my life simulator

In the eyes of the professors, Lu Li's knowledge was solid, his knowledge was profound, and he was so diligent and eager to learn.

This made every professor who was consulted by Lu Li full of praise for Lu Li, and also envied and hated Professor He's "shit luck".

When Lu Li was praised so much, Professor He and You Rongyan felt windy under their feet when they walked, they just barely floated up.

"Teacher, I plan to start research."

Lu Li said to Professor He: "I have learned a lot during this period of time. I feel that I have accumulated a certain amount of knowledge."

"Are you going to do research?"

Professor He nodded with a smile, "Yes. You submit the project report, and I will apply for project approval for you."

"Thank you, teacher."

Lu Li hastily took out a document and handed it to Professor He, "I've already written the project report, please take a look."

"Oh? So you have already prepared!"

Professor He reached out to take the document, opened it and took a look...he took a breath of air.

"Gene targeting technology?"

Looking at the project report, Professor He widened his eyes, "Are you targeting gene editing technology?"

A shot is a worldwide problem, should I say that he is so ambitious?Or is he aiming high?

Professor He felt that the document in his hand was a bit hot.

"This...Xiao Lu, it's not easy for you to come up with such a big subject to pass the review!"

After hesitating for a while, Professor He said to Lu Li: "After all, you have no achievements in this area, and you have not made any achievements. When you submit this project, the higher-ups think we are trying to get research funding!"

Get a project that is difficult to produce results, apply for funding, and then do nothing. When the time comes, say that there is no result and deal with it.This is a means for many scientific research units to obtain funds.

It's just... the review is now stricter, and such a small method can hardly pass the review.

"Xiao Lu, I think...you should start with simpler subjects first!"

Professor He glanced at Lu Li, and said, "Scientific research also needs to be carried out step by step. You are still a master's student, do some simple research first, and wait for your academic reputation to rise before you can start big projects!"

There is a sentence that Professor He has not said yet.In fact, if you apply for such a worldwide project as a master's student, who would believe it?It doesn't fit your academic status at all.

"So it is!"

After a little thought, Lu Li understood what Professor He meant.This clearly means that your academic status is not enough, and you are not qualified to engage in such cutting-edge research.

A master's student is engaged in such a worldwide topic.In other people's eyes, it's all nonsense like folk scientists inventing that water turns into oil!

"Teacher, let me choose the subject again!"

Lu Li had figured out the key and knew how to operate it.

Isn't it an upgrade?First come up with some papers with relatively high gold content, get a master's degree as soon as possible, and make your debut in the academic world.

Then continue to study for a Ph.D., and then publish some papers with higher gold content to obtain a Ph.D.

Then...continue to use papers and academic achievements to establish one's academic status and become a famous scientist.

At this time, Lu Li will naturally get affirmation and support for whatever he wants to study.

Without any scientific research experience, but directly reporting cutting-edge topics, this is hooliganism and completely inconsistent with scientific research laws!

I'm still too impatient!

Lu Li already understood how he should go in the future, and he already had plans.

"Change the subject? Well, it's good that you understand!"

Professor He returned the information to Lu Li, "Go down and think about it, start with simpler topics! Scientific research needs to be done step by step. You are still young, take your time!"

"Ok!"

Lu Li took the materials and put them away, "Teacher, I'll go back and think about it, and choose a new topic for you."

After speaking, Lu Li bid farewell to Professor He and returned home.

Sitting down on the sofa in the living room, Lu Li recalled the conversation he had just had with Professor He, and a smile appeared on his face.

Scientific research has the law of scientific research.

A trumpet who just came out of Novice Village, but told others that he can single out the big boss, naturally no one would believe it.

If you don't succeed in the duel, at most you will be ridiculed.If the heads-up is successful, it's over, and someone will definitely report it as cheating.

Lu Li just submitted the "gene target" project, just like the trumpet wanted to single out the big boss.

I was too impatient to even ignore this point.

Smiling and shaking his head, Lu Li closed his eyes and opened the virtual lab again.

The current virtual laboratory is equipped with experimental equipment that is already the world's top scientific research equipment.

Just think about it, and you can virtualize any kind of equipment that Lu Li needs.The current virtual laboratory is completely the most cutting-edge laboratory in the world.

"It's very simple to make some simple and high-gold projects!"

Lu Li's figure appeared in the huge virtual laboratory, and he ordered: "Virtually create a human body with advanced liver cancer."

With a flash of light, a virtual human body appeared on the operating table.

"Turn on the X-ray imaging device."

The X-ray imaging equipment installed on the walls on both sides of the operating room was turned on, and a huge display screen showed the cancerous tissue inside the human body.

In advanced stage of cancer, the cancer cells have spread.On the monitor, Lu Li saw countless tumor tissues appearing inside the human body.

Lu Li changed into his surgical gown, walked into the operating room, and used a puncture technique to extract some cancer cells and T cells from the immune system from the human body.

Lu Li is preparing to do research on CAR-T technology.

The so-called CAR-T technology is the latest gene editing technology used to treat cancer.

As we all know, cancer cells originate from the human body and are part of the human body, so... the human body's immune system is defenseless against cancer cells.

CAR-T technology is to artificially modify the T cells in the immune system, adding the genetic characteristics of cancer cells to the "hostile sequence" of T cells, modifying the friend-or-foe identification system, allowing the immune system to attack and kill cancer cells .

This technology has already appeared, and clinical trials have been done abroad.

It's just...the treatment effect is not obvious, but the lethal effect is particularly obvious!

Before the immune system can attack the cancer cells, it has already launched a saturated type of "clearing the wall and clearing the field" indiscriminately. Seeing gods and killing gods, seeing Buddhas and killing Buddhas, normal cells are also completely killed.

This is related to the accuracy of gene editing of T cells, as well as the human body itself.

The immune system of the human body likes to go crazy, and the tactics of strengthening the wall and clearing the field are the norm.

In addition to pathogens, all normal cells around the infection site are also within the attack range of the immune system.

Strategically, this is correct.Killing all the cells around the infected site is equivalent to establishing a quarantine zone, and the virus has no chance to erode and spread.

However... When the scope of infection is too wide and the virus spreads throughout the body, the immune system will go crazy, killing everything it sees, and killing everything!

In this case, before the virus kills, the immune system kills the human body first!

In today's "AIDS", most of the causes of death are not caused by viruses, but are all killed by one's own immune system.

What Lu Li has to do today is to improve this "factor storm" and reduce the chance of the immune system going crazy.

Chapter 355 Is this a major breakthrough?

After taking the specimen from the human body, Lu Li walked out of the operating room.

Arriving at a nearby test bench, Lu Li sat down and began to edit the genes of T cells.

Gene editing and modification, this technology has been around for a long time.

Genetic modification by natural means, such as fruit tree grafting technology, and even the familiar hybrid rice technology, are all genetic modification technologies.

People are also familiar with gene editing and modification by unnatural means, such as...transgenic technology.

Even if it is to tamper with human genes, it is not once or twice.

As early as 2016, a guy named He Jiankui manipulated human embryos and created a pair of so-called "AIDS-immune" gene-edited babies, and then... He Jiankui was arrested and imprisoned!

In a situation where the technology is completely immature, a pair of gene-edited babies are actually produced. Is this...does it still have the conscience and morality of a scientist?

If genetic technology is a way to reach the sky, human beings have just taken a small step, so they want to play God?How stupid, how presumptuous is this?

The more advanced human science and technology are, the more we must maintain a sense of awe.

Sitting in front of the test bench, Lu Li carefully took out some cancer cell samples and installed them under an electron microscope.

In the image of the electron microscope, the internal structure of the cell is clearly displayed on the display.

The endoplasmic reticulum, ribosomes, Golgi apparatus, lysosomes, mitochondria, microbodies, vacuoles, cytoskeleton, cytosol, and even the coiled DNA inside the nucleus are clearly presented.

DNA requires an electron microscope to see, but... if you straighten it out, the DNA strand is more than two meters long.

Manipulating the instrument, injecting Cas9 transcriptase into the cancer cells with a gene gun, Lu Li clearly saw that the transcriptase was close to the DNA chain and copied a piece of DNA information.

The gene information transcription of cancer cells is completed.

Lu Li started the next experiment.After installing the T cells under the electron microscope, Lu Li used a gene gun to inject the genetic information of the cancer cells into the T cells.

Soon, T cells take up this genetic information and incorporate it into the "hostile sequence" of the immune system.

By doing this, a weapon against cancer cells has been prepared.

But... Once injected into the human body, the T cells will divide crazily, which will inevitably cause the immune system to go crazy, killing the enemy without distinction.

As a result, the immune system kills the body before the cancer kills the person.

Therefore, Lu Li had to do one more operation.

This time, Lu Li planned to modify the "information transmission mechanism" of the T cells, so that it would no longer call for "air support" or "call friendly troops" everywhere, and only let it fight alone.

This way, perhaps, it might be possible not to trigger the immune system to go berserk.

This in turn involves another gene editing technology, CRISPR-Cas9.

This gene editing technology is derived from the mutation mechanism of bacteria against phages.

When bacteria fight against phage attack, they will mutate a special protein, which can cut off the gene chain injected by phage into the nucleus.

I have to mention here that phages are the most terrifying killers in the world.

Every moment, in every corner of the world, a war that has lasted for countless years is breaking out.The scale of the war has reached a terrifying order of billions of trillions.

This is the attack of phages on bacteria.

A bacteriophage is a virus with a regular shape. Its head is a twenty-sided dice, it has a stick-like torso, and a few spider legs underneath, like a nano-robot.

Phages are harmless to the human body, they just attack bacteria crazily.They inject their own DNA into the bacteria, split into countless phages inside the cells, kill the bacteria, and spread continuously.

In the face of phage attacks, bacteria have also evolved resistance means, which is a special protein mentioned above.This protein cuts the DNA injected by the phage.

Humans use this special protein to achieve the purpose of cutting genes, modifying genes, and even editing genes.

In the laboratory, Lu Li repeated the experiment of phages attacking bacteria, and obtained the special protein CRISPR used by bacteria to fight against phages.

This CRISPR protein, combined with Cas9 transcriptase, is then injected into the T cells to modify the genes of the T cells.

Gene mapping is a problem.

Lu Li did countless experiments in a row, but he failed to obtain the exact genetic modification effect.

Even if the transcriptase makes a genetic match, however... splicing proteins often cut in the wrong places.

Manipulating genes is not cutting with scissors. This kind of extremely microscopic operation cannot go deep into the nucleus with any tool, and this operation can only be realized by cutting proteins.

Fortunately, the transcriptase has a genetic match and is still functioning.

After repeating the experiment hundreds of times, I finally got it right once.

A gene-edited T cell was finally born.

Lu Li quickly stood up and injected the T cells into the virtual human body.

Then there is the wait!

After the gene-edited T cells entered the human body, they immediately detected the existence of "hostile target" cancer cells, activated the stress mechanism instantly, began to absorb nutrients from the human body, and divided crazily.

Half an hour later, the experimental body started to have a fever, and its heart rate increased sharply.