Rule department scholar
Page 427
Zhao Yi disinfected his whole body, put on a white coat and walked in, standing in front of No. [-] experimental tank, observing the mixed substances inside.
Zhang Wei explained, "A few days ago, director Han Hui submitted a new detection method for E. coli labeled with antibodies, which can be used to detect how many E. coli are labeled."
"We used this method to experiment, and found that this experimental tank is also the fourth generation of E. coli. After injecting the same bacillus antibody, the number and proportion of the labeled bacteria were significantly less than other experimental tanks."
"I discussed it with Professor Li Ming, and we all felt that there was a mutation against the bacillus antibody."
Zhao Yi nodded in approval of Zhang Wei's judgment, "Indeed, I think it should be a mutation."
What he said was 'I think'. In fact, he has already used the "Law of Cause and Effect" to make a judgment. It is indeed the reproduction of the fourth generation of E. coli, which has undergone some targeted mutations in response to the harsh environment that has been 'marked' by antibodies for a long time. .
this is normal.
Viruses and bacteria often mutate. Influenza virus is an example. In the process of transmission, various mutations will occur. Because of frequent mutations, the composition of influenza vaccines will also be targeted every year. Make adjustments and improvements.
A voice came from behind, "Mutation is just a possibility."
It's Li Ming.
Li Ming has been working on the left side, with a pen in his hand to take notes, he just greeted Zhao Yi, he really has no sense of presence at all.
After listening to Zhang Wei's explanation, he raised his head and added, "Other factors cannot be completely ruled out, such as Mrs. Han... Director Han's dyeing detection method, or a slight error occurred during the experiment. , mistakes, and so on."
"Ah."
Zhao Yi nodded slightly. "The Law of Cause and Effect" confirmed the existence of variation, and other explanations were meaningless. He just nodded slightly to express his recognition of Li Ming's professional ability, and continued to observe the experimental tank.
Zhang Wei asked, "Now that it's definitely a mutation, shall we conduct research on this discovery?"
"let me think again."
Zhao Yi asked, "Are there any relevant experimental records?"
Zhang Wei immediately said, "Yes, it's outside. I'll bring it to you when I go out, but it's nothing special."
"no……"
Li Ming couldn't help but reminded, "Mutation is only one possibility, and there are other possibilities."
"I know."
"Ah."
Zhao Yi's and Zhang Wei's reactions were the same. It was almost determined that it was a mutation, and those who were not mutations might be excluded.
Li Ming was suddenly depressed.
He stared at the two people full of doubts. He didn't understand why Zhao Yi mentioned that it might be a mutation, but Zhang Wei seemed to agree with it. It seemed that he was sure that it was a mutation, and he didn't consider other possibilities.
If they were only doing experiments with him, or discussing together normally, the situation would change when Zhao Yi came.
"Could it be... love?"
"Zhang Wei is also single, in her 30s, maybe it's because of Zhao Yi? It is said that women in love will have lower IQ..."
"Maybe!"
Li Ming really didn't understand what Zhang Wei was thinking. As for Zhao Yi, he didn't think about it at all. He still had self-knowledge, knew that his talent was limited, and he mainly relied on experience to do research.
Zhao Yi happened to be the complete opposite.
Since the beginning of the project, he has not come to the laboratory a few times, but he has clearly grasped the research direction, not to mention whether it is correct or not. Similar decisiveness is not possessed by ordinary people.
Li Ming could only stand aside depressed.
Zhao Yi carefully observed the No. [-] experimental tank, and then went out to look at the recorded data, which mainly recorded the rate of E. coli being marked and the situation during the dyeing experiment.
In addition, the computer also has the principle and process of the completed dyeing experiment.
That was the result of Han Hui's team.
There are many researches on E. coli in the world, but there is no staining research on the halfway mark by bacillus antibody. It is also a very good achievement to be able to track bacilli and stain the marked E. coli.
Zhao Yi read it carefully and found that the key point in the method is to grasp the labeling characteristics of the bacillus antibody.
The various antibodies in the human body generally have only two functions. One is to mark pathogens, that is, to play the role of 'detection', so that cells with cleaning functions know which ones need to be cleaned up.
Another role is to directly destroy pathogens, which is not very effective.
The reason why HIV cannot be immunized and killed by the human body is mainly because the virus plays a role in hijacking the special protein in the immune system, so that the immune system cannot produce corresponding antibodies, that is, it cannot label HIV, and the immune system cannot recognize it. It cannot be cleaned up.
Han Hui's group is tracking the bacillus antibody, and using the antibody to mark E. coli, to trace the staining.
After Zhao Yi read the entire information, he began to study it carefully. His research method was also very simple.
"Law of Karma"!
"Contact Rate"!
After knowing a lot of conditions, the "Contact Rate" can help improve the details, and he quickly discovered an important piece of information——
The mutation of Escherichia coli will produce a new substance that neutralizes the bacillus antibody, and the structure of the new substance is very similar to the 2-CV Bing hydrogen molecule. The neutralization process is to form a very complex organic waste.
It may be protein, or other substances, and the production of organic waste is to make the experimental tank turbid.
"Similar to the molecular structure of 2-CV hydrogen?"
Zhao Yi immediately grasped the key point, and said clearly to Li Ming and Zhang Wei, "These observation experiments will continue. At the same time, we will focus on studying the bacteria in No. [-] experimental tank, and what exactly happened."
"Let's do the training first."
"Under the same environment, cultivate one or two more generations, and then do careful research."
He spoke clearly and expressed his opinion, "I think that maybe the mutation caused the flora to secrete a certain substance, which prevented the bacillus antibody from being marked, or simply reacted with the bacillus antibody."
"This substance must be found."
Zhao Yi made an explanation but did not leave. Instead, he discussed with Li Ming and Zhang Wei how to design the experiment next.
……
For several days in a row, Zhao Yi went to the research institute, and spent most of his time in the laboratory, doing research with Li Ming and Zhang Wei.
The people in the institute were all surprised.
In the eyes of the people in the Biomedical Research Institute, the work in the laboratory is only done by Zhao Yi 'incidentally'. His main research direction is still in the theoretical research of mathematical physics. After all, compared with his mathematical achievements, the work in the laboratory The results are nothing at all.
Internationally speaking, many people do not know that Zhao Yi is also a researcher in a biomedical laboratory, and think that he is a pure mathematician and theoretical physicist.
Recently, Zhao Yi has also been mainly engaged in the research of particle mathematics. He used particle boundary theory to demonstrate supersymmetry issues, and introduced the logic of mass into it. The results of particle mathematics shocked the world.
The same is true of the Technology Department.
The relevant responsible departments of the Science and Technology Department have been discussing the research issues of the 'Particle Boundary Theory', because the 'Particle Boundary Theory' has spread all over the world and has been valued by many universities and scientific research institutions in many countries. They also hope to show their support for the 'Particle Boundary Theory' 'The emphasis on research.
That's why Du Defa and his assistant went to Yanhua University to ask Zhao Yi, and proposed to establish a 'Particle Mathematics Research Center'.
Research in the field of theoretical physics has always been at a backward level in China. Finally, a recognized theoretical physicist appeared and created a new set of theories. The results were recognized internationally, but there was no domestic support. I can't justify it.
After Du Defa returned to the Science and Technology Department, he reported normally. He said that Zhao Yi did not agree to be in charge of the Particle Mathematics Research Center, which surprised everyone else.
"Zhao Yi didn't agree?"
"why?"
"This is his theory, wouldn't it be good to develop it?"
Someone wondered about the reason, "Maybe it's because of biological research? I heard that Zhao Yi likes biomedical research, and he has achieved good results. The project he led the team won the National Science and Technology Progress Award."
"Yes, I know that too!"
"It was awarded at the beginning of this year. It was Zhao Yi's team. It seems to be about AIDS research, but Zhao Yi himself won the natural science award based on his mathematical theory."
"This is not doing business properly!"
The leader of the Science and Technology Department is also Du Defa's superior. His name is Li Zhenhua, and he is responsible for the innovation field of theoretical research.
Li Zhenhua frowned and sighed, and continued, "In my opinion, Zhao Yi should specialize in mathematics instead of biomedicine. What can medicine research? Can it reach the top international level?"
"Our domestic medical research is limited, and most of the scientific research equipment is imported from abroad. It is too difficult to come up with results in this field."
"Zhao Yi is not in charge of the Particle Mathematics Research Center. It is not a big deal. He is still young and devoted to academics. It is normal that he does not want to participate in administrative work. Just continue to do particle mathematics research."
"However, what he has to do wholeheartedly, can't be half-hearted."
Li Zhenhua finally made a decision, "Let's do this. If we can talk through Zhao Yi and let him concentrate on studying mathematics and establish a particle mathematics center, we will fully support it."
"Otherwise, we will study again..."
Chapter 386 Completely solve AIDS!
Li Zhenhua really felt that Zhao Yi's biomedical research was tantamount to wasting a genius in the field of mathematics, so he yelled "not doing his job properly" heartbrokenly, and hoped that Zhao Yi could devote himself to mathematics research.
He is the department leader of the Science and Technology Department, and his meaning was quickly passed on to the School of Science of Yanhua University.
The people in the Faculty of Science were shocked.
"Let Zhao Yi concentrate on doing mathematics research? Then, regardless of whether he is in charge of the particle mathematics center, the Science and Technology Department will absolutely support it?"
"Is there a relationship between the two?"
"and……"
"You (does he) think that we don't want Zhao Yi to concentrate on mathematics research?"
Zhou Zhengbin cursed a few times in a loud voice, and the results of the discussion were all the same. He even said that they should persuade Zhao Yi to concentrate on doing mathematics research?
"You're sick!"
Everyone in the Faculty of Science hoped that Zhao Yi would devote all his energy to mathematics research, but Zhao Yi was unmoved at all, and devoted himself to studying in the Faculty of Life Sciences, and even served as a researcher at the Biomedical Research Institute.
"That's impossible!" Zhou Li, who knew Zhao Yi better, directly concluded.
Of course, the Faculty of Science wants to persuade Zhao Yi to focus on mathematics, and their reasons are very good: Zhao Yi's research work in the medical field is somewhat replaceable, but research in the field of mathematics is irreplaceable.
Doing AIDS research?
The project won the National Science and Technology Progress Award?
This is not a big deal at all, and other medical institutions can also do it. As long as they are willing to invest a lot of money, they will definitely produce results one by one.
What about Goldbach's conjecture?
What about the three-dimensional tremor waveform?
What did Fermat conjecture?
Including the boundary theory of particles?
These cannot be solved by investing funds, and no amount of research funding is meaningful.
But Zhao Yi initially chose Yanhua University, and he applied for the School of Life Sciences. He came here to study biological sciences, and it was only natural that he would work in the field of biomedical research.
In addition, the School of Life Sciences will not let people go.
The Faculty of Science and the Faculty of Life Sciences have quarreled no less than a dozen times over the issue of competing for Zhao Yi, but there was no result at all, because Zhao Yi likes biomedical research work, and he can't put his personal interest just because of the research work in the field of mathematics. Hobby kills.
That's right!
Most people think that biomedical research is just a hobby of Zhao Yi.
Many people in the Biomedical Research Institute also think so. Even though Zhao Yi has completed many projects, there is really nothing comparable to his mathematical achievements.
Of course.
The Faculty of Science doesn't want to give up the Particle Mathematics Research Center because of this, and many people still go to persuade Zhao Yi.
Zhou Zhengbin, Zhou Li, Hu Zhibin...
Some familiar and unfamiliar people came to persuade Zhao Yi. Of course, they would not directly ask Zhao Yi to give up biomedical research, but said insinuatingly, "Your main research field is mathematics!"
"Mathematics is fundamental. The research of particle mathematics and theoretical physics is a major event that affects human beings and even the universe!"
"The boundary theory of particles has become a school of thought, that's your theory!"
"..."
Recently, Zhao Yi was in the Institute of Biomedical Sciences, and those who persuaded him went directly to the laboratory. Heck, it's fine to come here once or twice. If you come too many times, you will be bored.
Zhao Yi was very annoyed and printed a row of large characters, and posted it at the entrance of the Biomedical Research Institute.
It says--
Associated with the Faculty of Science.Members are forbidden to enter!
Not only did he put up the big words 'no entry', but he also told the security guard at the door, Uncle Zhong, "As long as you see professors, teachers, or even students from the Faculty of Science, don't let them in."
"Now we are conducting a confidential experiment!"
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