When the two fought, they were evenly matched at first. Although the third generation Hokage was called the "Strongest Hokage", due to old age and physical weakness,

His strength was not as strong as when he was young and he could not parry, so he had to use the ninjutsu of the Fourth Hokage to seal the Nine-Tails. The Third Hokage used two shadow clones to seal the First Hokage and the Second Hokage, and sealed Orochimaru with his own body, but During the sealing process, Orochimaru manipulated the Soyong Sword to severely injure the Third Hokage. In the end, Orochimaru was not able to completely seal Orochimaru, only his hands were disabled, making him unable to use ninjutsu.

After his hands were disabled, he lost the ability to use ninjutsu. Because most ninjutsu require hand seals and chakra extraction, he had to lead the sound ninja to retreat.

The Sand Ninja later learned that the real Kazekage had been assassinated by Orochimaru, so they renewed the peace treaty with Konoha. Orochimaru's "Konoha Collapse Plan" ultimately ended in failure.

In order to treat Orochimaru's hands, he and his subordinate Kabuto took the initiative to go to Tanshu Street to seek treatment from Tsunade, the medical master of the Sannin.

Due to Tsunade's tough attitude, Orochimaru offered Tsunade's dead brother and lover the forbidden technique of reincarnation, a forbidden technique of resurrecting Tsunade's dead brother and lover, as a deal, and the deadline was seven days. Seven days later, the two sides negotiated again, but Tsunade rejected Orochimaru's proposal, and Orochimaru and Kabuto showed murderous intentions when they saw this. At the same time, Jiraiya and Naruto also arrived at the scene.

At first Orochimaru took advantage of Tsunade's weakness of being afraid of blood to gain the upper hand, but then Tsunade was inspired by Naruto to get rid of her fear of blood and used Creation Regeneration, and the three ninjas started a battle.

Naruto used the newly learned ninjutsu Rasengan against Kabuto before the Sannin battle and succeeded in severely injuring Kabuto, but he also fainted due to lack of physical strength. At this time, Orochimaru and Jiraiya were fighting fiercely. Orochimaru wanted to take this opportunity to kill Naruto, but his sword was blocked by Tsunade, and Orochimaru failed. Afterwards, Orochimaru and all snakes were defeated, and Orochimaru and Kabuto retreated.

After that, Orochimaru couldn't bear the pain caused by the sealing of the woman's body and hands, so he sent four Oto ninjas to persuade Sasuke to join the Otogakure village. Before Sasuke arrived, Orochimaru had to abandon the beautiful woman who could no longer use her hands. The body of the woman was damaged by reincarnation, so she would not reincarnate easily while the container was still usable. Temporarily soul reincarnated into the body of the captured ninja Genyoumaru.

Although the four sound ninjas and Kimimaro, who had the blood inheritance limit, died completely later, they successfully brought Sasuke to the sound hidden village and actively trained him, trying to use Sasuke as the next container.

Three years later, Yamato, the captain of Konoha Village's "New Team 7", received news from Akatsuki's Scorpion that the undercover agent sent to Orochimaru would meet him at the Tenchi Bridge, and he wanted to use this to find clues about Sasuke. .

Naruto and others followed the instructions and arrived at the Tenchi Bridge, only to encounter Orochimaru. Orochimaru had a fierce battle with Naruto, who turned into a four-tailed demon fox out of anger. Kabuto called this a battle between monsters. However, because his body had reached its limit, he brought Kabuto and Danzo to negotiate. Sai left together.

However, everyone in the Yamato class did not give up. They tracked Orochimaru's lair, found it, and successfully persuaded Sai to return to the team. They then split into two teams in order to speed up the search for Sasuke's location.

On the way, Sai and Naruto's team encountered Orochimaru. Orochimaru and Naruto fought again, but Naruto asked Sai to go find Sasuke first. Later, Sakura and Yamato came to support, but Orochimaru did not want to fight and fled without a trace. Soon, Naruto, Sakura and Sasuke met again, but Sasuke did not accept the old love and wanted to kill them all.

At this time, Orochimaru suddenly appeared and surprisingly prevented Sasuke from killing Naruto and the others, because Orochimaru believed that they were still valuable and could kill a few more Akatsuki members for him because Orochimaru was once a member of Akatsuki and later rebelled. At the same time, Akatsuki is chasing him. Sasuke understood and gave up the idea of ​​killing Naruto and others, and disappeared with the wind together with Orochimaru.

After the three-year period of reincarnation ended, and even Kabuto's medicine could not save him, Orochimaru decided that it was time to use Sasuke's body to reincarnate in the spirit world.

On the other hand, Sasuke believed that Orochimaru had learned everything he was supposed to teach him, and his existence was of no use to him, so he took a preemptive strike and rushed into his room to assassinate him. Not to be outdone, Orochimaru revealed his true form, the white-scaled serpent, and prepared to reincarnate in the spirit world. However, he was ironically absorbed by Sasuke in the barrier where he was reincarnated and all his power was taken away, leaving him with the body of a big snake. As a result, he was extremely weak and lost to Zuo.

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