I Don’t Want to Win Lying Down

Beijing,

Academy of Sciences Institute of Biochemistry and Cell Biology.

An accident two months ago cast an indelible shadow here. Although there were no casualties, it caused irreparable economic losses. Although Huaguo has been recognized worldwide in the field of CRISPR-Cas9 gene editing leader, but this technique still has serious flaws.

How to make up for this defect has become a task for the Institute of Biochemistry and Cell Biology of the Academy of Sciences, although the CRISPR-Cas9 gene editing technology has quickly become the most popular technology in life sciences due to its simplicity, efficiency and diversity.

Especially in gene therapy related to human diseases, it is hailed as one of the most potentially transformative innovations in modern human medicine, but behind the success is often the accumulation of failures. The accident two months ago was the last good description.

a certain department,

Silence has always shrouded this office. A dozen top researchers in the industry are having a headache for upgrading the CRISPR-Cas9 gene editing technology. A whole month has passed without any gains.

For the research on clustered short palindromic repeats at regular intervals, many people present are elite figures, but how to upgrade has stumped everyone, many of whom are doctors.

at first,

Our goal is great, to establish an existence beyond the CRISPR system, but with continuous in-depth research, we gradually discovered that the cruelty of reality has surpassed everyone’s imagination. It is impossible for the CRISPR system to be surpassed at this stage. Only in the original Based on fine optimization.

However, the CRISPR system has been developed from the 1990s to the present. After numerous upgrades by biological scientists, it has reached the point where it can no longer be optimized. At present...the CRISPR system has entered a bottleneck period. If you want to break through... Unless there is a whole new theory.

Like physics, the span from classical physics to modern physics is hundreds of years, and from modern physics to new physics is still an unknown, while biology has just undergone a huge revolution, and when the next revolution will start is as unknown as physics.

well...

It's so difficult! A doctor in the office sighed, and his words were full of helplessness: The whole world knows that the main challenge in the standard CRISPR-Cas9 system is to reduce the probability of off-target, but who can do it? Even if it is done ...It is equivalent to borrowing the shell of the CRISPR–Cas9 system, but the content inside is completely different.”

Then what are you going to do? The frowning middle-aged man sitting next to him said with a wry smile: If this problem is not resolved, we may be greatly reduced in funding, after all, the shadow left by this matter is too great.

for a while,

Helpless emotions flooded the hearts of everyone present. This problem was not a sporadic difficulty. Unless there was a genius like Xu Mang, there was no way to succeed.

Xu Mang?

Many people thought of what just happened a few days ago. Regarding the artificial intelligence that predicts the three-dimensional structure of proteins from amino acid sequences, it is said that if Professor Xu Mang is asked to develop a similar gene editing AI, there may be unexpected results.

well?

Do you think... if Professor Xu Mang suddenly designs a gene-editing AI one day, will there be a world-class biological revolution? The doctor asked curiously: I think it is possible... at present, in terms of protein structure , has caused a huge response.”

Disaster!

It's hard!

I think the CRISPR system is already the most perfect existence, and it cannot be surpassed in a short period of time. The middle-aged man smiled wryly: This kind of thinking is different... After all, Professor Xu Mang is engaged in physics, and he accidentally played a role in other fields. A bit, but gene editing...I don't think it's possible!

When everyone was discussing this matter, Academician Zhong walked in,

He said to everyone present: Ahem...Be quiet first, I'm here to announce two things.

words fall,

The office fell into silence. Everyone looked at Academician Zhong standing at the door with a hint of doubt in their eyes.

First of all, I won the right to use the artificial intelligence 'Xuman system' that predicts the three-dimensional structure of proteins from amino acid sequences. Professor Zhong said: The system hunting will be carried out in the near future. In the future, everyone can use this technology to carry out The study of protein structure.

Second...Professor Xu Mang has accepted my request to help us achieve a breakthrough in the field of gene editing. Professor Zhong said: But...I hope you will not start to relax because of the joining of Professor Xu Mang Come down, you still have to go all out.

???

???

???

He...he really came?

Hearing Academician Zhong's words, many people were surprised and surprised, but then they questioned, not Xu Mang, but their own strength.

It's quite miserable to say, but to rely on a physicist to come to the rescue, this... Is this my own biology that I learned in vain?

In order to mobilize your enthusiasm, uh... Your entire team will compete with Professor Xu Mang to see who can take the lead in completing the innovative work in the field of gene editing. Academician Zhong laughed: He only has one person, but you There are about a dozen of them, so there shouldn’t be any problem, right?”

no problem?

This problem is not small!

If it was before, everyone was full of confidence. How could one person fight against a team of ten or so people, but now... sorry, we can really fight! And it's not just against one team. Not long ago, Xu Mang suppressed nine American AI teams with just one person.

It is conceivable that

It's not right to win more with less. It's not right to use one against a hundred. It should be one man guarding the gate, and ten thousand men should not be opened. This is Professor Xu Mang's routine operation.

Academician Zhong... are you kidding me? the doctor said, All kinds of stories tell us that none of those who competed with Professor Xu Mang ended well.

We lost before we even started? Academician Zhong said helplessly, Come on, we can't rely on Professor Xu Mang alone. What if he fails?

words fall,

Academician Zhong left, and on the way to his office, he met a colleague, Academician Chu, an expert in bioinformatics.

Old clock?

I heard that you went to Fuda University? Old Chu asked curiously: I remember you went there yesterday? Why did I meet you here today...this morning? Did you rush back overnight?

Academician Zhong smiled wryly: Yeah... It's not about solving the problem two months ago. The higher-ups hope to summarize the relevant experience based on a previous mistake, and then strive to make a breakthrough in this field, but the breakthrough is so simple.

so...

You just found Professor Xu Mang? Old Chu smiled and said, How's the situation? Did he agree?

accepted.

At the same time, I also got the right to use the 'Xu Man System'. Academician Zhong said, By the way, Old Chu... What do you think is the probability of Xu Mang breaking through the existing framework in the field of gene editing?

have no idea.

Don't ask me this question. Old Chu said bitterly: I won't say anything about him...

...

Academician Zhong said helplessly: Is it necessary to be so cautious? The probability of being able to and not being able to is only 50%. It is so difficult to give an accurate explanation?

It's not difficult!

But if the other party is Xu Mang, it will be very difficult...you should understand what I mean. Lao Chu said seriously: Don't think he's a physics guy, but he knows everything, and he's proficient in everything. It doesn't make sense at all.

Academician Zhong smiled: Talk to your department and assist the molecular biology department to complete breakthrough tasks in the field of gene editing.

good!

Are you planning to have a competition with Xu Mang? Old Chu asked.

almost!

I want to see how far the researchers in our department are from Professor Xu Mang. Academician Zhong said, Professor Xu Mang's job is to do physics, and they graduated from biology. Don't you want to know how much difference there is between them?

Old Chu opened his mouth, an unspeakable words stuck in his throat.

to be honest...

Not at all!

...

Magic City,

Yang Xiaoman and Xu Mang were walking down the street hand in hand, but Xu Mang didn't want to come out, it's so cold... and the cold in the south is different from the cold in the north, the north belongs to physical attacks, while the south belongs to magic attacks, with Humidity...If you can't fix it, you will get rheumatic bone disease in your later years.

well...

Wife?

Aren't you cold at all? Xu Mang asked cautiously, I'm about to freeze, please take care not to turn on the heat at home, why not go out for a walk, if I catch a cold... you know it will be a loss to our country How much? The progress of a large-scale research project is put on hold, and time is money!

Yang Xiaoman: (#￣～￣#)

Let's take a walk after dinner to increase the relationship between each other. Why are there so many nonsense?

I'm furious!

Will you die if you walk around? Yang Xiaoman said angrily, Aren't you studying gene editing? Can you edit your own genes first? You're too lazy to die...

After being educated by Xiaoman, Xu Mang became a lot more honest, and silently accompanied her, doing the activity of blowing cold wind.

At this time,

A couple who looked like they were in high school came over head-on.

Aunt?

Auntie, wait a moment! Suddenly the girl rushed to Yang Xiaoman, and asked curiously: Auntie...your dress is pretty, is it warm?

Ah...

Aunt?

When Yang Xiaoman heard the little girl call herself Auntie, her brain short-circuited and she looked at her in confusion.

Well...

It looks very warm, I want to buy one for my mother too! The little girl studied Xiaoman's coat carefully, as if she didn't notice how terrifying the expression of the owner of this coat was.

I...

Aunt?

Buy one for mom?

Yang Xiaoman has completely collapsed, it's like losing his nerves, he can't feel breathing, even the air is suffocating...

suddenly,

Xu Mang hugged Yang Xiaoman, and shouted nervously at the young couple, Run! Run! There's still time to run, or if you transform... you'll be drowned!

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