Xueba's life simulator

Chapter 71 Counting Biomolecules Using Bayesian Inference
On June [-]st, Zhou Ming finally started his thesis defense.

The thesis advisor arranged by the school for Zhou Ming is Yi Huaqing, the dean of the School of Engineering, Metal Engineering University, and there are four judges for this defense.

One of them is Huang Zhixing, the principal of Metalworking University, one is Mr. Liu, a teacher of Zhou Ming's bioseparation engineering class in the second semester of Zhou Ming's junior year, and the other is also a teacher who taught Zhou Ming's course before.

And the fourth judge was Yi Huaqing who should have been avoided.

In fact, with Zhou Ming's current strength, his knowledge and vision in this area, he is enough to be Yi Huaqing's mentor, but the form still needs to be changed, so the school arranged for Yi Huaqing who has a good relationship with him as his mentor.

Because Zhou Ming's graduation was quite special, Yi Huaqing, who should have been avoided, also sat down this time and became one of the judges for Zhou Ming's thesis defense.

Before several teachers entered the classroom, Zhou Ming had already copied the PPT he made to the computer in the defense classroom in advance.

Although all the teachers present knew Zhou Ming, Zhou Ming still made a self-introduction according to the rules, and then began to talk about his graduation thesis this time.

Before Zhou Ming could speak, the topic of his thesis defense appeared on the PPT. The four tutors in the audience were also a little surprised after seeing the topic on the PPT.

They didn't expect the topic of Zhou Ming's graduation thesis this time, but when they thought about Zhou Ming's talent in mathematics and the computer paper he published, they felt that it was not so strange.

Among these people, the most surprised one was Yi Huaqing. Although he was Zhou Ming's tutor, Zhou Ming had never told him what the title of his graduation thesis was before. He thought that Zhou Ming's graduation thesis this time was the one he had submitted before. "Cell" talks about several cell culture methods.

“The title of my graduation thesis this time is [Counting biomolecules using Bayesian inference]. It mainly uses a combination of Bayesian inference, physical modeling and Markov chain Monte Carlo sampling to allow the counting of biomolecules in cell clusters. Accurate inferences about numbers and their light physical states."

Bayesian reasoning is an inductive reasoning method discovered by the British priest Bayes. It is a new reasoning method developed on the basis of classic statistical inductive reasoning - estimation and hypothesis testing.Compared with the classic statistical induction method, Bayesian inference must not only draw conclusions based on the currently observed sample information, but also based on the past experience and knowledge of the reasoner.

Bayesian inference is used in a wide variety of fields, including science, engineering, philosophy, medicine, sports, law, and more.

Zhou Ming originally planned to use the paper he submitted to "cell" to fool this graduation defense, but then Zhou Ming thought about it and felt that this was his undergraduate graduation thesis after all, and it was only this time in his life, and He has so much biological knowledge in his mind that there is no need to be so frugal.

Therefore, Zhou Ming changed his original mind a few days before the defense and chose this paper as his graduation thesis.

"Biomolecule clusters are hotspots of cellular activity and signal transduction. Increasing the proximity of biomolecules within clusters, thereby improving the signal-to-noise ratio of molecular sensing, increasing biochemical reaction rates, and locating signal transmission through environmental biophysical engineering, these clusters It can accommodate dozens to hundreds or even more biomolecules.

Since the biological activity of these clusters is largely determined by the number of clustered biomolecules, counting them becomes crucial to provide the required conditions for biological signal transduction.However……"

The time for the self-reported thesis is very short, so Zhou Ming's PPT is not long. He talked for five or six minutes, and then it was over.

Thesis defense is called thesis defense because the focus is on the defense. Therefore, after Zhou Ming briefly described his thesis, the four defending teachers in the audience began to question Zhou Ming one by one.

"How do you understand Bayesian inference?" The first person to ask Zhou Ming was Teacher Liu.

To be honest, Zhou Ming’s paper touches on the blind spot of Teacher Liu’s knowledge. In fact, this paper not only touches on the blind spot of Teacher Liu’s knowledge. Except for Huang Zhixing, who covers a wide range of subjects, everyone else present None of the three knew much about this aspect.

Strictly speaking, although Zhou Ming's paper can be regarded as belonging to the category of biology, in more detail, it actually belongs to natural computing science.

"...Bayesian inference is an expansion of Bayes' theorem in probability theory, and it has a wide range of applications. In my paper, the Bayesian method and model architecture both illustrate..." Zhou Ming began to answer the first question from the respondent teachers.

After that, the other three defense judges also asked Zhou Ming their questions one by one, and Zhou Ming also answered their questions in detail.

Zhou Ming's answer made these teachers very satisfied. At least they could understand Zhou Ming's answer to their questions.

……

"I wish you a bright future." Finally, when the defense was coming to an end, Zhou Ming's nominal mentor, Yi Huaqing, took the lead in sending Zhou Ming his best wishes.

After Yi Huaqing's blessing, the other three teachers also sent the same blessing to Zhou Ming.

"Zhou Ming, the quality of your graduation thesis is still as high as ever! If you submit it, it will definitely be fine. You should know that the school has recently issued a new policy. If your thesis can be published District, you can also get 6 yuan." After the defense, two teachers left first, but Yi Huaqing and Huang Zhixing did not leave in a hurry. This is what Huang Zhixing said to Zhou Ming.

"Principal, I'm almost graduating. Even if I'm accepted by the first district, it won't be rewarded by our school, right?" Hearing what the principal said, Zhou Ming didn't understand. When those journals published his papers, he would After graduation, they may even have already taken classes at the University of Science and Technology of China.

"Of course you can. Although you had already graduated when the thesis was published, you still hadn't graduated when you submitted it! This shows that your thesis was still completed at our Metalworking University, and this will not affect our publicity. As long as This meets the requirements, and you can still get the reward." Huang Zhixing explained to Zhou Ming affirmatively.

After hearing what Huang Zhixing said, Zhou Mingke became interested.

Although the journals that reward 20 yuan are only "nature" and "science", "cell" is not among them, which makes Zhou Ming feel a little regretful.

But there are still 18, plus two other mathematics papers that have not yet been published, which can be regarded as area one, so there are three [-], a total of [-].

If Zhou Ming's paper is submitted to the first district again, it will be another [-].

In this way, a total of 24.

"Then I'll submit the article as soon as I get back." When he thought that he would be able to spend more than 20 yuan on the school for nothing after graduation, Zhou Ming immediately said to the principal with a smile.

After that, Zhou Ming chatted with Huang Zhixing and Yi Huaqing about other topics, mainly about the graduation ceremony, graduation certificate and degree certificate.

Zhou Ming didn’t know about outstanding undergraduate graduates of Metalworking University before, let alone applied for it, but this time when he chatted with Principal Huang and Dean Yi, they told him clearly that he not only wanted to participate in this 15 At the graduation ceremony, he was still an outstanding graduate.

Moreover, the school also decided to appoint Zhou Ming as the representative of outstanding graduates. He will speak on behalf of all the 15th class of graduates of JJTU on the day of the graduation ceremony.

Naturally, Zhou Ming's degree certificate and diploma cannot be obtained until he attends the graduation ceremony.

After all, the school knows that Zhou Ming's future development will definitely be promising, and now there is only this last chance. They have to let him show up more and leave more photos in the school.

(End of this chapter)