Break out of the courtyard

September 11th, Saturday.

Zhang Heping's two wives took advantage of the weekend holiday to bring the children back to the capital.

However, Zhang Heping has been very busy recently because the cancer cells in his grandfather's body had metastasized!

After Zhang Heping got out of the car, he ignored the strange looks around him, walked to the other side of the car, and together with his uncle Ma Zhiyi who got out of the passenger seat, helped his grandfather Ma Changming back home.

Grandpa Ma Changming underwent a full-body CT scan, brain MRI and other examinations today, and his condition is still not optimistic!

Although the combined chemotherapy of albumin-bound paclitaxel and carboplatin suppressed the growth of lung cancer cells in his body, it failed to completely suppress the cancer cells that had metastasized to the liver, kidneys, anterior ribs, thoracic vertebrae, lumbar vertebrae, etc.

In this regard, Zhang Heping is considering the feasibility of adding cisplatin, fluorouracil, epirubicin, cyclophosphamide and other drugs to combined chemotherapy.

Zhang Heping glanced at the shit hat on his grandfather's head. His hair had fallen out severely recently. Fortunately, he did not show obvious symptoms of nausea and vomiting, which showed that his grandfather was more tolerant to drugs such as paclitaxel.

In addition, Grandpa Ma Changming's memory has declined recently and he has experienced temporary blindness several times, which makes Zhang Heping suspect that the cancer cells have metastasized to his brain.

However, the MRI machine we bought from Magnesium is only 0.23T, and the low-field MRI image quality is very poor. If we had a 3.0T MRI machine to do a full-body examination...

time!

Zhang Heping really needs time now!

I hung up the treatment books related to cancer, but what I got was cytology skills.

Even though he had mastered [Cytology] to the Grand Master level (26%), he still hadn't found a way to cure cancer. Instead, he had to master other Western medicine skills such as [Drug Synthesis] and [Imaging].

It takes 1 minutes to increase the experience by 49% at the Grandmaster level.

It takes 1 hour to upgrade Grand Master by 1%.

In addition, Zhang Heping also has to synthesize drugs, teach those researchers, take care of grandpa's body, eat and sleep... there is really not enough time!

When the eldest son Zhang Bei saw Zhang Heping coming back, he quickly pushed open the glass door of the main room and said excitedly, "Dad, our server was attacked 86398 times this week! However, they were all blocked by the security guards."

"Yeah!" Zhang Heping was thinking about his grandfather's follow-up treatment and simply responded to his son.

After Zhang Heping helped his grandfather to sit at the first seat at the dining table, he went to the east gate room next to the toilet and began to draw the equipment engineering drawings.

The eldest wife Tang Xin and the second wife Chen Shuting brought over the food and soup and accompanied Zhang Heping in the gatehouse to have dinner.

"Honey, I noticed that grandpa looked good today. He didn't even cough on the way in. Is the new medicine working?" Tang Xin looked at Zhang Heping, but Zhang Heping frowned and looked at the drawings on the table.

Zhang Heping said casually: "The cancer cells in grandpa's body have spread. I now need to make a 3.0T MRI device to accurately locate the tumors. It is possible that I will also have to try targeted drugs to inhibit the growth of cancer cells in various areas!"

"Honey, eat first. The food is getting cold." The concubine Chen Shuting said as she picked up three slices of lean meat and cabbage for Zhang Heping.

"Ok!"

Zhang Heping responded without even looking at what was in the bowl, and just quickly put the food into his mouth.

Seeing this, the first wife Tang Xin hurriedly picked up some dishes for Zhang Heping.

Not long after the meal, Mrs. Zheng and Director Wang came again.

Mrs. Zheng's husband died of cancer. After looking at Ma Changming's medical checkup today, she smiled and comforted Ma Changming, "The test data here show that your condition is under control. You have a good grandson!"

Ma Changming laughed and sat in the rocking chair somewhat stiffly.

"Just relax and focus on your recovery. I'll go see what Heping is researching." Old Mrs. Zheng said as she put a few checkup sheets on the table and went to the east gate room.

……

"The country of Magnesium has rejected our application for a computer hardware patent, saying that it is Tingmei Trading's public technology and that no one else is eligible to apply." Director Wang sat at the desk and told Zhang Heping about what she had encountered recently.

"The reason why the Magnesium people don't allow us to apply for computer patents is simply because they want to produce computers for sale. However, the computers we and Japanese companies sell are cheaper than those made in Magnesium, so they have no competitive advantage."

"The 4.2 million magnesium yuan that Tingmei Trade paid for the factory construction has been deducted from last month's payment for goods. The higher-ups have no objection to this, and it's probably related to your establishment of a cancer treatment institute in the capital."

"I heard that your institute has applied for patents for anti-cancer drugs such as paclitaxel and carboplatin, and you have also founded a medical journal called Doctor. Are you planning to concentrate on medical research?"

"No!" Zhang Heping responded simply.

"That's good!" Director Wang said with a smile, "Director Sha asked me to tell you that we are receiving more and more inquiries about multi-axis technology."

Zhang Heping's eyes and hands did not leave the drawings on the table, but his tone was a little impatient, "There is no war recently, and there is no shortage of chips and computers. Return the letter to them and let them develop it themselves."

Director Wang glanced at Mrs. Zheng who had just come in, and smiled as he moved a chair to the side. "I'm waiting for this brat's information. He said it's the latest MRI equipment."

Old Mrs. Zheng glanced at Zhang Heping, who was concentrating on drawing under the white LED light, made a gesture to Director Wang to keep quiet, then sat on the chair and waited quietly for Zhang Heping.

Jingle Bell……

The landline phone on the desk suddenly rang. Zhang Heping put the microphone between his shoulder and ear and said "Hello".

“Once the cisplatin drug is developed, it will be handed over to the laboratory next door to conduct cell experiments. Remember to apply for a patent and publish the follow-up treatment data in the journal Doctor.”

"Well! If you don't have enough manpower, just apply. Funding is not a problem. I'm just worried that you will get too excited and work too hard. That would be irresponsible not only to yourselves, but also to our research project."

"Thank you for your hard work, go home early!"

After hanging up the phone, Zhang Hepingka finally put the relevant production technical data of the 8T nuclear magnetic resonance equipment on paper at 3.0: in the evening, before his grandfather went to bed.

"Huh!" Zhang Heping shook his right hand, then gathered the thick stack of documents and said to the two old men next to him:

"Mr. Zheng, Aunt Wang, this equipment is at least 10 years ahead of the world. With domestic technology, we can completely produce it ourselves. I suggest the export price is 3000 million magnesium yuan per unit!"

Zhang Heping said, smiling as he handed over the information, "Auntie Wang, please arrange for the factory to make it as soon as possible. I need it urgently."

"3000 million magnesium yuan?" Director Wang took the information in surprise, and his hands tightened.

"Heping, don't worry, I will urge them to make a prototype as soon as possible so as not to delay your treatment." Old Mrs. Zheng smiled and made an assurance to Zhang Heping.

"Yes! If they have any technical questions, please ask them to call my landline during breakfast, lunch and dinner."

As the three of them talked, they left Courtyard No. 7.

Then, they all glanced at the window of Yard No. 6 on the left, at the group of neighbors wrapped in cotton-padded jackets and watching black-and-white TV with their hands hunched.

The happiness of ordinary people...

Old Mrs. Zheng came to the car on the side of the road, turned to Zhang Heping, and said kindly: "Heping, if you need anything, just tell your Aunt Wang and me. The country will fully cooperate with your research!"

"Mr. Zheng, I called just now. You heard me. The lab is short of people." Zhang Heping said helplessly, "I didn't expect so many cancer patients would volunteer to participate in the new drug experiment, which greatly increased the workload of the researchers."

"In addition, I also need to coordinate with the cancer research team of Harmony Hospital to join us. It doesn't matter whether the research institute is Harmony Hospital or not, as long as they fully cooperate with me."

Old Madam Zheng frowned and asked, "Did someone over there trip you up?"

"Not to me, but being sarcastic to the researchers below is not conducive to research and development." Zhang Heping said with a smile: "After the institute is incorporated into Harmonious Hospital, I will trouble you to solve the hospital staffing issues for those researchers, so that they will not be regarded as outsiders when they go to the hospital cafeteria."

"The equipment in that research institute seems to have cost you 8000 million magnesium yuan!" Director Wang made a comment, "How could you be willing to give so much money to Harmonious Hospital?"

"Auntie Wang, there's something fishy going on here. Are you blaming me for not donating to the Hope Project this year?" Zhang Heping said as he opened the car door. "What have they done in the past two years? They built a few Hope Primary Schools, but they didn't even tell me the details of how the funds were used. I won't donate to them again."

When Mrs. Zheng heard this, she frowned and got into the car. It was obvious that she was also concerned about the Hope Project.

"Go to bed early!" Director Wang said, and got into the back seat of the car.

After Mr. Zheng and Aunt Wang left, Zhang Heping went to massage his grandfather's acupoints to promote blood circulation, and used herbal medicine and acupuncture to help him sleep.

That night, Zhang Heping took his two wives and seven children to a private room at the Capital Hotel.

He usually sleeps in the east gate room of Yard No. 7, but his two wives flew here from far away, so the lives of this man with two wives still need to be coordinated.

……

The next day, after Zhang Heping sent his wife and children on the plane, he waited at the airport for a while. After picking up He Zijiang, Bai Yun, Lao Zhao and others who came from Mengla Airport by plane, he took a car to Harmonious Hospital.

Old Zhao, Zhao Nanjiang, the former director of Nanla Town and current deputy county magistrate of Mengla, seemed a little taciturn when facing Zhang Heping.

"Director Zhao, don't you recognize me?" Zhang Heping looked at the serious old Zhao and said with a smile, "Are you still putting on airs in front of me?"

"Ahem!" Deputy County Chief Zhao Nanjiang, who looked like an old farmer, blinked at Zhang Heping, then tilted his eyes and looked at the young male driver in military uniform, as if to say that there was an outsider.

"Xiaotian and I are from the same department. We are both comrades who have been strictly examined and signed a confidentiality agreement. We are not outsiders." Zhang Heping patted the thigh of Lao Zhao, who looked weird, and then said to He Zijiang in the front passenger seat:

"Old He, the patent for paclitaxel is in the hands of the Magnesium people, but the research institute at Harmony Hospital has the patent for the semi-synthesis of paclitaxel and the patent for albumin-bound paclitaxel."

"If we equip your factory with some equipment, you can produce paclitaxel, but you don't have the conditions to produce human albumin."

"Unless you can make Mengla Airport a private one, or build a private airport in Jingcheng, and then airlift human blood collected from various places, and then equip you with complete equipment, you will have the conditions to produce human albumin, and then produce albumin-bound paclitaxel preparations."

"So, you are only a production base for the yew branches and leaves, and a paclitaxel raw material processing plant, and you do not have the right to export."

He Zijiang looked sideways at the back seat of the car and asked the question that Lao Zhao was most concerned about, "Heping, how is the price calculated?"

Zhang Heping said: "The anti-cancer effect of albumin-bound paclitaxel has been proven by effective experimental data. The export price I recommend is 100 mg per portion of albumin-bound paclitaxel, which is composed of 800 mg of paclitaxel and 4000 mg of human albumin."

He Zijiang asked hurriedly, "How many yew branches and leaves are needed to produce 100 mg of paclitaxel?"

"If it's tree bark, it would take about 3 kilograms. The bark of a century-old yew tree weighs about 4 kilograms." Zhang Heping explained with a smile: "But if you use the extract of yew branches and leaves for semi-synthesis, you only need 2 kilograms of fresh yew branches and leaves!"

"2 kilograms of branches and leaves? 4000 magnesium yuan?" He Zijiang was shocked!

"You wish!" Zhang Heping said with a smile, "Aren't the synthetic materials, human albumin, equipment, labor, and transportation considered costs?"

"Also, if we sell it to domestic hospitals, we definitely can't charge such a high price. It would be good enough if we can just break even."

"Whether you can make yew planting and paclitaxel processing the pillar industries of Nanla Town depends on you guys fighting for the price. The most I can do is help you get the paclitaxel raw material processing business."

After Zhang Heping took them to the guesthouse of Harmonious Hospital to drop off their luggage, he took them to the Cancer Treatment Research Institute of the hospital and asked the leader of the research team to negotiate with them the purchase price of yew branches and leaves, as well as the processing price of paclitaxel.

In fact, Zhang Heping has the right to set prices, but he only gave a pricing range and then asked the research team leader to negotiate and let He Zijiang and others negotiate for the price themselves. It was up to them to decide whether to offer more or less.

Otherwise, I will have to help the fellow villagers in Nanla Town find other profitable businesses in the future.

A moment later, the middle-aged male team leader trotted to Zhang Heping's experimental area and said with a smile: "Director, it's settled. The price of yew branches and leaves is 10 yuan per kilogram, and paclitaxel is 1 yuan per 100 mg. They estimate that next summer, without affecting the growth of yew, they can harvest 100 kilograms of fresh branches and leaves."

"3 kilograms of branches and leaves can only produce 1500 grams of paclitaxel at most, which is barely enough to treat 700 people. It's too little!" Zhang Heping shook his head, "Let's get ready to call it a day. I'll take you to have a good meal to replenish your nutrition."

After he finished speaking, Zhang Heping put down the documents in his hand, called home, and soon took the staff from the research institute and He Zijiang and others to Quanjude.

After Zhang Heping paid the foreign exchange coupons and set up the dinner party, he drank a few glasses of wine with Lao Zhao, He Zijiang, Bai Yun, the current director of the Mengla County Health Bureau, and a dozen researchers, and then went home. He also needed to give his grandfather Ma Changming some physical therapy and let him take a nap!

……

"The mainland has discovered a semi-synthetic method for Taxol!" The director of Hong Kong Sanatorium and Hospital opened the first issue of the medical journal "Doctor" in amazement, "Huh? These words are..."

"President, those are simplified Chinese characters that are being promoted in the mainland!" The secretary hurriedly handed over a document in his hand. "These are the traditional Chinese characters that I asked someone to translate in Shenzhen, and then I bought a dictionary and encyclopedia from the mainland to compare them. The mainlanders translated Taxol into paclitaxel."

The director of the Hong Kong Sanatorium and Hospital looked at the handwritten traditional Chinese characters, frowned and said, "If paclitaxel can be synthesized using yew branches and leaves, the production of paclitaxel can be steadily increased."

"Dean, I'm very curious, how can the mainland directly use new drugs for human experiments? This is so irresponsible!" The secretary's tone was a little indignant.

"The fact that they have been able to develop a semi-synthetic method for paclitaxel shows that the mainland has already been researching paclitaxel." The director of the Hong Kong Sanatorium and Hospital frowned and said, "We finally bought 3 grams of paclitaxel for experiments this year. The mainland has accumulated paclitaxel treatment data for 67 cancer patients."

"Director, look at the last case of lung cancer metastasis. It was a combination chemotherapy of albumin-bound paclitaxel and carboplatin. I haven't found any information about carboplatin yet. It may be a new anti-cancer drug. Should we send someone to Capital Harmony Hospital to confirm it? I feel that this combination chemotherapy is very important to our hospital!"

……