I just want to be a quiet scholar
Chapter 705 Very Reliable
Chapter 705 Very Reliable
Five experimenters entered the observation phase.
Five groups of rats were numbered as Han Meng group, Cui Hualin group, Tang Yaxing group, Du Yuan group and Wu Junqiang group, half of which were male and half male.
Miracle did not happen for a while, but tragedy happened soon.
After the anesthesia effect of the rats in the Du Yuan group ended, they died one after another within a day.
The experimental record is:
Mouse No. 1 in the Du Yuan group died at 12:42 due to intracranial hemorrhage.
Mouse No. 2 in the Du Yuan group died at 12:43 due to intracranial hemorrhage.
……
Mouse No. 10 in the Du Yuan group died at 12:51 due to intracranial hemorrhage.
To be precise, the 10 experimental mice in Du Yuan's group died one after another within 10 minutes, with an average of one dying per minute.
The cause of death was the same, both were due to intracranial hemorrhage.
"Hey, I failed." Du Yuan was so annoyed that his experimental plan proved to be a complete failure. Ten of his friends died suddenly and died in the laboratory before they had time to take the IQ test.
Du Yuan could only be annoyed for 1 minute. He had to race against time to dissect the 10 dead experimental mice. The main work content was to dissect and analyze the brain tissue of the experimental mice, sum up experience and lessons, and accumulate valuable data for the next experimental design.
Gene-editing experiments on living organisms do have risks.
Du Yuan just modified a gene of the experimental mice, which led to the annihilation of his experimental mice in a very short time.
"Brother, don't be discouraged, failure is the mother of success." Han Meng comforted Du Yuan, and he added: "You should sort out the analysis report of your experimental data as soon as possible, and give your conclusion, in the end it is homologous recombination. Is there a problem with the editing method, or is there a problem with your path selection based on this method? We can only take the exclusion method now, and try one by one until we find the relatively correct method and specific path.”
While Du Yuan summed up his experience and lessons, the other four experimenters continued to observe the rats in their group.
Soon after, Shen Qi joined the observers. He noticed that the rats in Cui Hualin's group became very manic. The rats in this group saw whoever bit someone, and bit the same kind if they couldn't bite, and bit the cage if they couldn't bite the same kind. metal net.
"Squeak!"
The rats in Cui Hualin's group bared their teeth and grinned hideously. Now they don't like fresh fruits and vegetables, they just want to bite live things.
"Hey, I failed." Cui Hualin sighed. His little friend was so crazy after gene editing that he couldn't take an IQ test at all.The craziest rat bit off its own front foot.
The smell of blood drove the rat crazy, slamming against the metal mesh, trying to break through the cage to bite the living creatures outside the cage.
Shen Qi patted Cui Hualin on the shoulder: "Extract living cells, preserve brain tissue, and then execute them."
"Director Shen, why don't we observe it for a while?" Cui Hualin was unwilling to fail like this, and he still had a glimmer of hope.
Shen Qi shook his head: "No need to continue to observe, all the experimental mice in your group will be executed. I want to see their raw data. Unexpectedly, the modification of their SHANK3 gene affects their neurons. This effect It's irreversible, and they're probably going to get even crazier."
"Okay..." Cui Hualin executed his friend with tears in his eyes.
Before being executed, Cui Hualin first used atomization anesthesia to stun his little friend, extract living cells, and then execute them by dislocation, dissection, and preservation of various organs and brain tissues.
There is no good news, and bad news comes one after another.
The rats in the Tang Yaxing group did not show crazy aggressiveness, but they became extremely autistic. They curled up in the corner of the cage motionless, like a stationary mouse with hair.
"Your group of autistic experimental mice cannot carry out follow-up experiments. Extract living cells and brain tissue for preservation, and then put them to death. I want to see their raw data." Shen Qi gave an order.
"It's a pity, it's a pity." Tang Yaxing shook his head and sighed, then executed his little friend.
At present, one group of rats died due to their own reasons, and the other two groups of rats with abnormal behavior were killed by the experimenter.
The progress of human science is inseparable from the contributions made by these experimental animals.
Scientific research continues, and the rats continue to contribute to the advancement of human science throughout their short lives.
After observation and various physical examinations, the experimental mice in the Hanmeng group and Wu Junqiang's group were temporarily normal in terms of physical indicators and animal behavior, and could be tested by T-maze.
I don't know if it's good news or bad news, but the T-maze test scores of the experimental mice in Wu Junqiang's group were the same as before.
This group of rats encountered a T-shaped junction in the T-maze, and their choice was always to go to the right.
Most rodents have the characteristic of one-way preference, and the Wistar rats selected by Shen Qi's team prefer rightward.
The T maze route designed by Wu Junqiang is eighteen right and one left.
Wistar rats continued to the right for 18 times and then left once to get out of the maze, thereby obtaining the food placed at the exit of the maze.
The spatial learning ability of the rats in the Wu Junqiang group did not become stronger.
That is to say, the IQ of the experimental mice of Wu Junqiang's group after SHANK3 gene editing remains unchanged, which is still at an ordinary level.
"The experimental mice of Wu Junqiang's group are worth continuing research." Shen Qi gave the above instructions.
"Okay, I understand!" Wu Junqiang rubbed his hands excitedly. His little friend will not be executed for the time being. His experimental plan has not been proved to be the most suitable plan, but it has not been completely rejected.
The five experimenters personally selected their rats, took care of them, and fed them, and they had more or less affection for their little friends.
A moment of life is also life. If you can give your friends a way to live, even if they live for a few more days, the experimenters are reluctant to immediately kill them with their own hands.
Thirty rats were killed and ten rats were kept. So far, the rats in the Han Meng group are in the best condition.
Han Meng designed a new T-maze route, and his first three experimental mice achieved better results in the maze than before they received the SHANK3 gene editing.
"Han Meng's group of experimental mice is very promising." Shen Qi finally received a piece of good news that seemed to be good.
"Brother Meng, this group of rats, their learning ability has become stronger!" Other experimenters gathered around to watch.
Rat No. 4 in Hanmeng's group entered the T-maze. It was a female rat.
Scientists have verified that females in this category of Wistar rats are smarter than males.
The essential reason why female mice are smarter still needs to be further confirmed.
But even smart Wistar females have a rightward bias.
Before the gene editing, the No. 4 female mouse in Hanmeng's group could only walk out of a T-maze that was completely right-handed.
In this new T-maze, Han Meng set up two right-left T-junctions.
After the first three female mice failed a few times, remembering the right and wrong routes, they walked out of the maze and ate food.
Female No. 4 fared even better, failing only twice before getting out of the maze.
Female rat 4's right-handed preference was still the main trait, but at the same time, her learning ability became significantly stronger.
When it realizes that there is no food going to the right, it makes a change and chooses to go left at the same intersection.
Cui Hualin was amazed: "Rat No. 4 is quite smart! If it fails once at an intersection, it can remember that the left direction is correct, and choose to go left in the next attempt! Brother Meng, it seems that your gene editing method is very reliable. what!"
(End of this chapter)
Five experimenters entered the observation phase.
Five groups of rats were numbered as Han Meng group, Cui Hualin group, Tang Yaxing group, Du Yuan group and Wu Junqiang group, half of which were male and half male.
Miracle did not happen for a while, but tragedy happened soon.
After the anesthesia effect of the rats in the Du Yuan group ended, they died one after another within a day.
The experimental record is:
Mouse No. 1 in the Du Yuan group died at 12:42 due to intracranial hemorrhage.
Mouse No. 2 in the Du Yuan group died at 12:43 due to intracranial hemorrhage.
……
Mouse No. 10 in the Du Yuan group died at 12:51 due to intracranial hemorrhage.
To be precise, the 10 experimental mice in Du Yuan's group died one after another within 10 minutes, with an average of one dying per minute.
The cause of death was the same, both were due to intracranial hemorrhage.
"Hey, I failed." Du Yuan was so annoyed that his experimental plan proved to be a complete failure. Ten of his friends died suddenly and died in the laboratory before they had time to take the IQ test.
Du Yuan could only be annoyed for 1 minute. He had to race against time to dissect the 10 dead experimental mice. The main work content was to dissect and analyze the brain tissue of the experimental mice, sum up experience and lessons, and accumulate valuable data for the next experimental design.
Gene-editing experiments on living organisms do have risks.
Du Yuan just modified a gene of the experimental mice, which led to the annihilation of his experimental mice in a very short time.
"Brother, don't be discouraged, failure is the mother of success." Han Meng comforted Du Yuan, and he added: "You should sort out the analysis report of your experimental data as soon as possible, and give your conclusion, in the end it is homologous recombination. Is there a problem with the editing method, or is there a problem with your path selection based on this method? We can only take the exclusion method now, and try one by one until we find the relatively correct method and specific path.”
While Du Yuan summed up his experience and lessons, the other four experimenters continued to observe the rats in their group.
Soon after, Shen Qi joined the observers. He noticed that the rats in Cui Hualin's group became very manic. The rats in this group saw whoever bit someone, and bit the same kind if they couldn't bite, and bit the cage if they couldn't bite the same kind. metal net.
"Squeak!"
The rats in Cui Hualin's group bared their teeth and grinned hideously. Now they don't like fresh fruits and vegetables, they just want to bite live things.
"Hey, I failed." Cui Hualin sighed. His little friend was so crazy after gene editing that he couldn't take an IQ test at all.The craziest rat bit off its own front foot.
The smell of blood drove the rat crazy, slamming against the metal mesh, trying to break through the cage to bite the living creatures outside the cage.
Shen Qi patted Cui Hualin on the shoulder: "Extract living cells, preserve brain tissue, and then execute them."
"Director Shen, why don't we observe it for a while?" Cui Hualin was unwilling to fail like this, and he still had a glimmer of hope.
Shen Qi shook his head: "No need to continue to observe, all the experimental mice in your group will be executed. I want to see their raw data. Unexpectedly, the modification of their SHANK3 gene affects their neurons. This effect It's irreversible, and they're probably going to get even crazier."
"Okay..." Cui Hualin executed his friend with tears in his eyes.
Before being executed, Cui Hualin first used atomization anesthesia to stun his little friend, extract living cells, and then execute them by dislocation, dissection, and preservation of various organs and brain tissues.
There is no good news, and bad news comes one after another.
The rats in the Tang Yaxing group did not show crazy aggressiveness, but they became extremely autistic. They curled up in the corner of the cage motionless, like a stationary mouse with hair.
"Your group of autistic experimental mice cannot carry out follow-up experiments. Extract living cells and brain tissue for preservation, and then put them to death. I want to see their raw data." Shen Qi gave an order.
"It's a pity, it's a pity." Tang Yaxing shook his head and sighed, then executed his little friend.
At present, one group of rats died due to their own reasons, and the other two groups of rats with abnormal behavior were killed by the experimenter.
The progress of human science is inseparable from the contributions made by these experimental animals.
Scientific research continues, and the rats continue to contribute to the advancement of human science throughout their short lives.
After observation and various physical examinations, the experimental mice in the Hanmeng group and Wu Junqiang's group were temporarily normal in terms of physical indicators and animal behavior, and could be tested by T-maze.
I don't know if it's good news or bad news, but the T-maze test scores of the experimental mice in Wu Junqiang's group were the same as before.
This group of rats encountered a T-shaped junction in the T-maze, and their choice was always to go to the right.
Most rodents have the characteristic of one-way preference, and the Wistar rats selected by Shen Qi's team prefer rightward.
The T maze route designed by Wu Junqiang is eighteen right and one left.
Wistar rats continued to the right for 18 times and then left once to get out of the maze, thereby obtaining the food placed at the exit of the maze.
The spatial learning ability of the rats in the Wu Junqiang group did not become stronger.
That is to say, the IQ of the experimental mice of Wu Junqiang's group after SHANK3 gene editing remains unchanged, which is still at an ordinary level.
"The experimental mice of Wu Junqiang's group are worth continuing research." Shen Qi gave the above instructions.
"Okay, I understand!" Wu Junqiang rubbed his hands excitedly. His little friend will not be executed for the time being. His experimental plan has not been proved to be the most suitable plan, but it has not been completely rejected.
The five experimenters personally selected their rats, took care of them, and fed them, and they had more or less affection for their little friends.
A moment of life is also life. If you can give your friends a way to live, even if they live for a few more days, the experimenters are reluctant to immediately kill them with their own hands.
Thirty rats were killed and ten rats were kept. So far, the rats in the Han Meng group are in the best condition.
Han Meng designed a new T-maze route, and his first three experimental mice achieved better results in the maze than before they received the SHANK3 gene editing.
"Han Meng's group of experimental mice is very promising." Shen Qi finally received a piece of good news that seemed to be good.
"Brother Meng, this group of rats, their learning ability has become stronger!" Other experimenters gathered around to watch.
Rat No. 4 in Hanmeng's group entered the T-maze. It was a female rat.
Scientists have verified that females in this category of Wistar rats are smarter than males.
The essential reason why female mice are smarter still needs to be further confirmed.
But even smart Wistar females have a rightward bias.
Before the gene editing, the No. 4 female mouse in Hanmeng's group could only walk out of a T-maze that was completely right-handed.
In this new T-maze, Han Meng set up two right-left T-junctions.
After the first three female mice failed a few times, remembering the right and wrong routes, they walked out of the maze and ate food.
Female No. 4 fared even better, failing only twice before getting out of the maze.
Female rat 4's right-handed preference was still the main trait, but at the same time, her learning ability became significantly stronger.
When it realizes that there is no food going to the right, it makes a change and chooses to go left at the same intersection.
Cui Hualin was amazed: "Rat No. 4 is quite smart! If it fails once at an intersection, it can remember that the left direction is correct, and choose to go left in the next attempt! Brother Meng, it seems that your gene editing method is very reliable. what!"
(End of this chapter)
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