. Now that the experiment has started, she will completely obey Li Zheng's orders.

After putting the oral medicine into Xu Mingsheng's mouth, Chen Sufen clenched her fists tightly, and the sound of the needle falling to the ground could be heard clearly in the ward's silence.

10 minutes later

"What is that red thing on the teacher's face?" A young man asked suddenly.

Chen Sufen rushed forward, and saw a red rash near Xu Mingsheng's ear. The rash was densely packed, and there seemed to be liquid in it, so it was scary.