Science and Technology Library
Page 257
Within 24 hours after exposure, the mice were injected with monoclonal antibodies, and 16 of the 11 monoclonal antibodies in four groups were effective; 48 antibodies were still effective at 5 hours; and only two antibodies were effective at 72 hours.
It is an antibody studied by the first group led by him, and an antibody studied by the third group led by British medical scientist Judson.
After finding two of these antibodies, they began to experiment with rabbits again. After 24 hours, both antibodies were effective; after 48 hours, the ability of monoclonal antibodies began to show obvious differences, and many of them lost their activity. getting weaker and weaker.
The incubation period of the VFV virus is far longer than this time. Such antibodies cannot be used for treatment at all, and the research has come to a standstill again.
Finally, after everyone's discussion, it was decided to adopt the "cocktail" method used in EBOR specific drug research, using a mixture of 4 monoclonal antibodies with the best effect, and using a virus that can produce human interferon as an adjuvant for the "cocktail" antibody , so that the 'cocktail' can still function after 72 hours of poisoning.
The 'cocktail' drug was named AG72 by them.
And now, the test result of AG72 is in Qiu Xiang's hands.
Looking at the report in his hand, he couldn't be happy because the result was different from what they imagined.
Qiu wanted to enter the meeting room with Judson and the others, and he felt dozens of eyes on them.Many researchers on the field did not look very good. Since the formation of the 72-member team, their research has made some progress, but not much progress, and now hope is in the reports in the hands of Qiu Xiang and Judson.
"Come on." Qiu wanted to pass the report in his hand to Judson.
"You come." Judson shook his head, but didn't reach out to take it.
Qiu Xiang nodded helplessly, and after everyone was seated, he asked his assistant to distribute the report in his hands to every researcher on the field, and walked up to the podium by himself.
"The results of the monoclonal antibody test came out, which were different from the results we predicted. We tested the effect of AG72 with two rhesus monkeys. On the 4th day of infection, the monkeys showed symptoms, and they were injected with AG72 as planned. But unfortunately, the virus in the monkey has not disappeared, and VFV has not been cured." Qiu Xiang said with a heavy voice.
There was a sigh in the meeting room, and many experts shook their heads with frowning faces.
Monoclonal antibodies are the most promising direction for success in a short period of time. If monoclonal antibodies fail, it will take longer for specific drugs to appear.
Now the number of people infected with VFV virus in the world has reached more than 26000, and this number is refreshing every day, and the death toll has also soared to 2378, and no case has been cured for the time being.If the treatment drugs do not come out, it means that the number of deaths will increase.
"But there is good news that is not so good."
Everyone cheered up instantly, pricked up their ears and waited for Qiu Xiang's answer.
"The condition of rhesus monkeys injected with AG72 did not deteriorate further within a week. AG72 could not cure the condition of VFV, but it could inhibit the metabolism of VFV and control the further deterioration of the condition. This result can buy more treatment time for the condition .”
Many people on the field applauded excitedly and wept with joy. At this time, any little good news is exciting good news.
The 'Angel Team' made a breakthrough in the VFV specific drug and successfully developed a monoclonal antibody drug that inhibits the progression of VFV.
When the news was released, it spread like crazy to every corner of the world, arousing the excitement of the whole people.
Now is the most serious period of the VFV virus. It is in a time of global panic, and the biological virus has almost reached the critical point of being completely out of control.At this time, the good news from the 72-man team is undoubtedly the most exciting time.
The victory against biological warfare has already dawned.
While the outside world is cheering for the achievements of the 72-member team, there is the same happy event in another corner.
Jianghe Institute of Microbial Medicine.
Xu Minsheng had a rare smile on his face.
After Jangho Company and Lanhong Pharmaceutical were merged by Marching Army Ant Group and reorganized into Jangho Pharmaceutical, he became one of the leaders of the drug development team of Jangho Pharmaceutical, responsible for the development of tumor vaccines.
The current Jangho Pharmaceutical headquarters is the main microbiological medical research institute of Haixing Company, and the main medicines of Haixing Company are all developed from here.
Some time ago, Chen Mo contacted them, told them a research direction, and also gave them some information, so that the team of their research institute can make medicines related to the information. The medicines may reduce the activity of VFV virus and help VFV treatment.
Now is the most terrifying time for the VFV virus to wreak havoc. With Chen Mo's order, the entire team of the research institute immediately gathered personnel to start developing the drug.
The team concentrated the strength of the elite personnel of the entire research institute, thoroughly understood the information given by Chen Mo, worked in shifts, and finally made progress.
During the period, I contacted Chen Mo several times and asked some questions about the research direction. After several major breakthroughs, I finally completed the required potion according to Chen Mo's intention.
They named the drug they developed HX3.
Now the VFV virus in the petri dish, after adding the drug of HX3, the metabolic activity is significantly reduced for 24 hours, and the drug has met Chen Mo's requirements.
"Successful." Xu Minsheng showed a rare smile.
"Successful." Several researchers around nodded and let out a deep breath.
"You guys sort out the report and hand it over to the boss. I'll ask the boss what to do with HX3." After speaking, Xu Minsheng turned and left the laboratory.
Chapter 468 I Believe
"what is this?"
After Chen Mo took out the medicine box with the starfish company logo on it, all the medical experts in the institute looked at Chen Mo.
"The medicine sent by Starfish Company." Chen Mo said.
Starfish Company?
The experts on the field looked at each other, as if they didn't have much impression of this company.
"Starfish Company is a pharmaceutical company indirectly controlled by Marching Army Ant Group." Wu Bing reminded slightly, and everyone suddenly understood.
When he opened the medicine box, he saw more than a dozen blue medicines lying quietly in the box. When everyone was puzzled, Chen Mo said, "This is a special medicine that reduces the activity of the virus that I asked the Jianghe Institute of Microbiology to develop. The name is Starfish. No. 3 (HX3)"
"A special medicine that reduces the activity of the virus?" Shi Hongtu was surprised, and looked at the HX3 medicine in the box hesitantly: "You mean, this medicine is effective against the VFV virus?"
"Reports from the institute show that it can reduce the activity of VFV virus, but cannot kill VFV virus," Chen Mo said.
"Really?" Shi Hongtu excitedly held Chen Mo's palm, eager to know the answer.
So far, they have not made any progress in VFV research. They have tried many methods and drugs, but all of them have failed.Now Chen Mo tells him that HX3 has an effect on VFV, and he can't help but be excited, even if it can't be eradicated, but at least he sees hope.
"This is the report of the research institute. The experimental data, the specifics, depends on the clinical effect." Chen Mo passed the report passed by Xu Minsheng to Shi Hongtu and others.
"Great, great."
Shi Hongtu and others looked at the report and were extremely excited.Although the AG72 developed by the WHO can inhibit virus metabolism, it has just been released. Although it is freely shared with the officials of various countries, its effect is limited. The effect of AG72 can only be maintained for about a week. After a week, re-injection is necessary to continue to inhibit the deterioration of VFV.
"Now test the effects of these potions immediately."
Shi Hongtu gave an order to let the team members leave to start testing the HX3 potion.That way doesn't work, so they have to find another way.
"You asked Haixing Company to send these medicines to treat Zhao Min? Is there a treatment plan?" On the way back to his laboratory, Wu Bing looked at Chen Mo.
"Yes, there is a specific plan, but it needs to be verified." Chen Mo said.
"Can you talk to me?"
When the two were talking about the treatment plan, a hurried voice interrupted them.A female nurse in clothes ran over with an anxious face.
"what's wrong?"
"Ms. Zhao's condition has changed," said the female nurse.
"What?" Chen Mo froze, and quickly walked towards the isolation room, followed by Wu Bing and the female nurse.
"Tell me about her situation." At this time, Chen Mo's eyes were a little anxious.
"Ms. Zhao woke up well this morning. Just now, she said that she had tightness in her chest and some red spots appeared on her body. I came to inform you immediately." The nurse almost trotted, and barely managed to catch up with Chen Mo's pace.
Not long after, the three put on protective clothing and entered Zhao Min's isolation room.
It's just that Zhao Min was still watching a movie on the bed, his face was calm, and he didn't seem to be affected by the virus outbreak.
"let me see."
Chen Mo walked to the bedside, without waiting for her to answer, grabbed Zhao Min's arm and opened the sleeve, and sure enough, he saw red bean-like spots on his arm, sparsely scattered, on the fair skin, extremely dazzling.Immediately afterwards, Chen Mo turned over the collar of Zhao Min's hospital gown. Spots also appeared between the collarbones and on the neck.
No other patient had the horrible pustules and erythema that flared up, but over time the condition worsened and pustules and blood spots appeared.
The VFV virus on Zhao Min's body broke out, and Chen Mo felt a stone hanging in his heart.
"How do you feel now?" Chen Mo asked while checking.
"It's fine, except for a little tightness in the chest, there is no difference." Zhao Min let Chen Mo check his body and replied calmly.
"Aren't these places itchy? Do you have a fever or other discomfort?"
Chen Mo pointed to the red dot on his arm.
"No itching, no fever." Sensing Chen Mo's concern, Zhao Min showed a relaxed smile: "Can't you die?"
"Don't worry, the treatment plan has been figured out, and we are preparing for clinical trials. If it succeeds, you will be cured." Chen Mo patted the back of Zhao Min's hand, signaling her to feel relieved.
"Then it's okay, you still owe me a hug, you can't run away. I don't feel uncomfortable right now, you go and do your work, now is not the time to waste time." Zhao Min said.
"You keep an optimistic attitude, leave other things to me, believe that I will cure you."
Zhao Min and Chen Mo looked at each other and smiled.
"I believe it."
After taking Zhao Min's temperature, Chen Mo and Wu Bing went to Lanxi's isolation room to check the situation again before leaving the isolation area and rushing to the research institute.
Now that Zhao Min's condition is getting worse, Chen Mo has a sense of crisis in his heart.
Although slowly, Zhao Min's condition is indeed deteriorating.Within a month, he must come up with a treatment plan, otherwise, after a month, no one knows what unpredictable consequences will be brought about if the condition continues to deteriorate.
Fortunately, HX3 has been successfully developed and delivered, and his next plan can be tested.
……
Haixing Company has successfully developed a specific drug that reduces the metabolic activity of the virus. It is effective against most RNA viruses and can delay the onset of VFV. It is currently preparing for clinical trials.
This news, like growing wings, once again caused a sensation.
This is the second company to announce the successful development of a drug against VFV after the 72-member WHO team.
The starfish company is most famous for its breast enhancement pills and 'Viagra' without side effects. These two medicines are women's favorite and men's artifact.Except at the beginning, everyone paid attention to Haixing Company, but then they gradually forgot and only knew about the company's products.
Now that it has reappeared in the public eye, many people have paid attention to the background of Starfish Company: Jianghe Pharmaceutical Holdings, a subsidiary of Marching Ant Group, is a pharmaceutical company jointly established with the Luo family.
There is a group of army ants in the background.
This fact makes more people ecstatic.
Since its establishment, the Army Ant Group has been synonymous with the most advanced technology.The name Chen Mo is a mountain in the hearts of countless scientific researchers.
The news of the VFV specific medicine released by a company under the Army Ant Group excited many people, especially in China, where the infected people were ecstatic when they heard the news.
On the second day after the news was announced, the Ministry of Health issued an announcement allowing Haixing Company to use the HX3 drug for human clinical trials.
Immediately after the news came from the World Health Organization, it sent personnel to seek cooperation with Starfish, and also obtained a batch of untested HX3 through official channels for emergency needs.
In a short period of time, two pieces of good news gave patients a glimmer of hope.
Once they could only watch the VFV worsen and die in despair, now at least there is some treatment and hope.
Unfortunately, whether it is the monoclonal antibody AG72 of the 72-person team of the World Health Organization or the HX3 of Haixing Company, the two drugs only prevent the continuous deterioration of the disease, and cannot really eradicate the VFV virus.
The clinical performance of the two drugs has achieved the desired effect, which is a good effect.As the production of the two drugs increased, the two drugs stopped the VFV epidemic on the verge of getting out of control.
When the world rejoiced that the epidemic was initially under control, a bigger news came out.
Chapter 469 Congratulations, you succeeded
"Kelly, don't worry, the WHO has now developed a drug to relieve the condition, and soon, a special drug to cure the VFV virus will appear." Hardik looked at the girl wearing a sanitary mask in the video, and his heart was wrenching pain.The once confident girl now doesn't even have the courage to face him with her true face.
"Hardik, I'm sorry." The blond girl fought back tears, her voice trembling: "Let's break up."
"No, don't break up." Hardik almost roared when he heard the last few words: "I have all the rings ready, don't break up, if you recover from illness, we will get married."
After speaking, Hardik took out a ring box from his pocket and put it in front of the camera.
"I'll wait for you to come out."
On the other end of the video, the blond girl couldn't hold back her tears anymore, but she didn't agree.
"Hardik, Hardik. Look, there is news that Amber Pharmaceuticals has developed a specific drug that can treat VFV virus. It also cured a VFV patient." When the two were talking on the phone, a person who looked like Hardik The young man ran in and put the phone in front of Hardik.
"Really?" Hadik snatched the phone as if a suffocating drowning man had seen a life-saving straw.
Seeing the content of the news, Hardik wept with joy.
"Kelly, look, the news about the special drug came out, and the research on the special drug was successful. It's true, I didn't lie to you." Hardik put the phone in front of the video, crying and laughing excitedly: "Wait until you get sick Okay, we'll get married, promise me, please promise me."
"Hmm." The blond girl couldn't hold back in the end and nodded her head heavily.
Seeing the blond girl nodding, Hardik finally couldn't help it, laughed and cried loudly, and cheered and hugged with the young man next to him.
A small pharmaceutical company in South Africa named Amber Pharmaceuticals announced that it has developed a special drug GBOY that can treat VFV virus, and cured a patient infected with VFV virus in clinical practice.
The news that appeared suddenly attracted the attention of the whole world.
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