Back To The Age Of The '80s

Li Zheng made an appointment to meet Mr. Yang on the second day after he returned from Jinjiang.

"When will Professor Li be free to ask me, an old man? Let me tell you first, I'm retired, don't ask me for things like taking a table with the leader." Yang Lao smiled as soon as he walked into Li Zheng's laboratory. Hehe took out a blue retirement card and shook it in front of him.

Li Zheng touched his nose, got up and made a cup of tea for Mr. Yang himself, "Mr. Yang, in your eyes, I am such a person."

"That's right, you don't have to go to the Three Treasures Palace if you have nothing to do." Old Yang didn't give Li Zheng any face.

Li Zheng...

But what Old Yang said was right, he really had something to do when he invited someone over.

"I hope that the HPV virus vaccine will be clinically used for the first time in China."

Yang Laocha drank half of it, a sip of tea stuck in his throat, and he coughed instantly.

He coughed for a while, and said dryly: "Oh, this is a good thing, a good thing."

Promoting the clinical work of HPV virus vaccines and promoting the reform of the national drug approval system are two different things. The latter has many disadvantages and has to be corrected. The former, Mr. Yang has also read papers on HPV carcinogenicity, and he still has doubts about the connection between HPV and cervical cancer. Be skeptical.

It’s good to say that the clinical trial is successful. If something goes wrong, this is a vaccine clinical trial after all, which means that the volunteers are not dying patients, but healthy people. After the healthy people are injected with the vaccine, they are immediately exposed to the virus to observe the effect of the vaccine.If this one is not done well, it will be condemned by the population.

Mr. Yang also knows that if the vaccine is successfully developed, this anti-cancer vaccine will bring great prestige and glory to Huaguo just like the previous hepatitis B vaccine. Don't like risk.

Li Zheng could see the embarrassment on Old Yang's face, and he sighed in his heart, "Old Yang, I am not asking you to support me, but I hope to hold a meeting of the drug review committee in your name, at least give me one This is an opportunity to present to seniors."

The drug approval committee meeting is equivalent to the highest authority of the drug control department. Once a month, the difficult drug approval issues in January are discussed intensively. Although Mr. Yang and others have retired from their positions, they are still participating in the January review process. A drug review meeting.

It's just that the drug review meeting is usually fixed at a fixed time and held in the drug control building. In addition to a group of experts, there are also officials from the drug control department. The newly appointed officials after the reform of the drug review system are really good and can do practical things, but Conservation is the nature of officials, and what Li Zheng has to do is to let the risk assessment department of later generations evaluate it, and it will not be approved.

Since Mr. Yang slapped the table three years ago on the reform of the drug review system, he has been almost universally echoed in the drug review committee. His old man's words are golden, and more than half of the important management committee members will come to participate.

As long as Li Zheng can take advantage of the situation to convince them, then his HPV virus vaccine will be half successful in clinical practice.

Old Yang looked at Li Zheng with a complicated expression, "Boy Li, are you really so sure? This is not a joke. The domestic clinical norms were established late, and the public's clinical understanding of this drug and The level of acceptance is not as good as in the West, and some people even regard this as a human experiment, if something goes wrong, no matter what genius you are, the people will drown you with every spittle."

Of course Li Zheng is sure that the localization of the HPV virus vaccine was promoted by him alone, but because of the constraints of 1990, he was unable to explain all this with rigorous data.

"Mr. Yang, the HPV vaccine is not a biological vaccine. It is neither a live vaccine nor an attenuated vaccine, so it is very safe! Moreover, the HPV virus itself is not fatal, and its carcinogenicity is also a chronic process, so this time The clinical risk is far lower than you think."

"We know what it's useful for. The common people only know that the virus is terrible and the cancer is deadly!" Elder Yang said loudly.

There was silence in the room, and after a long time, Old Yang said again: "Tell me the truth, how sure are you?"

"Nine percent."

"Jiucheng? Don't fool me!" Old Yang's eyes widened suddenly. He still admired Li Zheng, knowing that this biological genius is not a reckless person, so he thought in his heart, if Li Zheng had If he is more than [-]% sure, he will save face and help him.

But when the word "ninety percent" came out of Li Zheng's mouth, Mr. Yang hesitated instead.

Where did you get your confidence?The international community has not yet recognized the carcinogenicity of HPV. Now tell me, you are [-]% sure about the clinical application of drugs?Unless the drug goes through a clinical trial, that's almost impossible.

This medicine has actually been clinically tested more than once, but Li Zheng can't tell Mr. Yang like that, he can only express his seriousness and seriousness with a sullen face.

Elder Yang stared at him for a long time, "Success, I'll call someone for you, but I stick to my point of view for the time being, and I suggest that the clinical trial be postponed."

Hearing this, Li Zheng was delighted and more moved. He felt that he was very lucky. No matter in his previous life or in this life, the senior scholars he met had spared no effort in supporting the younger generation.

An old man in the scientific research circle of Huaguo said that the biggest feature of science is exploration and inheritance, and generations of scientists in Huaguo have also done this.

On the evening of April 1990, 4, which was a significant date in the history of the changes in the Huaguo drug review system, more than half of the members of the Huaguo drug review committee gathered in the conference room of the Yanjing Hotel.

The night in Huajing in April is already quite hot and humid, and the big electric fans are buzzing.Yanjing Hotel is rebuilt from an old hotel in Huajing, which means that the facilities are outdated. A group of bigwigs who play an important role in Huaguo's medical industry sat together in twos and threes, discussing why Mr. Yang asked them to come tonight.

When Mr. Yang and Li Zheng arrived together, they were almost full.

"Old Yang, Professor Li, you are here." The person who spoke was a fat man who was slightly fat, about his early forties, wearing a pair of black-rimmed glasses, and smiling very kindly.Someone next to him also smiled and raised his head to look at the two of them, it was Guo Kezhen.

"Old Yang, Professor Li." Guo Kexin said.

"I'm really sorry for calling you here in such a hurry. However, there is a wronged person and a debtor who has delayed your affairs, so you should look for him." Elder Yang pointed to Li Zheng, "It is our Professor Li who has something to ask you. "Old Yang said with a smile.

On the face of it, Yang Laoming pushed Li Zheng out, but the intimacy inside and outside the words meant that everyone present, as long as they were not fools, could understand.

Everyone naturally laughed out of face, and didn't even delay talking.

After exchanging a few pleasantries, Li Zheng didn't waste any time, and waved his hand to send the information in Zhang Chao's hand.

The HPV vaccine project was led by Li Zheng, assisted by Liu Sichao and Zhang Chao, and Li Zheng called Zhang Chao to participate in this meeting.

Some members of the drug review committee had heard about the HPV vaccine project. After all, Li Zheng had brought up the clinical practice of the drug with the drug administration department more than once, and the officials of the drug administration department had naturally sought the opinions of several experts.

However, this is the first time I have seen these detailed information.

They flipped through it, and started talking in twos and threes.

"The hepatitis B vaccine is clearly stated in the drug guideline that it can prevent acute hepatitis. In this way, if Professor Li's HPV vaccine is really successful, it is really worthy of the name to say that it is the first anti-cancer vaccine."

"Cancer is like our ancient people who looked at smallpox and turned pale when they heard it. Even if it is clearly a vaccine, it is very difficult to carry out clinical work."

"But if it is really made by Professor Li, Huaguo is the first to be clinically marketed, and this title may become famous internationally."

"Cancer is the enemy of the entire human race. If the Chinese can take the first step in defeating cancer, it will be of great significance."

"Who doesn't know, but we have to be practical. How to carry out clinical trials, and what if they fail? Although this HPV vaccine is not a biological vaccine, nor is it an attenuated vaccine, but to test whether it is effective, volunteers must be tested. Exposure to the virus, HPV virus can also cause cancer, how to carry out this work."

Everyone was discussing, and Li Zheng could hear clearly from the side.

He coughed twice, and the loudspeaker effect of the microphone allowed everyone present to hear him clearly.

The meeting room gradually became quiet, and Li Zheng turned on the projector.

"This is the preparatory data for the three-point project. The first is the data demonstration of the relationship between HPV virus and cervical cancer that can be found in the internationally shared data; the second is the data from Hong Kong Queen Mary Hospital. During the three years from 1987 to 1990, all cervical cancer The third is the analysis of blood samples from [-] cervical cancer patients of different age groups, genders, and races randomly selected by Li Zheng’s laboratory during the three-year project duration.”

"In the first data, the data of papers that recognize the carcinogenicity of HPV show that 70%-90% of cervical cancer patients have HPV virus subtypes in blood samples. The second data is more accurate, 6729 cervical cancer patients in Mary Hospital in three years HPV5621 or HPV16 viruses were found in blood samples of 18 patients. The third data was produced by our laboratory in three years. Among 100 cervical cancer patients, HPV subtypes were found in 76 blood samples. .”

"So, I personally have no doubts about the conclusion that HPV virus is carcinogenic."

"Then the next step is the HPV vaccine. The principle of the HPV vaccine is to use a special protein antibody on cancer cells to trigger the body to develop immunity, so the HPV vaccine itself is a protein, not a virus. Simple injection of HPV vaccine will not be infected with the virus."

When Li Zheng said this, he paused, looked around, and saw that everyone was listening to them carefully.

"For this clinical trial, Li Zheng's laboratory staff including me and the management of Zhenzhe Laboratory expressed that we are willing to be the first batch of drug clinical volunteers."