Technology: breaking the hegemony that monopolizes the world

Parkinson's disease is a common neurodegenerative disease that mostly occurs in the elderly, with an average age of onset of around 60 years old.

As experts in the industry, Li Weijian and others know that the prevalence of this disease in Daxia is extremely terrible. The probability of people over 65 years old in Daxia suffering from this disease is about 1.7%...

An expert from West Sichuan and Huaxi frowned and said: "The main pathological change of Parkinson's disease is the degeneration and death of dopaminergic neurons in the substantia nigra of the midbrain, which leads to a significant decrease in the content of DA in the striatum. sick.

At present, major research institutions at home and abroad have not grasped the exact cause of this pathological change, but based on clinical cases and years of analysis, most of us believe that this disease may be related to genetic factors, environmental factors, aging, oxidative stress, etc. Involved in the degenerative death process of PD dopaminergic neurons. "

"There are also factors such as traumatic brain injury and smoking that may increase the probability. However, in our previous research meeting, most of the data showed that smoking is negatively correlated with the probability of getting this disease." An expert from Yanjing added.

"Yes, if the patient cannot control symptoms with medication and psychotherapy, we need to consider DBS surgery, deep brain stimulation, globus pallidus or subthalamic nucleus destruction to relieve symptoms."

A group of experts started discussing with serious expressions. If Gu Qing and the others were patients, they would have lost their minds.

It's a pity that there is no if.

With the scrutiny of these industry leaders, Professor Chen slightly nodded at Gu Qing, and then said in a calm voice: "Yes, Parkinson's disease is a long-standing problem. The Global Burden of Disease Research Report once pointed out that our large Xia's Parkinson's disease patients account for about 23% of the entire global Parkinson's disease population. According to model calculations, by 1030, about half of the world's patients with this disease are likely to be middle-aged and elderly people in Daxia.

And besides shaking, another important symptom of Parkinson's disease is slow movement. In the late stage of Parkinson's disease, due to the inexorable loss of dopamine-releasing neurons, the drug levodopa becomes less effective in treating symptoms.

And our starting point is not in drugs.

In a paper report in the journal Nature, foreign scientists found that by selectively destroying the function of mitochondrial complexes in mouse dopaminergic neurons, they found that the dysfunction was sufficient to cause progressive Parkinson's disease-related motor deficits, and different Correlation between types of motor impairment and dopamine release at different sites.

This discovery gave us a breakthrough in our research.

Together with other departments, while sharing resources, we will conduct a more in-depth study of the neural transmission mechanism, the sensitivity of the animal and human body nerves to equipment, the coordination frequency and the synchronization degree of some confidential data.

The Applied Neurotechnology Laboratory of the Institute of Brain Sciences had some special achievements three years ago. In recent years, thanks to the sharing of the results and resources of several major projects of the company, it has achieved minimally invasive implantation of brain-computer interfaces, allowing patients It is possible to communicate stably even in the case of hemiplegia or Parkinson's disease.

Even if the patient's special nerve activity is high enough and the physical fitness can support the operation, then we can carry out more advanced treatment and replace the necrotic parts with mechanical parts. "

Professor Chen's composure surprised all the leading medical experts.

What is this kid talking about? Have you been able to do the surgery?

three years? So fast progress?

"I've been paying attention to this field, why haven't I seen your application documents?"

A professor with a stern expression walked up to Professor Chen quickly and asked in a questioning tone.

When a hospital institution conducts some clinical medical experiments, it is necessary to submit all clinical plans to the official institution, such as preclinical sauce test materials, planned test sites, sponsors, instructions for conducting clinical trials, and all conditions found in animal experiments. It must be reviewed and approved by the institutional review committee, and the progress and results of the clinical trial must be reported to the official institution once a year.

The professor who asked this question is not only a medical master of the University of Medical Sciences, but also works in related institutions.

So for this kind of problem in his own field, his first reaction was to find out the truth.

Professor Chen looked at the old teacher who was walking towards him. The aggressive appearance of the other party and the appearance of teaching the lesson plans in the department were like two people.

However, he did not retreat, but explained very naturally: "Our clinical trials are all carried out under the full supervision of special departments, and this part of the documents does not need to be reviewed by normal institutions.

If you have objections, you can use your own authority channels to understand the specific situation.

Of course, my personal suggestion is that you'd better investigate the specifics of this project in a safe environment, because this project is still in a state of extremely high secrecy for the time being. "

This set of speech skills immediately tied the old professor in place.

Then Professor Chen, the head of the laboratory, continued: "Next we can see a patient with advanced Parkinson's disease who has received our treatment. He still has an impression."

Seeing that Professor Chen has been able to guide these great masters in the medical field of Daxia, Gu Qing retired with peace of mind.

At present, the brain-computer interface of the Applied Neurotechnology Laboratory of the Institute of Brain Sciences can display many functions for this part. In addition to decoding-coding working memory, emotional and motor integration, it can also use feedback from special nerves. , to carry out self-adaptive regulation and sensory feedback to achieve a stable improvement of brain function.

And for these professors, after the investigation, will they ask the classic question "If neurotechnology can decode-encode consciousness and two-way adjustment, will it be possible to interfere and change people's free will in the future?"

Gu Qing didn't intend to continue arguing with them.

After all, the clinical application of this innovative neurotechnology in neurosurgery, in addition to causing these problems, is more important to save lives and heal the wounded, and to give those who desperately desire health and freedom a better future.

Under such circumstances, whoever dares to obstruct the implementation of technology will become the sworn enemy of all patients who pursue a better life.

Even if this person is a western white left or some top industry...

And this group of research teams composed of professors from top hospitals, in the following days, from the initial surprise and discomfort, gradually began to catch up in a short period of time.

Get up at 6:30 every day, and at 7:30, under the leadership of several leaders in the laboratory, learn about the application and development of the technology. In the afternoon, each person will start a medical case and a brief research report. Study and study harder than high school students until the dead of night.

Then I went to the cafeteria to settle the dinner hastily, and then continued to study overtime voluntarily.

And during this time, as an influential figure and veteran who formed the first multidisciplinary ischemic cerebrovascular disease treatment team in China, Li Weijian has already known Professor Chen, the head of the Applied Neurotechnology Laboratory, during the communication. identity of.

Chen Qinghai, a proud student of mine many years ago, it's just that this student became silent after entering a certain big hospital and experiencing some nasty things.

Looking at it now, this student is indeed better than blue, and he has done a good job in Kyushu Science and Technology.

And Li Weijian also realized later, why he looked for this student by himself two years ago, but he didn't get in touch with him.

The results of these trillion-dollar investment projects of Kyushu Science and Technology Titan Star Department, even if it is said to be shared, it is impossible to really get it for nothing. The extremely strict secrecy work must be stricter than that of our old troops.

However, with the deepening of the research, even though Li Weijian thought he was a materialist fighter who had seen the big wind and waves, he still had feelings in his heart many times.

"Why is Kyushu Science and Technology so concerned about these experimental projects? The results of projects with an investment of one trillion yuan can not only share data, but also share R\u0026D personnel.

Those teams of scientists and engineers, even if they focus on one project for a week, can create huge value, but how huge is the cost of doing so?

Moreover, the semiconductor department of Kyushu Technology actually customized the price of the chip for a small experimental chip, as well as the cooperation of the system architecture and algorithm. "

In the dead of night, Li Weijian closed his eyes and counted what he had seen and heard recently. He felt that Kyushu Technology was not a private enterprise pursuing profit at all, but more like the great projects he had healed. The unit where the soldiers are located.

That young man surnamed Gu has unknowingly mastered huge resources that ordinary developed Guo Jia does not have.

Tens of thousands of graduate students, engineers, and scientists, who don't know exactly how many trillions of project resources there are, are all under the management of this young man, and are rationally arranged and overall considered.

In the military field, such people are generally handsome talents that are rare in thousands of years.

Li Weijian's emotions made him even have an urge to write a separate investigation report on Gu Qing after the mission was over.

As it should be, apart from him, a large part of the officially organized research team has this idea.

What's more, they already want to find their original unit to resign and join Kyushu Technology Company.

This kind of scientific research environment with the assistance of massive resources, responsiveness, and simple interpersonal communication is hard not to be tempted.

When people are absorbed in certain things, they ignore the passage of time.

On November 29th, it came suddenly.

On this day, Li Weijian woke up early, and at five o'clock in the morning, he had already gone to the laboratory base to check medical records and research reports.

It's just that when he just finished eating two steamed buns, changed into his lab coat and entered the core laboratory of the experimental base, he found that his student was already busy on the workbench.

Looking at the working status of the assistants beside him, they should have been working for a while.

Li Weijian didn't disturb the other party's work, he stood outside the isolation window, like a student, watching Chen Qinghai's every move with full attention.

Twenty years ago, he was a teacher, imparting knowledge unreservedly on the podium and in the ward.

Twenty years later, he is a student, studying and exploring seriously outside the laboratory.

This morning self-study started very early, but there were not a lot of students who came.

A General Hospital of Junfang in Daxia, Neuromedical Research Institute of a hospital affiliated to Yanjing Medical University, the First Affiliated Hospital of Daxia Medical University, Affiliated Hospital of Tongji University, Affiliated Hospital of Fudan University, West China Hospital of Xishu University, etc. Hospitals and institutions The experts, as if they had made an appointment, came to this experimental base very early.

As usual, they observed in the observation room the operations and experiments that the laboratory could show to the outside world.

Followed by the exploration of drug medicine, the study of biological nerve signal transmission, and the working principle of neural converters.

It's just that they didn't go to the cafeteria to eat at mealtime as usual. They just ate some compressed biscuits at noon and continued to study without stopping.

Even if they learned the programming knowledge of Kyushu compiler in the afternoon...

But as one of the basic knowledge of neural application technology of Kyushu Science and Technology, these old men and women are still unwilling to let go of the slightest learning opportunity.

It wasn't until the last sunset that the official staff who accompanied them throughout the journey told the group of old students to pack their luggage, sort out the materials, and go to another place for the next task.

In fact, Li Weijian knew that the next task would not be easy without the official staff telling him.

But when he was drafting the draft, whenever he summed up a knowledge point, he would feel a kind of emotion.

The student I used to be has already taken too much lead on the professional road. If they study it according to their research and development ideas, in the future, human beings may really be able to achieve the level of immortality and immortality of the body.

And other medical professors have similar sentiments.

So a few days later, a bunch of research reports that were watched by countless people, but destined to be seen by only a few people, were submitted to the desks of certain people.

"Research Report on the Latest Scientific Research Achievements of the Applied Neurotechnology Laboratory of Kyushu Institute of Brain Science"

The name of this report is the most normal, but it is not placed at the top, because the person who wrote this report is not experienced, nor is he a professional. senior staff.

And the top file bag contained Li Weijian's investigation report.

He took it out with one hand and put it on the desk.

He opened it calmly, and opened the first page of the report. The words that came into view made this person's hand tremble subconsciously a few times.

Of course, this is not the onset of Parkinson's disease, but the subconscious shock of one's own nerves.

"Report on the Feasibility Investigation of Human Immortality Plan"

These few words made this person's breathing a little tense.