I can see the status bar

Chapter 744
Sun Lien's theory is very convincing, but the other doctors in the treatment group were surprised to find after careful consideration... Sun Lien's sudden statement is actually very credible.

Insufficient expression of AQP4 protein perfectly explained Tang Min's symptoms, and it also fully complied with the diagnostic aesthetics of "single cause".Coupled with Sun Lien's explanation - the insufficient expression of AQP4 protein seems to be the only hypothesis that can cover all doubts.

But...it's still a hypothesis.

"I've never heard of this genetic disease..." Zhou Ce seems to be positioning himself today as a role of throwing cold water.He shook his head and asked Brunn and Yuan Pingan, "Have you heard of it?"

"No." Zhou Ce's question was answered in the negative.Neither Dr. Brunn nor Yuan Ping'an have ever heard that insufficient expression of AQP4 protein can directly cause disease.And Xu Yourong said, "I even think... this may be a newly discovered disease."

"Isn't it?" Sun Lien felt flustered for no reason. He quickly took out his phone, opened PUBMED and started searching for relevant reports. After a long time, he raised his head and said with a guilty face, "Er...it seems that there is no such thing."

"There is no relevant report in the Chinese literature." Yuan Ping'an and Sun Li'en came to the conclusion almost at the same time.He glanced at Sun Lien in surprise, and then sighed sincerely, "It's really you..."

"You are definitely not praising my ability to diagnose." Sun Li'en countered with unceremonious white eyes for this exclamation.Then he refocused on Tang Min's condition, "The case report and the like can be put aside later, we still have to find a way to confirm the diagnosis and find a feasible treatment plan."

"Proving the diagnosis...it's difficult." Xu Yourong thought for a while, then shook his head, "You can't biopsy the edema area again, and then check the concentration of AQP4mrna in the sample, right?"

"If she really has insufficient expression of AQP4 protein, then the biopsy will cause too much damage to her." Sun Lien rejected the biopsy proposal almost as soon as it was proposed.The previous two biopsies had already caused almost irreparable damage to Tang Min, and now there is a more likely direction of diagnosis, but the plan to confirm the diagnosis is to biopsy again knowing that the sequelae of the biopsy are relatively large... This It's really unreasonable.

"I'll check the information again." When everyone was at a loss, Yuan Pingan took the initiative to stand up. "The AQP protein is a discovery of the Nobel Prize level, and there will definitely be no shortage of related research in the future. I am good at looking up information."

"When you check the information...you'd better stop by to see if there is any possible treatment method." Since Yuan Pingan volunteered to check the information, Sun Lien naturally put in other things that may need to check the information to find a solution. on his head. "The matter of inspection... I will also think of a way."

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Of course, Sun Li'en is not a fairy. Under the current circumstances, to directly confirm the insufficient expression of AQP4 protein in Tang Min's central nervous system, it can only be confirmed through a biopsy.Wanting to bypass the biopsy and get solid evidence right away is a completely impossible job.

But... there is no direct solution, but it does not mean that there is no tricky solution.Sun Li'en took out his phone confidently, and dialed a number to go out.

"Teacher Sun." The phone rang three times, and a woman's voice quickly rang out from the other end of the phone, "Hello."

"Hello, Qian Gong." Sun Lien spoke in a very polite tone. He first explained the reason for his sudden call, "Qian Gong, I would like to ask how long it would take to determine the gene on a single sequence. ?”

"Are you saying that you want to stop the full-sequence sequencing that is going on now?" Ms. Qian who answered the phone was the employee of the company entrusted by Sun Lien to carry out the full-sequence sequencing of the gene.She was a little confused, "The full sequence sequencing has already started, this...it's not easy to stop."

"The original full-sequence sequencing continues. I would like to ask, is the sample you keep there enough for another specific sequence sequencing?" Sun Lien guessed that the other party might think that he wanted to stop the test and not pay any money. So he quickly explained, "I have a new testing requirement here."

"Uh, if you want to measure a specific sequence...the samples are enough." Ms. Qian is also a smart person, and she quickly understood what Sun Lien meant.In actual operation, such a requirement is even simpler - there is no need to take any special samples, the original whole genome sequencing is the result one by one.If Sun Li'en needs it, they just need to adjust the order of testing.

“那就帮我先测一下……” AQP4的人类基因定位于常染色体18q11.2与q12.1之间的连接处，由4个外显子组成，它们分别编码127、55、27、92位氨基酸序列，其间有3个内含子，其长度分别为0.8、0.3、和5.2PB。如果唐敏的AQP4蛋白表达不足，那么这四个氨基酸序列就肯定会有异常。孙立恩磕磕绊绊的表达了自己需要检测的单位后问道，“这个大概多久能出结果、”

"Mr. Sun, if you are in a hurry..." Ms. Qian communicated with her colleagues for a while, and then gave the shortest time limit they could do, "The results will be available before get off work today. But a formal report is required. If it is a paper report, it will have to wait until tomorrow morning."

"No problem." Sun Lien was overjoyed, "Then I'll leave it to you."

These days, except for those giant-level bioengineering companies, most sequencing companies are struggling.Universities and scientific research institutions have the greatest demand for the service of gene sequencing.And most of these places can do their own sequencing—nothing more than maybe inexperienced graduate students doing the sequencing.

But the biggest advantage of letting graduate students do sequencing is that it is cheap—isn’t graduate students the free labor of professors and associate professors?If the sequencing results of the subject project are not too urgent, and the project team's own funds are relatively tight, it is even more impossible to entrust a sequencing company to do it.

But...if we can get the order from the hospital, maybe the company will change from the current "seriously underutilized" to "everyone dies from overwork".For these "professional experimenters" who work in sequencing companies, that is real happiness.

Without enough workload, the company can't even pay wages stably.For a young sequencing company, this is a matter of life and death.

After hanging up the phone, Sun Lien heard a little girl's crisp voice coming from the corridor outside the office.

"Little rabbit, be good, open the door..."

(End of this chapter)