Reborn Wife Strikes Back in the 80s

After dinner, Guo Xiang returned to the laboratory and received a call from Song Tingshen.

Mr. Song? Guo Xiang called out.

Guo Xiang, how is your HIV drug progress? Song Tingshen asked.

There's not much progress yet. Guo Xiang shook his head. He tried so many medicines, but the effect was not obvious. It might be the wrong combination or the wrong dosage.

Last time, the liver cancer patient had an AIDS outbreak. It may be because the body's resistance to surgery has become weaker, and the immune system will not work as soon as it is attacked. Now he has persistent fever, swollen lymph nodes, and a red rash on his body. Song Tingshen said.

That's the disease. Guo Xiang frowned, You can let him take the medicine first. Although our joint medicine has not yet come out, the ordinary medicine can still be taken first.

Then we have no choice. There is no department or medicine for this kind of disease in our country. We can only let him go back to our country for treatment. Song Ting sighed deeply.

Guo Xiang nodded, there was really no way. Although their laboratory had medicines, it was also used for experiments. It was not a place to see a doctor, and there was no other treatment equipment, so there was no way to help him.

Then let him go back to China, there is no way out. Guo Xiang said, I have to speed up the progress here and do it earlier.

Song Tingshen hung up the phone and could only tell the patient the truth. There was really no way to treat him. It would be useless for him to be hospitalized again.

The patient also understands that after going through the discharge procedures, he has been in the hospital for more than a month and it is time to be discharged, but he is so bad now that he is likely to relapse, but there is no way, no one can control this.

Guo Xiang told Li Yuanhang about the patient, and he nodded, I can only control it with medication first, and let's talk about it when the drug resistance is over. We have to speed up the progress.

Guo Xiang nodded, looked at the data on the computer, and took a new set of formula medicines for the mice to eat.

Mixing the medicine in the rat feed and preparing to feed it to the mice, Guo Xiang noticed that some of the mice who had been infected with AIDS were still very energetic, while others were not in good spirits.

She suddenly realized a problem. Western medicine is generally relatively fixed, but it will be differentiated according to the age of the person.

For example, adults take three capsules at a time, while children take half of the capsules and take one and a half capsules. This is generally the rule.

The guinea pig doing the experiment is small,

Dosages are generally recalculated by weight.

Just like some infants' medicines are calculated based on their weight, how many milliliters should be eaten within a few kilograms, and how many milliliters should be eaten if they are more than a few kilograms, and so on.

However, they are not classified according to the severity of the disease.

If it is said that Chinese medicine can do this, Chinese medicine generally diagnoses by feeling the pulse, and prescribes medicines according to the differences of each person's constitution and different conditions.

Therefore, the prescription and dosage of each patient may be different, which is one of the reasons why traditional Chinese medicine cannot be promoted like Western medicine.

However, the severity of AIDS is very obvious. Some may not have the disease but just carry it. Some are seriously ill with various symptoms and some are mild. So can they all use the same medicine and the same dose?

Does it have to be divided according to people's physique and illness like in Chinese medicine?

Guo Xiang suddenly felt that his idea was right, because the HIV virus attacks the human immune system.

Maybe the average person only has a very vague concept of the immune system, and does not know what it is.

In fact, the human body is a very sophisticated system that has its own defense forces to deal with foreign invaders.

And these defense forces are numerous immune cells. Lymphocytes, for example, are immune cells that fight infections and tumors. The most important ones are Th cells containing CD4 molecules and Tc cells containing CD8 molecules. In other words, T cells are disease-fighting guards.

The CD4 cells are equivalent to sentinels and play the role of tips, while CD8 cells are the combat troops, which have the effect of killing infected cells and cancer cells.

When HIV enters the body, it infects surface CD4 cells so that CD8 cells cannot kill infected cells and cancer cells, leading to opportunistic infections and cancer.

Therefore, once a person is infected with HIV, the CD4 cells will decline progressively or irregularly, indicating that the immune system is severely damaged.

Generally, the CD4 cells of a normal person are 500 to 1600 per cubic millimeter, which can be detected by drawing blood.

Therefore, the CD4 cells of each of these mice may be different, and the drugs and doses used should also be different.

Guo Xiang suddenly realized that they might have done useless work in the previous month.

She immediately called Li Yuanhang over and spoke out her thoughts.

Li Yuanhang listened very seriously, and nodded while listening, It's very likely that this is the case.

Did you not consider this when you were in the United States? Guo Xiang couldn't help but question, they had studied for so many years.

I entered the laboratory relatively late, and CD4 cells were also measured there, but at that time it was still a single drug, and now I don't think of this in combination drugs. Li Yuanhang said.

I think our previous thinking was wrong. We should use the drugs separately according to the number of CD4 cells in each mouse, so that it will be effective. Guo Xiang said.

Li Yuanhang nodded, Yes, we have tried so many medicines before, and it is impossible for them to have no effect. This should be the reason, there is no symptom!

Then we will immediately measure the CD4 cells of each mouse, and then adjust the medication and dosage. Guo Xiang said decisively, A normal human CD4 cell is 500-1600, and setting more than 500 is a safe value, and it may be detected. positive, but within the safe range, not yet sick, or a carrier.

Between 0 and 200, it is already very serious, there are complications, and it is a severe patient; between 200 and 500, it is a mild patient, although the symptoms are not serious. Guo Xiang continued, picking up the previous record book, Then We are also divided into groups, tenofovir, zidovudine, and lamivudine in one group, and efavirenz, nevirapine, and Kaletra in the other group, and the medication is differentiated according to the symptoms of different stages.

Okay, we'll re-test immediately. Li Yuanhang nodded, and at the same time admired Guo Xiang in his heart, he didn't think of this.

The two began to draw blood from the mice and tested them in a flow cytometer, all of which were purchased from the United States.

Each mouse was then numbered, indicating their number of CD4 cells, and then treated with different drugs and doses.

Both of them were a little excited after finishing these, and had a hunch that they might succeed this time.

After all the work was done, the two tidy up the laboratory and disinfected the operating table before leaving the laboratory, taking off their protective clothing and changing into a white coat.

Guo Xiang suddenly found Gu Zhennan standing outside the office window.

She opened the window, Why are you here?

What time is it? You don't even look at the time, I thought something happened to you. Gu Zhennan slightly complained.

Only then did Guo Xiang notice that it was already dark outside, and looking at the clock on the wall, it was already past eight o'clock, surprised, It's so late?

As soon as we did the experiment, we forgot the time. Li Yuanhang smiled and looked at Gu Zhennan. This should be Teacher Guo's lover, right?