Xueba's life simulator

Chapter 224 The first doctoral student (311 411)

Since that Karen Ash had nothing to do to trouble him, Zhou Ming took some time to expose the falsification of his thesis in advance.

"You didn't know before you called, but I know now. I will take care of this matter. Thank you, Dean Zhang, for telling me." Zhou Ming replied to Zhang Mingjie who called.

After Zhou Ming said he would handle it himself, but did not say how he would handle it, Zhang Mingjie didn't ask any more questions.

Soon, Zhang Mingjie hung up the phone.

After hanging up the phone, Zhou Ming went online and downloaded a paper titled "Specific amyloid beta protein assembly in the brain impairs memory" that was published in the journal Nature on March 2006, 3.

This article is with Lesné as the first author and Karen Ash as the corresponding author. It has been 2006 years since it was published by "Nature" in 11.

In these 11 years, it has been cited nearly 2000 times, which can be said to be the groundbreaking work in the field of Alzheimer's disease "amyloid" hypothesis.

But it is such an article that almost all scholars who study Alzheimer's disease have read, but it contains many doctored images.

"The pictures I have listed now are because the author of this article wants to prove that when the Alzheimer's disease model mice get older, the expression level of Aβ*56 protein will also increase, but it exists There are obvious traces of copying..."

In this article, Zhou Ming attached many pictures from the article "Specific amyloid beta protein assembly in the brain impairs memory", and indicated their specific problems on the pictures.

After Zhou Ming spent three days finishing the suspected fraudulent article revealing that "a specific amyloid beta protein assembly in the brain impairs memory", he immediately submitted the article to the journal "Science".

After all, this fake article was submitted to Nature, and it is impossible for Zhou Ming to expose the article and also submit it to Nature.

Let "Nature" be both a referee and an athlete, Zhou Ming would never do such a thing.

While submitting the article to Science, Zhou Ming also uploaded the article directly to the Internet for free reading by everyone with Internet access.

When Zhou Ming finished this article, submitted it and uploaded it to the Internet, it was already nine or ten o'clock in the evening on Huaguo's side. He uploaded it on both the Huaguo website and foreign websites.

Therefore, Zhou Ming's article was quickly clicked and browsed by netizens at home and abroad.

For some melon eaters in China who don’t even know how to eat melons, some caring melon eaters specially reposted Zhou Ming’s article, and incidentally shared the rumored Karen Ash Cannon that had previously been circulated on the Internet. The matter of Zhou Ming was also briefly popularized.

If Karen Ash's thesis fraud was disclosed by others, it would not cause much discussion in China. After all, there are not as many people who pay attention to academic issues as we imagined.

However, because the person who disclosed this time was Zhou Ming, and it seemed that the other party came to engage Zhou Ming first, this matter, which originally did not attract too much attention in China, was quickly discussed in the middle of the night. More than a million.

As for foreign countries, due to previous media reports, many people abroad have long been waiting for Zhou Ming's response.

Now that Zhou Ming published such an article, it also caused a lot of discussion.

After sending out the article, Zhou Ming washed up and went to bed.

When he woke up the next day and went to school, Zhang Mingjie soon found Zhou Ming.

"So that's what you said you would handle?" Zhang Mingjie came to Zhou Ming's office to find Zhou Ming, and said to him with a smile.

"How about it, is my way of handling it okay? There is no specific evidence for his responsibilities to me, and I don't need to explain anything specifically about it.

On the contrary, the article he was in charge of in 2006 had many problems, and I was not the first person to raise doubts. Shortly after the article he was in charge of was published by "Nature", some people raised doubts.

Oligomers like Aβ*56 protein are very unstable, and even after purification, there is no guarantee that there are no other subtypes of proteins in them.

Taking such a 'purified' sample for experiments is not so clean in itself, so no matter what the experimental results are, it is difficult to say that the Aβ*56 protein is responsible.

Denis Vivien, a cell biologist who had collaborated with Lesné at the beginning, found several pictures of immunostaining for antibody-stained proteins provided by Lesné to be suspicious, and he asked his students to repeat them. , but failed in the end.

However, Lesné did not admit that there was a problem with this result at the time, and Dennis Vivien withdrew the article and severed relations with Lesné. "

Zhou Ming talked to Zhang Mingjie.

"It seems that I am ignorant. I have never heard of this matter before." Hearing what Zhou Ming said, Zhang Mingjie also showed a curious look on his face.

"After all, you don't study this area. It's normal if you haven't heard of it. I also accidentally saw related news on the Internet when I was specifically learning about the current development and research status of Alzheimer's disease." Zhou Ming explained .

"However, your actions are quite fast. Have you noticed these problems before? But you haven't announced them yet? If Karen Ash didn't say anything about you this time, wouldn't you be there? Are you ready to announce it?"

When it came to the end, Zhang Mingjie's face obviously lost the previous smile, but became more serious.

This is normal, after all, Zhang Mingjie is a person who pays attention to scientific research, and Karen Ash's article exposed by Zhou Ming has influenced the research direction of Alzheimer's disease all over the world for more than ten years. If Zhou Ming did not disclose it , It may be affected for how many years later.

Such an important application, Zhou Ming did not announce it immediately when he discovered it, which naturally made Zhang Mingjie, who is concerned about the development of science and technology, unhappy.

"That's not true. I read a lot of related materials before I started Alzheimer's disease research. Although I was a little puzzled when I read Karen Ash's article, I didn't see those things at the time. The tricks of the picture come out.

This is why I dug up that article a few days ago, and after reading it many times with the idea of ​​finding fault, I discovered the problem with those pictures. "

Seeing Zhang Mingjie's serious face, Zhou Ming quickly explained that he definitely couldn't tell the truth about this.

After hearing what Zhou Ming said, Zhang Mingjie's serious expression softened.

Although Zhou Ming's current achievements in the field of biology can even be said to have surpassed him, Zhang Mingjie would not say that Zhou Ming's current achievements are higher than his, and he will let it go.

In Zhang Mingjie's view, Zhou Ming is still a junior, but unlike other juniors, Zhou Ming is a junior with outstanding abilities. In his heart, he still hopes that juniors like Zhou Ming can have a correct view of scientific research. He I don’t want Zhou Ming to be someone who doesn’t speak out when he sees injustice.

"Actually, when I read Karen Ash's articles before, I found that not only the article 'Specific amyloid beta protein assembly in the brain impairs memory' was problematic, but other related articles also had problems, but the specific problem was Where is this, I have to look through it carefully to find out.”

Zhou Ming said to Zhang Mingjie again.

"What? There's still a problem?" Zhang Mingjie was surprised again after hearing what Zhou Ming said.

At this time, Zhang Mingjie also realized that Karen Ash's problem might not be that simple.

"Some things only have zero and countless times, just like when you find a cockroach, it doesn't mean that there is only one cockroach, it's just that you only found one. In fact, there are already countless cockroaches in the dark. There are cockroaches.

As long as they have done it and tasted the sweetness, then they will not give up doing it.

After all, who wants to take the road full of thorns when there are shortcuts? "

Facing Zhang Mingjie's surprise, Zhou Ming did explain to him calmly.

"Well, that's what you said." Zhang Mingjie nodded.

Such things as academic falsification can be found both at home and abroad. He Zhang Mingjie has lived for so many years and he has not seen it before, such as the Obokata Haruko Stap cell incident, the South Korean cloning father Huang Yuxi’s falsification incident, the technetic scientist Schoen incident, domestic like The Hanxin incident, etc., these fraudulent incidents shocked the entire academic world when they were first exposed.

When many people in the country talk about the falsification of papers, they will say how bad the situation in Huaguo is, and how it will not happen in foreign countries. Those who say such things know at a glance that they have no understanding of the scientific research situation at home and abroad. learn.

In fact, when it comes to academic falsification, compared with foreign countries, the country is a bit insignificant. It belongs to Guan Gong who is wielding a sword in front of him. The domestic academic falsification is all learned by foreign students from abroad.

Shortly after Zhou Ming revealed that Karen Ash was the corresponding author's article "Specific amyloid beta protein assembly in the brain can impair memory" article forgery, "Science" also very quickly invited the famous independent image analysis Dr. Zhou Ming and the world's top Alzheimer's disease researchers reviewed the relevant materials provided by Zhou Ming.

There is no way, the matter between Zhou Ming and Karen Ash is already raging, and Zhou Ming submitted an article exposing Karen Ash's fraud to their journal, "Science" naturally moves faster.

And when Science was looking for someone to review the relevant materials provided by Zhou Ming, Zhou Ming did not stop there. Instead, he continued to write other articles that revealed Lesné as the first author and Karen Ash as the corresponding author.

Because this time involved dozens of papers they had published in the past, Zhou Ming's speed this time was not as fast as before.

Although Zhou Ming was in a hurry, he did not complete this article until NO.16, submitted it to the journal "Science" and uploaded it to the Internet.

As for the "Science" side, the review results of the article that Zhou Ming submitted to them that revealed that "specific amyloid beta protein assembly in the brain can impair memory" have also come out, and they finally agreed with the conclusion in Zhou Ming's article , that article is indeed falsified.

And as Zhou Ming's second super-long exposing article was released, "Science", which originally planned to disband the review team, had to continue reviewing Zhou Ming's second exposing article.

Shortly after Zhou Ming’s second exposing article was released, the discussion on Karen Ash and Lesné’s academic fraud case on the Internet at home and abroad also ushered in a surge again.

After doing this, Zhou Ming stopped paying attention to this matter.

Because Zhou Ming knew that after these two articles of his, faced with his conclusive evidence, the academic careers of Karen Ash and Lesné were completely over.

By the time of NO.18, Liu Haowen, Zhou Ming's first doctoral student, had finally finished his affairs at Peking University and officially joined Huaguo University of Science and Technology.

"How is it? Have you chosen the doctoral career topic I told you earlier?"

After Liu Haowen came to Luzhou, Zhou Ming invited him out for a meal. While in the restaurant, Zhou Ming chatted with him about his studies.

After confirming that Liu Haowen became his doctoral student, Zhou Ming provided him with some options, and these options were Liu Haowen's doctoral graduation project.

As long as he can complete it, Liu Haowen will be able to graduate.

The options given by Zhou Ming are the Collats conjecture, the new Mersenne prime conjecture and the Mersenne prime distribution conjecture.

Although these three conjectures are not as high as Goldbach's conjecture and Riemann's conjecture, they are all world-class mathematical problems. If you solve any of them in the past, you can get it steadily. Fields Medal.

It's just that now that there is more Zhou Ming, I'm afraid it may not be so easy.

Moreover, these three awards have also been resolved in Zhou Ming's mind.

Among them, the Koraz conjecture was something Zhou Ming had spent time solving before, while the new Mersenne prime conjecture and the Mersenne prime distribution conjecture were the solution process obtained by Zhou Ming based on the knowledge about the future he obtained through the life simulator.

However, Liu Haowen didn't know how Zhou Ming solved these three conjectures.

Therefore, these three conjectures are also very big challenges for Liu Haowen. If they cannot be completed, they will not be able to graduate.

When he heard Zhou Ming say that he would choose among these three for his doctoral graduation project, he had the idea of ​​quitting, but in the end he chose Zhou Ming.

Liu Haowen, who once won the gold medal in the International Mathematical Olympiad and was recommended to the Department of Mathematics of Peking University, is also considered a proud son of heaven.

He understood that those who study mathematics are like those climbers, and these unsolved mathematical problems are like mountains that have never been climbed.

Whether you go climbing or not, whether you can climb to the top of the mountain, the mountain is there, if you don’t go, someone will go back, if you can’t reach the top of the mountain, there will always be someone who can climb to the top of the mountain, even if there is no one now, there will be some people in the future.

Since someone is always going to climb to the top, why not me?
Now I have Zhou Ming, a mentor who can even solve Goldbach's conjecture and Riemann's conjecture. How many people want such resources can't ask for it. Why should I give up?Why do you think you can't do it?

This is what Liu Haowen thought after thinking about it.

Although he learned from Zhou Ming that becoming his doctoral student would have to solve all of these three conjectures alone, Liu Haowen still chose to go with Zhou Ming.

But for the choice of these three conjectures, he also thought about it for a long time.

"I've thought it over, and I've decided to choose the Mersenne prime number distribution conjecture as my doctoral graduation project."

After Zhou Ming asked Liu Haowen if he had made a good choice, Liu Haowen revealed his final choice.

"Oh? Can you tell me why you chose this conjecture?" Zhou Ming asked curiously after hearing what Liu Haowen had said.

Regarding the research on the distribution of Mersenne prime numbers, British mathematician Shanks, French mathematician Tolota, Technetic mathematician Burleigh Hart, and American mathematician Gillis have all put forward conjectures.

The conjecture of the distribution of Mersenne prime numbers that Zhou Ming and the others are talking about here is a conjecture proposed by the Chinese mathematician and linguist Zhou Haizhong in the article "The Distribution Law of Mersenne Prime Numbers" in 1992. It is also known as Zhou's conjecture.

周氏猜想的基本内容是，当2^(2^n)<p<2^(2^(n+1))时，Mp有2^(n+1)-1个是素数。

另外，他还据此作出推论：当p<2^(2^(n+1))时，Mp有2^(n+2)-n-2个是素数。

Here p is a prime number, n is a natural number, and Mp is a Mersenne number.

(End of this chapter)