Coroner Ke Xue

As soon as Miyano Shiho said these words,

Just like the head teacher who appeared outside the window during evening self-study, the air suddenly solidified.

In the dead air, Mr. Yuda's face became paler and his breathing suddenly became heavier.

At first glance, it was impossible to tell whether his symptoms had become severe due to mild tetrodotoxin poisoning, or whether he was suddenly told something that made him so shocked.

"Call the police?"

At this time, Lin Xinyi was still busy helping the poisoned lady perform heart compressions and artificial respiration, and could not open her mouth for a while.

However, Mao Lilan reacted with some shock:

"Ms. Miyano, what do you mean?"

"This is not an ordinary accidental food poisoning, but someone is deliberately poisoning?"

"Probably."

Miyano Shiho put his hands in his pockets and said casually:

"All puffer fish dishes have been detoxicated. Even if it is occasionally not cleaned, with the unexpected trace amounts of toxins remaining, such rapid and acute pufferfish poisoning is rare."

"This Mrs. Yuda must have been poisoned."

"And the one who poisoned"

"It's probably the only person in this box, Mr. Yuda."

This time, it was no longer a meaningful hint, but an undisguised suspicion.

Yuda's face suddenly turned extremely ugly.

He held on to his body, which was paralyzed and out of control by tetrodotoxin, and said angrily:

"Hey, what are you talking about?"

"How could I possibly poison my wife?!"

"Besides, I've been poisoned myself. There's obviously something wrong with the pufferfish food provided by the store!"

"This" Mao Lilan frowned tightly, a little unsure.

She thought about it carefully, and finally felt that the arguments given by Miyano Shiho were somewhat unreliable:

"Such acute poisoning is rare when eating puffer fish, but that doesn't mean it definitely doesn't happen, right?"

"It's not impossible that the store made a mistake in handling the pufferfish and left a lot of toxins in the dish."

"No, you are totally wrong if you think so."

"Because Mrs. Yuda's poison developed quickly and her symptoms were severe. It is no longer an ordinary acute poisoning."

Miyano Shiho sighed softly and continued:

"Perhaps you know that tetrodotoxin is very deadly."

"But it's different from what you might think. Even if you eat a lethal amount of tetrodotoxin, you won't get sick and die so quickly."

"Because eating puffer fish meat is equivalent to taking the medicine from the stomach and intestines through oral administration."

"Given drug administration from the gastrointestinal tract, because it involves the absorption rate of the drug in the gastrointestinal tract, the drug needs to eliminate interference from food and must pass through the cells of the intestinal epithelium, be processed by the liver, and finally enter the blood circulation."

"So the bioavailability of oral drugs, which is how quickly and to what extent the drug is absorbed into the body's circulation, tends to be low."

"Talk about it"

Miyano Shiho paused slightly and recalled:

"When I was 10 years old, I happened to publish a paper on "Pharmacological Analysis and Pharmacokinetics Study of Tetrodotoxin."

Yuda and Mao Lilan: "???"

Lin Xinyi: ""

Everyone's eyes were a little weird, but this genius science girl ignored the ordinary people's doubts and continued to speak:

“When I was doing animal experiments on mice, I found that the LD50 of intragastric administration was 38.12 times that of intraperitoneal injection. This shows that the bioavailability of TTX (tetrodotoxin) is greatly increased when administered through the gastrointestinal tract. reduce."

"By the way, LD50, the median lethal dose, means the minimum amount of toxin required to kill half of the animals of a certain weight or age through a specified infection route within a specified time."

In order to prevent Mao Lilan from not understanding, Miyano Shiho also made a special effort to popularize the professional terms he used.

But Mao Lilan was still confused.

Yuda was covered in cold sweat after hearing it - although he didn't understand it, he seemed to be very powerful.

"In short, the conclusion is"

"Oral administration of tetrodotoxin will greatly reduce the speed and degree of toxin diffusion in the human body."

"In other words, compared with direct intravenous injection, the time to onset of toxicity and the time to death will be greatly prolonged when administered orally."

Miyano Shiho finally said something slightly understandable:

"According to research, after a period of incubation period, the onset of tetrodotoxin in patients who take oral tetrodotoxin is generally 10 to 45 minutes."

"After the poison takes effect, death will occur within 10 minutes at the earliest and 4-6 hours at the latest."

"That is to say, the absorption and distribution of drugs in the human body itself takes time. From oral administration of tetrodotoxin to onset of illness and death, based on current real-life cases, the shortest time is 20 minutes."

"And Mr. Yuda"

She turned her head and looked at the pale-faced Yuda coldly:

"You just said that it only takes about 10 minutes to serve this puffer fish hot pot to the table, right?"

"How could the patient become so ill that he was on the verge of death in such a short period of time?"

"I" Yuda was speechless for a moment, and his expression was extremely exciting:

He didn't expect that in such a simple time of serving food, the girl in front of him could see such a big flaw.

How could it be that just after the poison was administered, I could meet scientists who were researching this toxin when I went out?

What kind of luck is this!

If I had known this earlier, I would have taken action later.

Yuda suddenly fell into anxiety and uneasiness.

At this time, Miyano Shiho continued to say:

"Why did Mrs. Yuda get sick to the point of dying within 10 minutes, maybe even less than 10 minutes?"

"Although there is no evidence for saying this, I would like to guess."

"You should have used a syringe or something like that to inject tetrodotoxin directly into your wife's vein."

"Because when tetrodotoxin is taken orally, the first thing tetrodotoxin irritates is the gastrointestinal part that it comes into contact with first."

"In this way, immediately after the poison occurs, while the fingers and limbs are slightly paralyzed, there should also be symptoms of nausea and vomiting like you just did, Mr. Yuda."

"But Mrs. Yuda had already developed extremely severe generalized neuromuscular paralysis before she developed symptoms of nausea and vomiting."

"This shows that it is very likely that she did not take the toxin orally, but was injected with the toxin."

"The toxin directly enters the blood circulation system, so it first causes muscle paralysis throughout the body without causing nausea and vomiting."

By analyzing Mrs. Yuda's condition, Miyano Shiho roughly guessed Mr. Yuda's poisoning method:

"In this way, the onset of disease is faster and the fatality rate is higher. It can almost paralyze the muscles on the spot and lose the ability to move, and then die in just a few minutes."

"With this quick-acting administration method, you can safely pretend to be a victim of food poisoning and rush to call for help or an ambulance for your wife."

"Because you know very well-"

"If administered orally, there is still a good chance of being rescued."

"But the wife who was injected with tetrodotoxin by you through intravenous injection will not be able to survive for long before she is poisoned and is on the verge of death. She will not be able to wait for the ambulance to come."

"Using this method, you can ensure that your wife will not be rescued after being poisoned, and you can ensure that your conspiracy to kill your wife will succeed!"

Miyano Shiho finished describing this dark and heavy speculation in a cold tone.

Yuda gritted his teeth tightly. He could not refute Miyano Shiho's "malicious speculation". After holding it in for a long time, he could only yell in a stern voice:

"Are you kidding me that I poisoned my wife by injection, but I was also poisoned myself!"

"There must be poison in that puffer fish hot pot, otherwise you should take it for testing."

Yuda defended himself hysterically.

But Miyano Shiho's face remained calm:

"There is poison in the puffer fish hot pot, and there is no contradiction at all with you injecting tetrodotoxin into your wife."

"After all, you should have poisoned the puffer fish hotpot yourself."

"If you don't poison the food, how can you disguise this conspiracy to kill your wife as an accidental food poisoning?"

"As for you yourself being poisoned, that was because you wanted to make the illusion of 'food poisoning' more credible, so you controlled the dose carefully and controlled yourself to be slightly poisoned."

Yuda was silent for a while.

He gritted his teeth and refused to admit it:

"Nonsense! This is all just the conjecture of a little girl like you."

"After learning some nonsense, I just come out and talk nonsense."

"You said I killed my wife, do you have any evidence?!"

"evidence?"

As if he thought of something funny, the corners of Miyano Shiho's mouth raised in a playful arc:

"Have you forgotten that your wife is still alive?"

"I" Yuda suddenly choked violently.

Miyano Shiho continued to mock him:

"Your conspiracy to kill your wife is indeed very vicious."

"But it's a pity that you didn't expect that you would run into Lin Xinyi and me as soon as you went out."

"The two of us work together to save even 'dead people' who have no signs of life."

"Now, your wife may not die."

"Am I making random assumptions, or are you making malicious excuses? When your wife wakes up, she will know everything."