Rebirth 1975: Tore up the call-back order at the beginning

After returning to the research institute, Zhou Yang pondered for a while, and then wrote about the second-generation hepatitis B vaccine.

How harmful hepatitis B is, no one knows better than Zhou Yang!

Compared with the actual situation, what Yang Chunhua and Duan Yinzhong said at the meeting just now is just superficial.

In the previous life, the state launched an extremely important investigation on this terrible infectious disease in 1992. This investigation lasted for three years and was the largest serological investigation of hepatitis B among the entire population after the founding of the People's Republic of China.

The results of this survey showed that the prevalence rate of hepatitis B virus carriers in China was as high as 9.75%. According to the population calculation at that time, the number of hepatitis B virus carriers in my country was 1.2 million (currently there are more than 7000 million hepatitis B virus carriers).

The result of this investigation was like a bomb that exploded suddenly without any attention, and rumors spread everywhere in panic.

The impact is great and the harm is deep. There is absolutely no disease that can be compared with this disease!

More importantly, even if hepatitis B is a serious disease, there is no way to cure it.

The only way is to develop a vaccine and prevent it in advance!

Therefore, after the establishment of this medical research center, Zhou Yang was determined to research the hepatitis B vaccine.

After all, for hepatitis B, an infectious disease, the vaccine is almost a salvation.

Of course, more importantly, once the vaccine research is successful, the economic benefits that can be created are also very considerable.

The world's first hepatitis B vaccine was successfully developed in Zeehawk in the 70s. However, due to many reasons such as technology and cost, this vaccine has not been popularized on a large scale. It is only an immunization program for high-risk groups.

The hepatitis B vaccine that has been commercially promoted on a large scale is Merck's second-generation vaccine. This vaccine was launched in 1986. Since then, the incidence of acute hepatitis B in Jaeger Eagle has dropped by 80%.

The results are naturally gratifying, but the price is also unbearable for ordinary people!

At that time, the hepatitis B vaccine was priced at US$100 in Javelin’s country, which would be equivalent to half a year’s income of an ordinary family in China.

Therefore, as long as the second-generation hepatitis B vaccine is successfully developed, it is almost equivalent to creating a non-stop money printing machine.

At that time, Weiyuan Company, which is controlled by Yan Gengdong, will be able to sell this vaccine to the whole world, and its income will definitely not be inferior to that of atorvastatin for chronic diseases and fluoxetine for depression.

Let’s not talk about making money. If we have a cheap and safe hepatitis B vaccine, given how much our country attaches importance to the common people, we will inevitably popularize this vaccine on a large scale. By then, how many lives and how many people can be saved? family.

Perhaps, if large-scale inoculation of hepatitis B vaccine is given to newborns from now on, the number of hepatitis B patients in our country may not reach the peak of 1.2 million.

Therefore, it is imperative to study the second generation hepatitis B vaccine.

It's just that Zhou Yang is not particularly sure about this vaccine, and the reason is simple, this is not his field of expertise.

Not only is Zhou Yang not good at it, but no one in China is good at it, because compared to the first-generation plasma-derived vaccine, the second-generation recombinant rDNA hepatitis B vaccine is a genetically engineered vaccine.

Fortunately, Zhou Yang had learned about the process of this genetic engineering vaccine in his previous life, and knew that its core is based on engineered yeast bacteria as the carrier, that is, the surface antigen of hepatitis B virus expressed by recombinant Saccharomyces cerevisiae is purified and made by adding aluminum hydroxide adjuvant.

It's just that knowing these things is not enough, and it may not be possible to develop a safe and reliable vaccine.

The reason is also simple. There are too many things that need to be controlled in the process of vaccine development. If there is a problem in one link, all previous efforts will be wasted.

This is like smokeless gunpowder. We all know that its main ingredient is black powder, and the classic black powder formula is one sulfur, two nitrates and three charcoals.

But if you bring all these raw materials in front of you, can you make smokeless gunpowder?

What's more, our domestic genetic engineering has just started, and there is a big gap with foreign countries in terms of talent pool and technical equipment.

Therefore, Zhou Yang originally used the second-generation hepatitis B vaccine as the third blockbuster product of Yan Gengdong's sickle plan, but after thinking about it for a while, he always felt that it was not suitable.

After all, he is not sure whether the second-generation hepatitis B vaccine will be developed, nor is he sure how long the development cycle will be.

Therefore, this can only be considered as a mandatory item.

Do the research first, it's good to have results, and it doesn't have much impact if there are no results in a short time!

As for the third product of the Sickle Project, Zhou Yang has already thought about it, which is the famous little blue pill.

Although it is a bit wasteful to take out such a big killer at this time, after all, the patent protection period of drugs is only 20 years. After the patent expires, it will be made public and become a patent that can be used by the public society, and contribute the patent to the whole society.

In other words, after the little blue pill is taken out now, it will become a public patent almost in 1997, which is somewhat a pity.

However, in comparison, we are now even more short of money and foreign exchange!

Perhaps by that time, we no longer need to obtain funds through this means.

Therefore, after some thinking, Zhou Yang decided to take out this big killer, and let Yan Gengdong and the others quickly harvest the whole world.

He asked Song Shi to contact Li Linzhang to come back just now, and he asked him to come back to host this project.

In fact, compared with the second-generation hepatitis B vaccine, the research and development difficulty of the small blue pill is almost negligible. As long as Zhou Yang explains the basic steps, with the scientific research ability of Li Linzhang and others, it will be developed soon.

It's just that Zhou Yang doesn't have time to do it himself, so he can only let Li Linzhang be the "father of Brother Wei"!

I hope Professor Li won't trouble him because of this...

........

All morning, Zhou Yang was making these things in the office!

However, just as he was about to leave work, a familiar voice suddenly sounded outside the door: "Report!"

"Come in!"

With Zhou Yang's permission, the door of the office was pushed open, and Fan Debiao was seen walking in from outside.

Seeing the guy's tanned skin covered with sweat stains, Zhou Yang asked with a smile, "Why are you sweating profusely again, what did you do at noon?"

"It's nothing, at the request of that boy Yun Changjie, he took them to Huangshiya to test the equipment!" Fan Debiao said.

"Why do you test again, didn't you just test it two days ago?" Zhou Yang frowned.

"Yes, I tested 7 units the day before yesterday, and tested 18 units today!"

Then Fan Debiao said helplessly: "That kid is the axis. I mean, those radars are all like a ball. Just do a spot check and test, and the same is true for other units. But he just can't do it. He insists on testing every one. !"

"He can test it if he wants to, why do you still have to follow him every time?" Zhou Yang asked puzzled.

"They are a bunch of new recruits, and live ammunition is used in the test. I am worried that they will have an accident, so I can only follow and watch!" Fan derbiao said.

Zhou Yang glanced at him up and down, and when he saw this guy's oily hands, he immediately said, "I think your hands are itchy and you want to play with a cannon!"

Seeing that Zhou Yang had dismantled his thoughts, Fan Debiao didn't feel any embarrassment at all, and immediately said with a smile: "Well...it's not idle, it's idle..."

"Don't play haha, how many shells did you consume today?"

"6 mortar shells, 22 howitzer shells!"

"Specially pick the expensive ones, you can take it easy, we are not a front-line combat unit, but we don't have so many ammunition rations, it's hard to apply for them if they are all gone!"

"Hahaha, if you really don't have one, just go to Yun Changjie, you boy, and ask him to apply to the higher authorities. Who told him to test one by one!"

"You've done a good job!"

Then Zhou Yang said again: "But if you are really energetic, don't take your anger out on Da Pao!"

"Uh... what do you mean, where else can I spread it?"

"Go to Wuzhina, do you know that Yunlong's wife is pregnant!"

"Really, that kid is going to be a father?"

"Yeah, so you have to work hard, the cannon is hitting your daughter-in-law, don't keep thinking about the few shells in the Huo Huo arsenal!" Zhou Yang said.

"Understood!"

Seeing that Fan Debiao seemed to be about to turn around and leave, Zhou Yang immediately asked, "Did you come here just to tell me this?"

"No, you made a fuss, I almost forgot the business!"

"What's the matter?"

"The matter of the kid surnamed Gao is settled, his father and mother are back!" Fan Debiao said.

Hearing this, Zhou Yang cheered up immediately!

........

ps: Please ask for a small free gift, I wish you all a real man, and you will never need such a small pill in your life!