Rule department scholar

Zhao Yi walked in and glanced at it, and knew that it must be related to the 2CV-Bing hydrogen molecule, because several people sitting were involved in the project.

Dai Tianqing, Han Hui, Li Ming, Ai Lixin, Chen Zhigang, Zhang Wei, plus Yan Xuelin.

Liu Chengjie, Yan Yi and others in the laboratory also knew about the 2CV-Bing hydrogen molecule, but their level and ability were not enough, so they did not participate in the follow-up research.

Seeing Zhao Yi walking in, Yan Xuelin quickly asked him to sit down, and said excitedly, "The pharmaceutical company we cooperate with has encountered problems in drug development!"

"what?"

This matter was just mentioned, and no one in the conference room knew about it. They looked at each other and didn't understand that 'drug development has encountered problems'. Why is Director Yan still happy?

Shouldn't you be depressed?

Anyway, they feel quite depressed, because the drug development encounters problems, and the results cannot be published for a long time. That is a major achievement in the medical field. After publication, it will definitely attract the attention of the world, and maybe it will win a prize for it.

Even if it is Zhao Yi who wins the award, they who participated in the project together will be able to follow suit!

In addition, they also publish papers related to the incidental results, and the papers of the main results can also be signed.

For scientific researchers in any field, influential results, results and papers that have received high attention from the world are very, very important. Research results and papers are the results of their work, and getting more attention means that the success of scientific research.

Everyone looked at Yan Xuelin with doubts.

Yan Xuelin said with a smile, "I went to Wucheng this time for the purpose of drug development, because the results belong to us, and they invited our institute to do drug development simultaneously."

"That is to say, another big sponsorship?" Dai Tianqing was the first to react.

Ai Lixin asked hesitantly, "However, we are not professional in drug development. We may not be able to solve the problems encountered by their pharmaceutical companies."

Yan Xuelin waved his hand and said, "It's okay, because of confidentiality issues, they can't share the information. They have no other choice but to ask us to develop simultaneously."

"Synchronize……"

Dai Tianqing said hesitantly, "It means that the information is not shared, and each develops independently?"

Yan Xuelin nodded affirmatively, "Yes! We develop at the same time, and they pay the funds. If the results are produced, we also have part of the patent fees. This time I am going to talk about this, and the initial sponsorship funds are 1000 million. If we Those that can be made can occupy [-]% of the drug patents.”

"They sponsored, three to seven points...it's pretty good..." Dai Tianqing commented.

Ai Lixin said, "But it may not be able to produce any results. The scientific research team of the pharmaceutical company must encounter big problems."

Yan Xuelin smiled and said, "Old Ai, don't lose confidence. This has not started yet. The most important thing is that even if we fail to produce results, we have nothing to lose."

"That's right." The others nodded in thought.

This matter is very clear.

The pharmaceutical company encountered problems in drug development and found that it could not be solved in a short time, so they simply asked the research institute to help develop it together. Compared with the research discovery of 2CV-Bing hydrogen molecule, no amount of research funding is nothing.

They can't find other institutions, because the secrecy is not only for the research institute, but also for those who know the information in the pharmaceutical company. They either conduct research on their own, or ask the research institute to help them do the research together.

Yan Xuelin went to Wucheng to discuss this matter, and the final result of the discussion was that pharmaceutical companies sponsored research institutes to simultaneously develop drugs, and the results were counted as patents, and they accounted for [-]% of the patent ownership.

Any scientific research institution hopes to attract external corporate sponsorship funds. The Biomedical Research Institute is a national scientific research unit, and most of the research and development funds come from the state, because most of them are engaged in medical mechanism research, and the real external corporate sponsorship Research funding is not much.

The scale of the Biomedical Research Institute is not small, but it has an initial funding of 1000 million, which is definitely a super-big project. More importantly, the Institute has almost any losses, and the funds are all provided by pharmaceutical companies. The results can also allow participating researchers to gain some experience in drug development.

It would be even better if there is a result. 2% of the patent ownership is actually quite a lot. It is the patent of [-]CV-Bing hydrogen molecular medicine.

The research institute is very familiar with the effect of 2CV-Bing hydrogen molecule. The drug developed with 2CV-Bing hydrogen molecule as the main body must have a good effect on AIDS. It may be sold domestically and internationally. [-]% of the drug patents can Bring a steady stream of large profits.

In addition, the development of AIDS drugs is also of great significance. So far, there is no AIDS drug that is independently marketed in China, and all drugs for treatment are imported. The title of related drugs', the honor must be doubled.

Financial interests, honor, the combination of the two is enough to attract anyone.

……

Yan Xuelin broke the big news about synchronous drug development, and the small internal meeting has just begun. He went to the drug research and development base of Wucheng Pharmaceutical Company and learned about the difficulties encountered in drug research and development.

To put it simply, there is currently no method for artificially synthesizing 2CV-Bing hydrogen molecules. The cost of producing 2CV-Bing hydrogen molecules in a laboratory environment is too high and the efficiency is too low.

The latter understands as soon as it is said.

In the process of studying 2CV-Bing hydrogen molecules before, the production method of the laboratory was to simulate the immune environment, to produce antibodies against the invasion of bacilli, and to produce 2CV-Bing hydrogen molecules by the way.

If you want to extract 2CV-Bing hydrogen molecules, you need to constantly interrupt the experiment and add many kinds of chemical materials. The process is very complicated. Extracting a small tube of solution containing a small amount of 2CV-Bing hydrogen molecules can easily reach the laboratory cost. Ten thousand.

This small tube of solution is used in actual treatment. It is estimated that it is only enough to inject two or three times into the human body, and it has been used up before even seeing the effect. However, the 2CV-Bing hydrogen molecular drug is generally estimated to be injected continuously. More than half a month, or even a month or two months, until all the HIV in the blood is 'controlled', it will have a very good effect.

To put it simply, once a day is injected, the cost of the drug is more than 3000 RMB, and the average use time is 10 RMB for one month.

This is the cost of the drug in the lab.

When selling in the market, research and development costs, profits, etc. must be considered. It is easy to increase the price by several times or dozens of times, and it is by no means affordable for ordinary people.

Pharmaceutical companies also have a bigger concern.

After the drug is officially launched, the ingredients will definitely be disclosed, and imitation drugs will appear immediately. However, many international pharmaceutical companies have stronger research and development capabilities, and may be able to manufacture 2CV-Bing hydrogen molecules in large quantities. It's like making a wedding dress for someone else.

After Yan Xuelin finished explaining the problems he encountered, Li Ming was the first to speak. Li Ming had done biochemical projects and had some relevant experience. Possibly, at least not in a short period of time, we still need to seek biological means for our research and development.”

Yan Xuelin nodded and said, "Don't worry about artificial synthesis, we still need to find a way in the field we are good at."

The artificial synthesis method is simple and direct, but it is difficult because of its simplicity. Not to mention the long time required, the research institute lacks relevant experience. Even if you try to study the method, you don't even have a lot of necessary equipment.

Research from the perspective of biological experiments is different.

The Institute is good at this direction.

Several researchers thought about it, and quickly came up with several directions--

"To find a way to replace the immune environment of the human body, as long as 2CV-Bing hydrogen molecules can be produced normally." Han Hui said that the solution is to reduce costs. The cost of simulating the immune environment of the human body is very high. Greatly reduce the cost of the simulation environment.

Dai Tianqing’s opinion is, “We can do research on the immune response of bacilli in other vertebrates, and we may be able to find 2CV-Bing hydrogen molecules, or similar small protein substances with similar anti-AIDS effects.”

His advice is somewhat 'hit and miss'.

If you are lucky enough to find that the immune system of mice can also produce small protein substances that can fight HIV through the immune process against bacilli, there will be many other research directions or methods for direct mass production.

Li Ming put forward a different proposal, "We can study the human bacillus antibody, which is a macromolecular protein, which is produced together with the 2CV-Bing hydrogen molecule, and there may be other discoveries."

This suggestion is somewhat vague, and it seems that it has little to do with drug development, but it may not be certain that there will be new discoveries. The research on drug development from a biological perspective is not as "simple and crude" as artificial synthesis. More Discovery can find a better way.

After several researchers expressed their opinions, everyone in the small conference room looked at Zhao Yi.

In fact, in similar meetings, Zhao Yi seldom expresses his own opinions, because he has little knowledge and experience, and it is difficult to give good suggestions.

Zhao Yi thought for a while, and did not express his opinion, but said directly, "I support Professor Li Ming's opinion, and research should be done on bacilli."

"Why?" Yan Xuelin asked with interest.

Zhao Yi thought for a while and said, "Intuition."

"intuition?"

Dai Tianqing couldn't help but said, "Zhao Yi, we can't rely on intuition when doing research, we must speak with science."

"Oh."

Zhao Yi nodded and accepted the education, but still insisted, "But I still think that we should mainly study bacillus antibodies, and other things can be assisted."

Yan Xuelin thought for a while and nodded, "Everyone's opinions are reasonable. Drug development is not a single research. Breakthroughs in every direction may reduce manufacturing costs."

"How about this, we will do research separately in the early stage, three groups, one group with one direction, all according to our own ideas, and finally merged together."

Li Ming nodded first and said, "Zhao Yi and I have the same opinion, let's go together."

Zhang Wei raised her hand and said, "I am also in this group. Zhao Yi is very busy and has to prepare academic reports. We have a lot of experience working together."

"No, you guys, I think..."

Ai Lixin remembered that he didn't finish his sentence. He wanted to be in a group with Zhao Yi, but Li Ming said it first, and Zhang Wei quickly raised his hand again. When he was depressed, Han Hui said, "You can be in a group with me." Bar."

He could only nod helplessly, thinking about the direction of replacing the human body environment, at least there would be no progress, it was better than trying luck with Dai Tianqing.

Dai Tianqing and Chen Zhigang looked at each other, nodded and said, "Then we'll be in one team."

……

After the small internal meeting ended, everyone came out one after another.

When Dai Tianqing went out, he said with a smile, "Zhao Yi, let me tell you, we have too little experience in drug development projects to keep up with the research and development capabilities of pharmaceutical companies. If they can't do it in a short time, it will be difficult for us. "

"So to do this, we have to try our luck. We divided into three groups. I think that if there is any result, it must be our group."

Chen Zhigang thought it made sense after hearing it, and immediately thought that it would be good to be in a group with Dai Tianqing passively.

Zhao Yi smiled and gave Dai Tianqing a thumbs up, "Well, I wish you success, come on!"

"Come on, you too!"

The two looked at each other and smiled at the same time.

Chapter 375 Discordant Nobel Laureates

The small meeting inside the Biomedical Research Institute is over. Every participating researcher and associate researcher is very much looking forward to the launch of the project, and also very much hopes that the research will produce results. Everyone is thinking about related issues, as if they have been injected with infinite vitality .

For example, Dai Tianqing.

After walking out of the conference hall, and talking to Zhao Yi, he dragged Chen Zhigang from the same group to the office for discussion.

Han Hui also called Ai Lixin to join him, but Ai Lixin looked reluctant and looked at Li Ming with resentful eyes, as if blaming Li Ming for taking his place.

Li Ming looked at Zhao Yi and Zhang Wei.

Zhao Yidao, "Brother Li, sister Zhang Wei, you can just talk about it. I have little experience, so you can discuss the planning and decision of the experiment."

"I still have classes in the afternoon, and I have to prepare reports for a few days."

"Well, come on!" Zhang Wei said with a smile on her face, she was used to Zhao Yi's way.

Li Ming is a little unclear, so he is the oldest and most experienced among them, but Zhao Yi has done several projects at a young age, including a major project on AIDS, and he discovered the effect of 2CV-Bing hydrogen molecule Yes, why don't you feel sad about drug research and development?

He dragged Zhao Yi and Zhang Wei to the office next to him, and reminded him in a low voice, "Zhao Yi, Brother Li still wants to tell you about the meeting just now, do you know? There is one thing that is defaulted. The director didn’t mention it, and neither did we ask.”

"What's the matter?" Zhao Yi asked.

Zhang Wei whispered, "You mean, drug patents?"

"Correct!"

Li Ming pouted and nodded, "Look at Lao Dai, including that old lady Han, everyone is actively working hard, and money is coming out of his eyes, understand?"

"There are clear rules in the work contract of our institute. There are no patents for national projects, but patents for cooperation with outside companies are jointly owned by the institute and the laboratory. The institute accounts for [-]% to [-]%."

"70.00% to 90.00%, in fact, it is 70.00%, everyone is tacit, we are a scientific research unit, not a company, we don't need to make profits, right?"

"The research institute is divided into [-]% or [-]%. It doesn't matter. Anyway, the money will go to the finance company in the end. It means that there are more spare funds in the institute, so it must be [-]%."

"The laboratory accounts for [-]%."

Li Mingdao, "I have done a cooperative biochemistry project, and I have a patent on the proportion of solutions. I share [-]%, the laboratory keeps [-]%, and the remaining [-]% ​​is [-]% for myself, and [-]% for the rest. Cheng Er." He patted his chest to express his generosity, "I will definitely not treat my own people badly."

Zhang Wei immediately gave Li Ming a high look, and asked, "How much was the patent fee for that year?"

"Last year it was...ahem, more than 600." Li Ming said a number in embarrassment, and immediately shook his head, "It doesn't depend on how much money you have in the end. Even a penny is extra money, right?"

"Yes, yes."

Zhao Yi expressed trust with his eyes.

Li Ming continued to say to Zhao Yi, "This joint research and development is great. There is no AIDS drug in China until now, and you know the molecular effect better than me, so the patent fee involved in it is too much."

"I can't say exactly how much, but I must strive for it! If it can be done, we will distribute it internally. In the end, Director Yan will definitely make the decision, but the higher the research contribution, the higher the ratio of distribution will be..."

"Now we are divided into three groups, which is competition! Our group has to work hard and make results first. As long as we see hope, when the time comes, everyone will follow the direction chosen by our group to do research and development, and we will have the right to speak , are you right?" Li Ming also looked at Zhang Wei after speaking.

Zhang Wei said, "Is there any difference between the people in that group?" She deserves to be the three of them.

Li Ming smiled and said, "Our team must look at Zhao Yi! My personality, you know, is straightforward. As for this drug research and development project, it is impossible for me to do it. So we still have to look at Zhao Yi." He She looked at Zhang Wei with some embarrassment, "Of course, Zhang Wei, you are also very important."

Zhang Wei shook her head and smiled.

Zhao Yi said, "I see, Brother Li, that is, if the project is completed, we will get the patent fee, right? And it's not a small amount."

"Right, that is it."

"Ah."

Zhao Yi continued to nod and said, "Then let's work hard." He looked down at the time and said, "Doing research? It's not a matter of a day or two. I'm going to have lunch first, and I have to go to class later. You and Zhang Let's study together, if there is any plan, just follow it, and I will keep an eye on the progress."

"That's it, let's work hard!" He said and walked out of the office.

Li Ming felt baffled, and asked Zhang Wei uncertainly, "Did he just say something ironic?"

Zhang Wei has long been used to it, and she explained, "Professor Li, Zhao Yi has always been like this, don't worry about it. Our projects are all done this way, he only comes to the experiment occasionally, and rarely participates in the experimental design, but, I feel Well, what he is best at is the analysis of experimental data and results."

She thought for a while and used two words, "sensitive and accurate."