Back To The Age Of The '80s

A relatively complete drug clinical specification is the basis of an efficient drug approval system.

In Li Zheng's last life, Huaguo gradually established drug clinical trial standards in 1999, and the long and inefficient drug approval process was not resolved until Li Zheng left.

"This is 20 drug samples that I asked Xiao Lu from our laboratory to randomly sample from the market. They are common cold medicines and emergency cardiovascular medicines. Our laboratory did a preliminary analysis of their ingredients and found a very Interesting things."

"Xiao Lu, please tell the professors." Li Zheng winked at Lu Keke behind him.

Lu Keke is not as talented as Meng Jie, nor as understanding as Sun Bin, but he is a good data analyst.

Lu Ke seemed a little nervous. He had only seen most of the people in this conference room on TV or even in textbooks before. He would never have dreamed that one day, these people would sit together and listen to him speak. .

Li Zheng could clearly hear Lu Ke's rapid breathing and swallowing, he got up and patted his subordinate on the shoulder, signaling him not to be nervous.

But obviously, Lu Ke became more nervous.

You can't embarrass Professor Li, you can't embarrass Professor Li, Lu Keke repeated it in his heart several times, and then he calmed down his fast beating heart a little bit.

He distributed the report in his hand to the professors present.

"This is the test report of [-] drug samples, as well as the clinical trial data of several related drugs that I can find." The sample test report was made by the Ninth Laboratory itself, and the drug clinical trial data is somewhat sensitive. It was not easy for Lu Keke to obtain such a few pieces of data.

All the experts present were experts in the industry, and the meaning of Li Zheng's words could be understood after a quick glance at the test report, and the atmosphere in the conference room suddenly became oppressive.

"Professors..."

Lu Keke managed to prepare his mind and started to speak, but he was interrupted by a furious voice just as he started.

"Nonsense! It's all nonsense, this is a life-saving medicine! Are they not guilty of doing this!" Mr. Yang couldn't help but slammed the test report and clinical data on the conference table.

"It's okay to use synthetic vitamins as the main ingredient of cold medicine, but what's the matter with this heart disease medicine? Is it okay if you can't take it to death? This is a joke with the lives of ordinary people!" Old Yang blushed with anger.

In the 80s when there were no drug clinical trial regulations, it was not uncommon for vitamins to be used as cold medicine. As for this heart disease medicine, it claimed to relieve early cardiovascular disease and dredge blood vessels. Containing trace iron elements, it is indeed beneficial to the heart, but the benefits are minimal at all, let alone relieve early cardiovascular disease, it is completely playing the piano.

Talk about ideals first, and then ask questions. This is a skill commonly used in negotiations in later generations. It may not be suitable for those "experienced in the market" of later generations, but it is surprisingly easy to use on these scholars who are obsessed with learning. .

Many old professors concluded on the spot that the clinical trial norms for drugs must be established as soon as possible.

"Seniors, the norms should be established as soon as possible, but how to build, how to build, how to advance in a logical manner, without causing backlash, we need to think about it in the long run." Li Zheng said with a smile.

In the half a year since Li Zheng left, there has been no breakthrough in the "Infinite Time Organ Storage Technology" experiment.As soon as Li Zheng came back, this matter was put on the agenda.

Although the accelerated approval time for erlotinib given by the FDA is 1-3 years, as long as the FDA confirms that erlotinib is clinically effective, the difficulties faced by the Human Genome Project will no longer be difficult.

After the laboratory is built, the Human Genome Project, which is widely participated by various countries and claims to be parallel with the Human Moon Landing Project and the Manhattan Atomic Bomb Project, can be officially launched around the world.

And Li Zheng wanted to drive out the results of the infinite-time organ storage technology project in the meantime.

"No. 1 and No. 2 are ready to thaw." Li Zheng was wearing a white lab coat, and a white mask covered half of his face, revealing only two slightly squinted eyes.

"The equipment is ready."

"The test equipment is ready."

"The computer is ready."

"Okay, one, two, three, thaw!" A lot of white liquid nitrogen gas burst out of the two transparent containers in the laboratory instantly, and the frost covering the storage organs melted at a speed visible to the naked eye.

"The container returned to temperature, and the temperature test was 12 degrees Celsius."

"Temperature test 15 degrees Celsius."

The experimenter reports data every 30 seconds, and when the environment in the container reaches the level of a simulated human body, the tester quickly measures the activity of the stored organ.

"Heartbeat, sixty beats per minute, no obvious abnormalities."

"Heartbeat, 76 beats per minute, no obvious abnormalities."

"Heartbeat, 73 beats per minute, no obvious abnormalities."

The voice of Sun Bin reporting the data was a little trembling. This was the first world-class project he participated in. Even if everyone told him that he was about to participate in the greatest biological project in human history, but for " Unlimited time organ storage technology" he still has a special "first love complex".

This kind of plot becomes especially obvious when the experimental results are about to become available.

10 minutes passed.

Half an hour passed.

The heart is beating normally!

The hearts of everyone in the laboratory seemed to be jumping out of their mouths. They dared to swear that their heartbeats were definitely much faster than the heart in the container.

For the next 48 hours, they stared at the data on the computer screen without blinking. Lu Ke quickly moved his hands on the computer keyboard, and beautiful data lines appeared on a screen following his movements.

Forty-eight hours later, until the hearts of those two stopped beating, their hearts were still running at a high frequency.Sun Bin clutched his chest, and said in a daze, "We... succeeded?"

In the simulated human environment, the longest storage time of the heart will not exceed 48 hours.

And judging from the data collected so far, half a year's storage has almost negligible impact on the heart's activity. According to the extent of this impact, under the technology of the Ninth Laboratory, the storage time of a heart can be as high as 70 years. above.

In terms of rigorous text description, this cannot be regarded as infinite storage, but in current science, it can already be called this.

A heart can be preserved for more than 70 years. Lu Ke calculated based on the current national organ donation situation that as long as a heart can be preserved for more than 40 years, the patient's demand and heart supply can be balanced.

And the scope of application of this technology is not only the heart, liver, kidney, and even the human brain.

Many biological scientists in the world have proposed human brain transplantation, using human brain transplantation to achieve human immortality.The technology of human brain transplantation is theoretically achievable, the only problem is the precise brain organ and brain storage technology.

The unlimited organ storage technology of the Ninth Laboratory completely solved the latter problem.

"Well, it worked." Li Zheng let out a long breath.

Organ regeneration and organ unlimited storage, the combination of these two technologies, will be the epitome of future medical care.In the previous life, because various patents were in the hands of various institutions, even if two technologies were realized, there were almost no clinical applications and joint practices.

To be honest, while patent rights protect the enthusiasm of researchers, they do hinder the progress of medical science to a certain extent.And in this life, he can probably make up for this regret.

"Professor, have we really succeeded?" Sun Bin always felt that he was still in a dream.

Li Zheng was dumbfounded.

"Have you finished writing your papers? When the project papers are published, your papers can be published one after another. If they are well written, I will recommend them to Cell."

""Cell"! That "Cell"? "Cell"?!" Sun Bin opened his mouth wide.

"I... I'll go back and write right away! Immediately! Immediately!" He suddenly jumped up from his seat, ran to the lounge next to him, turned his head while running, and said loudly: "Professor, what you said Count it! Cells, cells!"

"Science", "Nature", and "Cell" are the three top journals in biology. In the 80s, Huaguo had published these three journals, and he could count them on one hand.

Before Sun Bin was even surprised, he ran into the lounge and took out his half-written thesis, giggling while writing, "Cell".

Meng Jie and Lu Keke stood there hesitating to speak. Although their performance was better than that of Sun Bin, their inner excitement was no less than his. You could tell by their slightly trembling hands.

Li Zheng chuckled lightly, "Go ahead, let them deal with the rest." Li Zheng was referring to them, of course the two Huaqing students who helped.

The envy and jealousy in their eyes can hardly be expressed in words.As expected of the Ninth Laboratory.

After sorting out all the experimental data, Li Zheng called Liu Sichao and unceremoniously pushed him to write the thesis. Liu Sichao followed this project from beginning to end, and writing the thesis was not difficult for him.

Moreover, Li Zheng planned to give him a joint first author, so it was even more burdensome to throw the package.

As for himself, he wanted to start promoting the establishment of Huaguo's drug clinical trial norms.

As he said at the meeting, norms should be established as soon as possible, but how to build, how to build, how to advance in a logical manner, without causing backlash, this requires a long-term plan.

In fact, when Li Zheng decided to return to Huajing, he had already thought about this issue. After a year, the plan in his mind became clearer.

Although the drug approval system is related to the biological circle, it is more a matter of politics, and political events must be dealt with by political methods.