I Don’t Want to Win Lying Down

At twelve fifteen in the middle of the night,

One hour before take-off, Xu Mang was sitting in the VIP waiting room with a hint of anxiety on his brows. He had received a call from Academician Zhong and was told that his AI program had a very serious error. The experimental data and AI data There are several differences.

its not right...

Why did this happen? Xu Mang looked at the content on the laptop screen with a very confused expression. The data on the two sides did not match up. .

Could it be...

Dude is going to capsize in the gutter?

Faced with such a possibility, Xu Mang's self-esteem was unacceptable. He was used to success, but suddenly faced with failure, let alone... don't know what to do, panic? Overwhelmed? confused?

In short... at this moment, Xu Mang had mixed feelings in his heart, and he felt an indescribable discomfort.

If there is a problem with one of the experimental data, it’s fine. If there is a problem with all the seven data, it’s very clear. It must be a mistake. The artificial intelligence system of Xuman No. 2 seems to be a tragedy. It is to develop No. 3.

Professor Xu?

Your coffee...be careful it's hot. A beautiful and generous stewardess brought Xu Mang a cup of coffee. In fact, this stewardess was not supposed to serve Xu Mang, but the boss of Modu called Modu himself The chairman of the international airport must take good care of Xu Mang, which is why a flight attendant served Xu Mang alone.

Thanks.

Xu Mang replied absently, looking at the data on the screen to himself, completely turning a blind eye to the stewardess beside him. At this moment, the mobile phone beside him rang, and the caller was Yang Xiaoman.

Hello?

Don't you go to bed so late? Xu Mang picked up the phone and asked curiously: Going to bed too late will cause wrinkles. She was originally a beautiful girl, but after a few days, she will become a yellow-faced woman. Although I pursue spiritual Beautiful, but the premise is that the other party's appearance must meet the standard.

...

Idiot...I'm worried about you, and I can't sleep. Yang Xiaoman said in a sticky voice, What kind of trouble did you encounter? It's the Chinese New Year soon, and you are asked to go to the capital... I don't know at all Be considerate of others, I was happy to celebrate the new year, but now I have added a lot of trouble.

Facing Xiaoman's endless complaints, Xu Mang just smiled, and said calmly: This is normal... In fact, I am already very free. There are many scientific researchers who you don't know or know at all. They are more intelligent than me. Hard work...be willing to be an anonymous person, and achieve earth-shattering things.

Little Man...

This year's Chinese New Year...I may not be able to come back. Don't forget to come to my house on New Year's Eve. My parents miss you very much. Xu Mang said helplessly, I have encountered a problem that cannot be solved for the time being.

Yang Xiaoman was silent for a long time, and said questioningly: I see... Don't worry about the family affairs, I will take care of everything.

after,

The two had some whispers, and they didn't hang up the phone until fifteen minutes before takeoff.

...

got off the plane,

Xu Mang saw the long-awaited staff.

Thanks for your hard work.

Wait for me in the cold. Xu Mang smiled wryly, Is there anyone still in the research institute? There shouldn't be anyone at four o'clock in the morning, right?

Um!

Professor Xu, shall I take you to the guest house first? the staff member asked.

Xu Mang thought for a while, and said seriously: You can send it to my research institute first, I can't sleep for the time being, by the way... the guard should have the key to the laboratory, right?

...

Professor Xu, why don't you go back to the guest house first? Academician Zhong asked me to take you to the guest house. The staff member smiled bitterly: You just got off the plane, you should take a rest first, tomorrow... you may be a little bit late tomorrow. busy.

oh...

soon,

Xu Mang arrived at the so-called guest house, which was actually the place he had been to last time.

Perhaps because of the upcoming Chinese New Year, Xu Mang checked in quickly. When he came to his room, he didn't feel sleepy at all. He took out his notebook from his handbag and continued to look at the data.

Logically speaking,

Even if it is not the upgraded CRISPR-Cas9 system, it should have higher target accuracy, but why is the error rate of the upgraded CRISPR-Cas9 system 100%?

well...

I'm going to die! Lying on the bed, Xu Mang looked at the ceiling above his head. For a moment, emotions that he couldn't let go gradually came to his mind. He really had no idea. It just opened up Pandora.

Unconsciously,

Xu Mang fell asleep until four hours later, he was woken up by a phone call.

Hello?

Well...I'll be right over. Xu Mang yelled, washed up in a daze, and then went to the Institute of Biochemistry and Cell Biology of the Academy of Sciences.

soon,

Xu Mang met Academician Zhong, the head of the Institute of Biochemistry and Cell Biology of the Academy of Sciences, but his condition was very poor, his eyes were slightly bloodshot, it seemed that he didn't sleep well yesterday, thinking about it...he had this problem How could it be possible to sleep well.

Professor Xu Mang.

I finally waited for you. Academician Zhong said with a wry smile: The gap is too big, almost your AI calculation results are all wrong, and it is a very serious off-target error, Professor Xu Mang...what the hell is this? Condition?

Xu Mang shook his head, and said helplessly, I don't know either, so I hurried over here to find out the situation.

At this time,

Academician Chu walked in, was stunned for a moment when he saw Xu Mang, and hurriedly asked, Professor Xu Mang?

This is Old Chu, Academician Chu. Academician Zhong introduced.

Hello, Academician Chu.

After a brief exchange of pleasantries, the three of them began to talk about the root of the problem, but after ten minutes, they still had no clue, but the most embarrassing one was Xu Mang, after all, all the problems were on him.

Immediately afterwards, Xu Mang came to the laboratory, got a more detailed information report, and then applied to Academician Zhong for a temporary office.

Professor Xu Mang?

Have you found any problems? Academician Zhong asked.

Not yet. Xu Mang still shook his head, and said helplessly, But Academician Zhong, don't worry... Since I promised to help you upgrade the CRISPR-Cas9 system, I will definitely do it, right... yes Can't you give me a key to this office?

Well?

Professor Xu Mang?

Aren't you going back? Academician Zhong asked.

Um!

Pride won't let me go back. Xu Mang said seriously, This matter can't be settled, and I feel very uncomfortable.

for a while,

Academician Zhong didn't know what to say. He had heard from his old friend, Xu Mang's second grandfather, that this guy had an unusual head, and he couldn't pull ten cows back when he became stubborn. Mixed with some water, who would have thought... it's all true.

Professor Xu Mang.

It looks like the Chinese New Year is coming, why don't we do it after the next year. Academician Zhong said.

never mind...

I also lock myself up at home. It's better to be here than to go back with troubles. Xu Mang smiled wryly, It's better to be alone than to be happy, but it's better to be alone than to be sad. Academician Zhong... you Tell the researchers in the institute, come back during the Chinese New Year... I will give them a satisfactory answer and let them relax.

Hearing Xu Mang's words,

Academician Zhong knew that he planned to take all the responsibility alone.

...

There are still three days until the New Year's Eve,

The Institute of Biochemistry and Cell Biology of the Chinese Academy of Sciences was empty. Except for those who were on duty, almost everyone went home.

During these few days,

Xu Mang was not idle. He found the problem. The upgraded CRISPR system should not be edited by a nuclease like Cas9. It needs a smaller nuclease to cut a DNA strand, and then The reverse enzyme is guided by the RNA strand to perform the task of gene editing at the cut site.

at this time,

Xu Mang wanted to find a brand new pair of genetic scissors. The brand new RNA-guided nuclease needed to have three characteristics, smaller, more stable, and more complete.

Smaller means that it is easier to be used in clinical gene therapy that requires in vivo delivery, more stable means that it can maintain high enzyme activity in a wide temperature range and pH range, and safer means that there are fewer off-target effects.

but...

This is not so difficult!

actually,

Xu Mang has two brand new RNA-guided nucleases in his hands, namely Cpf1 and C2c1. These two proteins are smaller than Cas9 and easier to enter tissues and cells, especially Cpf1, which is far away from the recognition site when it cuts. Far, giving researchers more options in choosing where to edit.

However, Xu Mang prefers C2c1, an RNA-guided nuclease, which is smaller than Cpf1 and is easier to deliver between cells through viral vectors. However, C2c1 is thermophilic and difficult to develop into a useful gene editing tool. .

no way,

C2c1 comes from acidophilic thermostable bacteria, which need a certain temperature to operate normally. According to a foreign research report, its optimal temperature is 48 degrees Celsius, which can directly burn ordinary mammals to death due to high fever.

Redesigning the temperature of C2c1 was a challenge for Xu Mang. As long as he completed this challenge, all the following problems would be solved easily.

At this time,

the phone rings,

The caller is uncle.

Hello?

Uncle... Xu Mang said bitterly, Yes...I'm in the capital, and I won't be going back during the Chinese New Year, oh...I'll take care of myself, don't worry...um!

hang up,

Xu Mang continued to rush to solve the problem, but only ten minutes later, the phone rang again, this time it was Xiaoman calling.

Hello?

Husband... I bought five catties of superb tea for dad, and a necklace worth more than three million yuan for mom. It should be about the same? Yang Xiaoman asked, Speaking of your relatives and friends, do you want to buy it too? Bring it on?

Well...

Buy some gifts for your younger brothers and sisters. Xu Mang said calmly, For example, 5-year college entrance examination and 3-year simulation, 5-year high school entrance examination and 3-year simulation, College entrance examination must pass papers... let these Little guys, don’t even think about having a good year in peace.”

...

Why are you so bad? Yang Xiaoman said angrily, I'm also the older sister of these people, forget it... I won't tell you, work hard, I'll go shopping again.

Snapped,

hung up,

Xu Mang put down his phone and looked at the various documents on the table, wanting to cry for a moment.

What the hell,

Labor and capital are fighting with you!

 …