Hello 1983

Mason's ears were wrapped with white gauze, and he skillfully picked up a sauerkraut dumpling with chopsticks.

After everyone finished eating and changed into their work clothes, they went to the workshop.

The raw materials have been shipped, and twenty kilograms of dried yew seeds are quietly packed in a large glass jar.

At such a critical moment, everyone's hearts can't help becoming tense, and Kevin said:

"Paclitaxel is the most abundant in the bark of the yew. If the bark of the yew is used, it takes about 13.6 kilograms of bark to extract 1 gram of paclitaxel."

"I don't know how much paclitaxel can be contained in the yew seeds here?"

This is also the issue that everyone is most concerned about, and no one knows what to do.

This is why the drug paclitaxel is so precious. The yield is too low, and the bark of the yew is relatively thin. How much bark can a tree produce?

Treating one patient requires the bark of several yew trees, which are scarce and slow growing.

Things like cutting down trees and peeling yews to extract yews will be criticized by environmentalists.

The superimposition of various reasons has resulted in the preciousness of paclitaxel.

"Let's get started, I hope we can create a miracle."

Liu Qingshan waved his hand, he is very confident in the local yew, because it has been proved later.

These technicians began to perform their duties, and as the equipment was turned on, there was a humming sound in the workshop.

The laymen who came to visit all looked solemn, because they also knew the significance of this experiment.

Extracting paclitaxel is a very complicated process, because the structure of paclitaxel belongs to a tricyclic diterpene compound, and its structure is extremely complex.

There are also scientists who want to synthesize it artificially, and they did succeed in living a few years later.

It's just that the reagents and materials needed are expensive, and it is impossible to achieve large-scale mass production.

Later, a semi-synthetic method was developed, using a fir tree similar to the yew tree to synthesize paclitaxel. The process is also relatively complicated, so the price of paclitaxel has not dropped much.

The waiting process was a bit boring, so the fourth brother proposed to lead those singers to visit Daji in the countryside.

This idea was immediately welcomed, so everyone covered up tightly and happily followed the fourth and fifth.

"Little stool, don't go, I have something to do with you." Liu Qingshan yelled.

Little Stool likes to join in the fun, and immediately started pouting, and then heard Liu Qingshan continue to say: "I found a suitable song for you."

Wow, the little stool screamed strangely, and rushed towards Liu Qingshan.

Who doesn't know the company under the big tree, the songs created by Mr. Liu are basically classics, who doesn't want it?

The others also stopped and looked enviously at the small stool.

The little fourth was a little dissatisfied: "Brother, are you robbing me?"

Liu Qingshan waved his hand: "Everyone go for a stroll first, I just find a small stool to try it out first, if possible, everyone can participate."

Everyone couldn't help but be overjoyed: Is this the rhythm of holding a concert of [-] singers?

So they all followed the little brother, happily running away without a trace.

But there were also those who didn't go. Amao didn't like to join in the fun, so he stayed.

Coincidentally, Liu Qingshan also needed her, so he led the two girls, one older and one younger, into the activity room of the pharmaceutical factory.

It wasn't until the end of the market at noon that Xiao Lao Si returned with a full load of troops.

Some of these singers held candied haws in their hands, and some held large pieces of candy, all of them were very happy.

And even more gratifying news came from the workshop: Paclitaxel has been extracted!

When everyone heard this, they all rushed into the workshop, and when Liu Qingshan rushed in, they saw the technician named Karl holding a small test tube with half a small white crystal in it.

After weighing, Carl's face also turned red: "Oh, it's 30.5 grams in total!"

"We used 30.5 kilograms of yew seeds to extract 0.15 grams of paclitaxel, and the content reached [-]%, which is unbelievable!"

Laymen don't understand, but these experts know that even in the bark of Taxus brevifolia, which is recognized as having the highest content, the content of paclitaxel is only 0.069%.

And don't underestimate the [-] grams of paclitaxel, based on the current market price, the value is nearly [-] US dollars.

"Is there something wrong?"

Kevin did not follow the excitement, but suspected that there was a problem in some link, and the extracted paclitaxel was not paclitaxel.

"It has been tested, and it is indeed paclitaxel crystals." Carl was very dissatisfied with Kevin's suspicion.

Although he was also shocked, what shocked him was that the yew seeds here had such a high paclitaxel content.

But you can't question his professionalism.

"Success, we have succeeded!" In the workshop, cheers rang out.

Members of this temporary team embraced each other, with smiles on everyone's faces.

Kevin was also elated: a total of tens of thousands of catties of yew seeds, according to this ratio, can extract dozens of kilograms of paclitaxel, which is also worth millions of dollars!

"I'm coming!"

Lu Xiaolong had just picked up the bearded principal in a jeep, and the guy was still blah: "It's better to come early than coincidental. It's just made, and it's still warm. Give it to Principal Xu while it's hot!"

You thought it was just out of the drawer, paclitaxel is very toxic, the dosage must be carefully calculated.

Moreover, this substance is insoluble in water, and it is troublesome to inject, and it is easy to cause allergic reactions. You must first inject dexamethasone or the like to adapt.

In fact, as of this year, the clinical trial of paclitaxel has only been carried out to the second stage, and it will not be gradually improved until the 90s.

When Principal Xu saw the situation, he was also a little puzzled, just like Liu Qingshan asked:

"I'm afraid this thing is quite expensive. I'd better not use it. I feel pretty good now."

Liu Qingshan was about to lie and say it was the price of cabbage, but the little six next to him spoke quickly:

"Uncle Xu, of course it's expensive. Just a little bit like that is worth ten thousand dollars."

The bearded principal waved his hands again and again: "No, no, it's not worth the price if you sell me."

It made Liu Qingshan feel a little headache. He knew Principal Xu's temper, and he had the stubbornness of a scholar in his bones.

So Liu Qingshan could only say: "Principal, this thing is not in vain, you have to cooperate with clinical trials."

Principal Xu was also very happy: "Co-authors use me as a guinea pig, right? Then it won't work."

Of course he understood Liu Qingshan's kindness in his heart, but he really couldn't use such a valuable thing.

There was no other way, Liu Qingshan could only wave to Amao, it was time for her to come out and persuade the bearded principal.

Of course, Amao played to her strengths and began to sing the song Liu Qingshan had taught her just now.

Chapter 752 changed to what?

Accompanied by the quiet guitar sound, Amao's affectionate singing sounded:

"It's a very distant thing that Hongdou was born in the Northland. Lovesickness is nothing, no one cares for a long time..."

This is a song of lovesickness, everything starts with red beans.

"The most willing to forget the ancient poems, the most dismissive is lovesickness, guarding love for fear of being laughed at, and afraid of being seen clearly..."

The bearded headmaster couldn't help but be fascinated by this sad and joyful singing.

"Come to see the red beans bloom again in spring, but I don't see any lovers to pick them..."

Principal Xu's heart suddenly brightened, and then a sense of guilt surged: Everyone has worked so hard to pick red beans, and there is full of love in it, so why does he have any reason to refuse?

The bearded headmaster glanced at the faces around him, and his eye sockets couldn't help but get a little moist.

All of this, this love, he will never forget in this life!

After singing a lovesickness song, Principal Xu bowed deeply and accepted it frankly.

However, some preparatory work is still needed, this is a matter for professionals, nothing to do with Liu Qingshan and the others.

The singers surrounded Liu Qingshan and went to the activity room. Everyone was envious of Amao getting such a good song.

"Little stool, show everyone what you just practiced." Liu Qingshan cheerfully waved to Xiaosongzi.

Everyone also booed, wanting to see what true biography the little stool has obtained.

There is no stage fright in being a singer, so the little stool stuffed a tape into the tape recorder. The accompaniment is only a guitar, and it will be used for the time being.

The little stool stood in the middle of the house, and when the melody sounded, she stretched her limbs and danced.

Dancing is not difficult at all, and it is incomparable with professional ones. Square dancing is a popular route.

Everyone soon felt that the melody of the music was also very special. How should I put it, it made people have an urge to twist their bodies along with it.

Although the small stool is small, it has a very high voice, and began to sing:

"The boundless sky is my love, and the flowers are blooming at the foot of the green hills. What kind of rhythm is the most swaying, what kind of singing is the most joyful..."

Everyone was stunned when they heard it: What kind of song is this?

Mistral, no, rock and roll, no.

The lyrics seem straightforward, and the melody sounds simple, but it seems to have a magical power, making you want to relax and swing along with the melody.

Xiaosengzi just practiced for a while, and she is not yet proficient in dancing, but she has a good sense of music, and in the end, she just let it go freely.

Soon, a few more little girls joined in, the fourth, fifth, and sixth.

A few days ago, when Liu Qingshan was free, he taught them.

Then more and more people joined in, and the more people there were, the more vigorously they danced.

At first, Old Cui felt that Mr. Liu's work was a bit too vulgar.

As a result, after seeing this scene, he also understood: this is simply to entertain the public.

Even ordinary people can sing as soon as they learn it, and want to dance as soon as they sing.

Jumping and jumping, the sound of the music stopped abruptly, and everyone still didn't think it was enough, so they rewound the tape and played it again.

Liu Qingshan didn't join in, he planned to come up with a few more pieces suitable for square dancing, and then asked the professional dance teachers under the big tree to compose a few sets of simple and easy-to-learn dances.

At that time, under the big tree will become the initiator of square dance, just wait for the tape to be sold.

It wasn't until someone came over to invite everyone to eat that everyone stopped with unsatisfied enthusiasm, and many people's foreheads began to sweat slightly.

Today is the new year, and there is a celebration banquet in the cafeteria, so the dishes are very rich.

Little Lao Si and the others took out a lot of large candies and distributed them to the foreigners.

"What kind of candy is this?" Mason looked at the big milky white candy, he had never eaten it.

"It's made of maltose, don't worry about eating it." Liu Qingshan explained to them.

Only now did the foreigners start to bite into it, and it was quite crunchy.

After chewing for a while, Mason exclaimed, "Oh, sticky teeth."

Just stick your teeth.

Liu Qingshan helped these foreigners popularize Chinese culture by the way: "This is called Zao Tang. Today is the 23rd day of the twelfth lunar month in our place, and it is a day for worshiping Zao."

"That's why every family has to buy candy for the Stove Lord. After eating the candy, the Stove Lord's teeth got stuck. When he reported to the Jade Emperor, he couldn't speak ill of it. That's why it's called God's good deeds."

The group of foreigners still listened with gusto, and Mason muttered, "Then if we eat candy, will we also become the Stove Lord?"

Everyone laughed, and then drank happily to celebrate the initial success in refining paclitaxel.

The next step is to increase production, and Kevin is gearing up to bring paclitaxel back to ask for credit.

Dozens of kilograms of paclitaxel can not only sell for a good price, but also bring good reputation and contacts to the company.

In the afternoon, Liu Qingshan took people back to Jiapigou, where the singers gave a performance to the folks, and then presented the award to the third winner of the Jiapigou Literature Award.

On the second day, the group left Jiapigou in a hurry. During the Spring Festival, many of them had performance tasks, and how many of them were going to be on the stage of the Spring Festival Gala.

Writer Yu also left with him. After he was going to go back, he started writing behind closed doors.

After all, with the support of this bonus, I don't have to worry about making a living for the time being, and I can create with peace of mind.

I believe that as long as he is given a year or two, Writer Yu will have the confidence to complete this work.

Liu Qingshan has nothing to do for the time being, he is busy with his family, preparing for the festival.

On the 25th day of the twelfth lunar month, the elder sisters Yang Hongying and Zheng Hongqi, leading Lin Qingqing and others, rushed back from Shanghai to celebrate the new year.