I really don't want to lie down and win

At this time,

Academician Chu, an expert in bioinformatics, came to Academician Zhong's office. Seeing his helpless expression, he couldn't help but smiled wryly and said, "Old Zhong...you've been frowning for almost three months, and it's almost time to go. Chinese New Year is coming, can you change your expression?"

"Ugh..."

"I want to change too, but how?" Academician Zhong sighed: "The progress of the Molecular Biology Department is almost zero, and Xu Mang's situation is not very optimistic. I'm afraid it will be postponed indefinitely. It will be greatly reduced, at least in the field of gene editing, it will be reduced by about [-]%."

"No way."

"It's too big...Some people objected." Sitting opposite Academician Zhong, Lao Chu said silently, "But you are much better than Xu Mang, the collider project has been stuck, because of problems with this project, Xu Mang He even resigned as a professor, his difficulties are much more serious than yours."

Hearing what Old Chu said, Academician Zhong smiled wryly and said, "That's right...it's not about the difficulty level of a concept."

"Say..."

"Have you contacted Xu Mang?" Old Chu asked curiously: "How about... you can call now and ask, I have a strong hunch that Xu Mang may have completed a breakthrough in the field of gene editing Question, when did you call Xu Mang before?"

"Ten days ago."

"Ten days ago?" Old Chu showed a trace of bitterness on his face: "There is no such thing as ten days. If you ask now...it may give you an unexpected result, yes...hands-free!"

Academician Zhong:? ? ?

what's the situation?

Why is Old Chu acting weird today?

no way,

Academician Zhong called Xu Mang, and the call was connected soon.

"Hey?"

"Academician Zhong?" Xu Mang's voice came out, with a hint of playfulness in his words, he said, "New Year's is coming soon... I'll give you a New Year's greeting in advance, so I won't go...Magic City The distance from the capital is not so far.”

"..."

"..."

The two of them were very helpless. They seemed to be in a good mood, so should they ask next?After all, the Chinese New Year is coming soon, it is not good to cause trouble for others at this time, it is a bit unreasonable.

Academician Zhong hesitated, and wanted to ask about the progress several times, but he swallowed it back. After much deliberation... he gave up the plan to ask.

but,

Xu Mang brought it up.

"Academician Zhong called me, do you want to ask a question about the progress?" Xu Mang said with a smile, "I've almost finished it...a rudimentary AI system has been developed and is currently being tested. I guess...it's almost time."

"???"

"???"

do...

Got it?

This is too surprising, isn't it?

Academician Zhong and Academician Chu glanced at each other in bewilderment, with expressions of shock and a little disbelief on each other's faces.

"In my concept, I bypassed the problem of replacing the DNA fragment with the target sequence, and directly cut a DNA strand, and then the reverse enzyme was guided by the RNA strand to perform gene editing at the cut point." Xu Mang said seriously : "Although it is still a CRISPR–Cas1 system, I have modified Cas9."

Bypass?

This... this idea is okay!

Academician Zhong hurriedly said, "Can you be more specific?"

"can!"

"First, a DNA strand is cut and the target sequence Y is inserted, then the original sequence is excised, another unedited DNA strand is cut, and finally the CRISPR system repairs the cut DNA strand."

"In this way, the enzyme doesn't need to cut the double strand of DNA, so researchers don't have to rely on the cellular DNA repair system that they can't control to edit the cut DNA strand." Xu Mang paused, and said seriously: "It means that with the help of a new editing The system can develop genetic disease problems associated with gene mutations."

For a time,

The two academicians were completely silent. What Xu Mang said was based on the existing gene editing tools, which could not be done at all.

"correct!"

"I came up with another method the day before yesterday." Xu Mang said with a smile, "Its accuracy is comparable to my editing tool system. This technology can directly replace bases without cutting the double strand of DNA through chemical methods. For example, replace T with A, and G with C."

"The CRISPR–Cas9 gene editing system can't do this, but..." Xu Mang sighed: "This method can't solve the problem of polynucleotides, such as the translated Tay-Mongolian idiot symptom, which is It is caused by the mistaken insertion of 4 DNA bases in the HEXA gene."

This...

It's simply,

Too strong, right?

Hearing Xu Mang's introduction, the two bigwigs from the Academy of Sciences were so shocked that they couldn't speak, and they sat in their positions with blank faces.

"Anyway..."

"My positioning for the new system is that it is flexible, simple, and able to realize a variety of gene editing functions." Xu Mang said seriously: "A system composed of a variety of enzymes, including the improved Cas9 enzyme, can be edited in almost no time." Changing, deleting single bases, or inserting small stretches of DNA sequence without disrupting the double strand of DNA."

Academician Zhong took a deep breath and asked cautiously, "Xu Mang...how long will it take to finish?"

"Before the new year."

"Give me another five days, and I'll give it to you when I'm done testing..." Xu Mang said with a smile, "I've created an AI so you can use the AI ​​to conduct simulation tests, make modifications based on the test results, and then To the laboratory for the final test."

"Anyway, it is to reduce your workload. After all, the future is an era of artificial intelligence." Xu Mang said helplessly, "Academician Zhong... This is the result of my best efforts, if the result is still not satisfactory , I'm sorry... I really can't do anything later."

Not satisfied?

What a joke!

This was clearly completed beyond expectations!

What Xu Mang said is more advanced than any improved CRISPR-Cas9 system, because it does not rely on the cell's own repair system for gene editing.

"No!"

"Professor Xu...if all of this becomes a reality, I can swear...your new system will definitely become the most advanced gene editing tool in the world." Academician Zhong said seriously: "I'm not joking, this is already super Beyond any imagination."

Xu Mang opened his mouth, and said in a low voice, "Academician Zhong... I have a request, can the constraints in the field of gene editing be strengthened in the future? I feel... a little worried, worried that future humans may not be real human."