Rule department scholar

To get the highest honor now is almost like the country conferring a god.

……

End of the meeting.

Zhao Yi returned to Yanhua University, but he was not able to relax, because he was entangled by several technical experts from the anti-gravity team every day, especially the old academician Zhou Guifang, who waited on time for the small meeting at eight o'clock every morning In the room, the guards always urged Zhao Yi to come over, which made him feel very annoying.

This disrupted his normal life rhythm. He would get up after eight o'clock, stroll around the campus, exercise, have breakfast, and start working normally around ten o'clock.

Now he has to get up early at seven o'clock, which makes him feel very depressed.

Zhao Yi only persisted for a few days before he came up with a very good solution--

Leave homework!

Every day after the explanation is completed, there is a "homework" that requires careful thinking and research. The content of the homework is related to the content of the explanation, because the difficulty of mathematical theory is very high, and it takes a long time to complete even the ordinary content.

Then Zhao Yi became much more relaxed.

The old man Zhou Guifang never came early, sometimes even later than others. He is already in his 60s, and it is impossible for him to come to class without completing his homework.

He began to find all kinds of excuses for being late, such as 'getting old', 'not feeling well', 'going to the hospital to get medicine', and even once said that Dong Lihua insisted on discussing design issues with him, and the discussion lasted for two hours , it was very helpless to be late.

halfway.

In order to show that he was not lying, he even scolded Dong Lihua a lot.

Zhao Yi used "The Law of Karma" to easily know that Dong Lihua didn't call, and just watched Zhou Guifang's "performance" with a smile.

The old man's acting skills are really good, I don't know if he is making excuses, but he will really criticize Dong Lihua with him.

"Old Dong, it's hard for you, you were scolded even hundreds of kilometers away..."

"No idea!"

"I can't expose that old academician Zhou is lying. When the old man is so embarrassed that he has some troubles, it won't be too good..."

"Ugh!"

After Zhao Yi relaxed, he also had time to go to the laboratory of the medical center to care about the progress of neural transmission research and participate in related experiments.

It is too difficult to come up with results in this research in a short period of time. The research on the sense of touch has all been completed, and other fields are in the process of 'exploring', that is, conducting tentative experiments.

Zhao Yi's opinion is to let everyone do more experiments, instead of finding key research and development directions immediately, some experiments are done to make discoveries, and then to do targeted research.

This is mainly because the scope of neurological research is too large.

The study of nerves is not simply to study how nerve signals are transmitted, but includes various perceptions of organisms, nerve coverage, nerve responses, nerve cell analysis, and so on.

When there are too many fields involved, it is also very difficult to make a choice.

The laboratory has just completed a major achievement, so there is no rush, and the next direction is immediately started, just doing experiments normally, doing research on nerve cells, and preparing for the next research and development.

Simultaneously.

Zhao Yi is also concerned about technologies related to cancer immunotherapy. He has always kept his promise. If he is interested in immunotherapy, he will definitely learn about it. If conditions permit, he will definitely do some research.

Now just pay attention, know a general situation.

Cancer-related immunotherapy is a high-end medical treatment technology developed by various medical companies.

The treatment is simply to use the body's immune system to deal with cancer cells.

If the body's immune system can recognize and kill cancer cells, it can maximize the removal of cancer cells in the blood, and can directly inhibit and treat cancer.

The key to this technology is to allow the body's immune system to recognize cancer cells.

So how to do it?

Zhao Yi immediately thought of 'Tianqing protein', 'Tianqing protein' can mark HIV, so that the human immune system can recognize cells containing HIV as foreign virus cells.

So is there a simple way to directly label cancer cells?

What is wrong with Chapter 528?

The international medical field has long studied the technology of specific antibody labeling cancer cells.

In fact, cancer immunotherapy, in most cases, refers to the specific antibody labeling of cancer cells, which is to artificially produce an antibody against the patient's cancer cells, and inject the antibody into the blood of the human body to make the human body immune The system works to kill cancer cells.

This method belongs to the passive immunotherapy of tumors, and there is another name called monoclonal antibody tumor therapy.

Monoclonal antibody tumor therapy requires gene extraction and testing for each patient, and targeted production of antibodies, and the cost will be very high.

Therefore, international tumor immunotherapy requires millions of RMB per injection, which is not something ordinary people can consume.

In fact, there are several other methods for tumor immunotherapy, such as the most direct one, which is to stimulate the body with tumor vaccines, generate an immune response against tumor-specific antigens, and enhance the immunogenicity of tumor-associated antigens to stimulate specificity. Immunity to attack tumor cells.

There is also a method of infusing processed autologous or allogeneic immune cells or immune molecules to patients to enhance the patient's cellular immune function.

The other is gene-oriented methods, such as recombinant cytokine therapy, cytokine gene therapy, cytokine receptor gene therapy, etc., and so on.

However, in terms of treatment effect, the effect of monoclonal antibody tumor therapy is the best, which can greatly reduce the tumor cells in the blood of patients in a short period of time.

Some medical companies even claim that it can completely kill cancer cells in the body.

Of course.

After the treatment is over, whether the cancer is cured depends on whether it will recur after a few years, because cancer cells mutate very quickly, and monoclonal antibody tumor therapy may not be able to kill all cancer cells, but the treatment effect is indeed very good. good.

What Zhao Yi hopes to study is a method that can easily label cancer cells.

If cancer cells can be easily marked, there is no need to make special antibodies for each person, which can greatly reduce the cost and benefit ordinary cancer patients.

"Every person's genes are different, and the mutated cancer cells are also different."

"Normally, it is difficult for the immune mechanism in the human body to recognize cancer cells, because cancer cells are mutations of human cells."

"Expanding the killing effect of T cells may bring about great side effects..."

Zhao Yi thought carefully about the problem of killing cancer cells, and felt a little confused. He didn't want to find a way to treat cancer right away, but wanted to find a research direction.

As long as the research direction can be determined, the research can start normally.

It's hard.

"I still know too little." Zhao Yi thought, "It's just basic knowledge, and the limitations are too big. I still need to ask a few cancer experts."

He walked out of the laboratory thinking.

When he arrived at the entrance of the medical center, he happened to bump into Dai Tianqing who was coming over.

Dai Tianqing greeted Zhao Yi, and asked with interest, "I heard that you seem to be concerned about cancer treatment? Why?"

Zhao Yi said, "I have a friend who has cancer."

"Huh? Because of this?"

"Yes?"

Dai Tianqing opened his mouth wide in surprise, "Just because a friend of yours has cancer, so you plan to study how to treat cancer?"

"right?"

Zhao Yi asked strangely.

Dai Tianqing didn't know what to say, because a friend had cancer, he planned to conduct research on cancer. It sounded logical, but in fact there was no logic at all.

What if the friend has other diseases?

With such a large circle of friends, there will always be people who get sick. Should we study all diseases?

There was a strange look in Dai Tianqing's eyes. He shook his head with a wry smile and said, "I have done a research on cancer. It is the response mechanism of T cells against cancer cells."

"My research has proved that in most cases, even if the human immune system sends a signal, the function of T cells will be suppressed, thereby ignoring the cancer cells in the body."

"Oh?"

Zhao Yi didn't understand what Dai Tianqing wanted to say.

Dai Tianqing continued, "Because of this inhibitory effect, cancer immunotherapy can only be performed through external effects, such as the infusion of specific antibodies, or enhanced T-cell response, or genetic means, but other effects are not good."

"If it is a specific antibody, it has already been studied internationally, and there is already a mature treatment plan."

Now Zhao Yi understands

What Dai Tianqing meant was that the technology to artificially manufacture specific antibodies already exists in the world, and it is meaningless to continue research on specific antibodies.

Of course, affirmation also makes sense.

No domestic company has developed a mature antibody treatment method, and the research is still of great economic value.

Zhao Yi nodded and said, "I don't want to study the production method of specific antibodies, but a universal labeling method."

"Ah? Pratt & Whitney? How is it possible?" Dai Tianqing opened his mouth wide in surprise.

Zhao Yi said as a matter of course, "If it's not inclusive, what else is there to study? Wouldn't it be good if I directly funded him to go abroad for treatment?"

"……Right!"

Dai Tianqing understood Zhao Yi's logic this time, but he still had various impossibilities in his mind, because most cancer cells cannot be detected by the human body's immune system, and each patient's cancer cells are different, so how could it be possible to develop a universal What about antibodies?

……

Dai Tianqing's opinion is also the opinion of most people.

Zhao Yi consulted two cancer specialists in a row, and got the answer, "Impossible."

"Specific antibodies can only be produced for patients. To put it bluntly, cancer cells are human cells, but they have mutated."

"Everyone's genes are different, and the mutated cancer cells are also different, and the cancer cells will mutate rapidly. If you want to study universal antibodies, you don't even have a direction. It's impossible to kill human cells together, right?"

"..."

Among the various impossible answers, there are also some extraordinary ones.

At the partner hospital of the Institute of Biomedical Sciences, an oncologist named Shen Qian thought about it and said, "If you are doing inclusive specific antibody research, you can only start with the tumor cells themselves."

"Maybe there's a little hope."

Shen Qian said, "My recent research is to find out the detailed response mechanism of human immunity to the detection of cancer cells."

"only……"

"No progress at this time."

Shen Qian just heard Zhao Yi's inquiry and said a few words based on her own understanding. In fact, she didn't think she could bring any help.

She is an oncologist who focuses on clinical treatment rather than theoretical and research-oriented experts.

After the age of 50, most of the research she did was just for writing papers, rather than really producing any results.

After listening to Shen Qian's words, Zhao Yi gained a lot. He felt that he had found his way.

This direction is to study human immunity and the response mechanism of cancer cells. He can find a way to make universal antibodies if he does not determine the response mechanism, but at least he can fully understand the response of the immune system to cancer cells.

In the absence of a certain direction, knowing the detailed response mechanism may be able to find the right direction, unlike now, when you want to do research but have no clue.

So Zhao Yi thought for a while, and decided to invite Dr. Shen Qian to cooperate with Zhao Yi's laboratory to conduct related research.

Shen Qian couldn't believe this invitation.

Shen Qian is a very ordinary oncologist. The reason why she was able to talk about tumor problems with Zhao Yi was mainly because his hospital and the Biomedical Research Institute are partners.

Zhao Yi asked mostly doctors from cooperative hospitals.

Even in the hospital where she lives, Shen Qian is a very ordinary person, without any measurable results in medical research.

even say...

Her ability to do research is very, very average.

"Academician Zhao, are you sure you want to invite me? Your laboratory will cooperate with me?" Shen Qian thought she had heard it wrong.

"Correct!"

Zhao Yidao, "Because I heard what you said, I think it is very meaningful to study the mechanism of human immune response against cancer cells."

Shen Qian wondered, "There are already a lot of related research, even if you search the Internet, you can find a lot of related content."

Zhao Yi said indifferently, "I haven't really done research or experimented, and no one knows whether those claims are true or not. I only believe what I have seen and what I have researched."

"……All right."

Shen Qian didn't continue talking, and she couldn't find a reason to refuse.

As a very ordinary oncologist, he can be invited by the famous academician Zhao to cooperate with Zhao Yi's laboratory, which has a lot of top-level achievements, how can he refuse?

In addition, her hospital has a cooperative relationship with the Biomedical Research Institute.