Auto chess in the operating room

Chapter 390 I'm Too Busy, I Can Only Have a Video Consultation

Soon came to the drug research and development laboratory of Jin's Group in Modu.

Under normal circumstances, drug development is very difficult, and the process of drug development is extremely complicated.

The drug research and development of King's Group, from the early stage of research and development to the launch of the drug, has such a long process that it can be arranged from the letter A to the letter H.

A, the first is basic research.This process is to start with patients, clinical pathology, and statistical data to find and verify potential targets.

Under normal circumstances, this step would take the developers several years of effort, but here in Tanglou, it can be completed directly.

B, Pharmacology and biomarker development.Including pharmacology and druggability studies of targets, biomarker studies related to targets and prognosis.

Tang Lou also directly skipped this step. Under normal circumstances, Jinshi Group's laboratory would have invested at least tens of millions of dollars, and it would even take several years to complete it.

C, Lead compound discovery.Lead compounds are compounds with certain biological activity obtained through various ways and means, and are usually obtained by in vitro screening for further structural modification and optimization.

This step would cost tens of millions of dollars in the Jin Group's laboratory, and the R&D personnel would need some luck to discover it.Tang Lou also completed this step in an instant.

D, lead compound optimization, preclinical candidate compound confirmation, preclinical research to support declaration, production and quality control (CMC).In this link, potential drug candidate molecules are screened out, systematic pharmacodynamic studies and toxicology studies are carried out, and samples used to support clinical research need to be produced under the conditions of quality management (GMP).

At this step, for the King Group, it is considered very lucky that two or three of the dozens of drug research and development projects can enter this step.

Often, at this point, hundreds of millions of research and development expenses have been spent, and it has taken several years.

Therefore, for researchers in the pharmaceutical laboratory, a doctoral student's research project in Tanglou completed the compound synthesis of the high blood pressure drug felodipine, and the sample of the small reagent was astonishing to them.

The more he understands the difficulty of new drug development, the more he understands the hardships Tang Lou has had to get to this point.

The person in charge of the new drug research and development laboratory, Dr. Gao Jiangang, greeted Tang Lou with great admiration.

"Dr. Tang, it took you less than a year to develop this small sample of felodipine?"

Dr. Gao still asked in disbelief. Previously, when Tang Lou first cheated reagents from the laboratory, Dr. Gao was very disgusted, and even thought that Jin Yuner must have been stunned by beauty.

However, when he actually saw the demo, he was completely confused.

Relying on so few reagents from the laboratory, the lead compound was successfully synthesized. Such a smooth and bizarre research and development process was unheard of even in his more than ten years of career.

Therefore, when seeing Tang Lou today, Dr. Gao must ask carefully.

"It took a month or so, if it's less than a year, that's right."

Tang Lou said something lightly.

Dr. Gao received confirmation that looking at the tenement building was like looking at a god.In less than a year, I feel like my security guard’s salary is less than [-] yuan. Three thousand a month is less than [-] yuan.

"He is truly a man favored by the God of Medicine."

Dr. Gao led Tang Lou: "Dr. Tang, after you provided the lead compound, we officially entered the clinical research."

Namely: E, clinical research.It mainly conducts clinical trials, including Phase I, Phase II, and Phase III clinical trials.Each phase has a different goal and a different scale.

Dr. Gao took Tang Lou to see the first phase of the Linchuan experiment they had completed.

"Dr. Tang, you see, the first phase of clinical trials is mainly for preliminary clinical pharmacology and human safety evaluation experiments. The laboratory has completed the human body's tolerance to new drugs and pharmacokinetics, providing a basis for formulating drug regimens." in accordance with."

"Under your guidance in the early stage, we greatly reduced the range of drug doses, and quickly obtained the relationship between drug doses and drug side effects. At the same time, we also clarified the drug's kinetic properties and The determination of metabolites and the metabolic pathway of drugs in the human body."

"The end result is exactly what you predicted earlier."

Dr. Gao looked at Tang Lou in disbelief, his eyes full of admiration.

"After that, we put the felodipine project at the top of all other projects and put it at the highest priority, and quickly started the second phase of clinical trials."

Dr. Gao, continue to show Tang Lou the data and various materials of their company's phase II clinical trial.

Due to the deduction in the system's laboratory, Tang Lou is very clear about this information and knows the correct data.

Therefore, there is no need for Dr. Gao's detailed explanation at all, and Tang Lou is even clearer than Dr. Gao on some summary statistical results.

After all, Dr. Gao relied entirely on the laboratory staff to compile and compile experimental data and obtain the final results.

And Tang Lou is the standard answer to look directly at, and there will always be some deviations in the artificial statistics of the laboratory.

"Dr. Tang, the phase II clinical trial is the preliminary evaluation stage of the therapeutic effect, and its purpose is to preliminarily evaluate the therapeutic effect and safety of the drug on patients with target indications. In this step, it is also necessary to determine the research design and administration of the Phase III clinical trial. Dosage plan. This time, I invite you here because I want to work out the plan for this Phase III experiment together."

"Here is my preliminary plan and data support, you can read it first."

Dr. Gao himself has a lot of research on statistics and data processing. After all, his second major is mathematics, especially in statistics.

Seeing Dr. Gao's data and plan, Tang Lou was also very impressed. Dr. Gao's plan was very close to the standard answer.

Tang Lou looked at it, and said admiringly: "Dr. Gao's skills are indeed profound, and this plan is basically feasible. In this way, give me a day tomorrow, and I will give you my suggestion."

"of course."

Dr. Gao was very much looking forward to his return, so he arranged a special office for Tang Lou.

In the laboratory, the rest of the colleagues are also very curious and looking forward to whether this Dr. Tang has real talents under his reputation.

Retreat for a day, study the experimental data, and propose a plan for the third phase. Just listening to it will make the blood of the laboratory staff boil. If they can really draw a conclusion, then this Dr. Tang will really make them worship.

The following day, Tang Lou was in the office, of course it was just to deceive others, after all, it would be too scary to give an answer at a glance.

Moreover, after thinking about it, Tang Lou just took advantage of this day to have a remote consultation with the Second Hospital of Harbin Medical University.

After all, Professor Liu invited him so sincerely. It would be too disrespectful to not even participate in the consultation.

In order not to affect the Tanglou, Dr. Gao arranged the largest and quietest room for the Tanglou. Of course, there are also various supporting facilities, and naturally there is no shortage of remote systems.

Tang Lou put away a bunch of materials, and wrote out the dosage plan for the third phase and the clinical trial plan for the third phase.

Firstly, several sets of data of Dr. Gao were corrected, and then random blind selection method was used to control clinical trials, and placebo and marketed drugs were added as controls.

Soon, a rigorous scientific and detailed plan was completed.

After doing all this, Tanglou looked at the time and saw that it was the time for consultation at the Second Hospital of Harbin Medical University.

However, in the consultation room of the Second Hospital of Harbin Medical University at this moment, the expert group also broke out.

"This Dr. Tang, is he reliable or not? Didn't he agree to come for a consultation today, who?"

"Doctor Tang got on that plane at all. I waited at the pick-up gate for a long time but didn't arrive, and I didn't get through on the phone."

Dr. Chen's face was full of grievances, but he was a little happy in his heart. If Tang Lou really didn't come, he would be the one to help.

Professor Liu also didn't expect that Dr. Tang would run away.

When he was depressed, his cell phone rang, it was Tang Lou's number, and Professor Liu connected immediately.

"Professor Liu, I'm sorry, I'm in the same situation as you were at Union Hospital. I also have an emergency here. I was supposed to go to the Second Hospital of Harbin Medical University this morning, but I was captured by Manager Jin of the Jin Group and taken back to the Magic City. , the guidance laboratory is carrying out the plan for the third phase of the Linchuan experiment. Therefore, today we can only participate in the consultation through remote video."

Professor Liu didn't expect Dr. Tang to be so difficult to deal with.

Moreover, he even led the research and development of a new drug, and even went to the third phase of clinical trials?

What kind of fairy operation is this.

Professor Liu smiled bitterly: "Okay, then I will arrange a remote video."

After Professor Liu hung up the phone and said that Tanglou wanted to participate in the consultation via remote video, everyone in the expert team exploded.

"This is too arrogant, no one comes, and direct video consultation?"

"That's right, they don't take us seriously."

"I believe that a young doctor like him can lead the research and development of new drugs, and even enter the third phase of clinical trials."

"Could it be that you are not confident about participating in the second heart transplant, so you simply dare not come here, and find a reason in the consultation to shirk it."

"It's very possible. After all, the difficulty and complexity of ordinary heart transplantation and second heart transplantation are worlds apart."

"Hey, he lost the chain at a critical moment. I really looked up to him before."

All of a sudden, the expert group had a lot of discussion about the remote video consultation in Tanglou, and they were very pessimistic.

(End of this chapter)