The Technology Tree of Xueba
Chapter 172 Human Experiment
The Xinghuo Institute of Life Sciences officially launched the human experiment on elicitor.
The AIDS project researchers started to take away the volunteers according to the procedure set up by Director Wang Xiaoxiao.
Wang Xiaoxiao kept a close eye on the experimental situation of each researcher, and solved possible problems at any time.
It has been 72 hours since the volunteers were injected with the inducer, and all project teams are developing smoothly without a single death.
Wang Xiaoxiao felt relieved. The use of inducer can basically be regarded as safe. As long as it can achieve a certain therapeutic effect, the AIDS project can be officially ended.
He first walked to the laboratory of researcher Ma Pingfang.
Ma Pingfang here are all normal healthy people, mainly to observe whether elicitor can exist in healthy people for a long time without causing acute failure of organs.
As long as the inducer does not cause the rapid failure of human organs like a deadly poison, even if it produces some side effects, it can also be made into a drug for treating AIDS.
Compared with the threat of AIDS to health, it causes a certain degree of liver and kidney damage, or persistent low-grade fever, high blood pressure and other symptoms.
It can be completely controlled by current medical methods, and these side effects are much lighter than other AIDS treatment agents.
Seeing Wang Xiaoxiao coming to his laboratory, Ma Pingfang looked a little embarrassed, and said respectfully: Director Wang, you are here, we are basically normal here.
Wang Xiaoxiao saw that the volunteers were all in the laboratory. They were not lying on the hospital bed. They were all curious to use the VR smart glasses provided by the laboratory to experience the virtual world. Others are talking to family members.
Everyone had a healthy rosy complexion on their faces, and no one showed signs of organ failure.
Wang Xiaoxiao said with satisfaction: Old Ma, let me introduce your situation here.
Ma Pingfang had a clear tone, refined the key points, and reported: Director Wang, before I inject the volunteers with the inducer, I first conduct a muscle allergy experiment.
It was found that the human immune system did not have a strong response to it, so the volunteers were formally injected with inducer.
At the beginning, a very small amount of 0.05 mg was injected, and the blood of the volunteer was drawn every half hour to detect his immune system and various indicators.
The volunteers found no abnormalities, and I started to inject 0.5 mg, which is half the dose of the treatment.
After a period of observation, it was found that the lymph nodes were swollen, the lymphatic B cells were abnormally differentiated, and the lymphatic T cells became very active, but the volunteers still did not have any abnormal reactions.
The 3rd injection of inducer this morning, I injected the normal therapeutic dose of 1 mg.
It has been observed for three hours now, except that the immune system is more active, the spleen is a little enlarged, and no abnormalities have been found.
Now it can only be confirmed that the elicitor will not cause the hyperactivity of the immune system and attack the normal cells of the human body at will.
Inducin also does not have hepatotoxicity and nephrotoxicity, and there are no abnormal changes in the liver and kidneys.
According to our observation, inducin can exist in human blood and lymph for a long time, and its metabolic cycle is about 13 months.
When Wang Xiaoxiao listened to Ma Pingfang's report, he kept nodding. This situation was similar to what he predicted.
Human experiments on normal people have proved his pre-experimental inference that inducer has almost no damage to normal people.
He is a biological scientist, not an executioner, he is not sure, and he will not apply for human experiments.
Wang Xiaoxiao didn't dare to guarantee that there was no problem with the inducer before. After all, the human body is a complex biological system.
Modern medicine has not yet analyzed the specific components of the blood. Inducin may not be unable to interact with some unknown components in the blood. Fortunately, such a very difficult problem has not occurred.
Old horse, you continue to observe, and always pay attention to the changes in peripheral immune organs such as the spleen and lymph nodes.
Try to increase the dose within a safe range, and collect the maximum dose of inducer under safe conditions. Wang Xiaoxiao explained solemnly.
He came to Wu Minzhe's laboratory again, and he was in charge of HIV carriers.
As soon as Wang Xiaoxiao entered the laboratory, he met pairs of eager eyes.
After seeing him coming in, some people boldly asked him questions.
Director Wang, can you really cure AIDS?
Director Wang, I don't want your test fee, can you clear the HIV from my body?
Director Wang, I always feel like I'm going to die. I take care of myself like a porcelain doll every day. I'm afraid that a virus will invade and my immune system won't be able to kill it.
Wang Xiaoxiao said softly: You all be quiet, after the experiment is officially over, we will inform you about the relevant situation.
Seeing that Wu Minzhe was also comforting these volunteers, he called Wu Minzhe out of the laboratory and asked him for details.
Wu Minzhe immediately reported: Director Wang, we first conducted a small-dose experiment and found that the immune system seemed to be under command, and it was originally the lymphatic T cells that dealt with the AIDS virus.
With the participation of inducin, macrophages and lymphoid B cells also rapidly proliferate and differentiate.
Macrophages begin to eliminate HIV, and lymphatic B cells quickly differentiate into plasma cells, producing a large number of antibodies to eliminate free HIV in body fluids.
At the same time, the proliferation and differentiation speed of lymphoid T cells increased exponentially, and the greater the dose of inducer, the faster the growth rate of lymphoid T cells.
Now after only 72 hours, 28% to 37% of the HIV virus in these volunteers has been cleaned up, and the speed of cleaning up is related to the function of the individual immune system.
When inducin was injected, the volunteers developed low-grade fever, elevated blood pressure and other signs.
Excessive use of elicitors can lead to rapid synthesis of cells in the immune system, and related symptoms such as hypoxemia, hypoglycemia, and amino acid deficiency will occur.
As the AIDS virus is eliminated in large quantities, there will also be sediments that block blood vessels and cause local thrombus.
The immune system in the human body cannot cope with the bacteria and viruses in the body, and other viruses multiply at a high rate.
Wang Xiaoxiao smiled and said with satisfaction: It seems that the elicitor is very successful. The data you collected is very good. Keep up the good work and observe the changes of the spleen and lymph nodes in the peripheral immune organs.
He ended up in the lab of Qi Zhenyue, who was in charge of volunteers already suffering from AIDS.
As soon as Wang Xiaoxiao entered the laboratory, she heard volunteers begging.
Doctor Qi, is your medicine effective? Am I dying?
Doctor Qi, I feel like I can't do it anymore. I have a fever, nausea and vomiting again. Is it because your medicine has too many side effects?
Xiao Qi, your medicine is really good. I always feel groggy. After taking your medicine, I found that the symptoms are much better.
Wang Xiaoxiao didn't want to experience the situation of being watched just now, so he immediately called Qi Zhenyue out to learn about the effect of elicitor on AIDS patients.
I heard from patients that our inducer has a strong curative effect on AIDS patients. Wang Xiaoxiao said in a more positive tone.
Qi Zhenyue shook her head with a wry smile, and said helplessly: Director Wang, our inducer can play a certain role in treating AIDS patients, if the human immune system is not too severely damaged by the AIDS virus.
Inducin can stimulate the rapid proliferation and differentiation of mature immune cells in lymph nodes and spleen, and control the condition of AIDS.
According to my observation, as long as the drug is used carefully, the AIDS patient may be cured and become a long-term virus carrier.
But if the immune system has collapsed, there are very few mature immune cells in the spleen and lymph nodes.
This will only stimulate the spleen and lymph nodes, overdraw the vitality of the immune organs, resulting in a temporary improvement of the immune system, but it cannot curb the development of AIDS.
You continue to observe these data, especially for very severe AIDS patients. I have a basic idea now, and I will adjust the experimental plan later. Wang Xiaoxiao said with a serious expression.
He has basically understood the situation of elicitor in the human body.
After Wang Xiaoxiao returned to the office, he began to cooperate with Mozi to adjust the direction of the volunteers' next experiment based on the data of the human experiment.
Especially for severe AIDS patients, other adjuvant drugs are added to readjust the treatment plan.
Xiaomu disbanded the reader group today, what kind of group will the author build. Only one reader joins the group in half a month, and there are no more than five speeches in half a month, so there is no need for the group to exist.
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