From small clinic to medical empire

Chapter 258 Chimera

Chimera, in genetics, refers to an individual whose tissues or cells with different genetic material are chimerized with each other.

The Chinese name "Chimera" may be relatively unfamiliar to everyone, but when it comes to his English name, it must be familiar to those who have played Zhang Da's [-] in the Warcraft series.

That is Chimera, Chimera.

Chimera is a monster in ancient Greek mythology. Its original meaning is the Greek word "mother goat".

In "Homer's Epic" and later works of Greek mythology, it has become a dangerous monster, harming the world.

With the head of a lion, the body of a goat, and the tail of a boa constrictor, the Chimera is tyrannical and cunning.

It is worth mentioning that in the past ten years, a new English word has become very popular internationally.

That's Chinamerica.

This is a typical man-made word that splices China and America together, meaning the Sino-American union.

This term was born in the era of high integration between China and the United States. It was proposed by American scholars and was once talked about by the Chinese people.

Based on our simple and kind emotions, we take it for granted that this is a word that embodies the friendship between China and the United States and is an epitome of China and the United States joining forces to manage global affairs.

However, those who are familiar with the English context can see at a glance that the word Chinamerica has been inextricably linked with Chimera since its inception.

Whether it is pronunciation and spelling, or the incompatible but integrated reality of China and the United States, native English speakers will immediately think of that ancient legend.

A terrible evil that should not exist in the world.

Different from the simple vision of the Chinese people, Chinamerica has a strong negative color.

To a certain extent, it is not an exaggeration to say that it is stigmatizing because of the deep malice against the Chinese people who use overloaded labor to support the high-consumption world of the West.

Compared with chimera, in the Chinese context, the word chimera itself is very neutral, far more elegant than the word "hybrid" in "heterosis" in biology.

Of course, the difference between the two is also very big.

Hybrids are the offspring obtained by sexual reproduction of two different pure-line parents.

In essence, two different genotypes are compiled into a new set of genes through communication and integration.

Not so with chimeras.

There is no communication at the genetic level in chimera, but two living organisms are "mechanically" integrated together by splicing each other.

Most commonly, one of the fertilized embryos degenerates and is absorbed by the other early in twin development.

If the absorption is insufficient and incomplete, then what is often obtained is a chimera.

Generally speaking, the main genotype of the chimera occupies most of the body composition, while the chimeric genotype occupies only a small number of tissues.

They are so tiny in number that they are almost impossible to spot.

And if the twins were originally identical twins, there would be no difference.

Identical twins are two children who are genetically identical.

If they grow up smoothly, they will be two very similar people, but with different personalities.

But from a genetic perspective, they are actually the same person.

If they fit together, it is impossible to tell who is who.

Therefore, only when the fraternal twins, and the chimeric genotype happens to be chimeric in a relatively important position, can it be discovered.

The reproductive system is obviously a very important part.

……

To verify Yang Tingting's conjecture, the original DNA samples of Li Jiaxian, Li Miaomiao and his son are useless.

Because no matter how to expand the detected loci, at most it can only be verified that Li Jiaxian and Li Miaomiao have 1/4 autosomal homologous genes.

If the gene of Li Jiaxian's mother is not further tested, the possibility of the old man picking up ashes cannot be ruled out.

Because if the old man Li picks up the ashes and gives birth to Li Miaomiao, then Li Miaomiao and Li Jiaxian are half brothers, and 1/4 of the autosomal genes will also be homologous.

To further rule out this possibility, it is necessary to compare whether the autosomal gene of the old lady has homology with Li Miaomiao.

But this involves another possibility, that is, if Zhao Sirui is related to the old lady, it will cause interference...

In case Zhao Sirui is the old lady's illegitimate daughter, then...

All in all, such small-probability events as chimeric germ cells have occurred, and any possibility needs to be ruled out.

So starting from the child is really more troublesome.

The simplest, of course, is to compare the genotypes of Li Jiaxian's somatic cells and germ cells.

To put it simply, as long as it is confirmed that there is a genotype difference between the DNA of Li Jiaxian's somatic cells and the DNA of his sperm, then the truth will be revealed.

Since Haoran Hospital does not have an assisted reproductive center, it naturally does not have a professional semen collection room.

Fortunately, the fourth floor of the operating room is basically closed to the public, and the toilets are relatively clean.

Li Jiaxian walked in with the iPad in his hand, and handed the sample to the laboratory 3 minutes later with a look of embarrassment.

……

After spending a torturous night, Li Jiaxian's family was waiting at the door of the pathology laboratory early the next morning.

Zhang Zifan was pulled by Yang Tingting to continue eating melons.

After all, she was the first to propose the chimera hypothesis, and Yang Tingting was very curious about the final result.

Wang Jie communicated with the experimenter on the night shift, and soon came to the final conclusion.

Li Jiaxian's own hair follicles, oral epithelial cells, and sperm cell genotypes are not consistent, and they are close relatives.

"If I understand correctly... Miaomiao is really my brother's son?"

After listening to the doctor's explanation, Li Jiaxian was stunned.

He was actually green.

Being green by his brother who died more than 20 years ago...

And you can even say...

He was green by his penis!
Seeing the young man staring at his crotch, with Lin Pingzhi's and Yuezhangmen's tangled expressions before swinging their knives, Zhang Zifan quickly persuaded:

"Little brother, the external genitalia is just a part of the reproductive system. It is probably innocent. The culprit is the balls!"

Realizing that what he said still seemed to be suspected of instigating, Zhang Zifan hurriedly remedied: "On the good side, at least your wife really has a clear conscience, why don't you rush to make amends!"

Li Jiaxian was awakened by the words, and only then did he realize that the most wronged person in the whole incident was really not him who was cheated by his penis, but his beloved wife!
Being wronged by others, you can't argue with a hundred words, and you even have to bear the suspicion from your lover alone.

Zhao Sirui suffered a huge blow.

When Li Jiaxian thought of going to comfort his wife, she had already picked up the child and left angrily.

"Why are you still standing there, hurry up and chase after him!"

Zhang Zifan kicked Li Jiaxian on the buttocks, and the "Xinjin thug" on his chest became even more vivid.

At this time, the most embarrassing thing is the old couple.

At least Li Jiaxian never said anything bad to his wife, but the old lady beat people.

"Doctor...that child...Miaomiao..."

"Of course he is your grandson, both sociologically and biologically, 100%!"

Hearing Zhang Zifan's affirmative answer, the old lady let out a long sigh of relief, "I never thought there would be such a bizarre thing in the world...but Miaomiao is from the old Li's family, that's great!"

With that said, she and her husband left with a lot of gratitude.

Looking at the backs of the two old men leaving, Zhang Zifan shook his head helplessly.

From the beginning to the end, the old lady did not regard her daughter-in-law as her own, or, as the boxers said, she regarded other people's girls as tools to carry on the family line.

"So as the old saying goes, the right family is the most important thing, so why bother those girls who want to climb high!" Yang Tingting sighed while eating buns.

"Actually, Xiao Li is not bad. I think they are sincere. It's just a matter of a big family. Who can tell!" Zhang Zifan spread his hands helplessly.

"Then our Dean Zhang is also a big business! The little girl is a little scared!" Yang Tingting said half-jokingly.

"You! Don't always substitute yourself!"

Zhang Zifan smiled and scratched her nose, "Go to work quickly. Remember to come to my office at noon..."

"Hmph, you hateful capitalist, you're squeezing the bones! Both mentally and physically!"

Yang Tingting waved her paw viciously and left in a hurry.

……

Zhang Zifan started expert rounds at 8 o'clock as usual.

During this period, surgical patients increased significantly.

In addition to the concentrated occurrence of brain injury patients transferred from various hospitals in East China, there are also many severe patients with maxillofacial tumors.

This is because, at the Shanghai Annual Meeting, apart from the big names sitting in the first three rows, there are more young and middle-aged backbone doctors from various hospitals in East China.

Last year, both Zhang Zifan and Yang Tingting received invitation letters, and they were invited as young backbones.

And these people, who directly face patients, are the core force of medical care everywhere.

Haoran Hospital's strong surgical capabilities left a deep impression on them.

In particular, maxillofacial surgery and neurosurgery have been shocking for two consecutive years.

Therefore, when they encounter such difficult patients, they will subconsciously think of Haoran Hospital.

And they are more inclined to recommend Haoran Hospital than the big local hospitals.

After all, there is competition between hospitals in this city, but hospitals from other places, and they are private hospitals, have a far-reaching relationship with themselves.

This is not a scam patient. If Zhang Zifan or Yuan Qiang can get the name of two great experts, the level of treatment will definitely be above the top three in the city.

So when they push patients, they feel at ease.

This creates a strange phenomenon.

Or a continuation of a strange phenomenon.

That is, among the inpatients in Haoran Hospital, most of them are still from other places.

As we all know, the most complex language region in China is East China.

From Qilu to Hujian, the language is very different, not to mention the Zhejiang region where the pronunciation is different for ten miles.

Therefore, in the ward, local accents from all over the world came and went, and occasionally a few foreign words sounded, almost like a small exposition.

Of course, such an environment is actually not conducive to recuperation.

However, there is no way to take the path of public welfare medical care and lower some indicators to benefit the public.

When the second phase of the project is completed, Zhang Zifan may consider building a special needs inpatient department for patients who need to rest and those who are willing to pay high prices for services.

However, at present, the so-called VIP ward is actually just a single room, without a particularly superior hospitalization environment.

Currently, Zhang Zifan is directly responsible for seven patients.

Five patients with severe brain injury, one patient with maxillofacial rhabdomyosarcoma, and one patient with jaw teratoma.

Some of them have already undergone surgery and are waiting to recover.

Some have just been admitted to the hospital.

After a morning round, Zhang Zifan clarified the patient's condition again.

At 9:30, he came to the operating room to operate on patients with jaw teratoma.

Speaking of teratomas, this is a relatively common tumor.

In the early days when medicine was underdeveloped, this tumor was once considered a type of chimera.

Because benign teratomas have a highly differentiated tissue structure.

If Zhang Zifan were asked to select the most scalp-numbing tumor, he might have a difficult choice between teratoma and genital cauliflower tumor.

The so-called highly differentiated tissue structure refers to structures such as teeth, nails, hair, and even eyeballs.

Can you imagine removing a tumor and then cutting it open to find clumps of hair, a few teeth, and even an eye staring back at you?

This looks like a scene from a horror movie.

But in fact, trained doctors will not be afraid of these.

On the contrary, if these structures can be seen, the surgeon will show a satisfied and comfortable smile.

Because of the appearance of organs such as hair and teeth, it shows that the tumor is highly differentiated.

The higher the degree of differentiation, the less malignant the tumor is.

And these tissues are also differentiated from cancerous germ cells, not the original intention of the name "teratoma", but from swallowing other embryos.

The reason why this patient was handed over by Yuan Qiang to Zhang Zifan for surgery was naturally because of the difficulty of the operation.

Her teratoma was not in the usual abdominal cavity, but in the skull.

Moreover, based on physical examination and imaging data, it is suspected that the degree of differentiation is poor.

The results of the operation also proved Yuan Qiang's previous judgment that this was indeed a case of moderately differentiated teratoma.

In the tumor body, there are only inconspicuous tissue differentiations, which are generally diffused in the form of irregular mass.

Fortunately, the patient was treated in a timely manner. Zhang Zifan did a large-scale cleaning during the operation to ensure that the cancer did not metastasize.

As the reward reminder sounded in his ear, Zhang Zifan completed today's operation.

Looking at the time, it was already ten twenty.

Zhang Zifan decided to wash up, and then went to the construction site to have a look.

Zhang Zifan was rewarded with [Advanced Library] after spitting shit out of anger.

He has not directly built it, but plans to let the bald man of the construction team help him choose the site after the initial completion of the teaching building.

Again, professional things are left to professionals.

This bald man graduated from the Civil Engineering Department of Shanghai Jiaotong University and has dealt with the construction industry for nearly 20 years. He is right to listen to his opinion.

As for things like university town planning...

Zhang Zifan can only say that he tried his best.

After all, no one knows what the next building will be.

It seems that until now, the student cafeteria necessary for the university has not yet been found, but Zhang Zifan has already accumulated a pile of unnecessary architectural drawings such as [Junior Theater].

Zhang Zifan could only slowly complete it based on the general framework.

……

Coming out of the operating room, Zhang Zifan shook his hair and was about to go downstairs when suddenly the phone rang.

It was none other than Mr. Nie who hadn't contacted for a long time.

"Principal Zhang, the old man is here to disturb you again. I wonder if you have time tonight? The old man is preparing some beer at Shilinzhuang, and wants to invite Principal Zhang to have a get-together!"

Mr. Nie's angry voice came from the phone.

(End of this chapter)