Back To The Age Of The '80s

"These groups of experiments are carried out at the same time, pay attention to record the time." Li Zheng looked up at Zheng Lingling who came in wearing protective clothing, and nodded to her, "There are not so many protective clothing in the laboratory, so let them not enter the room. No. 2 There are beverages and desserts in the refrigerator in the laboratory, you can entertain your classmates."

Speaking of food, Li Zheng touched his stomach unconsciously with his right hand. Zhang Yuejun ran in before he had time to eat instant noodles yesterday.Yesterday's instant noodles are probably still on the table in No. 2 laboratory...

"Gululu~" His stomach made a very embarrassing noise.

Li Zheng pursed his mouth into a straight line.

Zheng Lingling looked at Li Zheng and said, "Did you eat? You didn't eat dinner or breakfast." She knew Li Zheng's living habits. She ate instant noodles for three meals a day, and she was hungry when she forgot.

She had just asked the agency to post a job advertisement for an aunt two days ago, and she wanted to choose another two days, but seeing Li Zheng's current state, she felt that it would be better to lower the requirements appropriately and let the aunt join the job earlier.

Li Zheng was silent for a while. From the corner of his eye, he glanced at Zhang Yuejun, who kept recording the data, and the little nurse who was carefully classifying the data, and said, "Take a rest for 10 minutes. Let's eat some bread to fill our stomachs." He remembered that he still had a lot in the refrigerator. Less bread.

After speaking, he took the lead in striding out of the laboratory.

"Li Zheng...are you doing experiments? Researching new medicines?" Seeing Li Zheng walking out, someone couldn't help asking.

Li Zheng smiled and shook his head, "It doesn't count. The P1 level laboratory of the No. 3 laboratory is not open to the public when the project is in progress. If you are interested, you can visit the other laboratories." He said, feet The pace on the road did not mean to stop at all.

Li Zheng's polite and alienated attitude made everyone a little embarrassed.But now Li Zheng doesn't have the heart to pay attention to the crookedness in the child's heart. After a whole night of experiments, his mood is getting more and more serious.

Existing antibiotics made them try it again.Based on the response of resistant bacteria to antibiotics, the most likely ones were Pseudomonas aeruginosa and Stenotrophomonas maltophilia.

If 20 years later, Li Zheng can name many treatment options with his eyes closed, such as aminoglycosides (amikacin) + third-generation cephalosporins (supson, ceftazidime) or quinolones (ciprofloxacin) ) + third-generation cephalosporins (Supson, Ceftazidime), or ciprofloxacin + β-lactam enzyme inhibitors (Tezhixing) and so on.

But now, in 1983, many of the drugs in those programs were not on the market.

"Li Zheng, it's not good for you to stay in the laboratory all the time. Sometimes you get inspired when you go out for a walk. Going to the hospital as a volunteer is a common practice in our medical school. You can go with us." The apple-faced girl Obviously not giving up.

Li Zheng took out bread and milk from the refrigerator and distributed them to Zhang Yuejun and others, "No, my experiment is at a critical juncture. Wang Jing, wait until you go back to the hospital. I need the patient's medication records and case information from last night. Also, I have just written several combined drug regimens on the white paper I gave you, you let Professor Chen try it, and tell me the patient's clinical response before noon."

"Zheng Lingling, ask someone to send a batch of white mice over, I'll be useful later."

"Okay." Wang Jing and Zheng Lingling nodded immediately, and Wang Jing didn't stay too long, greeted Li Zheng, ran out with milk and bread in her mouth, and as a nurse, she knew that every minute was right What it means to be sick.

Li Zheng stuffed the last bite of bread, looked at the watch on his wrist, it was 7 minutes, it was exactly 10 minutes to walk back.

The apple-faced girl saw that Li Zheng was about to leave within a few minutes, and couldn't help standing up anxiously. She reached out to grab Li Zheng's arm, but Zheng Lingling nimbly blocked it.

"Aren't you guys going to be volunteers? Go ahead. It's not too late for this kind of thing." The moment she stepped into the No. 1 laboratory, Zheng Lingling knew that this time she was in trouble.Well, she admits that she is indeed a little proud, especially after the governor and his wife had a cordial conversation with her at the unveiling ceremony of Li Zheng's laboratory, even her elders and relatives in her family were a little proud when they talked about it. Feel.

This feeling of being recognized as an individual rather than a family made Zheng Lingling a little swelled all of a sudden.

Although Li Zheng didn't talk about her today, she could see the dissatisfaction in Senior Zhang's eyes. Zheng Lingling touched her nose, no, she had to make up for it.

"But……"

"There's nothing wrong with it. The student union is familiar with all major hospitals, and I'll help you get in touch!"

Seeing Zheng Lingling's firm attitude, the students didn't want to say much.When a group of people were walking out, they happened to see seven or eight professors from the medical school walking quickly into the green garden.

"Where's Li Zheng?" Professor Zhao asked directly when he saw Zheng Lingling.

Seeing the dignified expressions on the faces of the professors, Zheng Lingling couldn't help but tremble, "Li Zheng just entered the laboratory."

The students hurriedly greeted each other. Professor Zhao glanced at the students and frowned, "What are you doing here? Don't hinder Li Zheng from doing business!"

Everyone, you look at me, I look at you, speechless.

The professors also ignored their intentions, and immediately walked to the laboratory quickly after receiving the message that Li Zheng was in the No. 1 laboratory.

When the professors arrived, Li Zheng and Zhang Yuejun were recording the reactions of the third group of drug-resistant bacteria. Looking at the newly released data, Li Zheng was 90.00% sure that the drug-resistant bacteria this time was Pseudomonas aeruginosa.

Damn it!He thumped the table hard.

When Professor Zhao came in, what he saw was this scene, and his heart ached.

"How is it? Is there any result?" A group of professors carefully put on their protective clothing and walked into the laboratory.

Li Zheng didn't say much, and handed the data in his hand to Professor Zhao.

When Professor Zhao saw the experimental data, his expression became more serious, and he passed the data to the professors for circulation.

After a long time, someone said with difficulty: "Are you sure it's multi-drug resistant bacteria?"

Li Zheng nodded.

There is silence in the laboratory. Multi-drug resistant bacteria in the 80s is a notorious clinical problem in the most advanced medical Western countries, let alone in Xiangjiang.

As far as they know, among the existing antibiotics, it is difficult to find one that can fight against Pseudomonas aeruginosa.

"I called Lao Chen in the morning. Lao Xu's high temperature was uncontrollable, and the wound was very inflamed. Lao Chen took three kinds of antibiotics at night, but there was no major reaction." Professor Wang's voice was very low.

Although Xu Mingsheng has a bit of a temper, he is very righteous. He fought for the project for the medical school. None of the professors here has benefited from him.

Li Zheng's nails sank deeply into his flesh, he took a deep breath, and tried to make his brain function normally, there is still time, it's not over yet!

Yes, he still has time.

Pseudomonas aeruginosa is only sensitive to carbapenems, so he will develop a carbapenem drug!

Carbapenem antibiotics are a type of β-lactam antibiotics transformed from penicillin, which were first used clinically in the mid-to-late 80s.Some pharmaceutical companies should have developed carbapenem antibiotics by now, but they are still in the stage of secret experiments and have not been promoted for clinical application.

Li Zheng focused on vaccines and cells in his previous life, and he was not proficient in antibiotics. Fortunately, vaccinology has a lot in common with him, so that he will not become a headless fly.

Li Zheng remembers that carbapenem antibiotics include imipenem-cilastatin, panipenem, meropenem, etc. Among them, imipenem-cilastatin is the first carbapenem to be marketed Antibiotics, the rest are developed with reference to press penem.

Li Zheng took out two penicillin tubes from the experimental refrigerator.Carbapenems are similar in structure to the penicillin ring of penicillin, and he had to start from scratch.

"Professors, do you believe me?" Li Zheng asked suddenly.

The professors were startled for a moment, and then they came to their senses. Professor Zhao said, "Do you have a solution?"

Li Zheng took out an appropriate amount of penicillin and poured it into a test tube, "Time is always passing by, you try hard to make it go this way, give up passively and let it go like this, why don't you try?"

Li Zheng said it very easily, but it fell into the hearts of the professors like a big stone thrown into a calm lake. Yes, it's useless for them to be sad and upset here, why don't they try hard.

Their colleagues are still lying on the hospital bed, and there are still more than 100 lives, and the fate of more than 100 families and hundreds of people after these more than 100 lives!Why don't they try hard!

The eyes of the professors turned serious. At such an age, their consciousness is not as good as that of a young man, and they couldn't help feeling a little ashamed.

"Li Zheng, do you have clues? To tell you the truth, we old fellows don't have any clues at all. If you have clues, don't be scruples. Tell us at any time. Hit me up. We are no worse than that young man!" Professor Zhao said very Said boldly.

All the professors nodded their heads. At their age, with their fame and status, they don't value these things very much. They don't feel any shame in beating a 17-year-old boy.

Hearing this, Li Zheng's face finally softened a little, "I have a rough idea." As he spoke, he drew the structure of the penicillium ring on the blackboard in the laboratory, and then, under the eyes of all the professors, slowly Change the penicillin ring.

"Carbapenems, a whole new class of antibiotics."

Li Zheng's words were so loud that everyone present stood still in place, brand new antibiotics?Did they hear correctly? ?