Auto chess in the operating room

Chapter 317

Without any hesitation, Tang Lou told Professor Liu about his idea of ​​developing a drug for high blood pressure.

After listening to Tang Lou's thoughts, Professor Liu was obviously a little surprised, and stared at Tang Lou seriously: "Tang Lou, your subject is a bit big."

In the tone, it is obvious that he does not believe that Tang Lou can complete such a grand project with his current ability.

"Professor Liu, of course I know how complicated the process of new drug development is, but I still want to give it a try."

The purpose of Tang Lou coming to Professor Liu's school was to develop new medicines. Of course, it was impossible to change his original intention, and he couldn't tell Professor Liu that he already had the technology to develop new medicines.

Seeing Tang Lou's insistence, Professor Liu smiled helplessly, and said, "Tang Lou, I can tell you responsibly that if your proposal is so ambitious, even if I pass it, the college will not accept it in the end. It may let you pass. After all, developing a new drug is not developing a new dish, there are too many things involved in it, and it needs enough financial support."

Of course, what Professor Liu said was true. If he hadn't known about Tang Lou's talent, a different student would have been kicked out by Professor Liu if he dared to set a subject like this. It was too unrealistic.

Professor Liu thought for a while and said to Tang Lou: "In this way, I will give you another week before you consider whether to change the subject. If you insist on trying, it is not impossible, but you have to find a way The experimental funds to solve this problem may be able to get those pharmaceutical companies to invest in your research and development in some way."

Professor Liu is very clear about the process of new drug development: "Tang Lou is not me hitting you, wait for you to get the basic research done first, understand the pharmacology and lead compounds before talking about the next details. Of course, the most important thing is that you have enough Financial support, otherwise everything is a castle in the air."

Tang Lou thought for a while: "Okay, Professor Liu, then I will give you an answer in a week."

"Okay, let's get here today first, I still have a meeting to hold, Tang Lou, you can go to the department this week, or you can concentrate on your opening report first. If you have any questions, you can contact Liu Qiqi."

After Liu Juzi took care of her, she asked Tang Lou and Liu Qiqi to leave her office.

Seeing Tang Lou's back, Liu Juzi rubbed the bridge of his nose, and sighed in his heart: This kid is really different from ordinary people.

All the way out, Liu Qiqi did not speak, but walked with Tang Lou for a while.

It wasn't until she bid farewell to Tang Lou that Liu Qiqi frowned slightly and sighed, hoping that this junior could retreat in spite of the difficulties.

After bidding farewell to Professor Liu and Liu Qiqi, Tang Lou went directly back to his dormitory. The dormitory for doctoral students in Zijingang Hospital is a single room, so it is very quiet to be alone.

Tang Lou directly entered the system space and opened the drug research and development laboratory for the first time.

The drug research and development laboratories in the system are no different from ordinary research laboratories. The only difference is that the raw materials and instruments in the laboratory are all virtual. Tang Lou only needs to think about it, and the relevant raw materials can be The instrument can appear, and Tang Lou tried it. In the laboratory, various chemical reactions and processes can be simulated at double speed.

Under the research and development technique of the antihypertensive drug CCB, countless knowledge appeared in Tang Lou's mind, CCB is calcium ion calcium antagonist.

There are several names of medicines in it: Nifedipine Controlled Release Tablets, Nifedipine Sustained Release Tablets, Nifedipine Tablets, Amlodipine Besylate Tablets, Levoamlodipine Besylate Tablets, Felodipine Sustained Release Tablets Tablets, Benidipine Tablets
Since it is still only a one-star level, only one of them can be developed. After looking at the profiles of several drugs, Tang Lou chose one of the felodipine sustained-release tablets as the first drug to be developed this time.

After Tang Lou finished the selection, the introduction of Felodipine Sustained Release Tablets appeared:
[Drug Name: Felodipine Sustained Release Tablets, a calcium channel blocker, used for hypertension, stable angina pectoris
Ingredients: The main ingredient of this product is felodipine.

Properties of finished medicine: Felodipine sustained-release tablet: film-coated tablet, white or off-white after removing the film coat.

Specifications: Felodipine sustained-release tablets: 2.5mg, 5mg
Usage and dosage: Oral, the dosage should be individualized.

The medicine should be swallowed with water in the morning, and the tablets should not be broken, crushed or chewed.

1、治疗高血压：建议以5mg一日1次作为开始治疗剂量，常用维持剂量为5或10mg，一日1次。可根据患者反应将剂量减少或增加，或加用其它降压药。剂量调整间隔一般不少于2周。对某些患者，如老年患者和肝功能损害的患者，2.5mg一日1次可能就足够。剂量超过10mg一日1次通常不需要。

2、治疗心绞痛：建议以5mg一日1次作为开始治疗剂量，常用维持剂量为5或10mg，一日1次。

3. Renal impairment: Renal impairment does not affect the blood concentration of felodipine.No dose adjustment is required.Patients with severe renal impairment should use this product with caution.

Clinical application and guidelines: insufficient level of drug development technology

Adverse reactions: need laboratory test verification
Contraindications: Insufficient level of drug research and development

Note: The level of drug research and development is not enough

Pharmacological effects: The level of drug research and development is not enough

Toxicological effect: the level of drug research and development is not enough

】

After reading it, Tang Lou was also speechless for a while. Sure enough, drug research and development is not an easy task.

Tang Lou looked at the main ingredients of Felodipine Sustained Release Tablets, and checked again:
【非洛地平：非氯地平;4-(2，3-二氯苯基)-1，4-二氢-2，6-二甲基-3，5-吡啶二羧基乙基甲基酯;4-(2，3-二氯苯基)-1，4-二氢-2，6-二甲基-3，5-吡啶二羧酸乙基甲基酯
Physical parameters: Density: 1.277g/cm3
Melting point: 142-145℃

Boiling point: 471.5°C at 760 mmHg
Flash point: 239°C
Vapor pressure: 4.62E-09mmHg at 25°C]

After reading it, Tang Lou felt dizzy for a while. If he researched it by himself, it would probably take more than ten years to make this compound alone.

Fortunately, Tang Lou has mastered fractional distillation, crystallization, various chromatographic techniques and other separation and purification methods under the one-star drug research and development technology.

Tang Lou began to try to prepare samples of felodipine in the system laboratory.

One by one, chemical equations and various preparation methods appeared in Naolou's mind, and countless chemical steps began to be sorted out automatically.

With a thought in Tang Lou's mind, various reagents and tools appeared on the laboratory table.

"Double speed!"

In front of Tang Lou, the process that originally took several days was shortened to a few seconds.

"Fractional distillation, double the speed!"

"Crystal, double speed!"

Tang Lou was completely immersed in the preparation of felodipine samples. In order to be able to prepare samples in reality, Tang Lou had to simulate all operations until he was fully proficient.

After a long time, Tang Lou finally mastered the synthesis route of the entire compound proficiently, and found the fastest way from many ways.

And in the virtual laboratory, under the condition of double speed, the main physical parameters are quickly measured.

After several attempts, Tang Lou was already very familiar with the synthesis route of felodipine, so he tried to synthesize it at a normal speed.

In the virtual laboratory, various instruments and reagents appeared continuously in Tang Lou's hands. With Tang Lou's concentration, finally a small tube of felodipine completely appeared in Tang Lou's hands.

Looking at the small dose of reagent in his hand, Tang Lou was very excited.

[Ding, a new achievement, the first tube of reagents was maturely prepared in the virtual laboratory.Reward: Animal Experiment Theory (3 star, [-])]

(End of this chapter)