Rule department scholar
Page 424
Zhang Wei answered and said indifferently, "Isn't the research just beginning?"
"It's just started and it can't go on anymore." Li Mingdao, "You all know the experiment we designed, and you don't know what to do next, and you don't know what direction to take." It's not that he really doesn't know, but that he has some Unsure, I expressed my opinion after finishing speaking, "If you want me to say, turn to the research on plasma cells, maybe you can find something."
"Is the cost too high?" Zhang Wei was a little worried.
Li Ming said indifferently, "Anyway, it's not us who pay the money. We can study whichever direction is the most promising."
"Right."
Zhang Wei said with a smile, "I don't know which direction is better. Now that I have the conditions, it is really good to study plasma cells. Even if I can't research how to make medicine, this opportunity is still very rare."
"Yes!"
Li Ming also smiled.
The biggest limitation of biomedical research is the experimental funds. Many of the top researches require a lot of funds, and the research on plasma cells is one of them. Maybe to do a simple experiment, the cost of materials required can exceed [-]. The cost is simply too high.
Now that there are research sponsors, it is indeed very tempting to take advantage of the opportunity to do high-end research without considering the cost of funding.
"Boom, boom."
The door of the laboratory was knocked suddenly.
"Please come in."
Li Ming turned his head and shouted, and saw Zhao Yi walking in. He was surprised and complained, "Academician Zhao, I thought you were so busy that you forgot about your research."
Zhao Yi was a little embarrassed by what he said, and explained, "I've been too busy recently."
He did come too rarely.
Since the last small meeting of the research institute, he was divided into a group with Li Ming and Zhang Wei, but he never cared about the progress of the research even once. As far as the group's research is concerned, it is indeed a bit not so good.
Zhang Wei went over to get a glass of water for Zhao Yi, and after sitting down, she talked about the experimental design.
The research and experiments of their group were designed together by Li Ming and Zhang Wei, because Zhang Wei is still very young and has no similar experience, and it is Li Ming who really takes the lead. The direction of research, so far several experiments have been carried out, and there are corresponding experimental data, but there is still no progress to speak of.
Zhang Wei knew Zhao Yi very well, knew what to say in great detail, and even took out all the experimental records, including the observation records during the experiment.
In fact, to put it bluntly, there are several conventional methods, including the research on the production process of bacillus antibodies, including the study of the biological response properties of bacillus antibodies.
and many more.
Zhao Yi listened carefully.
Li Ming felt a little depressed watching from the side, mainly because he found Zhang Wei's explanation was very detailed, and obviously hoped that Zhao Yi could give some advice, but they were all doing routine experiments, what great discoveries could they make?
And... count on Zhao Yi?
Zhao Yi didn't even participate in the experiment design stage, needless to say during the experiment process, what's the point of knowing the experiment process and results directly?
Li Ming couldn't figure it out.
Although when the group was first formed, he felt that Zhao Yi should be the core, but Zhao Yi did not participate in the whole process, and he is the oldest and most experienced, so he should be the center of the group. The key issue is that Zhang Wei should be more Trust him, not Zhao Yi who has never participated.
"Could it be because Zhang Wei is in Zhao Yi's lab?"
"Right."
"The people in my laboratory will definitely respect me, even if there are some experiments and researches, I have not participated in them at all..."
Li Ming understood Zhang Wei's attitude as a kind of 'respect'.
Zhao Yi listened carefully to Zhang Wei's explanation, nodding from time to time. He listened very carefully, and even read the computer and notes carefully.
Li Ming and Zhang Wei designed four initial experiments together, hoping to find the research route that is most likely to help drug development.
Zhao Yi looked at them one by one.
His frowning seemed to indicate that he was thinking seriously, and then he simply stood up, put on the white light, and went to the internal laboratory to observe the progress of the four experiments.
"What did he do?" Li Ming didn't understand.
Zhang Wei said as a matter of course, "Go and see the experiment? Maybe you can find something if you look at the experiment?" It is impossible to put it on other people, but it seems to make sense to put it on Zhao Yi. She has a feeling for Zhao Yi. Incomprehensible trust.
Li Ming watched through the glass window and didn't say anything.
soon.
Zhao Yi came out from the laboratory inside. He took off his white coat and put it on the back of the chair. Then he picked up a pen and drew an 'X' on the three previous schemes. He raised his head and said, "Next, we will follow this method. ", he pointed to the last item in the notes, which is to conduct research on bacteria that produce bacillus antibodies.
"Study E. coli and Proteus?"
Li Ming said with some incomprehension, "This item was added by Zhang Wei. I don't think it's very meaningful. Haven't you already done research on the 2CV-Bing hydrogen molecule produced by human immunity against bacilli?"
Zhao Yi said, "It's Escherichia coli, and we only do research on Escherichia coli. Your design is to observe the process of bacilli antibodies functioning. My idea is to continue to do this research in depth, and it is best to find out the E. coli antibodies to bacilli. Response issues."
"Marked?" Li Ming's tone was full of doubts.
"What about after being marked?"
Zhao Yi asked back.
Most of the antibodies produced by human immunity respond to pathogens by "marking" or "clearing". , or other cells with similar functions, will come to eliminate pathogens.
But what about out of the human immune environment?
Bacillus antibodies can only mark E. coli, and cannot directly achieve the effect of elimination. What will happen to the marked E. coli?
As soon as this question was asked, Li Ming frowned. He thought carefully for a long time, as if he had figured it out, and asked, "Zhao Yi, what do you mean, let's study the alienation reaction of Escherichia coli? "
"Alienation reaction..."
Zhao Yi thought about it and said, "It can also be understood in this way."
Dissimilation reaction, which can be understood as catabolism, means that the body degrades molecules (such as sugars, lipids, proteins, etc.) The process of the end products (such as carbon dioxide, lactic acid, ethanol, etc.).
Li Ming said that the alienation reaction of Escherichia coli is the whole process of Escherichia coli being eliminated by the human immune system and being 'digested'.
He was partly right.
The reason why I only say 'part' is that Zhao Yi himself doesn't know what direction he wants to do research. He is very good at grasping the direction of research, but it is not the general direction of the whole, but draws conclusions from experiments. Knowing which experiment is helpful for research.
Of the four routine research programs designed by Li Ming and Zhang Wei, only the research program for Escherichia coli is helpful for the development of 2CV-Bing hydrogen molecular drugs, so the research on the reaction of Escherichia coli and Bacillus antibodies is the most likely to produce helpful discoveries or results.
Li Ming didn't continue to say anything, but he didn't understand.
Studying E. coli?
What could this mean?
If it is the dissimilation reaction of Escherichia coli, or hope to have new discoveries, such as the research that Escherichia coli can react with certain proteins and chemical substances, it is possible to think that the connection is artificially synthesized proteins.
Escherichia coli is a very extraordinary bacterium. Human beings have successfully used biotechnology to transform E. coli to produce valuable drugs such as insulin and interferon.
This is how proteins are synthesized artificially.
However, when the Institute held a meeting, it directly denied the direction of artificially synthesizing 2CV-Bing hydrogen molecules. What is the point of doing research in this direction?
……
Li Ming didn't say anything in the end, because he found that he had no right to speak.
Even though he has the most experience and is a serious old researcher, the group still takes Zhao Yi as the core, and Zhang Wei shows absolute trust in Zhao Yi.
So what else can he say?
"Since Zhao Yi has already made a decision, he is only doing research in the direction he said." Li Ming sighed and thought, he still wants to study plasma cells, and he can accumulate a lot of experience if there is no result in high-level research. If you miss the opportunity, there will be no next time.
pity……
Zhao Yi is not optimistic about this direction at all, and seems to have no interest in it.
"Ah~"
After Zhao Yi walked out of the laboratory, Li Ming couldn't help but sigh regretfully.
Zhao Yi didn't know Li Ming's depression, he just did what he should do, determined the direction of research, and let Li Ming and Zhang Wei design experiments.
He still has very little experience and is not good at designing experiments.
Zhao Yi walked out of the laboratory and did not leave the research institute. Instead, he went to learn about the experimental progress of Han Hui's group. By the way, he asked Ai Lixin about some small projects in the laboratory.
Ai Lixin and Han Hui participated in the research on the development of 2CV-Bing hydrogen molecular drug, but the research is only his private "part-time job", the main work is still in the laboratory, and he is responsible for many small projects, including Liu Chengjie, For Yan Yi's personal project, Ai Lixin needs to help guide and give pointers.
Small projects in the laboratory are also very important, allowing young researchers to accumulate more experience and making the results and data of the laboratory more attractive.
In addition, it is the progress of Han Hui's team.
Zhao Yi chatted with Han Hui for a few words, then asked Ai Lixin, and he almost learned about the progress of 'replacing the human immune environment', and also knew that this research had a huge bottleneck.
Although the research can reduce the cost of producing 2CV-Bing hydrogen molecules in the laboratory, the reduction is very limited, just like a computer running a program, even if it is only a small program, the computer must be started instead of turning into a small computer .
Therefore, no matter how well the research is done, the cost reduction is very limited.
"It can effectively reduce the cost of making 2CV-Bing hydrogen molecules...is it considered an achievement? It will save money for the next research."
Zhao Yi said comfortingly.
Ai Lixin was a little depressed and complained, "When we were in groups, I wanted to be in a group with you, but the old woman Han Hui insisted on pulling me, and I didn't want to be with her. No way, I have to divide into three groups. Group, it should be..." He sighed and stopped suddenly.
Han Hui was coming out of the laboratory, his round eyes were full of anger, "You..."
She just said a word.
Ai Lixin quickly changed his tone and said, "You should be allowed to come to our group, don't you think so, Zhao Yi? There is an excellent sister Han, you, plus me, let's do this research together, maybe we can reduce the cost Ten times, twenty times, or even hundreds of times."
"I don't have much confidence in myself, but I have great confidence in Sister Han and you!"
He turned his head with a righteous face, as if he had just seen Han Hui, and said in surprise, "Sister Han, when did you come out? I thought you were still in the laboratory."
"Coincidentally!"
"I want to let Zhao Yi come to our group, and you can help me persuade..."
Chapter 383 When the time comes, we will be God!
Ai Lixin performed a face-changing on the spot, which was even more shocking than the stage show.
Zhao Yi was shocked on the spot.
He had never seen such Ai Lixin before, which was enough to show how terrifying this woman Han Hui was.
Fortunately, Han Hui was very gentle to him.
Han Hui gave Ai Lixin a hard look, then looked at Zhao Yi with a smile on his face, and said, "Zhao Yi, I think Lao Ai's proposal is very good, you should come to our group, our research is not the core, But there will definitely be results, and there are some results now.”
"Like this project now."
Han Hui shook his head as he said, "It's too difficult to do it. There is no way for the pharmaceutical companies, what can we do? We are not specialized in high-level drug development, we can only say that we do incidental research .”
"so……"
Han Hui blah blah blah, blah, blah, blah, blah, blah, blah, blah, blah, blah.
Zhao Yi's forehead hurts when he heard it.
He knew that Han Hui was kind enough to remind him. Most people thought so, including Dai Tianqing, Li Ming and others. Dai Tianqing was just trying to get lucky. If something was discovered, it would be a result. Li Ming said it several times in a row , "It is unlikely that there will be results." Even the director Yan Xuelin was not confident. At the beginning, he said that it does not matter if there is no result. It is also good to add experience to the people in the new research direction.
Zhao Yi is the one who is confident. He has confidence in his ability, and he also feels that it is right to go in the direction of completing the research.
What if it was successful?
There are a lot of interests involved, and maybe it can bring a lot of honors.
The research content of Han Hui and Ai Lixin's team is just like what they said, it's just an incidental research to reduce the experimental funding, it doesn't involve the core research content, but what's the use of not involving the core?
Even if there is a result, it is just a simple note, and it will not be noticed at all.
So, it doesn't make much sense.
Zhao Yi listened to Han Hui's Ula Ula talking a lot, found a free time and quickly slipped away, he even regretted coming here for a turn, he was tortured!
"Brother Ai, it's hard for you!"
"Amen!"
Zhao Yi walked out of the institute with emotion.
The work in the laboratory is really simple for him, because he didn't plan to directly participate in the experimental design stage, he just analyzed the experimental process and results, and helped him find a correct path.
That's it.
In fact, "finding the right path" is the most important thing. As long as you grasp the direction of research, you will not do useless work and greatly improve the efficiency of research. As long as you continue to move forward, you will definitely make progress.
Next, Zhao Yi occasionally went to the research institute to care about the research progress of drug development.
Other times are easier.
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