I reach the pinnacle of life by learning

From the outside, the Yanda Genetic Laboratory is just a simple and unpretentious laboratory, located on the top floor of the experimental building.

Because there is no direct elevator, all scientific researchers need to take the elevator to the reading room on the 5th floor, and then walk upstairs by swiping the access control card.

From the perspective of equipment, it is just an ordinary laboratory with a total value of over [-] million.

But when the laboratory is fully staffed, this very low-key laboratory is like a sweeping monk at the gate of Shaolin Temple, just waiting to become famous all over the world.

Yu Hanxi looked around the laboratory with critical eyes, and commented: "It's only a little better than the coal kiln factory."

After all, this is a laboratory arranged by himself, and Qiao Yu still has some weak feelings for it: "I hope you can evaluate it objectively."

With hands behind his back, Yu Hanxi walked around the laboratory like a leader inspecting, and finally stopped on the bulletin board at the door.

This thing is like the honor roll when I was in school. When I was studying, I praised the scores, and now I praise the papers.

Although there is a bit of formalism, this is what schoolmasters eat.

For most of the top students in their student days, if they cannot be envied by the scumbags around them, their sense of accomplishment should be less than half.

Yu Hanxi said: "Hey, have you posted three CNS articles? That's not bad."

On the one hand, Professor Qi, who just came from Tsinghua University, couldn't help but look sideways.

Maybe this is the confidence of foreign scholars, saying that publishing CNS papers is as simple as drinking water.

He has worked for more than 20 years and has not published a CNS paper yet.

These three CSNs were all brought back by Qiao Yu from Cold Spring Harbor.In two months time, one after another passed the trial.

A professor's publication of CNS is far less shocking than that of an undergraduate student's publication of CNS, and basically did not cause any splash outside the circle.

But people in the circle are still fascinated by it.

I am less than 30 years old, and I have already published 5 CNS papers... at least I can do it for another 30 years.

Even if you live on your laurels until you retire, that's enough.

Yu Hanxi condescended to put his golden buttocks on the chair in the meeting room, and said, "Where is the project design book, take it out and let me have a look."

Because Qiao Yu was still playing with the newly arrived CRISPR/Cas9 system (genome fixed-point editing technology) in another laboratory, this task fell on Tan Zirui's shoulders.

Tan Zirui took out the experimental design from the safe, and couldn't help but asked, "Did you talk to your colleagues like this when you were in Tsinghua University?"

Professor Qi from Tsinghua University stood up: "This is purely a misunderstanding. Professor Yu didn't talk to us back then."

Yu Hanxi's emotional intelligence is not high, which is recognized within Tsinghua University.It is completely possible to turn the experiment of everyone's cooperation into a single person's fight alone.

If it weren't for the outstanding academic achievements, and Shi Wen's mediation, I'm afraid he would have been suppressed long ago and couldn't get along.

Professor Zhao, who came from Wuhan University, had no choice but to smile stupidly because his performance was not outstanding.

His position is embarrassing, he is not the oldest, and his achievements are the most mediocre among so many professors. In other places, he can still win a burst of respect. In a genetic laboratory where big bosses gather, it is really not enough.

Even Qiao Yu, who graduated three years ago, published more papers than him.

Yu Hanxi didn't want to start arguing the next day after returning to China, so he started to read the project proposal directly.

The so-called cancer is a kind of gene mutation. The cells in the body do not obey their orders and become diseased by themselves. Targeted drugs precisely target cancer-causing sites, causing tumor cells to specifically die, thereby delaying death.

Yes, very sorry.There is no medicine in the world that can cure cancer.

The reason is that cancer cells will transfer silently, and it is difficult for drugs to kill all cancer cells. Some fish that slip through the net will wander around in the body, looking for the next target.

There are three types of targeted drugs on the market today.

The first is traditional cytotoxic drugs, including platinum and camptothecin, which are still the bulk of the targeted drug market.

The second is non-cytotoxic drugs.

The third is other categories, including some photosensitizers, apoptosis inducers, and some compounds that have not been approved by the FDA and whose ingredients are difficult to classify.

Yu Hanxi, Ge You's paralyzed body gradually sat up straight, with one hand propping his chin, his brows were furrowed.

Generally speaking, the design idea of ​​targeted drugs is to find the mutation point and prescribe the right medicine.

These cancer cells are also called primary cancer cells.

However, people without cancer may not know that targeted drugs cannot be taken casually, and genetic testing is required before taking them.

Qiao Yu's idea is to make this targeted drug take effect on as many gene mutation points as possible, so as to cover more patients.

The complexity of cancer lies in its individual differences, and the locations of lesions are ever-changing. For liver cancer, there are five possible types of tumors.

Generally speaking, a targeted drug can only treat one branch of cancer.

If this drug is successfully developed... it will basically belong to the panacea for cancer.

There really will be a day when pharmaceutical companies producing targeted drugs all over the world will unite to assassinate Qiao Yu.

If it wasn't for Qiao Yu who wrote this plan, Yu Hanxi would suspect that he was reading some fantasy YY literature.

"...He just read this to the Science and Technology Committee? The Science and Technology Committee's letter??"

But even out of trust in Qiao Yu, Yu Hanxi felt that the plan was like Qiao Yu's dream.

Just as he was thinking this, the glass door of the conference room was pushed open.

Qiao Yu, who was wearing a white coat, came in from the door, just in time to hear Yu Hanxi's questioning.

Qiao Yu: "No, the blue book for the Ministry of Science and Technology is another one. It is an EGFR (epidermal growth factor receptor) phase III lung cancer drug."

Yu Hanxi was restless, and even a little angry: "I don't think this is possible."

This feeling is like a skilled cook who came to the stove and found that there was only a bowl of porridge and side dishes, but the diners ordered abalone and olong.

Qiao Yu reassured him and said, "It's okay, let's find the uniqueness of the gene first. I have used the newly bought CRISPR/Cas9 system, and it works very well by cutting gene fragments, so I don't need to go to a biological company for gene editing at a high price."

Before this technology came out, the gene editing work in the laboratory was outsourced to outside companies.

Yu Hanxi's face was heavy, and his face was very ugly.

Qi Shaopeng said: "It's already here, Professor Yu. Bear with it, how can you let go?"

For some reason, Tan Zirui felt that the current scene was like a young couple arguing, and Qi Shaopeng was the one who persuaded them to make peace.

Although there were some stumbling blocks, the work of the genetic laboratory was still carried out in an orderly manner.

The CRISPR/Cas9 system is a new technology in the world, and the benefits of returning from studying abroad become obvious.Many domestic professors don't know how to use it yet, and the three-person group studying abroad has already designed experiments proficiently.

Even Qiao Yu has to admit that a person's thinking is indeed full of limitations.

Tan Zirui pays attention to the basics and likes to play steadily, while Yu Hanxi is active in thinking and dares to take the edge of the sword. Although disputes still happen occasionally, but generally speaking, it is not a big problem.

This kind of dispute is not a dispute over who publishes the paper or who wants money, but a dispute over how to further advance the experiment.Those who lose don't take it to heart.

In terms of operation, Qiao Yu, who has undergone systematic training, is impeccable. When the success rate of all the graduate students was still hovering around 20.00%, Qiao Yu performed gene excision and transcription, and the success rate remained above 90.00%.

If researchers from foreign laboratories were to come, the success rate should be [-]%.

To be honest, this failure rate is a waste of money, but it is a helpless waste.

If we don't cultivate this group of skilled workers, why should Qiao Yu spend his days cutting genes in the laboratory?

Fortunately, after more than a week of training, the success rate of the scientific research dogs has stabilized at around [-]%.

Li Hua basically lives in the laboratory with a group of graduate students these days.Repeated training every day, I almost vomited after doing experiments, and even fell asleep when I got home, so tired.

After a period of time, the scientific research dogs in the genetic laboratory described themselves as haggard, and they could smell the rotten smell of each other through the protective clothing.

But their spirits are very good.

Doing scientific research, especially low-level scientific researchers, is actually very poor.With their academic qualifications, going out to find a job is probably more profitable than staying in the laboratory.

Even in an environment where the salary is relatively high in Europe and the United States, the cost-effectiveness of becoming a scientific researcher is very low.

But they are still willing to stay in the laboratory, more or less, have expectations for the future.

I hope to gain a place in the brutal competition, I hope to make amazing achievements in the future, and I hope I can contribute to this world...

To be honest, these ordinary graduate students still don’t know what experiment they did last, and which part of the production line they are in, but the fact of “being able to learn something” itself is full of excitement. strength.

After the success rate increased to a certain stage, the entire laboratory was formally divided into five groups. A professor led a group to look for cancer specificities caused by different tumors.

This is not only technical work, but also mental work.

Several professors of biology gathered together, holding a draft book as high as a mountain, and started to perform pure theoretical calculations.

Qiao Yu is used to calculating with mathematical methods, but other people also use physical and chemical methods to calculate.

The advantages of Professor Zhao Zhirui of Wuhan University finally revealed at this time.

Both his undergraduate and postgraduate studies were in physics. When he was a Ph.D. student, the Human Genome Project was taking the world by storm. Zhao Zhirui heard that biology was a good job, so he changed his career in a daze.

The male was afraid of entering the wrong profession, and Professor Zhao thought that he would never need the big things he had studied for six years in his life.

Unexpectedly, now, he has become the one with the fastest progress in all the groups.

But Tan Zirui became the one who calculated the slowest because of bad math.

He has always been high-spirited, and he hasn't been frustrated by this for a long time. Seeing that everyone else has started the second stage of the experiment, a red stress pox appeared on his chin.

Stress is the worst thing for middle-aged people.Not only prone to acne, but also affect endocrine, leading to premature baldness.

In order to release the pressure, Professor Tan had to transfer the pressure to the graduate students under him.

The scientific research dog under his command has recently become trembling when doing experiments, for fear that he will be ridiculed if he is not careful.

It took Qiao Yulu more than a month to calculate the data of his group.

He said to Professor Tan: "You also count on me."

Tan Zirui stiffened his neck and replied very stiffly: "No. I can do it myself."

There is a feeling of rather bending than bending.

Qiao Yu sighed: "It's normal for people to have things they're not good at. Now the laboratory burns hundreds of thousands a day, so I can't afford to delay. Don't be willful."

Tan Zirui stared at Qiao Yu for two seconds, then suddenly got up, dropped his pen and ran away.

In the middle of the night, Yu Hanxi was thinking about life in the toilet when he suddenly heard a rush of footsteps.

After a while, there were a few whimpers from the private room next door.

It sounded like Kevin Tan from Cambridge University.

Fuck?what's the situation.

Yu Hanxi originally planned to go out, so he had to stop slowly and continue to think about life.

Avoid embarrassment.

It's true that he has a low EQ, and he often acts recklessly with his talent and arrogance, but he is not mentally retarded.

Professor Yu had already finished a set of radio gymnastics in the small toilet cubicle because of numbness in his legs.

The neighbor sobbed for a long time, and finally the voice gradually became smaller.

Then, Yu Hanxi heard the sound of metal colliding, and Deputy Director Tan roared angrily: "Who the hell ran out of paper and didn't put in a new one!"

Yu Hanxi hesitated for a moment, then passed a pack of napkins from under the door.

"or?"

Tan Zirui: "... hiccup."

The atmosphere was awkward for a while.