Fall in love with the technology tree [Three Kingdoms]
Chapter 30 Penicillium
In winter, everything withers.The sky and the earth are gray, as if only Luoyang City, where people gather, is full of lively fireworks.
"Master, Madam asked Madam Zhang for the identity deeds of ten more people because of the banquet on the first day of this year."
Ah Sheng washed his face in a daze while listening to Luo Chi's gossip. "Well."
"Ms. Zhang cried to Lang Jun, and Lang Jun gave her 15 people."
"Oh. Is there anyone we're interested in there?"
Luo Chi handed the linen face towel to A Sheng: "No, I've seen it all. Master, don't worry, we have secretly selected the new servants who have entered the mansion, but those who know all kinds of crafts will be sent to the other courtyard in the eastern suburbs first." .There is an old man and an old lady here, so we can't treat us badly."
"I have never felt that I have been treated badly. A truly capable craftsman is either doing his job under the aristocratic family or entering the imperial court. How can he sell himself as a slave in our house? Digging for gold in the sand, only a few pieces are found. Gold sand." After sighing this part, Ah Sheng made some comments on Zhai Dou's new progress, "This mother, her methods are a bit honest."
Nurse Zongshi interjected from the side: "After all, the new wife comes from a noble family, so she can't do dirty things."
Luo Chi's opinion is different: "She is weak. Taking advantage of her status, if she wants three today and two tomorrow, it's enough for Mrs. Zhang to feel uncomfortable. Slowly cutting flesh, tsk tsk, this taste."
"Father still loves Mrs. Zhang the most, so even if she becomes an unrefined general, she can pull up an army in the blink of an eye." After rinsing his mouth, Ah Sheng put on a linen mourning dress over his fleece jacket, "Let's see for a while. No threat When it comes to me and brother, then let them make trouble."
Cao Cao got up early to do some exercise again, and Ah Sheng was not too happy to move. After doing ten leapfrogs, he went back to the house to sort out the reports sent by the other courtyard, most of which were written by the craftsman Ai: the design drawing of the hydraulic stone mill, The raw material processing and proportioning of graphite refills, the standardized papermaking process, in addition to Liu’s chicken raising report, the results of new crop interplanting written by Zhao Xiaogou for Zhao Gou... The latest is the ongoing coal smelting iron and small In large-scale ceramic firing technology, the furnace temperature is still not high enough. It is rare to burn molten iron and finished ceramics, let alone glass. To make a breakthrough, refractory bricks and a blast furnace with a more reasonable structure are necessary.
Ah Sheng looks for inspiration from these reports every day, recalls the contents that he may have forgotten, and adds them one by one.After reminiscing, she pretended to lock the drawings into the wooden box, but actually threw them all into the space.
Asheng has no intention of carrying out large-scale production in Luoyang's farm. Whenever a technology is tested and matured, she records all the technical parameters, and then orders Carpenter Ai to completely tear down the experimental workshop and start the next one. item of work.Her intuition told her that the capital city is not a good place for large-scale industrial development due to its many people.
Only agriculture and breeding are relatively free from taboos.
Ah Sheng felt guilty in her heart, and this kind of guilt was particularly strong when she saw the refugees driven out in the suburbs of Luoyang.Perhaps taking out Qu Yuanli could save some of them.
But Ah Sheng refused to do it.
Reason told her that instead of saying that these farmers lack better farming tools, it is better to say that they are victims of the social system.Even in the Tang, Song, Yuan, Ming and Qing Dynasties who owned Quyuanli, the same scene was still repeated over and over again.She will develop productivity, but not in the present where the feudal dynasty is dancing with false prosperity, nor is it in Luoyang City where singing and dancing are flourishing.
If she wants to play the greatest role, she has to wait for the collapse of the Han Dynasty, the rise of war in troubled times, and... Cao Wei's banners are planted all over the Central Plains.
Compared with those distant and terrifying futures, Ah Sheng now has one relatively happy thing: she got penicillin.
Three months ago, she turned three years old.
After a whole year of accumulation, the water in the space has formed a water column that can reach the sky.This time, Ah Sheng behaved well, and she began to take the initiative to make demands on the unknown consciousness.
"I want the history books of the end of the Eastern Han Dynasty and the Three Kingdoms period."
The water column pretended to be dead and didn't respond at all.
"No... can't it? It really can't." Ah Sheng made the next best thing, "Then give me a high-yielding penicillin strain." Bacteria cultivation, separation, and purification can all be realized slowly under limited conditions, but it must be done from the beginning. Finding low-toxic and high-yielding Penicillium strains in the vast world is a long-term global work, and it is precisely the biggest bottleneck in the local method of penicillin production.
Night is never seen in the small world of space.The huge water column connects to the sky, like a round and cute jelly.
"This...doesn't work either?" Ah Sheng puffed up his cheeks, "Then I don't need anything."
"Crack!" With her words falling, a dozen amoxicillin wrapped in white light fell down.
Asheng was almost laughed at by the space: "Do I look easy to fool? Oral penicillin drugs are of course very advanced, but they are consumables. Let alone the issue of amoxicillin. The shelf life of amoxicillin is at most three years. What should I do? I'm not going to play Fairchild, I want to let people in this era learn to save themselves. Do you understand what self-help is? Even if I die, they can produce antibiotics, vaccines, and medical development , let more people survive the post-disaster plague, and prolong the average life expectancy of the people at the bottom...
"You can't fool me like this. There is no free lunch in the world. Since you gave me cheats, you must let me work. I don't know what you want me to do, but let me tell you, cheats are not good. Do you know, I'm going on strike, do you know..."
The invisible and intangible consciousness may be unbearable by her nagging.
There was a loud bang, and the huge water column evaporated instantly, and the rising water vapor blurred Ah Sheng's eyes.When the white mist dissipated, I saw a small spot of light carefully falling from the sky.
Asheng rubbed his eyes.
It is a petri dish with only a small colony in the middle of the culture medium.
Very well, mold clusters with a diameter of less than one millimeter used up all the space water share in the third year.The person in charge of the exchange work in the dark obviously has a considerable understanding of the value of each item, so she won't have too many loopholes to exploit.
Making native penicillin is a long work, but the lesson of Ding's death made Ah Sheng not want to delay at all.She asked people to boil the culture solution with sorghum, millet, and meat.Boil and sterilize everything from the earthen jar to the solution, then take a little precious Penicillium fungus and put it into the jar, seal it well and start cultivating it.
Although she is a medical student, she does not work in a pharmaceutical factory after all. Temperature, humidity, culture solution concentration and ratio all have to be tested repeatedly to find the best production standard.She needs to grow more high-yielding Penicillium.Without ion-exchange column equipment, she needs to explore the method of purifying penicillin by activated carbon adsorption.
Before all conditions are ripe, penicillin, which has not been tested for medicine and toxicity, can only be used to clean the wound and prevent suppuration.In the actual administration of injections, the issues of purity and allergies must also be considered.
However, in the past three years, the 100 capsules of amoxicillin that the space fooled her has become a life-saving treasure.After mastering the life-saving medicine beyond the era, Ah Sheng's back straightened all of a sudden.
The first person to receive penicillin was a girl in the Foundling Hall.Coincidentally, she was the only girl that Nianqi pulled out from the beggar's den in Southwest City.She didn't have a name at first, but she was named Ding Xi only after entering the Yuyingtang.Due to long-term malnutrition and poor sanitary conditions, many wounds on her body festered, and she had alternating high and low fevers.Seeing that it was going to be winter again, the steward of the Yoyingtang couldn't bear it, and finally begged A Sheng.
Ah Sheng didn't have the conditions to test for allergies, so she could only use a small amount of drug testing.First, I took a little tablet powder and gave her to drink it. After half a day, when there were no allergic symptoms, I divided the rest of the tablets into three days for her to eat.
Bacteria at this time are generally not resistant to antibiotics, so the effect of antibiotics is immediate.Ding Xi improved significantly after taking a piece of amoxicillin, and recovered on his own in less than a week with sufficient nutrition.
Because of this, Ding Xi's little friends ran outside the fence of the other courtyard and kowtowed to Ah Sheng. "As expected of a nobleman, even the talisman water of the noble family is more magical than the talisman water used by the head of Guizhou." Come on, you guys continue to go back to the Yuyingtang to accept ideological reform, feudal superstition is not a thing.
A long way to go.
What made Ah Sheng feel that there was a long way to go was that his grandfather fell ill due to a cold.Cao Teng started to drink ginger soup and kudzu root since the evil wind entered his body. After drinking for a month, his condition became more and more serious.
Ah Sheng thought, she had to do it herself.My grandfather is getting old and can't stand the tossing of Chinese medicine at the primary stage. If the cold lasts for a long time, it will be troublesome if it turns into pneumonia.
Wind-cold is a very general term, and the symptoms are very similar to colds.When seeing a doctor in Western medicine, the first thing to look at is the pathogen.There are two types of colds: bacterial and viral.Viruses are easily contagious, while bacteria are mostly sporadic.Ah Sheng inquired with Uncle Qing that among the dozen or so servants who served Cao Teng, only one was infected, and the others were all fine, so he felt confident.
Bacteria is good, bacterial colds, antibiotics can be used.
In order to be more sure, Ah Sheng tried his best to convince Uncle Qing, and was able to see Cao Teng who was recuperating behind closed doors.The grandfather felt sorry for the younger generation, for fear that they would catch the cold, and since he became seriously ill, he even ate meals alone.
"What are you doing here? Don't mess around, get out." Cao Teng rushed away as soon as he saw her, his voice was hoarse, and he had pharyngitis or tonsillitis.
"I haven't seen my grandfather for a long time, and I'm very worried." A Sheng's eyes were red, and he looked like a baby who was aggrieved.
Cao Teng sighed, he also missed his precious granddaughter. "What do you want to ask? Did you fail the homework assigned to you? Did Geely get into trouble?"
Ah Sheng hit the snake with the stick, and talked with his grandfather while observing his symptoms.The tonsils are inflamed, there is purulent sputum, and there are no other symptoms such as diarrhea.This is a very typical bacterial infection of the upper respiratory tract, and the amoxicillin provided by the space is just symptomatic.She has verified the effectiveness and safety of these batches of antibiotics several times, and the only thing she needs to watch out for next is that her grandfather is allergic to penicillin.
Ah Sheng was more cautious with the medication this time, and carefully weighed the dose and time interval based on previous experience.Then sneak the ground medicinal powder into grandfather's ginger soup.
She waited nervously for three days.
Strangely, from what Uncle Qing said, Cao Teng had no symptoms of allergies, nor did his condition improve.
Ah Sheng held his bun face, could it be that she misdiagnosed it?It shouldn't be.
"Master, Madam asked Madam Zhang for the identity deeds of ten more people because of the banquet on the first day of this year."
Ah Sheng washed his face in a daze while listening to Luo Chi's gossip. "Well."
"Ms. Zhang cried to Lang Jun, and Lang Jun gave her 15 people."
"Oh. Is there anyone we're interested in there?"
Luo Chi handed the linen face towel to A Sheng: "No, I've seen it all. Master, don't worry, we have secretly selected the new servants who have entered the mansion, but those who know all kinds of crafts will be sent to the other courtyard in the eastern suburbs first." .There is an old man and an old lady here, so we can't treat us badly."
"I have never felt that I have been treated badly. A truly capable craftsman is either doing his job under the aristocratic family or entering the imperial court. How can he sell himself as a slave in our house? Digging for gold in the sand, only a few pieces are found. Gold sand." After sighing this part, Ah Sheng made some comments on Zhai Dou's new progress, "This mother, her methods are a bit honest."
Nurse Zongshi interjected from the side: "After all, the new wife comes from a noble family, so she can't do dirty things."
Luo Chi's opinion is different: "She is weak. Taking advantage of her status, if she wants three today and two tomorrow, it's enough for Mrs. Zhang to feel uncomfortable. Slowly cutting flesh, tsk tsk, this taste."
"Father still loves Mrs. Zhang the most, so even if she becomes an unrefined general, she can pull up an army in the blink of an eye." After rinsing his mouth, Ah Sheng put on a linen mourning dress over his fleece jacket, "Let's see for a while. No threat When it comes to me and brother, then let them make trouble."
Cao Cao got up early to do some exercise again, and Ah Sheng was not too happy to move. After doing ten leapfrogs, he went back to the house to sort out the reports sent by the other courtyard, most of which were written by the craftsman Ai: the design drawing of the hydraulic stone mill, The raw material processing and proportioning of graphite refills, the standardized papermaking process, in addition to Liu’s chicken raising report, the results of new crop interplanting written by Zhao Xiaogou for Zhao Gou... The latest is the ongoing coal smelting iron and small In large-scale ceramic firing technology, the furnace temperature is still not high enough. It is rare to burn molten iron and finished ceramics, let alone glass. To make a breakthrough, refractory bricks and a blast furnace with a more reasonable structure are necessary.
Ah Sheng looks for inspiration from these reports every day, recalls the contents that he may have forgotten, and adds them one by one.After reminiscing, she pretended to lock the drawings into the wooden box, but actually threw them all into the space.
Asheng has no intention of carrying out large-scale production in Luoyang's farm. Whenever a technology is tested and matured, she records all the technical parameters, and then orders Carpenter Ai to completely tear down the experimental workshop and start the next one. item of work.Her intuition told her that the capital city is not a good place for large-scale industrial development due to its many people.
Only agriculture and breeding are relatively free from taboos.
Ah Sheng felt guilty in her heart, and this kind of guilt was particularly strong when she saw the refugees driven out in the suburbs of Luoyang.Perhaps taking out Qu Yuanli could save some of them.
But Ah Sheng refused to do it.
Reason told her that instead of saying that these farmers lack better farming tools, it is better to say that they are victims of the social system.Even in the Tang, Song, Yuan, Ming and Qing Dynasties who owned Quyuanli, the same scene was still repeated over and over again.She will develop productivity, but not in the present where the feudal dynasty is dancing with false prosperity, nor is it in Luoyang City where singing and dancing are flourishing.
If she wants to play the greatest role, she has to wait for the collapse of the Han Dynasty, the rise of war in troubled times, and... Cao Wei's banners are planted all over the Central Plains.
Compared with those distant and terrifying futures, Ah Sheng now has one relatively happy thing: she got penicillin.
Three months ago, she turned three years old.
After a whole year of accumulation, the water in the space has formed a water column that can reach the sky.This time, Ah Sheng behaved well, and she began to take the initiative to make demands on the unknown consciousness.
"I want the history books of the end of the Eastern Han Dynasty and the Three Kingdoms period."
The water column pretended to be dead and didn't respond at all.
"No... can't it? It really can't." Ah Sheng made the next best thing, "Then give me a high-yielding penicillin strain." Bacteria cultivation, separation, and purification can all be realized slowly under limited conditions, but it must be done from the beginning. Finding low-toxic and high-yielding Penicillium strains in the vast world is a long-term global work, and it is precisely the biggest bottleneck in the local method of penicillin production.
Night is never seen in the small world of space.The huge water column connects to the sky, like a round and cute jelly.
"This...doesn't work either?" Ah Sheng puffed up his cheeks, "Then I don't need anything."
"Crack!" With her words falling, a dozen amoxicillin wrapped in white light fell down.
Asheng was almost laughed at by the space: "Do I look easy to fool? Oral penicillin drugs are of course very advanced, but they are consumables. Let alone the issue of amoxicillin. The shelf life of amoxicillin is at most three years. What should I do? I'm not going to play Fairchild, I want to let people in this era learn to save themselves. Do you understand what self-help is? Even if I die, they can produce antibiotics, vaccines, and medical development , let more people survive the post-disaster plague, and prolong the average life expectancy of the people at the bottom...
"You can't fool me like this. There is no free lunch in the world. Since you gave me cheats, you must let me work. I don't know what you want me to do, but let me tell you, cheats are not good. Do you know, I'm going on strike, do you know..."
The invisible and intangible consciousness may be unbearable by her nagging.
There was a loud bang, and the huge water column evaporated instantly, and the rising water vapor blurred Ah Sheng's eyes.When the white mist dissipated, I saw a small spot of light carefully falling from the sky.
Asheng rubbed his eyes.
It is a petri dish with only a small colony in the middle of the culture medium.
Very well, mold clusters with a diameter of less than one millimeter used up all the space water share in the third year.The person in charge of the exchange work in the dark obviously has a considerable understanding of the value of each item, so she won't have too many loopholes to exploit.
Making native penicillin is a long work, but the lesson of Ding's death made Ah Sheng not want to delay at all.She asked people to boil the culture solution with sorghum, millet, and meat.Boil and sterilize everything from the earthen jar to the solution, then take a little precious Penicillium fungus and put it into the jar, seal it well and start cultivating it.
Although she is a medical student, she does not work in a pharmaceutical factory after all. Temperature, humidity, culture solution concentration and ratio all have to be tested repeatedly to find the best production standard.She needs to grow more high-yielding Penicillium.Without ion-exchange column equipment, she needs to explore the method of purifying penicillin by activated carbon adsorption.
Before all conditions are ripe, penicillin, which has not been tested for medicine and toxicity, can only be used to clean the wound and prevent suppuration.In the actual administration of injections, the issues of purity and allergies must also be considered.
However, in the past three years, the 100 capsules of amoxicillin that the space fooled her has become a life-saving treasure.After mastering the life-saving medicine beyond the era, Ah Sheng's back straightened all of a sudden.
The first person to receive penicillin was a girl in the Foundling Hall.Coincidentally, she was the only girl that Nianqi pulled out from the beggar's den in Southwest City.She didn't have a name at first, but she was named Ding Xi only after entering the Yuyingtang.Due to long-term malnutrition and poor sanitary conditions, many wounds on her body festered, and she had alternating high and low fevers.Seeing that it was going to be winter again, the steward of the Yoyingtang couldn't bear it, and finally begged A Sheng.
Ah Sheng didn't have the conditions to test for allergies, so she could only use a small amount of drug testing.First, I took a little tablet powder and gave her to drink it. After half a day, when there were no allergic symptoms, I divided the rest of the tablets into three days for her to eat.
Bacteria at this time are generally not resistant to antibiotics, so the effect of antibiotics is immediate.Ding Xi improved significantly after taking a piece of amoxicillin, and recovered on his own in less than a week with sufficient nutrition.
Because of this, Ding Xi's little friends ran outside the fence of the other courtyard and kowtowed to Ah Sheng. "As expected of a nobleman, even the talisman water of the noble family is more magical than the talisman water used by the head of Guizhou." Come on, you guys continue to go back to the Yuyingtang to accept ideological reform, feudal superstition is not a thing.
A long way to go.
What made Ah Sheng feel that there was a long way to go was that his grandfather fell ill due to a cold.Cao Teng started to drink ginger soup and kudzu root since the evil wind entered his body. After drinking for a month, his condition became more and more serious.
Ah Sheng thought, she had to do it herself.My grandfather is getting old and can't stand the tossing of Chinese medicine at the primary stage. If the cold lasts for a long time, it will be troublesome if it turns into pneumonia.
Wind-cold is a very general term, and the symptoms are very similar to colds.When seeing a doctor in Western medicine, the first thing to look at is the pathogen.There are two types of colds: bacterial and viral.Viruses are easily contagious, while bacteria are mostly sporadic.Ah Sheng inquired with Uncle Qing that among the dozen or so servants who served Cao Teng, only one was infected, and the others were all fine, so he felt confident.
Bacteria is good, bacterial colds, antibiotics can be used.
In order to be more sure, Ah Sheng tried his best to convince Uncle Qing, and was able to see Cao Teng who was recuperating behind closed doors.The grandfather felt sorry for the younger generation, for fear that they would catch the cold, and since he became seriously ill, he even ate meals alone.
"What are you doing here? Don't mess around, get out." Cao Teng rushed away as soon as he saw her, his voice was hoarse, and he had pharyngitis or tonsillitis.
"I haven't seen my grandfather for a long time, and I'm very worried." A Sheng's eyes were red, and he looked like a baby who was aggrieved.
Cao Teng sighed, he also missed his precious granddaughter. "What do you want to ask? Did you fail the homework assigned to you? Did Geely get into trouble?"
Ah Sheng hit the snake with the stick, and talked with his grandfather while observing his symptoms.The tonsils are inflamed, there is purulent sputum, and there are no other symptoms such as diarrhea.This is a very typical bacterial infection of the upper respiratory tract, and the amoxicillin provided by the space is just symptomatic.She has verified the effectiveness and safety of these batches of antibiotics several times, and the only thing she needs to watch out for next is that her grandfather is allergic to penicillin.
Ah Sheng was more cautious with the medication this time, and carefully weighed the dose and time interval based on previous experience.Then sneak the ground medicinal powder into grandfather's ginger soup.
She waited nervously for three days.
Strangely, from what Uncle Qing said, Cao Teng had no symptoms of allergies, nor did his condition improve.
Ah Sheng held his bun face, could it be that she misdiagnosed it?It shouldn't be.
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