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Chapter 97 Successful research and development
Chapter 97 Successful research and development
The information given by Tang Xiaochuan is very detailed. Qi Kai and other researchers in the R&D center do not need to look for the direction of research and development. The research direction has been clearly given in the information, and there are specific and detailed steps, but some detailed parameters still need to be carried out by them. Obtained trial after trial.
In the next ten days, Tang Xiaochuan mixed with Qi Kai and others, participated in their research, and everyone worked together. When the researchers encountered difficulties, Tang Xiaochuan, who was familiar with all the processes and details, sometimes had a big brain hole , provided them with ideas, which greatly accelerated the research progress. Many problems that originally took a lot of time to think about were immediately enlightened by Tang Xiaochuan.
In only twelve days, the new drug was synthesized, and the research center obtained all the relevant processes and various detailed parameters of its synthesis.
"That's it!" Qi Kai, wearing a white coat, mask and gloves, said to Tang Xiaochuan holding a glass tube.
Tang Xiaochuan leaned over and took a look. The liquid in the glass tube was green. "Start the test immediately to see if it is really effective against hepatitis B virus!"
"Okay, I will let the three groups proceed immediately!"
There were four people in a group, and Qi Kai asked two of them to take samples from the virus freezer and thaw them in the laboratory, and then culture them in petri dishes. After a period of time, wait for the virus to recover, and then use this new substance to try the effect .
Tang Xiaochuan did not leave, he has been waiting in the R&D center, for convenience, he also asked Qi Kai to set up an office in the R&D center, when Qi Kai and others were doing experiments, he was in the office of the R&D center to see the medical aspects book of.
Three hours later, Qi Kai rushed in and said, "Mr. Tang, it has worked. Within two hours, one-fifth of the virus in a unit was killed, and the replication speed of the virus was obviously not killed. The speed is fast, if according to this speed, with the dose of medicine injected just now, one unit of virus can be completely killed within three days!"
Tang Xiaochuan immediately said: "Separate experiments with different doses, gather all the people in the first, second, and third groups, and each person conducts experiments with different doses to obtain a large amount of data and parameters. You arrange and assign tasks to this matter." !"
After obtaining the accurate and detailed drug synthesis process technology and parameters, the subsequent synthesis becomes much easier. A test drug is synthesized, and then the virus test is carried out in an orderly manner.
A few days later, Qi Kai came to Tang Xiaochuan's office with a copy.
"Mr. Tang, look, this is the result of killing the virus with different doses. At this dose and within this dose range, the drug is effective against hepatitis B virus. If the dose is lower than this, the killing speed will not be able to keep up with the virus. Copy speed!"
"Looking at this dose again, if the dose is higher than this, there will be no obvious effect of increasing the anti-virus speed, because it takes time for the drug to kill the virus, and reaching this dose will reach a critical value. There are only so many drug molecules involved in killing the virus. Drugs are superfluous and wasted!"
Tang Xiaochuan looked at the data, nodded and said: "This is the data of in vitro experiments. Next, we will conduct animal experiments? Should we consider the resistance and rejection of drugs by animals' bodies and the decomposition and excretion of drugs by body organs?"
Qi Kai said: "Yes!"
Tang Xiaochuan thought for a while and said: "I think the research center needs to increase its manpower, otherwise your work tasks are too heavy, we need to increase the speed of drug research and development, apply for patents and manufacture the finished products as soon as possible, and then conduct clinical trials! So , You have to communicate with the personnel department in the past few days, and recruit some high-level researchers to come in and work!"
With the efforts of Qi Kai and the personnel department, high-level drug researchers were recruited one after another, which greatly enriched the R&D and testing capabilities of the R&D center.
In less than a month, the staff of the R&D center headed by Qi Kai produced satisfactory results.
"Mr. Tang, the good news is that monkeys, mice, cats, dogs and other animals with hepatitis B virus have all recovered after receiving our new drug treatment. It took [-] days, and through blood tests, it was found that there was no hepatitis B virus in their bodies! However... no antibodies were detected in their bodies!"
Tang Xiaochuan was taken aback: "Could it be that this drug also kills the antibodies? Or, will it kill other antibodies?"
"That's not true. After testing, we found that the other antibodies in these animals were not destroyed!"
Tang Xiaochuan breathed a sigh of relief, "That's good, immediately arrange manpower to configure the granular solid; prepare relevant materials, I will call a company high-level meeting to announce the news!"
"Okay, I'll make arrangements immediately!"
On this day, Tang Xiaochuan held a high-level meeting of Meihui Pharmaceutical, and announced that the company had developed a new drug, quintin, that could kill hepatitis B virus. Once the news was announced, Bai Shiju and others at the company's high-level meeting were in disbelief. How could this be possible?The R&D department of the company has such a strong research and development capability. You must know that this is a worldwide problem. So far, there is no drug in the world that has a specific effect on hepatitis B virus.
Bai Shiju said excitedly, "Mr. Tang, we must immediately apply for a patent and conduct clinical trials!"
Tang Xiaochuan nodded: "I have asked Director Qi of the R&D Center to arrange for scientific research personnel to start the configuration of solid state granules and pills! The next thing is to apply for patents and find a hospital for clinical trials. Mr. Bai has rich experience in this area. Experience, these things are left to you. The company is still in a state of huge losses, and the drug must be launched as soon as possible, so I hope you will try your best to shorten the time for patent application, production license approval, clinical trials, etc. time!"
Bai Shiju knew very well that no matter how hard he tried, no matter how well connected he was, the domestic regulatory measures were strict, and it would be difficult to market the drug in a short period of time. After all, this was a new drug, and the relevant government departments would not easily allow it to be marketed.
Bai Shiju said at this time: "Mr. Tang, you are also very clear about the domestic mechanism. It is not an easy matter to launch a new drug. We can try our best to shorten the time for patent approval. It can’t be done inside! See if this works. We have partners in Luzon, Tianzhu, and Siam. Their regulatory measures are relatively lax. When the patent application is approved, we will find hospitals in China to carry out the procedure. Clinical trials; on the other hand, directly find partners in countries such as Luzon, Siam, and Tianzhu to cooperate with them, authorize them to act as agents, and sell in these countries first, what do you think?"
Tang Xiaochuan thought about it, nodded and said: "Okay, let's do it like this!"
(End of this chapter)
The information given by Tang Xiaochuan is very detailed. Qi Kai and other researchers in the R&D center do not need to look for the direction of research and development. The research direction has been clearly given in the information, and there are specific and detailed steps, but some detailed parameters still need to be carried out by them. Obtained trial after trial.
In the next ten days, Tang Xiaochuan mixed with Qi Kai and others, participated in their research, and everyone worked together. When the researchers encountered difficulties, Tang Xiaochuan, who was familiar with all the processes and details, sometimes had a big brain hole , provided them with ideas, which greatly accelerated the research progress. Many problems that originally took a lot of time to think about were immediately enlightened by Tang Xiaochuan.
In only twelve days, the new drug was synthesized, and the research center obtained all the relevant processes and various detailed parameters of its synthesis.
"That's it!" Qi Kai, wearing a white coat, mask and gloves, said to Tang Xiaochuan holding a glass tube.
Tang Xiaochuan leaned over and took a look. The liquid in the glass tube was green. "Start the test immediately to see if it is really effective against hepatitis B virus!"
"Okay, I will let the three groups proceed immediately!"
There were four people in a group, and Qi Kai asked two of them to take samples from the virus freezer and thaw them in the laboratory, and then culture them in petri dishes. After a period of time, wait for the virus to recover, and then use this new substance to try the effect .
Tang Xiaochuan did not leave, he has been waiting in the R&D center, for convenience, he also asked Qi Kai to set up an office in the R&D center, when Qi Kai and others were doing experiments, he was in the office of the R&D center to see the medical aspects book of.
Three hours later, Qi Kai rushed in and said, "Mr. Tang, it has worked. Within two hours, one-fifth of the virus in a unit was killed, and the replication speed of the virus was obviously not killed. The speed is fast, if according to this speed, with the dose of medicine injected just now, one unit of virus can be completely killed within three days!"
Tang Xiaochuan immediately said: "Separate experiments with different doses, gather all the people in the first, second, and third groups, and each person conducts experiments with different doses to obtain a large amount of data and parameters. You arrange and assign tasks to this matter." !"
After obtaining the accurate and detailed drug synthesis process technology and parameters, the subsequent synthesis becomes much easier. A test drug is synthesized, and then the virus test is carried out in an orderly manner.
A few days later, Qi Kai came to Tang Xiaochuan's office with a copy.
"Mr. Tang, look, this is the result of killing the virus with different doses. At this dose and within this dose range, the drug is effective against hepatitis B virus. If the dose is lower than this, the killing speed will not be able to keep up with the virus. Copy speed!"
"Looking at this dose again, if the dose is higher than this, there will be no obvious effect of increasing the anti-virus speed, because it takes time for the drug to kill the virus, and reaching this dose will reach a critical value. There are only so many drug molecules involved in killing the virus. Drugs are superfluous and wasted!"
Tang Xiaochuan looked at the data, nodded and said: "This is the data of in vitro experiments. Next, we will conduct animal experiments? Should we consider the resistance and rejection of drugs by animals' bodies and the decomposition and excretion of drugs by body organs?"
Qi Kai said: "Yes!"
Tang Xiaochuan thought for a while and said: "I think the research center needs to increase its manpower, otherwise your work tasks are too heavy, we need to increase the speed of drug research and development, apply for patents and manufacture the finished products as soon as possible, and then conduct clinical trials! So , You have to communicate with the personnel department in the past few days, and recruit some high-level researchers to come in and work!"
With the efforts of Qi Kai and the personnel department, high-level drug researchers were recruited one after another, which greatly enriched the R&D and testing capabilities of the R&D center.
In less than a month, the staff of the R&D center headed by Qi Kai produced satisfactory results.
"Mr. Tang, the good news is that monkeys, mice, cats, dogs and other animals with hepatitis B virus have all recovered after receiving our new drug treatment. It took [-] days, and through blood tests, it was found that there was no hepatitis B virus in their bodies! However... no antibodies were detected in their bodies!"
Tang Xiaochuan was taken aback: "Could it be that this drug also kills the antibodies? Or, will it kill other antibodies?"
"That's not true. After testing, we found that the other antibodies in these animals were not destroyed!"
Tang Xiaochuan breathed a sigh of relief, "That's good, immediately arrange manpower to configure the granular solid; prepare relevant materials, I will call a company high-level meeting to announce the news!"
"Okay, I'll make arrangements immediately!"
On this day, Tang Xiaochuan held a high-level meeting of Meihui Pharmaceutical, and announced that the company had developed a new drug, quintin, that could kill hepatitis B virus. Once the news was announced, Bai Shiju and others at the company's high-level meeting were in disbelief. How could this be possible?The R&D department of the company has such a strong research and development capability. You must know that this is a worldwide problem. So far, there is no drug in the world that has a specific effect on hepatitis B virus.
Bai Shiju said excitedly, "Mr. Tang, we must immediately apply for a patent and conduct clinical trials!"
Tang Xiaochuan nodded: "I have asked Director Qi of the R&D Center to arrange for scientific research personnel to start the configuration of solid state granules and pills! The next thing is to apply for patents and find a hospital for clinical trials. Mr. Bai has rich experience in this area. Experience, these things are left to you. The company is still in a state of huge losses, and the drug must be launched as soon as possible, so I hope you will try your best to shorten the time for patent application, production license approval, clinical trials, etc. time!"
Bai Shiju knew very well that no matter how hard he tried, no matter how well connected he was, the domestic regulatory measures were strict, and it would be difficult to market the drug in a short period of time. After all, this was a new drug, and the relevant government departments would not easily allow it to be marketed.
Bai Shiju said at this time: "Mr. Tang, you are also very clear about the domestic mechanism. It is not an easy matter to launch a new drug. We can try our best to shorten the time for patent approval. It can’t be done inside! See if this works. We have partners in Luzon, Tianzhu, and Siam. Their regulatory measures are relatively lax. When the patent application is approved, we will find hospitals in China to carry out the procedure. Clinical trials; on the other hand, directly find partners in countries such as Luzon, Siam, and Tianzhu to cooperate with them, authorize them to act as agents, and sell in these countries first, what do you think?"
Tang Xiaochuan thought about it, nodded and said: "Okay, let's do it like this!"
(End of this chapter)
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