Infrastructure masters in the red building

"What do you want me to say about you?" Jia Fang said rather bluntly to Zhang Youshi, "Since there is no evidence that this herbal medicine is effective, why do you just rely on one or two lines of records in the book to rashly Are you saying that you have found a special medicine?"

"It's better to have no books than to believe in books. Brother Zhang understands this truth better than me, right?"

Zhang Youshi drooped his head, looking very depressed.

He still had the "Schistosomiasis Prevention Manual" in his hand, turned to the most important page, rolled up the book and held it in his hand. "Students...students just saw the word 'Qinghao' and thought that Qinghao could cure the bloating disease. I never thought that now it looks... like a joy in vain."

On that day, Zhang Youshi yelled loudly at the gathering of all Taoyuanzhai residents, saying that he had found a special medicine for treating bloating.

The scene was really spectacular. More than half of the residents knelt down to Zhang Youshi and Jia Fang, and half of them called Zhang Youshi "Zhang Immortal" and Jia Fang "Living Bodhisattva". up.

But as the saying goes, the greater the hope, the greater the disappointment.

Zhang Youshi revealed his mystery in public, saying that the herbal medicine to treat the disease is "Qinghao".

"Qinghao?" The villagers who came all the way from Yujiang looked at each other, and then someone asked: "Shenxian Zhang, you are talking about... the Qinghao we often eat?"

Zhang Youshi scratched his head: "It should be. It is recorded in "Materia Medica" that this herb has the effects of clearing away heat, cooling blood, relieving heat, dispelling wind, and relieving itching. It can relieve hot flashes due to yin deficiency, night sweats, and heat stroke..."

In the time and space Jia Fang lives in, there has never been a person like Li Shizhen who compiled "Compendium of Materia Medica".

But more than one person at the scene had read medical books like Zhang Youshi, and one of the immigrants from Yujiang suddenly said, "You're talking about the Artemisia annua in "Rescue the Wilderness Materia Medica"? If it is Artemisia annua, we often eat it. I have never seen it before." What effect does it have on bloat disease?"

Zhang Youshi was not sure now, and said hesitantly: "There is still a difference between taking it for daily use and taking it as medicine. Since the medical book says so, we should try it."

His words immediately stopped all kinds of rhetorical questions, but failed to stop doubts immediately.The villagers from Yujiang looked at each other without speaking.

Zhang Youshi soon confirmed that the special drug "Qinghao" he thought was exactly the evil wormwood recorded in "Materia Medica for Rescuing Famines".This is a kind of wild vegetable, which grows scattered in the field, beside the forest and roadside. It is quite common, non-toxic, and has a special aroma (some people think it is a bad smell). It can be picked and eaten during the year.

Therefore, the clinical experiment on whether "Qinghao" can treat bloating disease was launched in Taoyuanzhai.Zhang Youshi was very ambitious. He selected 200 chronic patients suffering from bloating and gave them a medicinal soup made from leaves of Artemisia annua.The other patients were all the control group of [-] people.

Unexpectedly, among the [-] bloated patients, after taking Qinghao decoction for ten days, not one of them improved, and two of them could not hold on and passed away.

On the contrary, in the control group, they were all alive and well.

The villagers from Yujiang all shook their heads at Zhang Youshi, the "miracle doctor".At this time, Jia Fang had just started to implement his various new measures, and he generally felt serious resistance, and the work could not be carried out.

Jia Fang naturally wanted to blame Zhang Youshi—Zhang Youshi was a little too anxious, and he found out that it didn’t matter whether it was useful or not, so he yelled first, but it turned out that the highly anticipated "miracle medicine" didn't work, and everything Zhang Youshi said before was doubted. Even the reforms implemented by Jia Fang were also affected.

Now the two of them were sitting on the stilted building of Tao Village Chief's house chatting. Zhang Youshi was blamed, his self-esteem was hit, and he was listless.

"But I can't blame you—I've seen the two people who died of the disease. They were all bloated. I'm afraid they already had ascites. Unless the ascites is pumped out and the diseased organs are removed, there is really no way to save them."

Zhang Youshi was dumbfounded when he heard this: "Drain the ascites and remove the organs?"

Jia Fang sighed: "I just said it's not possible for the time being!"

Zhang Youshi: "You mean... one day, doctors can still treat patients in this way?"

Jia Fang: "Yes!"

Zhang Youshi was completely dumbfounded—what kind of unfathomable young man was in front of him!

"Brother Zhang, I admired you very much before, especially when you personally went to Yujiang Township to find out the cause of the spread of the bloating disease. I really admired you at that time, and I have said this more than once. But this time, regarding the drug Artemisia annua, I think you are indeed a little anxious."

Jia Fang, a 15-year-old boy, sat upright and lectured the 23-year-old Zhang Youshi opposite him, how weird it looked.

But Jia Fang's psychological age is no longer 15 years old. After he criticized, he immediately comforted him patiently, "But Brother Zhang, I believe that as long as you are good at observation and diligent in experimentation, your future achievements will be infinitely higher than what you are now."

"I have read the report you wrote, and it is very clear. I will find a way to submit it and sign your name. If we can find an effective anthelmintic in the last half month, I will connect you The prescription is also handed up together. In the whole world, you are the No.1 of 'schistosomiasis'."

What Jia Fang said made Zhang Youshi's eyes warm.

Although Zhang Youshi is obsessed with medical skills and is obsessed with curing diseases and saving lives, he is still an extremely "enthusiastic" person at his core.He has traveled all over Yujiang in a down-to-earth manner, trying to find the cause of the bloating disease, but he also wants to make a name for it, and the two do not conflict.

But Jia Fang withheld Zhang Youshi's note and hasn't sent it out yet, just waiting to fill in the item of "special medicine".Only in this way can this report truly become a "schistosomiasis prevention" report comparable to the "Schistosomiasis Prevention Manual".He, Zhang Youshi, was able to take this opportunity to become famous all over the world.

Zhang Youshi was stunned suddenly, and asked: "Jia Sanye, why don't you just submit this "Schistosomiasis Handbook" directly... Isn't the credit all yours?"

Jia Fang laughed: "What credit do I want?" He is a person who is going to slap his ass and leave when the time is up.

"Besides, if I submit this "Schistosomiasis Handbook", can it be used directly? The Holy Majesty and officials from all over the country asked whether the prevention and treatment methods written in this book have been tried in any state or county, and is there a way to succeed?— - How should I answer? I said, no, this is an isolated copy dug out from the pile of old papers, I don’t know whether it can be tried or practical!”

He shrugged his shoulders and spread his hands: "It's really meaningless to strive for credit like this, right?"

Zhang Youshi opened his mouth wide, feeling that he understands Jia Fang more and more now.

"Well then, let's spend more time on the main topic—the antidote to the blood plague. How did you come up with the idea of ​​'Qinghao'?"

Seeing Jia Fang asking, Zhang Youshi took out the "Schistosomiasis Prevention Handbook" he was still holding, and pointed to a line of small characters to show Jia Fang: "Here!"

Jia Fang took a look and saw that it said: "The drug of choice - praziquantel." Then there was a line of small words: "Artemether or artesunate can also be used."

"Artemether? Artesunate?" Jia Annuan thought, it seems that this friend only recognized the word "Qinghao" among the seven characters, so he thought of the herbal medicine Qinghao.

This is a very normal association, and he would probably think of it if asked, and then go to the field to try to pull Artemisia annua.

But in real experimentation, Artemisia annua is obviously just a common wild vegetable.

"Why is that?" Jia Fang said to himself.

"Third...Third Master, what is methyl ether and what is succinate, these are after Qinghao, so...isn't Qinghao?" Zhang Youshi asked beside him.

Jia Fang's mind was in a mess.He thought of many things in another time and space: Academician Tu Youyou, the only female in China to win the Nobel Prize in Medicine, whose most outstanding contribution was the discovery of artemisinin in traditional Chinese medicine.

He remembered that artemisinin was originally an antimalarial drug.Anti-malarial, that is, against Plasmodium, can it also be used to fight against schistosomiasis in the human body?

But the point is, why does artemisinin work so well, but why is artemisinin just a younger brother?

Jia Fang suddenly stood up from the stilted building, looked at Zhang Youshi who was staring at him in panic, and said, "Come on, let's go outside to see the wild Artemisia annua."

The two went down the stilted building together.The location they are in is currently the territory of Taoyuan Village. After they came down, everyone in Taoyuan Village stopped to say hello to Jia Fang.

"Mr. Zhang, do you have any clues about the matter of Qinghao that you said that day?" A villager asked Zhang Youshi, "We also hope that the newcomers will get rid of their illnesses soon. Besides, we have found the magic medicine. Aren't we also not afraid?"

"I have a clue... Soon!" Facing the enthusiastic villagers, Zhang Youshi faltered and felt uneasy.

But Jia Fang turned a deaf ear to this, and walked forward alone, heading straight to the edge of the dense forest where "Qinghao" was growing as pointed out by Zhang Youshi.

He walked up to a verdant plant and squatted down, staring blankly.

"This is Qinghao!" Zhang Youshi hurried to catch up, his face full of shame.Earlier, he just regarded this as a panacea, but it turned out to be useless after experimenting.

Jia Fang murmured, "Artemisinin doesn't come from Artemisia annua..."

Zhang Youshi couldn't understand again: "What is artemisinin?"

But Jia Fang didn’t pay attention to Zhang Youshi any more, and only thought about his own memories: In modern society, it seemed that he had seen a report saying that artemisinin did not come from “artemisia annua” in the botanical sense, but from another source. plant.

But what is the name of that plant?Can the finally extracted active ingredient be named "artemisinin"?

Jia Fang frowned.

Suddenly, a group of children from Taoyuan Village came bouncing along the field ridge. When they saw Jia Fang and Zhang Youshi, the children stopped together, made a long bow to them, and said in unison: "Hello, Mr. Jia!"

This is the rule taught by Jiang Fuzi in the school, so that children should salute and greet everyone when they meet.Now at least seventy school-age children in Taoyuan Village have learned this set very well.

One of the children came to Jia Fang with a newly made wreath in both hands. "Master Jia, this is what we gave you!"

Jia Fang came back to his senses, took the garland, smiled immediately, stood up, saluted those children, and said, "Thank you for thinking about it."

This is a wreath made of wicker, with emerald green willow leaves on it, and a few brightly colored small yellow flowers embedded in the middle.Many villagers in Taoyuan Village like to wear this kind of garland, especially men.This seems to be a local custom among them.

Jia Fang's eyes fell on the bright yellow flower, but he couldn't move it away, and even held the wreath in a daze.

Zhang Youshi looked sideways.

But Jia Fang suddenly turned around, stared at Zhang Youshi closely, and said loudly, "I remembered, it's Artemisia annua!"

He was excited and excited, his eyes were particularly bright, and his hands were still holding the garland full of small yellow flowers. It was this garland that aroused his memory.

"It's Artemisia annua! It's not Artemisia annua, artemisinin is not extracted from Artemisia annua, but Artemisia annua, Artemisia annua!"

Before Zhang Youshi could react, Jia Fang had already put the wreath in Zhang Youshi's hand, pulled a passing villager by hand, and asked repeatedly, "Do you know what Artemisia annua is?"

Artemisia annua and Artemisia annua are two different plants in the botanical sense.But for various reasons, artemisinin, an antimalarial drug, is extracted from Artemisia annua, not Artemisia annua.

Artemisinin comes from Artemisia annua, not Artemisia annua.

The artesunate written in the "Schistosomiasis Handbook" is exactly dihydroartemisinin①, which is an "upgraded version" of artemisinin.

Zhang Youshi next to him heard Jia Fang's words, and couldn't help but smile wryly: "Master Jia, what does the student know about Artemisia annua!"

By the time the second clinical trial started, the new immigrants from Yujiang had given up hope for the "special medicine" advertised by Zhang Youshi.

The "hygienic measures" vigorously promoted by Jia Fang are obviously effective, because after the people from Yujiang stayed here, except for those who were already sick, no one had the bloating disease anymore.And the local aborigines didn't find anyone who had a headache—this bloating disease obviously didn't spread locally.

It's just that the sick people are procrastinating at the moment, neither getting better nor getting worse—the villagers know well: if they can't get the right medicine, these people will just procrastinate.

But Zhang Youshi really lost his face this time. He knocked on the door one after another to explain, saying that he could not absolutely guarantee that it would be effective, but for the sake of the patient's suffering, he must ask the patient's consent to let him try it.

Who else can refuse? ——Most of the sick patients nodded in agreement with Zhang Youshi's treatment plan with the mentality of treating a dead horse as a living horse doctor.

Zhang Youshi divided the patients with blood plague into several groups. Among them, the group with abdominal distension like a drum took the medicine made together with Artemisia annua and Lobelia; those with hepatosplenomegaly but no massive abdominal distension were treated with Artemisia annua The medicine is mainly boiled; in addition, for mild patients who do not have "bloating" but have symptoms related to blood plague, they are divided into two groups, half of which take Artemisia annua, and the other half take Bupihegan Decoction.

Among them, among the critically ill patients, lobelia was used to treat the ascites caused by the disease, which was another effective drug that Jia Fang found in the medical books he took out from the Xiaoxiang Pavilion.

During this period of treatment, Jia Fang suggested that Zhang Youshi be meticulous and write down all the details as much as possible: how many times the patient takes the medicine every day, what happens after taking the medicine, and the day after the symptoms improve...Everyone should remember , Write it down in detail.

"When the world reads the prescriptions you wrote, they don't know how much effort you put in to get them. Only by using this method can the world see the hard work behind your back." Jia Fang reminded Zhang Youshi.

Zhang Youshi's eyes lit up as soon as he heard it: this was exactly what he wanted, and a concise statement could not directly reflect how much effort he had spent and how much hardship he had endured.

But the numbers can, and a detailed record attached to the report can let the numbers speak for themselves.

"Also, the more detailed the data, the more confidence it can give others, knowing how useful this prescription is." Jia Fang continued to instruct, "You can write it down, for example, if 100 out of 87 people can recover, others will know. This cure rate is 80.00% seven..."

Zhang Youshi finally understood what Jia Fang meant by "percent", and thought: He could write "cure rate: [-]%" at that time.

……

But whether it can cure so many people, Jia Anxin has no idea, Zhang Youshi has no idea, and the family members of the patients are even more uncertain.In the short few days since the experiment started, everyone was in high spirits, and there was no peace for a moment.

On the seventh day after the experiment started, Jia Fang was sitting in a corner of Xiaoxiang Academy, looking through the census book that Zhang Youshi and others had made before.Suddenly a woman with a puffy stomach rushed in, and when she saw Jia Fang, she immediately asked, "Mr. Jia, have you seen Mr. Zhang?"

Jia Fang had an impression of the woman's appearance, but in his impression she didn't have such a belly.Surprised, he stood up and pointed at the woman, and asked extremely uneasily: "Big... sister-in-law, you, you, you, are you also dyed..."

——It's over, the habit of speaking was infected by the fourth prince!

Seeing that Jia Fang was so startled, the woman was stunned, she suddenly came to her senses, laughed and helped her waist, and said, "Master Jia...I'm not sick!"

She supported her stomach contentedly, with a comfortable smile on her face, and said, "I have a baby in my belly."

Jia Fang finally breathed a sigh of relief, his face was a little hot, and he thought: Misunderstanding, a misunderstanding!

He had never paid attention to the figures of women before, which caused a big joke today.

"Mr. Jia, I'm here to tell you and Mr. Zhang that our family is much better——"

"Really?" Jia Fang asked, "Which group does your husband belong to?" He and Zhang Youshi didn't dare to call it "serious disease group" or "mild disease group" before, so they directly blurred the name of the group and called it "Group A." ""Group B" and "Group C".Group A is the group with the worst condition.

"It's from Group A!" The woman was relieved, "The swelling has subsided since this morning."

She lowered her eyes so that Jia Fang would not see the crystal tears in her eyes. "He can already sit up and laugh with energy that my belly is bigger than his..."

……

In the next 30 days, in addition to completing the report, Zhang Youshi also wrote the first "Schistosomiasis Prevention Report" in this time and space, with nearly ten thousand words in it, which listed extremely detailed data and detailed his How did they treat the more than [-] people who were infected in Taoyuan village, what kind of medicine was used, how effective the medicine was, and how did the medicine work for different people after receiving the medicine...

At the same time, this "Schistosomiasis Prevention Report" also describes how the various epidemic prevention measures in Taoyuan Village prevented the blood epidemic from spreading to the local area.

This report is second to none. Once it spread among the people, it was regarded as a classic by doctors.And Zhang Youshi was also famous, and was once hailed as "Schistosomiasis No. 1".

However, Zhang Youshi refused to recognize this title until he was old. Whenever someone asked him, he would say with shame: "There are other people, there are other people!"