Rule department scholar

"Academician Zhao is still very rich..."

Hearing what the acquaintances in the group said, Deng Bingcheng thought for a while and suddenly his heart moved.

……

The scientific research foundation has issued grants, and the laboratory has also begun preparations.

Recently, Zhao Yi's laboratory has been discussing the research plan of 'neural signal transmission', mainly focusing on the initial direction.

What they applied for was 'animal nerve research', which does not involve the human body for the time being, and the cost of experimental materials is not much.

Several researchers have come up with their own proposals. Li Ming's suggestion is to start with nerve cells and study the substances and chemical reactions that occur in the cells during the nerve reaction process.

This is research done from a biological point of view.

No matter how mysterious the transmission of nerve signals is, the transmission depends on the action of nerve cells. Direct research on the reactions of nerve cells may reveal the secret of signal transmission.

However, Li Ming's plan seems very reasonable, but it has not been recognized by others, because many people have done research from this angle, and what can be found has already been discovered.

Ai Lixin and Zhu Qi have the same opinion. They believe that a combination of physical and biological methods should be used to collect a large amount of data for analysis by testing the neural responses of various animals.

This direction is to find the common ground of the neural responses of various animals, hoping to rely on a large amount of data to analyze something.

Zhang Wei's suggestion is somewhat 'basic', she said, "We seldom do neural-related research, and there are only theories at present. I think we can consider restoring the famous experiments of neural research, so as to deepen our understanding of neural responses. There are new discoveries."

"Reduction experiment?"

"Doesn't it mean that there is no innovation at all?"

Everyone else listened and shook their heads.

What's the point of restoring the experiments that have been done and the things observed in the experiments?The results have been made public anyway, and they know what to expect.

Zhao Yi listened to the discussion of several people, thought carefully for a while, and suddenly said, "I think what Sister Zhang Wei said makes sense!"

"None of us have done neurological research. We have no experience. We can do reduction experiments first. Different people have different Hamlets, and we may make new discoveries. What's more, most experiments do not require expensive materials. ..."

What he meant was that it doesn't cost much anyway, so it's a good idea to do some reduction experiments first to see the situation.

Ai Lixin and Zhu Qi looked at each other.

The biggest difference between their suggestion and Zhang Wei's is that many animal neural response experiments need to be done, while Zhang Wei's suggestion is to do reduction experiments, that is, refer to public information to do it, only need a few animals, and do fewer experiments , The cost of consumption must be less.

Zhao Yi supported Zhang Wei's idea, certainly not because of funds, their funds can be said to be very, very sufficient.

Is it because Zhang Wei is a girl?

It is possible!

Immediately.

The two looked at Zhao Yi from the left and Zhang Wei from the right, their eyes looked weird.

At this time, I heard Zhao Yi say, "I did research two days ago, and there seems to be a famous experiment, which was concluded by testing the nerves in the legs of crabs. In this way, we will do more research on crabs."

"It seems to be the season to eat crabs now, right? Yes, buy more crabs, big ones, female ones, delicious ones, raise them first..."

He said and swallowed.

The others froze in place for a long time, thinking about buying a bunch of big crabs with funds, and after testing the nerve response of their legs, they put them in a pan for deep frying, and put some soy sauce, light soy sauce, and sugar to cook in brown sauce...

Sounds pretty good!

"This experiment is good, I can't wait!"

"Just do it!"

"support!"

"Zhao Yi is really smart!"

"..."

Yan Xuelin, who was about to come in, stopped for a moment, then stepped in immediately, and said, "How many crabs do you use for your experiment?"

"I asked Fan Lei to buy it together with the breeding box. I heard for a while that river crabs are at their most plump..."

Zhu Qi looked over and grinned, and asked, "Director Yan, are you using the research institute's money?"

"You want to do experiments, of course with your funds!" Yan Xuelin said as a matter of course.

"That won't work."

Several people in the laboratory shook their heads unanimously, and Ai Lixin followed suit and said, "The country's money should not be wasted. We are here for experiments, not for food."

"Correct."

"That's it!"

"When we talk about eating crabs, we just don't waste resources. It's no different from picking up crabs in the trash."

Yan Xuelin was speechless for a while. He found that it was getting harder and harder to guide the researchers in the institute.

Tired of heart!

Chapter 492 This is called being kind to scientific researchers!

Putting aside how attractive hairy crabs are for the time being, several researchers in the laboratory are still discussing the experimental direction of neural signal transmission.

It is very, very important to find the direction at the beginning of the experiment. Perhaps the initial choice can determine how far you can go.

Zhao Yi said that he supported Zhang Wei's idea, but he just felt that what Ai Lixin and Zhu Qi said, doing a large number of animal neurological experiments to collect data is tantamount to spending money for nothing, because he can find out from a single experiment. To figure out the key, there is no need to do too many similar experiments.

At the same time, they also agreed on another direction, that is, Li Ming's suggestion, to conduct research on nerve cells.

Nerve cells have been studied countless times, and it is indeed difficult to obtain results from ordinary experiments, but researchers at the Institute of Biomedicine are very good at studying cellular mechanisms.

This is their specialty.

When doing a difficult research, it is not a good decision to abandon one's own expertise.

Even if there is no result in the study of nerve cells, they can still get some data from it, or some characteristics of nerve cells, to compare the situation in other experimental directions, that is, to provide a certain reference value.

Conducting research in two directions at the same time is nothing to Zhao Yi's laboratory. They have enough researchers and sufficient financial support to conduct multi-directional research.

Li Ming and Ai Lixin were responsible for the research direction of nerve cells, while Zhu Qi and Zhang Wei were responsible for restoring classic experiments.

After the work is assigned, the preparatory work begins.

Leaving aside the study of nerve cells, the restoration of the classic experiment of nerve signal transmission did not start with 'hairy crabs'. They first did the experiment of British scientists Alan Hodgkin and Andrew Huxley 60 years ago. It is to measure the change of the motor membrane potential when the signal passes through the nerve conduction.

The purpose of the reduction experiment is to see the discovery of the two Nobel Prize winners, that is, when neurons are excited, sodium ions rush into the cell membrane from the outside of the cell membrane, and then potassium ions rush from the inside of the cell membrane to the outside of the cell membrane. The membrane potential returned to normal.

This is where the classic hodgkin-huxley model comes in.

Afterwards, the 'hairy crab' experiment will be done, following the research history of Kazuji Tasaki, studying the nerves of the pan crab's legs, and using a microscope to observe the platinum sheet placed on a small reflective piece, and then irradiating the platinum sheet with a beam of laser light.

By measuring the angle at which the laser light is reflected, it is possible to detect whether there is a slight change in the width of the nerve bundle as the action potential passes through.

This requires subtle manipulations and many experiments.

It is said that Tasaki Kazuo and his doctoral students made hundreds of measurements and made detailed records, and came to the conclusion that 'when the action potential passes, the nerve bundle will be slightly widened and then narrowed', and the process of change , taking only a few milliseconds.

When Tian Qiichi was doing research, the technology was not so advanced, and the experimental equipment he used was certainly incomparable to what it is now.

Now with the help of high-tech precision instruments, it is very easy to measure the exact time of the reaction.

The main purpose of this experiment is to prove that there is a direct relationship between nerve conduction and cell membranes.

The report given by Kazuto Tasaki was that when the nerves reacted with excitement, the cell membrane would be deformed, and the surface would rise about a kilometer.

The deformation of the cell membrane plays a role in the transmission of nerve signals, which can largely explain that nerve transmission depends not only on electrical signals, but also on mechanical waves, and only mechanical waves can cause tremors.

Of course.

Tasaki did not get much recognition, because many people think that the deformation of the cell membrane is a by-product of electrical signals.

But in any case, the most important thing is that the problem has not been solved.

What Zhao Yi's laboratory is doing now is to restore the two experiments that discovered the electrical and mechanical signals transmitted by nerves. They need to measure and record subtle data in the experiments for analysis.

The above two experiments do not sound like biomedical research, but a bit like physical experimental research. At first, everyone didn’t pay attention to it. When the experiment was actually designed, it was found that it was not so easy to restore. The problems of equipment and measurement tools were still there. It is easy to solve, but it is best to have a professional physicist help

Industry specializing in surgery.

Biomedical researchers do physical experiments and measure physical data, which is definitely not so smooth.

So Zhao Yi decided to seek help from a physicist. He didn't need a top international experimental physicist, even someone who knew some physics experiments would do.

Then he found Gao Yihua.

Gao Yihua is Zhao Yi's physics teacher, and he is still very familiar with Zhao Yi, but Gao Yihua is mainly engaged in education work, and has few achievements in physics research.

When he heard that Zhao Yi asked him to help with neural experiments, Gao Yihua was a little dazed, "Are you sure you didn't find the wrong person?"

"of course."

Zhao Yidao, "I'm here to look for you, Mr. Gao, our laboratory is doing experiments to measure neural responses, and we need someone who understands some physical experiments and some sophisticated measuring equipment."

The most important thing is the latter.

Zhu Qi and Zhang Wei have been engaged in biomedical research for a long time, and they do detailed physical experiment measurements. There is no major problem in operation, but there may be data errors, and the measurement data during the experiment is the most important thing.

And Zhao Yi...

It's better to let him study theoretical physics, but I don't understand if the experiment is weak.

Gao Yihua is not a professional scientific researcher, but at least he is a professor of physics, and he often goes to the physics laboratory to do research, which is definitely helpful for their experiments.

After Gao Yihua heard this, he nodded readily, "You have already asked for help, and I definitely agree, it's nothing."

Zhao Yidao, "Helping is helping, but you still have to agree in advance that if you have relevant results, your name will also be put on the paper."

"That's not necessary."

Gao Yihua didn't care at all.

Zhao Yi said, "Just do whatever you want." He still takes good care of his friends.

Although Gao Yihua only helped in the past, but if it is because of his help that the experiment goes smoothly and new discoveries are made, it must be recorded.

Zhao Yi brought Gao Yihua in to help Zhu Qi and Zhang Wei's group do experiments, and his mind became active. He felt that the team still lacked people.

There are five researchers in the laboratory, plus Gao Yihua equals five and a half, plus associate researchers who can do research together, the number can exceed ten, and each one is very good.

But the team has a problem that everyone is good at the same field, all of which are biomedical mechanism research.

Nerve signal transmission is not only medical research, but also involves professional neurology and physics. Gao Yihua and him are enough for physics, but there is no neurology expert among them.

Neurology can be said to be medicine. It is best to have someone who specializes in neurological research. Come and do research together. It will definitely be of great help in theory and experiments.

"Who are you looking for?"

Zhao Yi thought about it carefully, and found that there were really no neurologists in his social circle.

At this time, Qian Hong suddenly called and said that a doctor named 'Deng Bingcheng' came to visit.

"Deng Bingcheng...doctor?"

Zhao Yi was at a loss for a while, so he asked Qian Hong to bring Deng Bingcheng over.

It is not easy for people outside the school to find Zhao Yi directly. He is indeed in the school, but his whereabouts are kept secret. When someone comes looking for him, he will be taken to Qian Hong.

Qian Hong would simply ask, and contact Zhao Yi only if there was no problem.

In a small conference room of the Medical Science Center, Zhao Yi met Deng Bingcheng who was visiting. Deng Bingcheng was nearly 50 years old, and his figure was a little thin, and he seemed to have a bit of a "literati" atmosphere.

After he walked into the conference room, he immediately shook hands politely and said with a wry smile, "Academician Zhao, it's not easy to meet you."

This is a sigh from the heart.

Deng Bingcheng didn't know Zhao Yi's contact information, so after he arrived at Yanhua University, he went directly to the Academic Affairs Office to ask about Zhao Yi. When he went out, he was questioned by two armed policemen.

After an interrogation, he saw Qian Hong, and then Qian Hong asked again. After waiting for more than half an hour, he followed the armed guards to the Medical Science Center.

This set feels no worse than seeing a big leader.

Zhao Yi said apologetically, "I can't help it. The higher-ups are always worried about my personal safety. In fact, I feel quite safe."

"That's right!"

Deng Bingcheng said, "You are the pillar of the country's science and technology, and nothing is more important than safety. If there is a problem with your safety, it will be a great loss to our country."

"Thank you."

Zhao Yi responded politely and asked Deng Bingcheng to sit down.

Deng Bingcheng also got into the topic directly, talking about the reason for his visit, "I applied for a brain nerve research project, and it turned out..." He smiled wryly, "The above approval is approved, so I will give you [-] funds. Not enough money."