Signing from HK Comprehensive becomes a legend

Chapter 25 What Homework Should I Copy?
With Zhao Xueyan's current brainpower, recalling the various huge information chains he had received before crossing, he wanted to find a way to make a fortune in the current Hong Kong Island...

In fact, it is very simple. Is the business of A goods okay?At present, the society of Hong Kong Island is gradually becoming richer, and all kinds of famous brand clothes, women's bags, shoes, etc. are popular all over the world, but how many people can afford genuine products?

If you control a clothing factory and shoe factory to make A products, then the profit is almost gold and silver, but this is not suitable. This kind of business needs the support of the community, or it is almost a gold mountain that belongs to the community.

He is still on the way to clear his grievances, and it is too much trouble to make A goods, so he can't always get along with the clubs and gangs.

Aside from this idea, there are just as many ways to make money, or the famous Wanglaoji, herbal tea drinks?This is a century-old store, and it became famous in the late Qing Dynasty. It seems that the brand and formula are in the hands of Guangzhou Pharmaceutical Group.

The battle between the famous Wanglaoji and Jiaduobao in later generations is not the reason for the brand.

Now in 86, it will not be until 92 that Guangyao can produce boxed and canned herbal tea.

Choose Wanglaoji and go to the mainland to find Guangyao for business?This... how to solve the identity problem?

How about abandoning Wanglaoji and choosing Wahaha?How about Master Kong instant noodles?This is something that only emerged in the late 80s or 90s.

Fast food and beverages are all over the place.

Mineral water, black tea and green tea beverages, Jianlibao, etc., as long as you know how to advertise, such as sponsoring advertisements for the Asian Games, or if you are afraid of getting angry and drinking Wanglaoji, drinking Wahaha, eating is fragrant and other very smooth advertising slogans can be sung stand up.

It's really not that hard to create your first foundation.

The initial funds can be found in mahjong halls and casinos. It is said that he has easily collected more than [-] by small bets these times, which is a real record.

You must know that Wahaha Group is a school enterprise in normal history. In 1987, Boss Zong brought two retired teachers and borrowed more than [-] yuan to start a business. The output value exceeded [-] million yuan in just three years. The greatest convenience is accurate positioning and Ad bombing.

The hard part is that he doesn't have an ID card. He has a Stanley hukou on Hong Kong Island, but when he returns to the mainland... he is a bigger black household!

After thinking about it, Zhao Xueyan felt that he was a little tragic at the moment.

"There are various ways to make money. Whether it is fast money or slow money, I have a lot of attention in my mind, but if the identity problem is not solved, how do I get started?"

"Even if I want to overtake from my old corner, it's super troublesome."

What is Zhao Xueyan's old business?In fact, it was medicine. Before he crossed over, he was a sophomore at Huaxia Pharmaceutical University.

You ask him to develop a new drug from scratch, of course, it's nonsense, he can't overtake him in a corner, and when it comes to the blockbuster drugs in the history of the pharmaceutical industry, the name Humira cannot be avoided.

Its Chinese name is adalimumab, or Humira.

这个重磅炸弹牛在哪里？穿越前那个时代，2018年一年全球销售199亿美刀，19年196亿美刀，2020年前三个季度146亿刀。

Since it was listed on the Bald Eagle in 2002, it will easily sprint to the cumulative sales of 2020 billion knives by 2000.

His profession is there, and he is familiar with all kinds of knowledge points about the world's best-selling blockbuster Humira.

Humira is specially used to treat rheumatoid arthritis. Before the advent of Humira, countless rheumatologists around the world were helpless about the erosion of human joints by the disease.

In the 20s, there was a drug, cortisone and other steroid hormones, which had amazing curative effects in the treatment of rheumatoid arthritis. However, during the carnival of countless patients, nightmares followed. Osteoporosis, diabetes and other serious hormone effects.

Those side effects are even scarier than rheumatoid arthritis alone!
Cortisone and so on withdrew from the stage of history.

In the 67s, a new NSAID drug was born, which once again brought a carnival to patients with rheumatoid arthritis, but the side effects such as kidney failure and gastrointestinal damage once again crushed the dreams of countless people.

Until the early 80s, when Mark Feldman, an immunologist in Kangaroo Country, was studying a disease that causes hyperthyroidism, he found that some thyroid cells would overexpress a type of molecule that can activate the immune response. Behind it is the stimulation of cytokines.

Mark Feldman put forward a bold hypothesis, and it may be cytokines that trigger autoimmune diseases.

In order to test this idea, Feldman searched for patient tissue in various ways. He couldn’t find enough diseased tissue in hyperthyroid patients, so he searched from other patients with similar diseases, and then he found rheumatoid arthritis patients.

Because of this inexorable disease, doctors and specialists often remove diseased tissue directly from patients to relieve the patient's symptoms.

Feldman led the research team to confirm that a large number of pro-inflammatory cytokines appear in the joints of rheumatoid arthritis patients. When these factors appear, the patient's immune regulation mechanism is out of control.

From this principle, Feldman and his research team began to study the way to treat rheumatoid arthritis. Animal studies have shown that IL-1 is the potential cause of rheumatoid arthritis. Then, which cytokine promotes rheumatoid arthritis? IL-1 issued?

If we can find and inhibit this cytokine, wouldn't it be equivalent to restraining IL-1 and restraining the patient's condition?

The outside world is not optimistic about the therapeutic potential of targeting a single cytokine, but Feldman and other professionals finally proved that as long as he can cultivate TNF-α antibodies that inhibit various cytokines, he can almost completely inhibit the Production of IL-1.

Blocking TNF-α with TNF-α antibody can greatly relieve the symptoms and condition of rheumatoid arthritis.

In terms of animal experiments, this new drug went well. It was very good to inject TNF-α antibodies into sick mice. The only problem is that the antibodies from mice are not suitable for humans, and there are many side effects.

Until the early 90s, the human-mouse chimeric antibodies developed by many companies had mediocre therapeutic effects.

It was not until the birth of the fully human TNF-α antibody that the finished product, Humira.

Benefit countless rheumatoid arthritis patients around the world.

In the late 21s, Humira was a blockbuster in the medical world!
It is now 86, and Mark Feldman's bold hypothesis has long been established. He may have also developed TNF-α antibodies in sick mice, but he is troubled by the fact that the antibodies in mice are not suitable for humans.

The birth of fully human TNF-α is closely related to phage display technology in the biomedical field.

In 1985, Professor Smith pioneered the phage display technology, and with this technology, won the 2018 Nobel Prize in Chemistry.

In the 20s, after Professor Winter optimized multiple processes of phage display, he successfully obtained a fully humanized antibody from mouse TNF-α antibody.

This also involves the isolation technology of the genes encoding the variable regions of human antibodies.

This fully human antibody was named D2E7.

This is Hummel!

Now in 86, the TNF-α antibody should already have a sick mouse version, as well as the phage display technology pioneered by Smith. As long as you learn from Professor Winter and optimize multiple processes for many times, you can get Humira.

Global listing, the cumulative sales of hundreds of billions of dollars in the next ten years, and in the evaluation of the global pharmaceutical industry, it will become a new generation of global medicine king.

If relying on his explosive brainpower to copy the achievements of Professor Winter, Zhao Xueyan is the medicine god of rheumatoid arthritis patients all over the world!

(End of this chapter)