Back To The Age Of The '80s
Chapter 118
"There is not one left, and the test shows that the maximum drug tolerance of a 20g mouse is 0.08g. According to this calculation, a 50kg adult, the maximum drug tolerance is 200g. Of course, this is just the experimental calculation data. It is obviously impossible to draw accurate experimental conclusions based on small white mice."
Li Zheng took the experiment notebook handed over by Kent and quickly browsed it.
The progress of the experiment was fairly smooth, and "Tycetaxel" was successfully copied. However, the drug toxicity of Taxine was much higher than what Li Zheng remembered.
0.08 grams of the drug, even after being diluted with a large amount of normal saline, still caused severe convulsions, vomiting, and hair loss in the mice.
Without exception, the fifty mice lost their basic mobility.However, what is exciting is that there is indeed no active Doc virus in the blood samples of mice treated with taxane.
"It's really amazing. Ignoring its poor vital signs data, yew did kill the virus." Kent couldn't help but marvel at the results of the blood sample.
However, there was no trace of relaxation on Li Zheng's face.
"According to such data, when drugs are used in humans, five out of ten patients may not survive. The five who survive will also have a long recovery period, and even some sequelae will be lifelong."
Li Zheng couldn't help but think of the boy they rescued at the border when they first came to Doman and the indifferent words of the big black man. People who have lost their labor force and need long-term care don't live long in Africa.
"Notify the Doman military that I need ten cats of the same breed and similar weight." The cat's reflex function is similar to that of a human, with a well-developed circulation and nervous system, and it is most suitable for observing drug reactions.
That General Doman rushed back the second day after the helicopter incident. He ordered people to surround the hospital tightly, in the name of creating a good experimental environment for Li Zheng, but anyone with a discerning eye could see that this It is house arrest in disguise.
However, he was very cooperative with the experimental matters, and within two hours, three or four pickup trucks were parked downstairs of the temporary hospital.
A dozen Dorman soldiers carefully unloaded a dozen cages from the back of the truck, and Kent watched dumbfounded as the soldiers moved the caged animals to the open space behind the laboratory.
"Is this... is it a cat?"
The creature in the cage was about 100 centimeters long, sandy-yellow in color, covered with black spots, and looked like a small cheetah from a distance.
This is a cat?Everyone looked at each other in blank dismay.
"Mr. Li, given our current situation, we can't find ten cats that meet your requirements in a short period of time. These were intercepted by our defenders at the border. I think they look similar to cats, and they should also be cats. I don't know if it will work."
Serval?
Li Zheng recognized this rare and famous animal the moment the cage was unloaded from the truck. It was included in the Convention on International Trade in Endangered Species of Wild Fauna and Flora because of excessive poaching for its beautiful fur.
How much does a pet serval cost? 20?
"It's troublesome, it can be used." Li Zheng rubbed his temple with some headaches, and gave an affirmative answer under the slightly nervous eyes of the Doman soldier.
"Test the vital signs. If there is no problem, start the second round of experiments." Li Zheng said.
Three months is enough time for many things to happen. For example, the martial arts film starring Zhou Sitian was introduced to the mainland, and her screen image was regarded as a goddess by many young men; Huaguo is determined to take back Xiangjiang.
Another example is that the United Nations medical support team headed by Li Zheng was besieged in Doman, and the global biopharmaceutical community united to put pressure on Washington and the United Nations Building, so that the eyes of people all over the world fell on this land of Africa.
On this day, the police force around the hospital tripled, and soldiers in two different uniforms occupied one side of the hospital.
"I really didn't expect that we would still have the opportunity to sit together and communicate peacefully." The officer's clothing was clearly not from the government's side.
"We have never initiated a war." The black general looked at his opponent coldly.
That's right, the two parties are the Doman government and the opposition.
Doc's disease is a disease of a nation. On this special day today, even the greatest hatred and differences among Domans should be put aside.
At about nine o'clock in the morning, a bus with the flag of the United Nations garrison stopped in front of the temporary hospital, and countless reporters got off the bus with long guns and short cannons.
That General Doman looked a bit ugly, he knew that this time, no matter whether Li Zheng developed the drug to treat Doke's disease as promised, he would not be able to keep this Mr. Li.
"Li, are you a little nervous? I only saw such a scene during the presidential election." Kent looked through the window and couldn't help but marvel at the dense crowd of soldiers and reporters below.
Li Zheng's hands hanging by his side were clenched unconsciously, and he breathed out lightly, "Well, it's a little bit." Even if the two lifetimes add up, this is the biggest scene Li Zheng has ever seen.
The crowd outside the window became agitated, and two convoys slowly approached the hospital.One convoy flew the Dorman flag, the other the opposition flag.
"It's President Doman and the leader of the opposition, they actually came together!" A reporter exclaimed.
The reporters who were still trying to squeeze in, suddenly turned around and rushed towards the direction of the two convoys.
The two most powerful people in Doman got off their respective cars.President Dorman is older and wears a traditional Dorman costume, while the leader of the opposition is younger and wears a crisp Western-style suit.This also represents two different governing philosophies.
"Mr. President, if you and the opposition leader appear on the same occasion at the same time, does it mean that the two sides have a chance to coexist peacefully?"
"Mr. Monchi, it is generally believed that this war was deliberately provoked by the opposition. Do you have any disagreement with this statement?"
…………
In the messy English, there are one or two sentences in Doman's local language.
Mr. President walked in under the protection of the guards. Seeing that these reporters were too persistent, he stopped in time.
Under the flattered gaze of a certain reporter, he took his microphone.
"Disease and war are the sharpest contradictions in Doman today. If Mr. Li Zheng can really help the people of Doman out of the nightmare of disease, then I promise here that I will work hard to find a path to peace." Mr. President solemnly said.
"Mr. Monkey, what do you think?"
Monchi glanced at President Doman, pursed his lips and said, "Health and peace have always been the dreams pursued by the people of Doman, and it's also my dream since I was a child."
Kakaka, the flashes blared.
All the reporters got excited. It was almost Dorman's declaration of peace.if only!if only!That Mr. Li Zheng's drug will really come out smoothly!
"This is a declaration of peace between the two parties!"
"Mr. President, Mr. Monchi, please answer one more question."
"Mr. President! Mr. Monkey!"
"I can only say that I am very grateful for this opportunity, allowing Mr. Monchi and I to sit down and understand each other's thoughts."
Witness a nation's declaration of peace!What an exciting historical moment!Not only the reporters present, but also the motionless Doman soldiers standing next to them also had a strange light in their eyes, and many of them even secretly blushed.
They who have been numb by war after war, see hope today!
As long as the drug can be successfully launched!As long as the drug can be successfully launched!The two events, which are obviously irrelevant, seem to have a causal logical relationship at this time, and everyone pins their hopes on this Chinese biologist.
The sound insulation effect of the composite board is not very good, and Li Zheng can clearly hear the answers of the president, Mr. Monchi and the reporters outside.
There was a wry smile on his face, and he became Doman's hope for peace in a daze.
Now that both sides have the intention of a truce, there is only one opportunity left, and he is the best opportunity.It's a bit stressful.
"Mr. Li Zheng, it's time for you to go out." Dr. Kaqi knocked on the door, and his expression was very excited. He has been helping in the laboratory for the past three months, so he naturally knows the progress of the experiment. He has a hunch that this It will be a turning point in his life!
"I see." Li Zheng smiled and nodded.
Kent Blair paid attention to his leader, and stared at the glass on the biological cabinet for a while before getting up in satisfaction.
"Let's go." He said with a smile.
Li Zheng couldn't help but laugh. He checked the information in his hand again, but when he was about to get up, he accidentally knocked over the paper cup next to him.
He hastily took out a paper towel to blot the water dry.
It's okay, the data is fine.
At this time, an unfamiliar inspection report came into Li Zheng's eyes.
Serval's blood test results?
The ten serval cats were used by Li Zheng to observe the drug reaction of yew.During these three months, he and Kent spent most of their time reducing drug toxicity, alleviating drug reactions and reducing patient pain.
Because of the previous examples of carbapenem antibiotics and the memory of Li Zheng's previous life, the progress of the two of them is relatively smooth. Although the toxicity of the drug is still impossible to pass the international standard, it is at least within the acceptable range of the human body. .
After reaching the goal, the two put Serval aside and didn't pay much attention to it.
When he was doing drug reaction tests, he once told the medical team members who helped him that he should take blood samples for serval cats every day.
The member of the medical team persevered conscientiously, but Li Zheng never paid attention to the data of the few days after the drug reaction test.
However, when he saw it today, he could see that it was unusual.
"Where are the ten serval cats! Immediately! Immediately! Retest the results of their blood samples for me! Two pairs! Absolutely ensure the accuracy of the data!" Li Zheng roared.
Everyone, including Kent, was taken aback.
"The Serval has moved to the backyard! But Mr. Li, now Mr. President, Mr. Monchi and reporters from various countries are waiting, you..." Kaqi said cautiously, and he couldn't help but feel uneasy , There will be no mistakes in this experiment.
"I don't understand human words! I said, immediately! Immediately!" Li Zheng felt his heart beating so fast before, all the blood in his body rushed to his brain, and an unprecedented excitement appeared in his heart On him, he felt that the breath coming out of his nasal cavity was hot!
"Li..." Kent frowned tightly.
"Blair, look at these indicators!" With a sweep of his right hand, Li Zheng swept all the experimental data to the ground. He put the pile of serval cat blood test results on the table one by one, and then took the white paper casually.
"Look, these few, and these few more, these indicators are transformed into a line chart with the date as the horizontal axis and the indicator value as the number axis. Have you seen it!" Li Zheng's voice trembled slightly.
When Kent heard this, he leaned his head over, and then took a deep breath!
"This...impossible, how is it possible! Taxine can only kill active viruses, this indicator..." Kent stuttered because of his excitement.
Li Zheng took the experiment notebook handed over by Kent and quickly browsed it.
The progress of the experiment was fairly smooth, and "Tycetaxel" was successfully copied. However, the drug toxicity of Taxine was much higher than what Li Zheng remembered.
0.08 grams of the drug, even after being diluted with a large amount of normal saline, still caused severe convulsions, vomiting, and hair loss in the mice.
Without exception, the fifty mice lost their basic mobility.However, what is exciting is that there is indeed no active Doc virus in the blood samples of mice treated with taxane.
"It's really amazing. Ignoring its poor vital signs data, yew did kill the virus." Kent couldn't help but marvel at the results of the blood sample.
However, there was no trace of relaxation on Li Zheng's face.
"According to such data, when drugs are used in humans, five out of ten patients may not survive. The five who survive will also have a long recovery period, and even some sequelae will be lifelong."
Li Zheng couldn't help but think of the boy they rescued at the border when they first came to Doman and the indifferent words of the big black man. People who have lost their labor force and need long-term care don't live long in Africa.
"Notify the Doman military that I need ten cats of the same breed and similar weight." The cat's reflex function is similar to that of a human, with a well-developed circulation and nervous system, and it is most suitable for observing drug reactions.
That General Doman rushed back the second day after the helicopter incident. He ordered people to surround the hospital tightly, in the name of creating a good experimental environment for Li Zheng, but anyone with a discerning eye could see that this It is house arrest in disguise.
However, he was very cooperative with the experimental matters, and within two hours, three or four pickup trucks were parked downstairs of the temporary hospital.
A dozen Dorman soldiers carefully unloaded a dozen cages from the back of the truck, and Kent watched dumbfounded as the soldiers moved the caged animals to the open space behind the laboratory.
"Is this... is it a cat?"
The creature in the cage was about 100 centimeters long, sandy-yellow in color, covered with black spots, and looked like a small cheetah from a distance.
This is a cat?Everyone looked at each other in blank dismay.
"Mr. Li, given our current situation, we can't find ten cats that meet your requirements in a short period of time. These were intercepted by our defenders at the border. I think they look similar to cats, and they should also be cats. I don't know if it will work."
Serval?
Li Zheng recognized this rare and famous animal the moment the cage was unloaded from the truck. It was included in the Convention on International Trade in Endangered Species of Wild Fauna and Flora because of excessive poaching for its beautiful fur.
How much does a pet serval cost? 20?
"It's troublesome, it can be used." Li Zheng rubbed his temple with some headaches, and gave an affirmative answer under the slightly nervous eyes of the Doman soldier.
"Test the vital signs. If there is no problem, start the second round of experiments." Li Zheng said.
Three months is enough time for many things to happen. For example, the martial arts film starring Zhou Sitian was introduced to the mainland, and her screen image was regarded as a goddess by many young men; Huaguo is determined to take back Xiangjiang.
Another example is that the United Nations medical support team headed by Li Zheng was besieged in Doman, and the global biopharmaceutical community united to put pressure on Washington and the United Nations Building, so that the eyes of people all over the world fell on this land of Africa.
On this day, the police force around the hospital tripled, and soldiers in two different uniforms occupied one side of the hospital.
"I really didn't expect that we would still have the opportunity to sit together and communicate peacefully." The officer's clothing was clearly not from the government's side.
"We have never initiated a war." The black general looked at his opponent coldly.
That's right, the two parties are the Doman government and the opposition.
Doc's disease is a disease of a nation. On this special day today, even the greatest hatred and differences among Domans should be put aside.
At about nine o'clock in the morning, a bus with the flag of the United Nations garrison stopped in front of the temporary hospital, and countless reporters got off the bus with long guns and short cannons.
That General Doman looked a bit ugly, he knew that this time, no matter whether Li Zheng developed the drug to treat Doke's disease as promised, he would not be able to keep this Mr. Li.
"Li, are you a little nervous? I only saw such a scene during the presidential election." Kent looked through the window and couldn't help but marvel at the dense crowd of soldiers and reporters below.
Li Zheng's hands hanging by his side were clenched unconsciously, and he breathed out lightly, "Well, it's a little bit." Even if the two lifetimes add up, this is the biggest scene Li Zheng has ever seen.
The crowd outside the window became agitated, and two convoys slowly approached the hospital.One convoy flew the Dorman flag, the other the opposition flag.
"It's President Doman and the leader of the opposition, they actually came together!" A reporter exclaimed.
The reporters who were still trying to squeeze in, suddenly turned around and rushed towards the direction of the two convoys.
The two most powerful people in Doman got off their respective cars.President Dorman is older and wears a traditional Dorman costume, while the leader of the opposition is younger and wears a crisp Western-style suit.This also represents two different governing philosophies.
"Mr. President, if you and the opposition leader appear on the same occasion at the same time, does it mean that the two sides have a chance to coexist peacefully?"
"Mr. Monchi, it is generally believed that this war was deliberately provoked by the opposition. Do you have any disagreement with this statement?"
…………
In the messy English, there are one or two sentences in Doman's local language.
Mr. President walked in under the protection of the guards. Seeing that these reporters were too persistent, he stopped in time.
Under the flattered gaze of a certain reporter, he took his microphone.
"Disease and war are the sharpest contradictions in Doman today. If Mr. Li Zheng can really help the people of Doman out of the nightmare of disease, then I promise here that I will work hard to find a path to peace." Mr. President solemnly said.
"Mr. Monkey, what do you think?"
Monchi glanced at President Doman, pursed his lips and said, "Health and peace have always been the dreams pursued by the people of Doman, and it's also my dream since I was a child."
Kakaka, the flashes blared.
All the reporters got excited. It was almost Dorman's declaration of peace.if only!if only!That Mr. Li Zheng's drug will really come out smoothly!
"This is a declaration of peace between the two parties!"
"Mr. President, Mr. Monchi, please answer one more question."
"Mr. President! Mr. Monkey!"
"I can only say that I am very grateful for this opportunity, allowing Mr. Monchi and I to sit down and understand each other's thoughts."
Witness a nation's declaration of peace!What an exciting historical moment!Not only the reporters present, but also the motionless Doman soldiers standing next to them also had a strange light in their eyes, and many of them even secretly blushed.
They who have been numb by war after war, see hope today!
As long as the drug can be successfully launched!As long as the drug can be successfully launched!The two events, which are obviously irrelevant, seem to have a causal logical relationship at this time, and everyone pins their hopes on this Chinese biologist.
The sound insulation effect of the composite board is not very good, and Li Zheng can clearly hear the answers of the president, Mr. Monchi and the reporters outside.
There was a wry smile on his face, and he became Doman's hope for peace in a daze.
Now that both sides have the intention of a truce, there is only one opportunity left, and he is the best opportunity.It's a bit stressful.
"Mr. Li Zheng, it's time for you to go out." Dr. Kaqi knocked on the door, and his expression was very excited. He has been helping in the laboratory for the past three months, so he naturally knows the progress of the experiment. He has a hunch that this It will be a turning point in his life!
"I see." Li Zheng smiled and nodded.
Kent Blair paid attention to his leader, and stared at the glass on the biological cabinet for a while before getting up in satisfaction.
"Let's go." He said with a smile.
Li Zheng couldn't help but laugh. He checked the information in his hand again, but when he was about to get up, he accidentally knocked over the paper cup next to him.
He hastily took out a paper towel to blot the water dry.
It's okay, the data is fine.
At this time, an unfamiliar inspection report came into Li Zheng's eyes.
Serval's blood test results?
The ten serval cats were used by Li Zheng to observe the drug reaction of yew.During these three months, he and Kent spent most of their time reducing drug toxicity, alleviating drug reactions and reducing patient pain.
Because of the previous examples of carbapenem antibiotics and the memory of Li Zheng's previous life, the progress of the two of them is relatively smooth. Although the toxicity of the drug is still impossible to pass the international standard, it is at least within the acceptable range of the human body. .
After reaching the goal, the two put Serval aside and didn't pay much attention to it.
When he was doing drug reaction tests, he once told the medical team members who helped him that he should take blood samples for serval cats every day.
The member of the medical team persevered conscientiously, but Li Zheng never paid attention to the data of the few days after the drug reaction test.
However, when he saw it today, he could see that it was unusual.
"Where are the ten serval cats! Immediately! Immediately! Retest the results of their blood samples for me! Two pairs! Absolutely ensure the accuracy of the data!" Li Zheng roared.
Everyone, including Kent, was taken aback.
"The Serval has moved to the backyard! But Mr. Li, now Mr. President, Mr. Monchi and reporters from various countries are waiting, you..." Kaqi said cautiously, and he couldn't help but feel uneasy , There will be no mistakes in this experiment.
"I don't understand human words! I said, immediately! Immediately!" Li Zheng felt his heart beating so fast before, all the blood in his body rushed to his brain, and an unprecedented excitement appeared in his heart On him, he felt that the breath coming out of his nasal cavity was hot!
"Li..." Kent frowned tightly.
"Blair, look at these indicators!" With a sweep of his right hand, Li Zheng swept all the experimental data to the ground. He put the pile of serval cat blood test results on the table one by one, and then took the white paper casually.
"Look, these few, and these few more, these indicators are transformed into a line chart with the date as the horizontal axis and the indicator value as the number axis. Have you seen it!" Li Zheng's voice trembled slightly.
When Kent heard this, he leaned his head over, and then took a deep breath!
"This...impossible, how is it possible! Taxine can only kill active viruses, this indicator..." Kent stuttered because of his excitement.
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