godfather of surgery

Chapter 1057 Accident
The independent ward is a newly opened ward of the Surgical Research Institute. It was originally used as an ICU to support the Surgical Research Institute. It is fully equipped with various equipment, all of which are world-leading medical equipment. It’s just that the staff are not in place yet, so this ICU has not been put into use yet.

Now, because of Sisi's experiment, Yang Ping selected the doctors and nurses who participated in the experiment to move into this ward, which is equivalent to an ICU with elite medical staff. Sisi is the only patient, and Yang Ping is the attending doctor.

Sisi was lying in the ward. She suffered cardiac arrest during the third experiment. Her heart was extremely weak after being rescued. The tumor in her brain seemed to have broken through the critical line, causing her heart to beat weakly. The two combined made her heart extremely weak. She can only rely on ECMO to maintain her life and cannot be taken off the machine for the time being.

With the support of ECMO, Sisi remained somewhat lucid. Yang Ping asked the nurse to place her cactus in the corner beside the bed to keep her company. Her parents saw their daughter at this time through the glass every day. Although they had prepared themselves mentally, they still felt heartbroken.

Yang Ping stood beside Sisi's bed and smiled at her: "Can you still hold on? We will win soon."

Sisi stretched out a hand and clenched her fist, touching Yang Ping's fist. A smile appeared on her pale and dry lips: "Have you done what I asked you to do?"

That thing?

It's about body donation.

Yang Ping did not give a direct answer: "You have to ask me first. If I don't agree, then it can't be done."

"What's wrong?" Sisi said weakly. The sound of machines running could be heard beside the bed.

"I didn't agree, so how could you have a chance? Don't worry, nothing I agree to will happen." Yang Ping grabbed Sisi's hand, his tone firm and unquestionable. The little girl's hands were very cold. He turned his head to check her blood pressure, which was within the normal range.

"I believe you. I see the strong confidence in your eyes, just like the first time I saw you. This feeling can make everyone believe in you, and this look can heal everything." Sisi said calmly.

Yang Ping smoothed her hair that was floating on her forehead and said, "That's right. You have to trust your teacher. I told you to study medicine with me, and I will definitely do it. Come on."

Sisi nodded.

Song Zimo next to him said, "Do you want to use a sedative?"

When using ECMO, even if the patient is awake, she will usually be injected with some sedatives to put her into a sleeping state. This makes care easier, reduces her energy consumption, and reduces her irritability and fear.

Yang Ping nodded and decided to let the little girl sleep, which would reduce a lot of psychological pain.

After coming out of the ward, Yang Ping saw Dean Xia and Director Han in the doctor's office. They were also very concerned about Sisi's condition.

"Are you okay?" Dean Xia, who was waiting for Yang Ping, stood up from his chair, held Yang Ping's hand and patted his shoulder.

Yang Ping looked a little haggard: "It's OK. There is no problem with ECMO now, but it is difficult to get off the machine."

"We won't go in to see Sisi for fear of disturbing her rest. If you need our help in coordination, just let me know. If you need staff from other departments, just tell me directly," said Director Han.

Yang Ping nodded: "I will tell you in time if there is any need."

Dean Xia and Director Han just came to express their importance of this experiment. They did not dare to stay for long for fear of affecting everyone's normal work. After learning about Sisi's condition for a few minutes, they quickly evacuated.
-
The fourth experiment is about to begin. This time Yang Ping will take part in it personally. He wants to experience for himself what it feels like after the K virus is injected into the human body. Except for Song Zimo, Xu Zhiliang, and the doctors and nurses participating in the experiment, no one else knows about this for the time being. Yang Ping does not want to worry others.

If the news leaked out, Dean Xia would definitely not agree to it. Given his style, he would not think it was a big deal even if Yang Ping demolished the Sanbo Hospital. But if Yang Ping took the risk of injecting the virus himself, he would definitely not agree to it no matter what, and would probably ask the security guards to tie Yang Ping up.

I also said hello to Yang Ping at home, telling him that he would be staying in the independent ward to do experiments this week and would not be going back, and sometimes I might not be able to get through to him by phone.

Yang Ping believes that after the fourth modification of the K virus, this is the best configuration and it must have found a balance between safety and effectiveness.

Professor Zhang Zhiwei, who delivered the virus preparation, was stopped by the security guard at the door and was not allowed to enter the ward. He was very puzzled as he was able to enter the ward several times before, but the security guards did not know the reason either, they were just following orders.

Professor Zhang heard that the girl doing the experiment was admitted to the ICU and was in critical condition, relying on ECMO to maintain her life. The girl might be in danger of death after the fourth experiment, so other personnel were not allowed to enter the ward to witness the tragedy. Professor Zhang Zhiwei did not continue to inquire, and went back after delivering the virus preparation.

Yang Ping was lying on the hospital bed alone, with Song Zimo, Xu Zhiliang and Xia Shu beside him. The nurse's hand holding the syringe was shaking a little, and she didn't know whether to give the injection or not.

"Don't be afraid, just give me the injection!" Yang Ping encouraged the nurse.

The nurse was nervous, but she mustered up the courage to slowly inject the virus into Yang Ping's blood vessels. Everything was calm and nothing happened.

While Yang Ping was expressing his feelings, Song Zimo was taking notes. He did not feel any discomfort at the moment.

Half an hour later, Yang Ping began to feel hot. The nurse quickly took his temperature and found that Yang Ping began to have a low fever. The nurse measured her temperature every half an hour. In order to ensure the accuracy of the data, in addition to measuring the ear temperature with an ear thermometer, she also used a primitive mercury thermometer to measure the armpit temperature.

Yang Ping's body temperature was gradually rising, about one degree every two hours. By evening, his temperature had risen to 42 degrees, and sometimes even exceeded 42 degrees.

Under the high fever, Yang Ping's whole body was shivering with chills, feeling extremely uncomfortable, as if his body was being torn apart and reassembled. In a daze, he felt that his body was suddenly very large, and then very small, like a balloon that was shrinking. Now he understood how strong the will of this little girl Sisi was.

Although he was dazed, Yang Ping still maintained a vague consciousness and was not completely unconscious.

With a high fever, his heart rate also began to speed up. In fact, a fast heart rate is the most dangerous, and the heart can easily collapse under high load. Various instruments, including ECMO, were ready to save lives at any time. Song Zimo, Xu Zhiliang, and Xia Shu were all standing by. They took turns on duty and guarded the bed 24 hours a day.

The high fever lasted for 3 days and then slowly began to subside. During the whole process, Yang Ping was not completely unconscious. Even at the most serious time, he still had a hint of consciousness, but it was a vague consciousness.

Blood was drawn three times a day and sent to the Virology Laboratory of Nandu Medical University for examination, but they called to ask: Is there any problem with the experiment? Is there any error in the procedure? Why didn't the virus titer gradually decrease, but gradually increased, then decreased, and finally maintained at a level?

This is totally against common sense. The injected virus is a virus that cannot replicate. If one dies, there is one less virus. Logically, after three days of immune resistance, there should be very few viruses left. This was the case in the first three experiments.

Why does this virus titer change curve look like a live virus that can replicate?
To confirm, the nurse drew several more tubes of blood from Yang Ping. To prevent any problems along the way, Lu Xiaolu and two doctors were sent to deliver the blood samples.

The test results surprised Yang Ping and all the people involved in the experiment. The virus was not eliminated by the immune system, and its number increased. Could it be that it successfully replicated in the body? How could it be possible? The virus had its replication gene knocked out.

In order to solve the mystery, Professor Zhang Zhiwei immediately sent the virus to the genetics laboratory for gene sequencing.

Indeed, the genetic sequence of the virus is actually complete, that is, the replication genes that were knocked out have been replenished. This is impossible and violates the current laws of biology.

This result made Yang Ping very puzzled. There are two possibilities. One is that the virus may really repair itself in the body and restore the replication genes. The second possibility is that during the culture process, K viruses whose genes were not knocked out were mixed into the virus sample. These viruses have the ability to replicate. Other castrated viruses have died under the attack of the immune system, but these viruses not only survived through replication, but also proliferated in large numbers.

I didn't expect such an accident to happen in this experiment. As for the cause, it cannot be found out for the time being. The most urgent task now is to eliminate the virus in Yang Ping's body, otherwise it will definitely be a big trouble.

Read more latest popular novels at 6.9*shuba!

The experimental team became anxious. Yang Ping was now carrying the virus, which was equivalent to being infected with a new viral disease. If the immune system could not eliminate the virus, it would remain in the body for life.

However, what puzzled Yang Ping was that these viruses had no reaction in his body. Could it be that they coexisted with his own immune system?

With this question in mind, Yang Ping asked the nurse to draw blood from him again, and then took the sample to the virus laboratory of Nandu Medical University for observation. He did not dare to leave the isolation ward of the independent ward. At present, he did not know whether the virus in his body was contagious. If it was contagious, how it was transmitted. Until the virus laboratory could not reach a conclusion, Yang Ping could only be isolated.

Soon, the analysis conclusion from the virus laboratory came out that the virus was not contagious because it was very fragile and died within seconds of being separated from human blood and body fluids. It could not survive in an in vitro environment, including the air.

This at least makes Yang Ping feel more at ease. If it is not contagious, then at least it will not pose a danger to others, and the danger will only be to himself.

There is also a very special phenomenon. When the viruses taken out of Yang Ping's body are cultured in vitro, the K factor will be shed in the second generation of viruses, that is, they will become ordinary viruses and no longer have the function of K virus.

Professor Zhang Zhiwei believes that the K virus in Yang Ping's body has now mutated and has become an independent species that can only survive for a long time in Yang Ping's body.

In order to verify this conclusion, Professor Zhang Zhiwei decided to conduct some experiments using experimental monkeys. He drew blood containing the virus from Yang Ping and injected it directly into the monkeys. These viruses miraculously lost their ability to replicate in the monkeys' bodies and were slowly killed by the immune system.

These viruses can only survive in Yang Ping's body. Could it be that they have reached some kind of tacit understanding with Yang Ping's immune system? This is a side issue arising from the experiment. Not only Yang Ping himself is interested in it, but Professor Zhang Zhiwei is also interested in it.

In order to verify whether this accident was replicable, Professor Zhang Zhiwei conducted experiments on monkeys. Without exception, these viruses had no reaction in the monkeys' bodies and all died, even those whose replication genes were not knocked out.

It seems that Yang Ping was right to enter the clinical trial directly, because the monkey's immune system is completely different from the human immune system. Especially in the process of evolution, the viruses that humans come into contact with are completely different from the viruses that monkeys come into contact with in the jungle. This determines that humans and monkeys have completely different reactions when facing some new viruses.

The virus in Yang Ping's body is most likely caused by a mutation with an extremely low probability. If it is a mutation, it would be impossible to replicate such a low-probability event.

Professor Zhang Zhiwei also showed great interest in the virus in Yang Ping's body. In fact, many major scientific research in history were produced from unexpected events. For example, the creation of penicillin was somewhat accidental.

Since the virus in his body is not contagious and has not caused any negative impact on him for the time being, Yang Ping is not too worried for the time being. He will slowly study ways to eliminate it when he has time later.

Since he hadn't been home for a few days, he called Xiao Su to let her know he was safe.

Yang Ping now really wants to study what would happen if the virus in his body was injected into another person. From a speculative point of view, there should no longer be a fierce immune confrontation and it should be compatible with the human immune system.

But there are also risks. These viruses will remain in the body, and we don’t know what negative effects they will have.

"How about I give it a try?" Professor Zhang Zhiwei was eager to try, because these viruses, whether theoretically or clinically verified, will cause high fever, but will not be life-threatening. Now the two volunteers participating in the experiment are safe and sound, and even Yang Ping looks in good spirits.

"You can try it if you want."

After personal experience, Yang Ping is now very confident about the nature of this virus and is confident that nothing serious will happen.

Mr. Li Ke, a once famous traditional Chinese medicine doctor, was very good at using the traditional Chinese medicine aconite to treat difficult and complicated diseases. Aconite is a toxic traditional Chinese medicine. Most doctors dare not use it casually, let alone in large quantities, but Mr. Li dared. He used aconite to cure many difficult and complicated diseases.

Why did he dare to do that? Because he had once tested poison on himself, taking aconite personally to see what the reaction would be after taking a certain amount of aconite. In this way, he thoroughly understood the characteristics of aconite through his own poison testing and was able to use it with ease.

On the premise of ensuring a certain level of safety, Yang Ping agreed to let Professor Zhang Zhiwei give it a try.

PS: The last chapter was a bit messy, and this chapter is not very good either, but I will slowly recover later, thank you! It won't be finished so soon, there are still a few major events that have not been written.