Micro-check

Zhou Xun used three methods to take Chen Jingsheng's blood sample. Although he was worried that the result of the diluted sample would not be good, it is always good to try it first.

On the way, Senior Sister Yang Yan called him and told him the result of the blood sample she had taken from Sister Zhao. She said: "I was worried that I could not get good DNA, but I was lucky, and the result this time is not bad. It’s just that the result is good, as you know, it’s positive. I also made her the mutations 23SA2508G and A2509G, but fortunately there are no mutations, so there should be no azithromycin resistance.”

Their side has always been very busy, and it is not as easy as ours. She also helped with the drug resistance test, which is really grateful.

But talking poorly with her, of course she can't be poor, Zhou Xun just said: "Thank you very much, I will definitely treat you to beef jerky in the future."

She said: "It's nothing, anyway, it's just an additional case result, you know I'm doing azithromycin resistance mutation recently. Is she being treated? Or not? If not, you can come to our hospital for treatment. Since it is Your acquaintance, I can also do regular drug resistance monitoring for her."

Zhou Xun said: "The treatment should not have started yet. When I tell her the result, I will explain it clearly to her."

After finishing the experiment and getting the results of the three methods, it was already late when Zhou Xun came home, and he called Wang Fei when he went to the parking lot to pick up the car.

Wang Fei answered it quickly: "Zhou Xun, is there a result?"

"Yeah." Zhou Xun often gave bad results to many people, and he still couldn't treat these results with a normal heart. He didn't know what tone to use to tell Wang Fei about this matter, but when he said it, it was like The tone is like giving a lecture, and I don’t know if it will make people feel disgusted. Before, the director said that he didn’t have empathy for some patients when he talked about the test results. He really wanted to ask her how to speak to be empathetic. Heart?

"Your aunt's test is indeed positive, but the good news is that there should be no drug resistance, and the treatment is much easier. If your aunt has not started treatment, then she can come to our hospital for treatment, and then we can give her a more comprehensive treatment." Serological and molecular tests, so that the monitoring of her treatment process will be better."

Wang Fei was not very disappointed, and said: "I checked several times before, and we all know that the possibility of a false positive is very low. Anyway, it's not a terminal illness, as long as it can be cured. It's just that her illness, usually Is the probability of infection high? My dad came back from work and was arguing with my mom about it."

Zhou Xun was a little surprised. He often thought that others should know things with common sense. In fact, many people around him didn't know. So he tried to make himself feel reasonable when Wang Fei's father would make a fuss, saying: "In fact, as long as there is no sexual contact, no blood transmission, and no mother-to-child transmission, the other probabilities are very low. If she lives in your house, as long as she doesn't mix toothbrushes and towels, and doesn't use the toilet, she should be fine."

Originally wanted to tell her about Chen Jingsheng, but because he had arrived at the parking lot and the signal inside was not good, Zhou Xun had no choice but to hang up the phone, sat in the car, and when he was about to drive away, he felt dizzy and almost fell into the car. He was startled when he hit a post behind the driveway, but he hit the brakes just in time.

But it took him a long time to calm down, and then he remembered that he didn't seem to have eaten from morning to noon until now.Uh, he actually forgot to eat!If Zhou Ning knew about this, she would definitely be scolded.

Afraid of accidents on the road, he had no choice but to give up driving, but walked out of the parking lot and called Didi.

When I got home, it was already past eight o'clock in the evening. Zhou Ning had finished dinner, and stared at Zhou Xun who entered the room with a frown, "Didn't you say you can come back early, it's very early now?"

Although Zhou Xun knew that he was not really angry with him, Zhou Xun was not afraid of him, but guilt was more difficult for Zhou Xun to relieve than other feelings. He often couldn't let go of guilt for a long time, and other emotions , but always quickly forgotten.

Zhou Xun knew that he had to explain this kind of situation, but his body was faster than his reason, so he had hugged him. When Zhou Xun recovered, he had already leaned his face on Zhou Ning's shoulder and said to him: "Ningning, I'm sorry, are you angry, don't be angry."

Zhou Xun thought to himself that he obviously had no intention of doing this, it really wasn't what he wanted to do, it was just his body's self-awareness.

This is really not my intention, I am not such an irresponsible person! ——He thought he shouldn't change the subject to Zhou Ning.

He realized that this was wrong, and quickly raised his head to take responsibility: "I didn't do it on purpose today, I suddenly forgot the time... Ah, no, it was that experiment that took more time... No... It's just that I really won't do it next time That's it..."

He doesn't know what the hell he's talking about, too bad.

He explained it in a mess, but Zhou Ning was really not angry. He rubbed Zhou Xun's face: "You have dark circles under your eyes. Hurry up and eat, take a shower and sleep."

"Thank you." Zhou Xun said quickly.

"Wash your hands and eat!"

Zhou Ning's tone was very fierce, Zhou Xun hurriedly followed and took his hand, but fortunately he didn't shake it off.

Seeing that there were no hairy crabs on the table, Zhou Xun asked, "Didn't you say you want to eat hairy crabs?"

"There's nothing to eat." Zhou Ning replied angrily.

Zhou Xun had no choice but to obediently not ask.

Maybe he was too hungry, Zhou Xun didn't have much appetite.

After only drinking a bowl of chicken soup, eating a bowl of rice and few vegetables, Zhou Xun sat there and waited for Zhou Ning to finish eating and clean up the table. Zhou Ning said, "Go take a shower and go to sleep, I will clean up by myself."

Zhou Xun was unwilling to leave, and said, "Let me clean it up."

"Go!"

When taking a bath, Zhou Xun felt that I was really like a parasite, but he was too sleepy. He fell asleep after taking a shower and climbed into bed. There was really no time to help the family. This feeling was really uncomfortable.

While sleeping in a daze, Zhou Xun felt the sound of the hair dryer, and the warm air on his head, Zhou Ning was blowing his hair? !

He opened his eyes and wanted to say that there is no need to blow it, and it dried quickly, but Zhou Ning didn't stop, he kept blowing his hair.

Zhou Ning rubbed Zhou Xun's ears, her fingers were soft, Zhou Xun was confused, but she really wanted to hug Zhou Ning tightly in her heart.

Zhou Ning said: "Sleep with you. Every time I see news about the sudden death of a doctor on the Internet, I think of you."

Sorry, I shouldn't have worried you.Zhou Xun thought guiltily.

When Zhou Xun woke up, the curtains were closed tightly, the room was very dark, and Zhou Ning was lying beside him.It should be very late, Zhou Xun was stunned for a moment, rolled up the quilt for Zhou Ning, and looked at him carefully in the dim light.

He is such a good person, he is actually with me. In my previous life, even if I didn’t save the Milky Way, I saved the solar system.Thinking of this, Zhou Xun stood up cautiously, and wrapped the quilt for Zhou Ning again. Then he went to the bathroom, went to get another glass of water to drink, and then got a glass for Zhou Ning, and put it behind his bedside. Only then did he put on a coat, took out his cell phone and left the bedroom.

Their cat Taotao is now a nocturnal animal, eating and sleeping during the day, but likes to run around the house at night.Zhou Xun went downstairs, he jumped out from nowhere, startled Zhou Xun, but he raised his head and looked at Zhou Xun, then walked away arrogantly.Both of them have their own affairs to do, and they don't want to pay more attention to each other—no, Taotao is not a man, he is already a father-in-law...Zhou Ning sterilized him.

It was past twelve o'clock at this time, and Wang Fei was probably still awake. Zhou Xun called her, and she answered it very quickly.

"Wang Fei, I tested your uncle's blood with three methods, and I have some personal judgments to tell you."

"Ah, what is it?" she asked eagerly.

"Our laboratory now has several methods that can be used for syphilis detection, but the most commonly used method in China is generally to use RPR as a non-specific antibody test for primary screening. Sexual antibody test for confirmation. RPR is the abbreviation of rapid plasma reagin, which is rapid plasma reagin test, TPPA..."

Before Zhou Xun finished speaking, Wang Fei interrupted him, "I don't quite understand what you said, can you say that I understand, for example, what is your personal judgment? Is my uncle also positive? , he infected my aunt, right?"

Although she was indeed half right in her guess, Zhou Xun still said, "You have to listen to me before you know about your uncle's problem."

She had to agree to listen to me in detail.

Zhou Xun: "I have to tell you the principle before you know where the problem is. RPR is a non-specific antibody test. I won't talk about its specific principle. Its principle allows it to detect symptomatic syphilis, but it cannot detect it. Very early syphilis. Your uncle's PRP test is indeed negative, indicating that he is not currently an active syphilis patient, or he is very early syphilis."

Wang Fei said, "It's not like that?"

Zhou Xun: "Because his RPR test result was negative, the hospital that examined him will no longer perform TPPA test for him. TPPA is a method of specific antibody detection, which can directly detect syphilis antibodies in the body. And as long as he has been infected with syphilis, no matter whether it is current syphilis or the previous infection has been cured at this time, the syphilis antibody will exist in his blood for life, so I tested his TPPA result to be positive, which means that he has been infected before. It’s just that it’s cured now. In order to verify, I did an IgM test that is still under evaluation and is not on the market. The IgM test can detect very early syphilis, but it cannot detect cured syphilis, and the result is negative. This ruled out that he is not He was just infected with syphilis at a very early stage, and it can be confirmed that he was infected in the past and has now been cured. In this way, his TPPA positive cannot be blamed on your aunt, saying that your aunt infected him, and it can be confirmed that it should be him Infected your aunt."

Zhou Xun spoke dryly, and he didn't know if Wang Fei understood. Zhou Xun actually didn't like to explain this kind of professional knowledge to others.

Wang Fei said: "I can't understand the methods you said, but if I understand the conclusion you said, my uncle infected my aunt, and then he cured himself, and then slandered me in turn. Auntie?"

"That's right." Zhou Xun said.

Wang Fei became excited: "He, Chen Jingsheng, really had a good idea. I'll tell my aunt about this, and I'll trouble Chen Jingsheng tomorrow."

Zhou Xun: "..."

Zhou Xun wanted to persuade her not to be impulsive, but she had already hung up the phone.

Back in the bedroom, Zhou Xun climbed onto the bed lightly, afraid of waking Zhou Ning up, but he still woke up.Zhou Xun quickly got into the bed, hugging his shoulders, Zhou Ning glanced at Zhou Xun, and said with sleepy eyes: "Where did you go just now?"

"I went downstairs and made a phone call. Do you want to drink water?" Zhou Xun asked.

He shook his head.

"Then go to sleep, it's already one o'clock." Zhou Xun kissed his forehead, pulled the quilt again, and covered Zhou Ning. Now the weather has cooled down. If you don't cover your shoulders well, your shoulders will hurt easily.

Zhou Ning embraced Zhou Xun's waist and leaned over. Zhou Xun held him in his arms. The quilt of the two of them was really warm, which was great.

The author has something to say: The mutation of base A to G at positions 23 and 2508 of Treponema pallidum 2509SrRNA[-] will cause azithromycin resistance.