Xueba's life simulator

Chapter 223
"It's easy to plant a tree, let it grow and get its fruit. But it's very difficult to plant fruit directly instead of planting a tree."

At this time, it was in the office of a professor of the School of Life Sciences of Huaguo University of Science and Technology. This office was the office of Zhang Mingjie, the dean of the School of Life Sciences.

Huaguo University of Science and Technology has been in session for some time now. At the beginning of the semester, there have been some personnel adjustments in the School of Life Sciences.

Xue Tian, ​​the executive dean, is still the executive dean, but Zhang Mingjie, the original honorary dean, has now removed the word "honor", and he is already the complete dean of the School of Life Sciences of Huaguo University of Science and Technology.

In fact, since the Huaguo University of Science and Technology College of Life Sciences changed leadership in 2014, there has been no dean. Only Xue Tian has served as the executive dean, and the others are vice deans.

A year later, in 2015, when Academician Zhang Mingjie began to serve as the honorary dean of the School of Life Sciences, the School of Life Sciences still had no appointment for the post of dean.

之前2010年到2014年的时候华国科学技术大学是有院长的，再之前的2003年到2009年和1998年到2003年，也都是有院长的，而且还都是院士。

From 2003 to 2009, in addition to the dean, there was also an executive dean.

Therefore, it is not surprising that academician Zhang Mingjie has changed from honorary dean to dean now.

As for the difference between the dean and the executive dean, the dean is fully responsible for the college, while the executive dean is usually responsible for leading and managing the overall work of the college, similar to an executive manager, who is a specific affairs manager.

In fact, the executive dean is also one of the vice deans.

It's just that its position is not the chief dean, but its administrative level is the same as that of the dean, and it is also the one with the most real power.

Zhang Mingjie himself has no interest in politics. His purpose of being the honorary dean before was to make a contribution to the life sciences of Huaguo, and the same is true for being the dean now.

This is also because there is Zhou Ming in the School of Life Sciences of Huaguo University of Science and Technology. Otherwise, Zhang Mingjie would not agree to change from the honorary dean of the School of Life Sciences to the dean. The main reason is that he is really not very interested in these administrative tasks. interest.

And what Zhang Mingjie said now was to Zhou Ming who came to him.

After Zhou Ming decided to set up a new experimental group to conduct technical research on cloning, he came to Zhang Mingjie.

After all, Zhang Mingjie has high prestige, great fame, and a lot of acquaintances. It will be easier for Zhou Ming to recruit members for the new experimental team he is about to set up when he finds him.

After Zhou Ming and Zhang Mingjie talked about his technical research on cloning human organs, Zhang Mingjie said these words to Zhou Ming.

Zhang Mingjie’s analogy is very appropriate. In today’s science and technology, it is indeed better than directly cloning a cloned human being, and then transplanting the corresponding organs from the cloned human being to the “original person”. Some organs should be easy to implement.

No matter what kind of organ donation, there will be more or less some transplant rejection reactions.

Transplant rejection refers to that after recipients undergo allogeneic tissue or organ transplantation, foreign tissues or organs and other transplants are recognized by the recipient's immune system as a "foreign component", and the latter initiates attacks, destruction and Clearing immunological response.

However, the organs extracted from the clones, because the genetic material is all from the "original people", the genetic matching and tissue matching of the two will not cause transplant rejection, so this is indeed a very good method .

However, this method of sacrificing one person to save another is neither cost-effective nor ethical, and cannot be tolerated by today's society.

Because although the clone is cultivated from your cells and has exactly the same genes as you, he is not you and does not have your memory. He has his own life experience and experience since he was created. Thought.

Like identical twins, you can't say that one of them is the other, each of them is a separate person.

Not to mention anything else, even if you use gene editing technology to edit the genes of human embryos out of good intentions, so that they can naturally resist certain viruses or possess certain abilities after birth, this is also a violation of the law. ethical.

And it not only violates ethics and morals, but also violates the law, at least the current law of Huaguo.

In addition, this kind of behavior will be condemned by the global society and the scientific community, and the purpose of this matter is not up to you. Who knows if you are really out of good intentions or for your own self-interest?

Just doing this will be condemned by law and ethics, not to mention sacrificing clones to save the "original people".

Organ cloning is completely different from human cloning. It is a "directed development" technology. What is cloned is not a life, but a certain organ of a human body. You cannot say that an organ also has life.

Therefore, the research on organ cloning has never been interrupted, but developmental genetics can be said to be the most challenging and attractive research field in human genetics, and its difficulty is much higher than cloning a certain living body.

The main difficulty in cloning organs is how to realize the three-dimensional growth of cells. The three-dimensional growth of cells refers to how to make cells grow in coordination with each other into the shape of organs, that is, cell differentiation.

The essence of cell differentiation is the selective expression of the genome in time and space, through the switching on or off of the expression of different genes, and finally the production of signature proteins.

It's just that cell differentiation can only be achieved in the human body, and the process of cell differentiation is generally irreversible
Although currently theoretically speaking, stem cells can be directed to induce osteoblasts, chondrocytes, adipocytes, nerve cells, cardiomyocytes, vascular endothelial cells, etc., and can also induce cardiomyocytes in tissue scaffolds, which can grow a fully functional heart for those who need a heart replacement.

However, the actual situation is that as far as the current technology is concerned, if stem cells are cultured in vitro, they will not grow a complete heart, it will only grow into a pile of meat.

If it were really that easy, human organ cloning technology would have matured long ago, and the lifespan of the upper elite would probably be greatly improved.

However, it is very difficult to induce stem cells to grow into fixed organs in vitro.

There are too many types of cells in an organ, including nerve cells, vascular cells, mucosal cells, etc., so it is difficult to conduct precise directional induction in specific parts.

In addition, it is difficult for organs to survive in vitro. Even if the induction of differentiation is successful, the normal growth process of the cells of the organ after division is very complicated, and in the process of organ growth, many other organs are required to coordinate with each other. For example, hormones and nerve stimulation are needed, which involves how to make different cell types form tight physiological structures and physiological connections.

"Dean Zhang, you know me. I don't always fight unprepared battles. I understand what you mean. I also know the difficulties in research on organ cloning in the world, but I am confident to overcome them. .

What I lack most now is the help of someone with rich experience in this field. "

After Zhang Mingjie and Zhou Ming finished talking, Zhou Ming also said to Zhang Mingjie.

The research on organ cloning technology this time is different from the previous ones. Its experiments mainly rely on those researchers who have rich experience in this field. Otherwise, if something goes wrong, it will cost a lot just to re-cultivate. time.

"That's right, you always look so confident, since I saw you, I haven't really seen you feel sad about something in your research.

Since you understand the difficulties and still have to do it, it means that you already have an idea in your heart, so I won’t say anything more.

As for the manpower, don't worry about that, I will definitely introduce you.

Not to mention anything else, as long as your name is mentioned, many people will rush to come over.

It's just that the demand for researchers on your side is far less than the people who want to join.

But I have to say that you just solved the Riemann Hypothesis in mathematics in January this year, and it has already caused a heated discussion.

Afterwards, your company also said that it would study drugs for Alzheimer's disease, which caused another discussion.

If your organ cloning technology is successful this year, if it is in China, I guess I will have to go to the Great Hall again next year.

In foreign countries, you may also have a share of internationally authoritative biomedical awards such as the Wolf Prize in Medicine, the Lasker Prize in Medicine, and the Nobel Prize in Physiology or Medicine. "

When Zhang Mingjie saw Zhou Ming say that, he also smiled and said to him.

"I don't care too much about the Nobel Prize. Speaking of this award, I'm also planning to set up an award..."

Zhou Ming talked to Zhang Mingjie about the award he was going to establish again.

As for what Zhou Ming said that he didn't care much about the Nobel Prize, although Zhang Mingjie knew that it might be Zhou Ming's real thoughts, he still gave Zhou Ming an angry look.

Sometimes I really have to say that people are more popular than people.

The Nobel Prize is a coveted dream for scholars, but Zhou Ming doesn't care much about it.

This is why there is no mathematics prize in the Nobel Prize, and there is only one Nobel Prize in Physiology or Medicine for biological awards. This award will only be awarded to those who have made important discoveries or inventions in the field of physiology or medicine.

The physiology mentioned here, although it is said to study various life phenomena of biological organisms, the Nobel Prize will only be awarded to those who have made outstanding research achievements in human-related physiology.

As for Zhou Ming's super bean project, although it seems really remarkable now, the Royal Swedish Academy of Sciences will not award the Nobel Prize in Physiology or Medicine to Zhou Ming.

Otherwise, Zhou Ming could win the Nobel Prize this year.

After chatting with Zhang Mingjie for a long time, Zhou Ming finally left Zhang Mingjie's office.

After returning to his office from Zhang Mingjie, Zhou Ming began to sort out some knowledge points in mathematics.

This was prepared by Zhou Ming for his postgraduate students. Li Zhiming contacted him earlier and told him that Liu Haowen, a direct Ph.D. The Faculty of Mathematical Sciences of the University of Science and Technology is here.

Currently, Liu Haowen is still dealing with transfer matters at Peking University and has not come over yet. It is estimated that he will not be able to come over until mid-April and officially become a doctoral student in the School of Mathematical Sciences of Huaguo University of Science and Technology.

Zhou Ming can also take advantage of this opportunity to sort out a set of mathematics knowledge points specifically for his graduate students, so as to save them from coming to Zhou Ming to ask questions when they are asked to conduct related research.

Although Zhou Ming didn't object to them coming to him to ask questions, if they didn't prepare for them in advance, I'm afraid they would have to come to Zhou Ming every day when they encountered problems.

Zhou Ming is not a big idler, he is usually very busy and doesn't have so much free time to deal with their problems.

Now get a knowledge point and let them learn by themselves. As long as they study this knowledge seriously, they can solve most of the problems they encounter, and it will also allow Zhou Ming to spend more time.

Time passed quietly like this, and on April [-]th, a phone call brought Zhou Ming's attention back to Alzheimer's disease.

This morning, Zhou Ming was busy with his own affairs in the office of the Academy of Mathematical Sciences, when suddenly a phone call came.

When Zhou Ming saw that the name of the caller on the phone was Zhang Mingjie, he thought he was looking for Zhang Mingjie before, and he had finished the matter he had told him so quickly, so he answered the phone excitedly.

But when Zhou Ming pressed the green answer button, the news from Zhang Mingjie on the phone was not about his new experimental team members, but about Alzheimer's disease.

"Did you see a recent report in the foreign media? About Karen Ashe bombarding your article on Alzheimer's disease published in Nature."

When Zhang Mingjie on the other end of the phone heard that Zhou Ming had connected the phone, he hurriedly said to Zhou Ming.

"Karen Ash? What did he say?"

Zhou Ming knew a little about the Karen Ash that Zhang Mingjie mentioned, but he didn't know why he bombarded himself.

This Karen Ash is a professor at the University of Minnesota and a well-known neuroscientist. As the corresponding author, he published an article on "amyloid" in Nature in 2006, and concluded that "from the disease small Purified Aβ*56 protein from mouse brain leads to cognitive deficits in Alzheimer's disease" is a major conclusion.

This article has been used thousands of times so far, and it can be said to be the foundational work in the field of Alzheimer's disease "amyloid" hypothesis.

But four years later, Karen Ash's article was revealed to be fake.

Zhou Ming, who knew about this matter, was very busy recently. After finishing his work on Alzheimer's disease, he was busy with new experimental groups and mathematics, so he forgot about Karen Ash.

He didn't seek trouble from others, but now other people took the initiative to seek trouble from him, and Zhou Ming and this man had no interaction at all, so he really couldn't figure out why this man suddenly fired at him.

"After the publication of Karen Ash's article on Aβ*56 protein, some people in the academic circle questioned the conclusion of his article. Come up with actual evidence.

However, after the publication of your article on Alzheimer's disease, the statement in your article about the relationship between the 'amyloid' hypothesis and Alzheimer's disease has once again aroused some people's suspicion of Karen Ash Questions about Aβ*56 protein.

A few days ago, the media interviewed Karen Ash about this matter. What he said at the time was basically that your main research field is not neuroscience, and the conclusions in your article are all layman’s terms. Yes, your article is not credible or something like that.

After the media interviewed later published his words, discussions arose. "

Zhang Mingjie explained to Zhou Ming.

What he didn't tell Zhou Ming was that there are two main factions about Zhou Ming's article published on "Nature" on the Internet, one faction supports it, and the other faction opposes it.

After all, Karen Ash is now a very well-known expert in the field of neuroscience, and Zhou Ming has not produced outstanding results in this area before, and it is normal for some people not to believe him.

However, since there is no domestic media reporting relevant news for the time being, this matter has not aroused large-scale discussions in China.

　According to the situation last month, 10 chapters need to be updated, let’s finish adding the previous ones first.

　　Thanks to "Lu la la zao la po" for the reward of 1500 starting coins.

　　
　
(End of this chapter)