I Don’t Want to Win Lying Down

What academician Zhong saw could no longer be described in words. A problem that the whole world could not solve was suddenly solved at this time of the first day of the Lunar New Year in Huaguo?

at this very moment,

Academician Chu, who was on the other end of the phone, heard the rapid breathing of his colleague Lao Zhong, and was a little dazed for a while, and asked curiously: Old Zhong...what did you see? Why do you feel that you are breathing rapidly? gone?

I...

I couldn't believe it...what I saw. Academician Zhong said sincerely: Solved! Finally solved...I simply compared the two data reports, and the final result is almost the same...

The words came to an abrupt end.

What Academician Zhong wanted to say suddenly got stuck in his throat, and his expression gradually changed from shock to panic, as if he had seen something that subverted his perception.

wrong!

No, no, no! Academician Zhong kept repeating a word with his frightened face, and the hand controlling the mouse kept sliding the scroll wheel. His eyes became a little frightened at this moment, and he discovered something that couldn't exist at all.

What's wrong?

What's going on? Academician Chu was about to go crazy at this moment, wishing that wings would appear on his back, and then fly to Academician Zhong to see what he saw. This mystery whetted people's appetite.

Professor Xu Mang...he...he replaced the original Cas9 with another RNA-guided nuclease in the brand-new CRISPR-Cas gene editing system. Academician Zhong said in surprise: This is incredible. ..so... amazing!

Academician Chu:? ? ?

The more you can't see something, the more you want to have it.

Academician Chu is going crazy, listening to the constant exclamation of his colleagues, eating away his curiosity bit by bit, he is almost on the verge of collapse at the last point.

God!

He not only upgraded the CRISPR-Cas gene editing system, Professor Xu Mang also solved a... a problem that troubled all biologists in the world! Academician Zhong said hurriedly: He redesigned the C2c1 nucleic acid Enzymes, now... C2c1 nucleases are fully adapted to most organisms!

Suddenly,

Academician Chu has completely collapsed. If the successful upgrade of the CRISPR-Cas gene editing system is just the beginning, then the redesign of the C2c1 nuclease is the last straw that breaks the camel's back.

C2c1 nuclease has thermophilic characteristics, which is impossible to develop into a gene editing tool, and the key is that the original structure of C2c1 nuclease will cut the non-target single strand in double-stranded DNA, the lower the temperature, the more errors, resulting in Editing is less efficient.

This problem is a problem of the whole world. Many teams have tried their best, but they all failed...However, Professor Xu Mang managed to break through this predicament?

this...

Is this killing two birds with one stone?

Old Clock!

Hurry up and send me the data! Academician Chu urged impatiently: I'm so itchy because of you... Hurry up... Hurry up... Send me the data, this so-called redesigned C2c1 nuclease, what is it? what's going on?

Ahem!

It only introduced the function of the redesigned C2c1 nuclease, but did not give a detailed report. Academician Zhong frowned and said seriously: Wait a minute...I need to give Professor Xu Mang a Call and ask what's going on.

words fall,

Academician Zhong hung up the call directly, and then hurriedly called Xu Mang.

Hello?

Professor Xu...you redesigned the C2c1 nuclease, is this true? Academician Zhong asked nervously: Is there any related research report? And this needs to be verified by experiments, just relying on AI simulation Not convincing enough.

Xu Mang said indifferently: There are relevant research reports,

Although it has not been verified experimentally, from the research reports on C2c1 nuclease all over the world, the results have been fully obtained by using AI technology. It is not that C2c1 nuclease cannot be used for gene editing, but it is very suitable.

simply speaking...

The CRISPR-C2c1 gene editing system I developed has higher sensitivity, which can realize sensitive DNA detection and single-base discrimination. Xu Mang said with a smile: Using my gene editing system, it can quickly achieve Bacterial and viral infection, genotyping, and SNP mutation detection in cells, blood, and animals and plants.

I'll ask Xiaozhang and Xiaocai to help me with the experimental data later. Xu Mang said with a smile, By the way... Can academician Zhong apply for a patent?

...

Can!

You can give us free use. Academician Zhong said hastily: By the way...call me immediately if you have any results.

Um!

I want to publish it on Nature, should it be possible? Xu Mang asked.

Academician Zhong hurriedly said: It's absolutely possible!

hang up the phone,

Academician Zhong sent all six documents to his old friend's e-mail, but only half an hour later, he received a call from Old Chu.

this...

This is unbelievable! Old Chu said with surprise: There is only a research report on the redesigned C2c1 nuclease. If Xu Mang can publish it, it will be even more perfect!

This is just the initial stage... A brand-new gene editing system like this needs to constantly accumulate experimental data and improve on the original basis, but... being able to come up with such a framework concept is enough to prove Xu Mang's greatness. Academician Zhong smiled wryly: Old Chu... I have to feel that the waves behind the Yangtze River push the waves ahead, and each wave is stronger than the last wave.

at the same time,

Xiaozhang and Xiaocai were very helpless, and they were arrested by Xu Mang again, but this time they did not have any complaints. They came into contact with Xu Mang's latest research results, about the redesigned C2c1 nuclease.

at this time,

The two are conducting related experiments for this brand-new CRISPR-C2c1 gene editing system, and at the same time, they are more detailed about the C2c1 nuclease.

And this process,

It took two full days. To Xu Mang, these two days didn't feel much, just sitting in the laboratory, kneading melon seeds, and sending WeChat messages with Xiaoman, but to Xiaozhang and Xiaocai, The harvest of these two days has been great.

As a new intern researcher in the institute, it is rare to have access to such top-level research projects. However, Professor Xu Mang can let himself join this research and become a part of this research without caring about his own experience. in return.

Ok?

This speed is not bad... Xu Mang said with a smile, Go and rest...or go outside, I'm here at the institute.

don't even say,

At this time, the two were exhausted, and after greeting Xu Mang, they hurried back to their dormitory.

Xu Mang checked the relevant research reports, went to his office silently, turned on the computer and started editing the paper, and wrote the name of the paper at the beginning - CRISPR-C2c1 Gene Editing System.

...

London,

Headquarters of the famous scientific magazine Nature\

,"Originally, this day was an ordinary day for the editorial staff of Nature, but some people did not want to make life too easy for this group of people. At this time, a paper that was about to shock the world came to Pete quietly. Editor's email.

Nature's top ten figures of the year will be published in the order of this list. Editor-in-chief Pete said to one of his subordinates: Be sure to pay attention to the order.

In the list submitted by Editor-in-Chief Pete, Xu Mang was ranked first. There is no way...Although the entire Western world is unwilling to see Xu Mang ranked first, his achievements this year have been beyond measure. Controlled by shady.

Editor Pete...

Let the Hua people be ranked first...Many people are very upset. The young editor said: How about...move it to the back?

no!

You can't move at all. Editor-in-Chief Pete said seriously, Look at the achievements of the next nine, they add up to only half of Xu Mang's. What theory do you think Xu Mang won't take the first place?

for a while,

The young editor was speechless, this is really the case.

moment,

The editor-in-chief Pete was the only one left in the office. I don't know what happened recently. The quality of the paper was very poor, and the man he was looking forward to had never appeared, probably because Huaguo was in what they called the Chinese New Year.

Well?

New mail alert?

It shouldn't be Xu Mang, he is celebrating the most important festival in Huaguo, so...who sent this?

Editor-in-Chief Pete didn't care about it, and he didn't bother to open it. He was doing his own thing silently. At this moment, he classified the email just now into the category of unfamiliar contributors.

bang bang bang,

There was a knock on the door of the office, and a middle-aged man walked in after a call to come in.

Editor Pete.

Which of these three papers should you choose as the cover paper? The middle-aged man handed the text messages of the three research reports to Pete.

After flipping through it briefly, editor-in-chief Pete revealed a trace of dissatisfaction, and said seriously: It's not shocking enough...Although it can be placed in the main journal, it must not be placed on the cover. I'm excited.

This middle-aged man is quite helpless, how can there be so many papers that can shock the whole world.

Editor Pete...the quality of recent papers is generally not high, maybe Valentine's Day is coming... The middle-aged man smiled wryly: Many young scientists also need a touch of romance.

...

It doesn't seem to have anything to do with Valentine's Day. It's just a trough. Pete said with a smile, Wait a little longer...Anyway, there are still two days left, and maybe within these two days, we can receive a message that shocks the world. research report.

At this time,

Pete opened his mailbox and saw the name of the first email - CRISPR-C2c1 Gene Editing System.

Well?

By the way, do you know what the CRISPR-C2c1 gene editing system is? Pete couldn't help being stunned when he saw the title of the email, and asked curiously: I remember... there is no CRISPR-C2c1 gene editing system in this world, right?

should not.

The CRISPR-Cas9 gene editing system does exist, and it is very popular in the biological field, said the middle-aged man.

Pete frowned, and subconsciously clicked on the email.

just a few seconds,

Pete yelled in horror, It's him!

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