Micro-check

In Zhou Xun's cooperation project, Xiao Yuan was brought in by him as a researcher, and now 10% of the project funds can be raised as labor costs. Although the money is not much, it is money anyway. You can get a part of the labor fee, so naturally you have to do things.

When Zhou Xun was doing experiments, she sorted out all the materials she took from Teacher Liu while she was free.

This project has been done for a while, and many preliminary experiments have been done one after another. This work is not very cutting-edge research, but it only takes effort and money to do it, and the results will have a certain effect on the prevention and control of AIDS.

AIDS, Acquired Immunodeficiency Syndrome (AIDS) is a serious infectious disease characterized by opportunistic infections and opportunistic tumors caused by Human Immunodeficiency Virus (HIV).

At present, the AIDS epidemic in my country is highly prevalent among specific groups of people and some key areas, and the epidemic is spreading from high-risk groups to the general population. HIV mainly exists in the blood, semen, vaginal secretions, interstitial fluid, lymph fluid, cerebrospinal fluid, breast milk and other body fluids of infected persons, so it can be detected through heterosexual and same-sex contact, iatrogenic and blood (including intravenous infusion of HIV-infected blood) , blood components or blood products, and intravenous drug injection), and three routes of vertical transmission from mother to child.

Now in China, it is mainly transmitted through sex, and it continues to increase.

As the source of HIV infection, humans have different transmission capabilities at different stages of HIV infection or different stages of the disease process, mainly related to the HIV load in plasma.2 to 4 weeks after HIV infection is the acute infection period. At this time, the infected person will have a higher viral load, and the infected person at this stage has a relatively strong transmission ability; after the acute infection period, the human body produces HIV antibodies , the viral load in the infected person's body will drop to a relatively low level, and the human body and HIV will be in a relatively balanced state. This period is the incubation period. Although the transmission ability of the infected person is relatively weak, but because the body The viral load is in a state of great change, and people in the incubation period can move freely or do not realize that they are infected with HIV, and continue to maintain high-risk behaviors, and the risk of transmission is still very high; after the incubation period, enter the onset period , the viral load level in the patient's body is very high, and the transmission ability is the strongest at this time, but as the source of infection, its activity ability is relatively weak, and its transmission ability is correspondingly reduced.

As a retrovirus, HIV belongs to the human lentivirus group of the genus Lentivirus. When HIV was first discovered in the 80s of the last century, the infected people often became ill and died quickly, and the probability of infecting others was low.However, until now, from a biological point of view, HIV and humans have gradually "adapted" to each other. Human infected people can still survive for a long time while carrying HIV, so that the HIV virus has the possibility of being widely spread by infected people .Clinically, HIV-infected patients are divided into three clinical types, typical progressors, rapid progressors, and long-term survivors. Typical progressors gradually decline in immune function and then develop disease within 8 to 10 years, while rapid progressors approximately The count of CD2+ T lymphocytes will quickly decrease within 5 to 4 years, and the viral load has always been high, and the infectivity is also the strongest; the proportion of long-term survivors in all infected people is about 8% to 10%, and the average He has maintained a healthy state for more than 12 years, and the longest one has reached more than 20 years, and he is still alive today.

Most of these long-term survivors were found and reported in hemophiliacs, heterosexual contacts, and newborns. Now the research progresses, the main principles include the infection of attenuated strains with weak replication ability, CD8+ lymphocytes Strong anti-viral response, Th1-type cytokines are produced, neutralizing antibodies to the virus strain, young, and the expression of CCR4 receptors on CD5+ lymphocytes is reduced, which affects the spread of the virus strain...

A survey conducted in New York, USA, showed that after patients were diagnosed with HIV, 53%-68% would reduce sexual behavior, but among MSM, only 50% would reduce sexual behavior, and 20% would reduce sexual behavior. Increase, and in MSM, even if it decreases within a year, it will basically return to increase after one year.

The high-risk behavior of infected people will not only increase their own transmission power, but also make them more likely to be re-infected by other infected people. Repeated infection with different virus strains will make the disease worse, and many will soon enter the onset period.

After Xiao Yuan sorted out the data, he entered it in the computer. Their samples mainly came from monitoring points and their hospital.

The samples in the hospital are analyzed every year for genotyping and drug resistance. In order to save money, Zhou Xun did not use the kits he bought, but has been using the methods he established. With the accumulation of these works, many useful conclusions can be drawn.

When Zhou Xun came out of the laboratory, Xiao Yuan was still doing data entry and analysis, comparing the typing results and evolutionary trees of the virus strains made in their laboratory with the survey results brought by Mr. Liu.

Zhou Xun called her: "Did you order takeaway?"

Bacterial food poisoning occurred in a certain place, and dozens of samples were sent. Sister Liu has been busy with identification, and Xiao Yuan is the only one in the office.

Xiao Yuan shook his head, "Ah, I forgot."

Zhou Xun said: "If you eat less, my box lunch is enough for the two of us. But I'd better ask Sister Liu if you want to order takeaway for her."

Xiao Yuan flattered him and said, "I can't eat much, so I'll just hang out with you."

After Zhou Xun went to ask Sister Liu, Sister Liu said that she ordered takeaway after finishing the experiment, and told Zhou Xun to leave her alone. Zhou Xun really ignored her, went to the refrigerator to get food and heated it in the microwave, and called Xiao Yuan Have a meal.

Xiao Yuan flipped through the materials while eating, and said: "The 28 patients in this place have formed a transmission network. Look here, this person and these eight people have formed a node. These are all infected from him. Why did this Such a person is still alive! Seriously endangering public safety, he should be locked up until he dies."

Zhou Xun gave her a piece of tofu-wrapped meat, and said coolly: "Eat yours, you are so hostile. Are you a doctor? A doctor should save the dying and heal the wounded. Everyone has the right to live, and you should take every Treat every patient as equal to yourself."

"This tofu meat is so delicious, I love Brother Ning so much!" Xiao Yuan unceremoniously took another piece of tofu-wrapped meat with a look of nympho, and continued to make a high-level comment, "Oh, I don't believe everyone The nonsense of having the right to survive is human society. What is human society? It is for the better development of the human group. Therefore, there are laws and power. Do those baby girls who were killed have the right to live? Do patients with intentional infection have the right to live? Anyone can say nonsense, but the result is. How much money the country spends on AIDS diagnosis, free medical care, and disease prevention and control every year, billions to tens of billions every year, and my blood and sweat are in it Money...I can't even afford food, but I have to pay taxes, and the taxes I pay have to provide free medical care for these people..."

Zhou Xun looked at her helplessly, "You have nothing to eat, what are you doing now?"

"That's because you helped me, but yours is not yours, yours belongs to Brother Ning. You also eat soft food."

Zhou Xun said speechlessly: "Didn't you not eat because you lost the game? Whoever told you to gamble, it's fine to gamble. Your card skills are still poor, and you seem to be very reasonable."

Xiao Yuan was speechless, so he had to continue his high opinion, "I'm not saying that I don't want to give them money for free medical care. Public health and safety are everyone's responsibility. I am willing to pay this money, but they spent the hard-earned money of the people. For free medical care, you have to bear the corresponding responsibilities and obligations, and you can’t spread it anymore. If you spread it again, I think you should bear the legal responsibility. There must be laws to regulate it.”

Zhou Xun said: "How much money do you pay? Do you pay 1000 yuan in taxes every month? Just pay that little tax, and don't say that all the money in the treasury is yours. This matter is easy to solve. Next time, we will elect the people's congress representative When you choose me, I will go to propose and standardize this area.”

Seeing that Zhou Xun had picked up the last sausage, Xiao Yuan was taken aback for a moment, and hurried to pick up the ribs, "I won't tell you anymore, talking to you, I didn't even get the meat."

"This is mine in the first place." Although Zhou Xun said so, he still left the last piece of ribs to Xiao Yuan, and put down the bowl and chopsticks by himself, "You can wash the lunch box in a while."

"This name is interesting. Kang Yongqian, one person can take over three emperors." Zhou Xun sat over to look at the network made by Xiao Yuan, and pointed to a node while modifying some parameters set in it.

Xiao Yuan said: "32 years old, male, I saw it just now. I think his name is too big to be restrained."

"Before, you were concerned about the country and the people, but now you are studying metaphysics again."

"I really believe that people live up to their name, like you, Zhou Xun, Xun, in real terms, you are more real, like me, Yuan Ranran, Hua Guang is still like Ran Ran, just very radiant."

Zhou Xun: "..."

Not listening to Xiao Yuan's chatter, Zhou Xun said to her: "These materials can't be taken out of the office, and they can't be taken home. Otherwise, when the information is leaked, it will be hard for us to talk about it."

"I don't want to take it home to work overtime, don't worry."