Rebirth of science and technology academic master

After handing the scratch paper to Perelman and seeing that Perelman didn't react, Qin Yuanqing smiled proudly and strode away from the Institute for Advanced Study.

The next step is to leave it to Perelman. Qin Yuanqing estimates that with Perelman's ability, he should be able to solve it in about a year.

Qin Yuanqing went to the Shahe Campus. It was already the end of April. The construction of the entire Shahe Campus lasted for more than a year. The Automobile Research Institute and the Aerospace Engine Research Institute were almost completed. It is expected that the decoration will be completed in mid-May and will be idle for two days for ventilation. In about a month, the two institutes will be able to officially move into the new location.

It can be said that up to now, except for the decoration that has not been completed, communications, communications, electricity, water, etc. have all been completed. There are still more than 4,000 workers working on the Shahe campus every day.

The construction speed of the entire Shahe campus is nothing short of miraculous. Normally, it would take four to five years to complete the construction. However, with the help of a large amount of manpower, material and financial resources, the ‘Pengcheng speed’ was achieved.

Of course, this is also related to the fact that there are no high-rise buildings in the Shahe campus. Without high-rise buildings, foundation treatment will not be so troublesome.

Seeing the Shahe campus built from scratch, bit by bit, Qin Yuanqing was filled with pride and pride. After all, he also invested a lot of effort in the construction of the Shahe campus.

"According to this progress, it should be no problem to have them all completed before the Spring Festival this year!" Qin Yuanqing estimated in his mind that according to the plan, the Aero Engine Research Institute and the Automotive Research Institute will be completed next month, and they will move in in August. Then other departments will gradually move into the Shahe campus. Around the Spring Festival, the relocation of scientific research institutions and major departments will basically be completed.

Entering the laboratory, Qin Yuanqing was surprised by the result. This was a paper. The paper introduced that some bacterial mutations were discovered in a mixed substance during the experiment.

"Is it accidental or inevitable?" Qin Yuanqing looked thoughtful after reading the paper. However, Qin Yuanqing felt the need to check it. Of course, Qin Yuanqing still agreed to let the paper be published. Whether this discovery was accidental or inevitable, it was There is some meaning and it is worth exploring.

Qin Yuanqing arrived at the laboratory and looked at a pile of mixed substances, which were all leftover from the experiment.

This kind of mixed substance cannot be handled casually. Although this is only the researcher's own hobby, and studying norovirus is not among the subjects listed in the laboratory, the laboratory does not prohibit researchers from studying their own hobbies, as long as it does not affect the Laboratory topics.

This paper is about a researcher who discovered a strange phenomenon in this mixed substance while studying norovirus, and then wrote such a paper. Such a paper cannot be published in first-class journals, but it can be published in second-class journals. Grade journals are more than enough.

Norwalk virus, also called norovirus, is the prototype representative strain of the genus Norovirus in the family Caliciviridae in humans. It is a group of virus particles with similar morphology and slightly different antigenicity. Norovirus infectious diarrhea is prevalent all over the world, and infection can occur throughout the year. The infection targets mainly adults and school-age children, with a high incidence in cold seasons. Norovirus is responsible for 60-90% of all non-bacterial diarrhea outbreaks in the United States. Among Chinese children with diarrhea under the age of 5, the detection rate of norovirus is about 15%. Surveys on serum antibody levels show that norovirus infection is also very common in the Chinese population.

"Norovirus" infectious diarrhea is a self-limiting disease. There is no vaccine or specific drugs. At present, people's understanding of it is still relatively limited.

"Director!" A young doctor greeted Qin Yuanqing quickly when he saw him.

"Pang Bo, I read your paper, and this discovery is very interesting." Qin Yuanqing said.

That paper was written by Pang Bo. Pang Bo graduated from the School of Medicine at Yanda University, where he studied for bachelor's and master's degrees together. Later, he went to study in the United States. After graduating from the Ph.D., he worked in the doctoral station for three years. Qin Yuanqing happened to be recruiting, so Pang Bo submitted his resume. ,Selected.

Pombo was studying norovirus in the United States.

Qin Yuanqing looked at the pile of mixed materials. These mixed materials were cleaned and specially treated on a regular basis every day. After all, although the harm of norovirus is not high, it is difficult to tell if you are infected.

In that large pile of experimental waste, the cellular materials are almost dead. It must contain a large amount of norovirus and a lot of bacteria. There may be a war between bacteria and viruses inside, and we don’t know the new bacteria that are breeding. Can you be infected by norovirus?

Qin Yuanqing looked thoughtful, thinking about the phenomenon introduced in the paper. There are still surviving primitive cells in the mixed material, but the number is very small. Most of the primitive cells are not infected and died by norovirus, but in an inappropriate chemical environment without suitable material supply, the surrounding cells still breed. A large number of bacteria crowd out the living space, causing cell death. Furthermore, some noroviruses have mutated. Such mutations are invisible to the naked eye, and there is uncertainty.

Qin Yuanqing began to write symbols, numbers and graphics with chalk on a blackboard in the laboratory.

"Pang Bo, you did the experiment as I told you, let's do a dyeing experiment!" Qin Yuanqing stopped writing and said to Pang Bo.

"Okay, Director!" Pang Bo's eyes flashed with joy. He did not expect that his research would arouse Qin Yuanqing's interest.

Researchers like them all know that Qin Yuanqing has extremely terrifying theoretical attainments that are bottomless. Therefore, there is a popular saying among their researchers that if you encounter any difficulty and cannot overcome it, the easiest way is to let it arouse the interest of Academician Qin. As long as Academician Qin is interested, then solving it will be a matter of course. .

Under the command of Qin Yuanqing, Pang Bo prepared some virus materials, and then began to divide ten groups into dyeing experiments according to Qin Yuanqing's requirements. He also added a new virus and performed two sets of the same dyeing experiments.

The main purpose of staining experiments is to observe chromosomes.

Unlike in the past, when the glassware was disposed of after the experiment, Qin Yuanqing asked to leave it there, keep it, observe it every day, and record the corresponding data. Do the same experiment at the same time and repeat.

Daily data are recorded in computer tables.

Finally, after ten days of experiments, extraction began. Of course, it was not to extract samples but to isolate a large number of viruses from them.

With the end of the experiment, Qin Yuanqing was finally able to determine that the virus had mutated. In the environment of the staining experiment, the cells themselves will be affected by the harsh environment. If no intervention is taken, more cells will die due to the harsh environment than those infected by the virus. This will also affect the living space of the virus. Without cells that can be invaded, the virus cannot reproduce. Because it cannot reproduce the next generation, under special circumstances, the virus mutates, becoming more infectious and less virulent.

It can be said that through this month, the characteristics, infection mechanism, and direction of mutation of the norovirus have been thoroughly explored, and the vaccines and specific drugs proposed based on this will be a matter of course.

"Pang Bo, Yan Ning, the experiment has verified my idea, and then the paper will be handed over to you." Qin Yuanqing said with a faint smile.

In this month, Qin Yuanqing theoretically established a mechanism model that fully reflected the infection and mutation pathways of norovirus, and then listed its formula, as well as proposed vaccines and specific drugs.

Although norovirus is very common, has a wide range of infectivity, and is of great significance, in fact, this result is not as good as the last time myocarditis. After all, myocarditis studies heart disease, and its breakthrough represents the human progress in the field of heart disease. Taking a step of extraordinary significance is an achievement at the level of the Nobel Prize in Physiology, so the country decisively awarded the first prize of the National Natural Science Award to Qin Yuanqing and Yan Ning.

In comparison, norovirus is much worse. After all, norovirus is not very toxic, and infection by this virus can be prevented by strengthening drinking water hygiene, food hygiene, and personal hygiene. And even if it is infected, the fatality rate is very low.

Of course, there is no problem that this time the results on norovirus have produced twenty or thirty papers, and each paper is enough to be ranked in a first-level journal.

And in comparison, the application value of vaccines will be very wide. Everyone needs to be vaccinated, so the economic benefits of this achievement are also very prominent.

"Director, don't worry, the next paper will be left to me and Director Yan!" Pang Bo said excitedly.

During this month, he spent most of his time in the laboratory and went home to sleep every day. Now he was entering the harvesting stage.

According to Qin Yuanqing's personality, he could not escape from one paper to another. With this result, it is only natural for him to select professors or first-level researchers.

More importantly, norovirus is Pang Bo's hobby. Now that norovirus has made breakthrough progress, it can benefit the entire human race. The sense of accomplishment in Pang Bo's heart is far beyond what he can get from money.

He originally chose to study medicine because his younger brother was infected with norovirus. As a result, his parents had little medical knowledge in rural areas, causing his younger brother to die of dehydration. Moreover, after filling out his application form after the college entrance examination, Pang Bo did not hesitate to choose the School of Medicine at Yanda to study for a bachelor's degree and a master's degree together. After graduating from graduate school, he felt that his knowledge of norovirus was still very shallow, so he chose to study abroad and specialize in research in this area. His postdoctoral workstation was also engaged in research in this area.

After returning to China and joining Qin Yuanqing's laboratory, Pang Bo will continue to study norovirus in his spare time because he has a wish in his heart to solve norovirus so that humans will no longer suffer from norovirus. He can also go to his brother's grave, burn incense for him, and then tell his brother that he finally solved the norovirus.